HOCl‐triggered amino or carboxyl uncaging platform and its application for imaging and drug design

The overproduction of hypochlorous acid (HOCl) is highly correlated with diseases such as atherosclerosis, rheumatoid arthritis and cancer. Whilst acting as a marker of these diseases, HOCl might also be used as an activator of prodrugs or drug delivery systems for the treatment of the corresponding disease, an area that is so far unexplored. In this work, a new platform has been developed that can be used to design and synthesize HOCl probes that integrate detection, imaging and therapeutic functions. The probes derived from this platform can be used to detect HOCl using both NIR emission and the naked eye in vitro, with high sensitivity and selectivity at ultralow concentrations (the detection limit is at the nM level). Basal levels of HOCl can be imaged in HL‐60 cells without special stimulation. Moreover, the probes provided by this platform can rapidly uncage amino or carboxyl groups from prodrugs during HOCl detection and imaging to realize a therapeutic effect. This platform thus provides new opportunities for the design of multifunctional probes that integrate detection, imaging and therapeutic functions.

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