Dehydrocostus lactone (DHC) Suppresses Estrogen Deficiency-Induced Osteoporosis.

Dehydrocostus lactone (DHC) Suppresses Estrogen Deficiency-Induced Osteoporosis.

Biochem Pharmacol. 2019 Feb 02;:

Authors: Li Z, Yuan G, Lin X, Liu Q, Xu J, Lian Z, Song F, Zheng J, Xie D, Chen L, Wang X, Feng H, Zhou M, Yao G

Abstract
Osteoporosis is a chronic bone lytic disease, because of inadequate bone ossification and/or excessive bone resorption. Even though drugs are currently available for the treatment of osteoporosis, there remains an unmet need for the development of more specific novel agents with less adverse effects. Dehydrocostus lactone (DHC), a natural sesquiterpene lactone, was previously found to affect the differentiation of inflammatory cells by the inhibiting NF-κB pathways, and garnered much interest for its anti-cancer properties via SOCS-mediated cell cycle arrest and apoptosis. As NF-κB pathway plays an essential role in osteoclast differentiation, we sought to discover the biological effects of DHC on osteoclast differentiation and resorptive activity, as well as the underlying mechanisms on these effects. Our research found that DHC inhibited RANKL-induced osteoclast differentiation, bone resorption and osteoclast specific genes expression via suppression of NF-κB and NFAT signaling pathways in vitro. We further demonstrated that DHC protected against ovariectomy (OVX)-induced osteoprosis in the mouse model and the protective effects may be mediated through the attenuation of NF-κB signaling pathway. Thus, this study provides insight that DHC might be used as a potential pharmacological treatment for osteoporosis.

PMID: 30721671 [PubMed - as supplied by publisher]

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