Glioblastoma Multiforme of the Conus Medullaris - Management Strategies and Complications.

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Glioblastoma Multiforme of the Conus Medullaris - Management Strategies and Complications.

World Neurosurg. 2019 Jan 10;:

Authors: Goodarzi A, Thaci B, Toussi A, Karnati T, Kim K, Fragoso R

Abstract
Primary spinal glioblastoma multiforme (GBM) of the conus medullaris is a rare and devastating pathology. Presenting symptoms commonly include progressive neurologic deficits in the lower extremities, bowel and bladder dysfunction, and low back pain. Histologically, these tumors have high-grade features similar to their intracranial counterparts, however, recent advancements in the field of molecular oncology are beginning to elucidate a unique molecular blueprint for these spinal gliomas. Given the lack of standardized treatment strategies, we present our institutional experience in treating a small series of patients suffering from conus medullaris GBM and review the literature on relevant molecular markers, management strategies, and complication avoidance for this malignant pathology.

PMID: 30639501 [PubMed - as supplied by publisher]

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