Ultrahigh specificity in a network of computationally designed protein-interaction pairs

Ultrahigh specificity in a network of computationally designed protein-interaction pairs

Ultrahigh specificity in a network of computationally designed protein-interaction pairs, Published online: 11 December 2018; doi:10.1038/s41467-018-07722-9

The molecular basis of ultrahigh specificity in protein-protein interactions remains obscure. The authors present a computational method to design atomically accurate new pairs exhibiting >100,000-fold specificity switches, generating a large and complex interaction network.

from A via a.sfakia on Inoreader https://ift.tt/2UAlqFB