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Σάββατο 22 Δεκεμβρίου 2018

Total Synthesis of (–)‐Merochlorin A

The first asymmetric total synthesis of the meroterpenoid (–) merochlorin A is described. The route features enantiospecific gold‐catalyzed tandem 1,3‐acyloxy migration/Nazarov/aldol reaction sequence to furnish the bicyclo[3.3.0]octane core in a single step from a linear propargylic 1,3‐enyne aldehyde. After completion of the central skeleton by reductive enol lactone rearrangement, late stage Diels–Alder cycloaddition/aromatization sequence installed the resorcinol. An additional salient feature of the synthesis is the assignment of the absolute configuration, which had not been determined previously.



from A via a.sfakia on Inoreader http://bit.ly/2QMy3ii

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Δημοσίευση σχολίου

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

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! # Ola via Alexandros G.Sfakianakis on Inoreader