The efficacy of gamma knife radiosurgery for cavernous malformation: a meta-analysis and review.

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The efficacy of gamma knife radiosurgery for cavernous malformation: a meta-analysis and review.

World Neurosurg. 2018 Dec 21;:

Authors: Wen R, Shi Y, Gao Y, Xu Y, Xiong B, Li D, Gong F, Wang W

Abstract
OBJECTS: This meta-analysis is to evaluate the clinical efficacy of gamma knife radiosurgery for treating cavernous malformation.
METHODS: PUBMED, OVID EMBASE, and OVID MEDLINE electronic databases are searched. The primary outcome is hemorrhage rate and this meta-analysis is performed with REVMAN 5.3.
RESULTS: 9 studies are included in this meta-analysis. The overall RR of hemorrhage rate of pre-GKRS and post-GKRS is 6.08(95% CI: 5.04-7.35). The overall RR is 3.03(95% CI: 2.65-4.11) between the hemorrhage rate of pre-GKRS and the first 2 years of post-radiosurgery, and the overall RR is 12.13 (95% CI: 1.73-85.07) comparing pre-GKRS with 2 years after GKRS. There is no significant difference of the hemorrhage rate between the first 2 years of post-radiosurgery and 2 years after GKRS (RR =2.81, 95% CI: 0.20-13.42). The neurological deficiency is the commonest radiosurgery related complications.
CONCLUSION: Patients with cerebral CMs, especially who were deep seated and surgically inaccessible, seems to benefit from GKRS due to a reduction of annual hemorrhage rate in the first 2 years, and after that time, despite of a number of cases that suffer from negative side effects of radiation.

PMID: 30583131 [PubMed - as supplied by publisher]

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