The Asymmetric Aza-silyl-Prins Reaction: Synthesis of Enantiopure Piperidines.
Org Lett. 2018 Dec 28;:
Authors: Mittapalli RR, Guesné SJJ, Parker RJ, Klooster WT, Coles SJ, Skidmore J, Dobbs AP
Abstract
The design and development of the first asymmetric aza-silyl-Prins reaction is reported, giving rise to valuable and diverse piperidines and pipecolic acid derivatives in both high yields and as single enantiomers. The creation of a novel chiral auxiliary-homoallylic amine for the aza-silyl-Prins reaction is essential to its success.
PMID: 30592613 [PubMed - as supplied by publisher]
from A via a.sfakia on Inoreader http://bit.ly/2rWbBEO
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,