PTP1B markedly promotes breast cancer progression and is regulated by miR-193a-3p.

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PTP1B markedly promotes breast cancer progression and is regulated by miR-193a-3p.

FEBS J. 2018 Dec 07;:

Authors: Yu M, Liu Z, Liu Y, Zhou X, Sun F, Liu Y, Li L, Hua S, Zhao Y, Gao H, Zhu Z, Na M, Zhang Q, Yang R, Zhang J, Yao Y, Chen X

Abstract
The protein tyrosine phosphatase PTP1B, which is encoded by PTPN1, is a ubiquitously expressed non-receptor protein tyrosine phosphatase. PTP1B has long been known to negatively regulate insulin and leptin receptor signalling. Recently, it was reported to be aberrantly expressed in cancer cells and to function as an important oncogene. In this study, we found that PTP1B protein levels are dramatically increased in breast cancer tissues and that PTP1B promotes the proliferation, and suppresses the apoptosis, of both HER2-positive and triple-negative breast cancer cell lines. Bioinformatics analysis identified that the miRNA, miR-193a-3p, might potentially target PTP1B. We demonstrate that miR-193a-3p regulates PTP1B in breast cancer cells and that it regulates the proliferation and apoptosis of breast cancer cells by targeting PTP1B, both in vitro and in vivo. In conclusion, this study confirms that PTP1B acts as an oncogene in breast cancer and demonstrates that miR-193a-3p can serve as a tumour suppressor gene in breast cancer by targeting PTP1B. This article is protected by copyright. All rights reserved.

PMID: 30548198 [PubMed - as supplied by publisher]

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