Comparison of Abbott Architect®, Siemens Immulite® and Diasorin Liaison® for determination of Epstein–Barr virus serological diagnosis

Publication date: Available online 7 November 2017
Source:Diagnostic Microbiology and Infectious Disease
Author(s): Catherine François, Christine Segard, Maryline Bouvier, Martine Stefanski, Christine Pannier, Patricia Zawadzki, Catherine Roussel, Denise Hecquet, Gilles Duverlie, Etienne Brochot, Sandrine Castelain
This study compared the performance of three automated immunoassays, Architect® (Abbott), Immulite^® (Siemens) and Liaison^® (Diasorin), for Epstein–Barr virus (EBV) serology. Ninety-one serum samples collected in Amiens University Hospital were analyzed for the presence of Viral Capsid Antigen (VCA) IgG and IgM and Epstein–Barr Nuclear Antigen (EBNA) IgG. The agreement between the three assays was calculated for each marker individually and for determination of the EBV profile, based on interpretation of the combination of these three EBV markers.Although similar results were obtained with Architect^® and Liaison^®, several discordant results were observed with Immulite^®, particularly for EBNA IgG. A large number of EBNA IgG-positive results was observed, which interfered with interpretation of the EBV profile. In contrast, Immulite^® performed similarly to the two other assays for detection of VCA IgM.



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