The wnt/β-catenin pathway is deregulated in cemento-ossifying fibromas

Cemento-ossifying fibroma (COF) is an odontogenic tumour whose surgical treatment is associated with morbidities. Its molecular pathogenesis is unclear, limiting any attempt to tailor treatments. The purpose of this study was to investigate mutations in 50 oncogenes and tumour suppressor genes, including APC and CTNNB1 in which mutations have been previously reported in COF. In addition, we assessed the transcriptional levels of the Wnt/β-catenin pathway genes in COF.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2gErABC
via IFTTT