Stress2TF: a manually curated database of TF regulation in plant response to stress

Publication date: 5 January 2018
Source:Gene, Volume 638
Author(s): Xiaodan Zhang, Chensong Yao, Sicong Fu, Hongdong Xuan, Shuxian Wen, Chao Liu, Fangdong Li, Aiguo Liu, Shoudong Bi, Shihua Zhang, Shaowen Li
Considerable studies demonstrate that plant transcription factors (TFs) play key regulatory roles in abiotic/biotic stress conditions, such as drought and pathogen attack. However, there is no effort dedicated to curate experimentally validated stress-TF regulatory relationships from these individual reports into a central database, which put an obstacle in the exploration of stress-TF regulations in plants. To address this issue, we presented a literature-curated database 'Stress2TF' that currently documented 1533 regulatory relationships between 71 abiotic/biotic stresses and 558 TFs in 47 plant species. Each entry in Stress2TF contains detailed information about a stress-TF relationship such as plant name, stress name, TF and brief description of stress-TF relationship. Stress2TF provided a user-friendly interface for entry browse, search and download. In addition, a submission page and several useful tools (e.g., BLAST, network visualization) were integrated. Stress2TF may be a valuable resource for the research of stress-TF regulatory mechanisms in plants. Stress2TF is available at http://ift.tt/2y1x3w9.



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