IJMS, Vol. 18, Pages 2207: Tubulin Post-Translational Modifications and Microtubule Dynamics

IJMS, Vol. 18, Pages 2207: Tubulin Post-Translational Modifications and Microtubule Dynamics

International Journal of Molecular Sciences doi: 10.3390/ijms18102207

Authors: Dorota Wloga Ewa Joachimiak Hanna Fabczak

Microtubules are hollow tube-like polymeric structures composed of α,β-tubulin heterodimers. They play an important role in numerous cellular processes, including intracellular transport, cell motility and segregation of the chromosomes during cell division. Moreover, microtubule doublets or triplets form a scaffold of a cilium, centriole and basal body, respectively. To perform such diverse functions microtubules have to differ in their properties. Post-translational modifications are one of the factors that affect the properties of the tubulin polymer. Here we focus on the direct and indirect effects of post-translational modifications of tubulin on microtubule dynamics.

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