A histopathological study of autopsied thyroid

Murari Mohan Das, Bhawna Bhutoria Jain, Biswajit Sukul, Sarbani Chattopadhyay

Thyroid Research and Practice 2017 14(3):112-117

Introduction: To find the prevalence and frequency of different thyroid lesions, especially papillary carcinoma in our population, we conducted a histopathological study of thyroid glands obtained from medicolegal autopsy in cases with no obvious history of thyroid disease in our region. Methods: The study population comprised deceased undergoing medicolegal autopsy in police morgue under the Forensic Medicine Department of our institution over a period of 18 months. Thyroid gland was dissected out at the time of autopsy. Gross and histopathological findings of each specimen were documented in details. The data were collected, compiled, and tabulated, and statistical analysis was done using IBM SPSS version 20 software and Microsoft Office Excel 2007. Results: The total number of samples was 240. The mean age of the study participants was 42.35 years. About 60.4% were male, and 39.6% were female. Mean weight of thyroid was 34.08 g. In 56 cases (23.3%), single or multiple nodules were observed on cut section of thyroid. Minimum and maximum size of the nodules was 0.40 and 1.30 cm, respectively, with mean size of 0.74 cm in diameter. On microscopic examination, 54.6% of the cases were seen to be normal in histological examination while 45.4% had one or other histopathological changes. Among the nonneoplastic lesions, the most common lesions seen were nodular colloid goiter (20%) and lymphocytic thyroiditis (7.5%). Papillary thyroid carcinoma was seen in 5 (2.1%) cases. Among the five cases of papillary carcinoma, three cases had papillary microcarcinoma (<1 cm). All cases of papillary carcinoma showed strong diffuse reactivity with cytokeratin-19 immunostain.

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