Suvorexant as an orexin antagonist may regulate serum glucose levels in psychiatric patients with insomnia.

Suvorexant as an orexin antagonist may regulate serum glucose levels in psychiatric patients with insomnia.

Psychiatry Clin Neurosci. 2017 Sep 25;:

Authors: Nakamura M, Nagamine T

Abstract
Disrupting circadian rhythms and sleep disorder have been implicated in the dysregulation of blood glucose and insulin levels and increasing the risk of type 2 diabetes (T2D). Hypothalamic orexin neurons, which are known to regulate sleep/wake stability, feeding behavior, autonomic nerve activity and energy metabolism, can bidirectionally regulate hepatic gluconeogenesis via control of autonomic balance, leading to generation of the daily blood glucose oscillation and preventing insulin resistance.(1).

PMID: 28945327 [PubMed - as supplied by publisher]

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