Patient-oriented toxicity endpoints after head and neck reirradiation with intensity modulated radiation therapy

Reirradiation (reRT) is a treatment option for select patients with recurrent or second primary squamous cell carcinoma of the head and neck (SCCHN) [1] and can result in prolonged disease control and even cure in select patients [2]. However, improvements in local-regional control rates must be balanced with the significant risks of treatment-related toxicity. Shared-decision making regarding the benefit of reRT must involve a discussion of possible side effects of treatment and the time course over which these side effects are likely to occur.

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