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Δευτέρα 18 Σεπτεμβρίου 2017

IJMS, Vol. 18, Pages 2001: The Impact of Non-Lethal Single-Dose Radiation on Tumor Invasion and Cytoskeletal Properties

IJMS, Vol. 18, Pages 2001: The Impact of Non-Lethal Single-Dose Radiation on Tumor Invasion and Cytoskeletal Properties

International Journal of Molecular Sciences doi: 10.3390/ijms18092001

Authors: Tim Hohmann Urszula Grabiec Carolin Vogel Chalid Ghadban Stephan Ensminger Matthias Bache Dirk Vordermark Faramarz Dehghani

Irradiation is the standard therapy for glioblastoma multiforme. Glioblastoma are highly resistant to radiotherapy and the underlying mechanisms remain unclear. To better understand the biological effects of irradiation on glioblastoma cells, we tested whether nonlethal irradiation influences the invasiveness, cell stiffness, and actin cytoskeleton properties. Two different glioblastoma cell lines were irradiated with 2 Gy and changes in mechanical and migratory properties and alterations in the actin structure were measured. The invasiveness of cell lines was determined using a co-culture model with organotypic hippocampal slice cultures. Irradiation led to changes in motility and a less invasive phenotype in both investigated cell lines that were associated with an increase in a "generalized stiffness" and changes in the actin structure. In this study we demonstrate that irradiation can induce changes in the actin cytoskeleton and motility, which probably results in reduced invasiveness of glioblastoma cell lines. Furthermore, "generalized stiffness" was shown to be a profound marker of the invasiveness of a tumor cell population in our model.



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