IJMS, Vol. 18, Pages 1629: Overview of β-Glucans from Laminaria spp.: Immunomodulation Properties and Applications on Biologic Models

IJMS, Vol. 18, Pages 1629: Overview of β-Glucans from Laminaria spp.: Immunomodulation Properties and Applications on Biologic Models

International Journal of Molecular Sciences doi: 10.3390/ijms18091629

Authors: Patrícia Bonfim-Mendonça Isis Capoci Flávia Tobaldini-Valerio Melyssa Negri Terezinha Svidzinski

Glucans are a group of glucose polymers that are found in bacteria, algae, fungi, and plants. While their properties are well known, their biochemical and solubility characteristics vary considerably, and glucans obtained from different sources can have different applications. Research has described the bioactivity of β-glucans extracted from the algae of the Laminaria genus, including in vivo and in vitro studies assessing pro- and anti-inflammatory cytokines, vaccine production, inhibition of cell proliferation, and anti- and pro-oxidant activity. Thus, the objective of this article was to review the potential application of β-glucans from Laminaria spp. in terms of their immunomodulatory properties, microorganism host interaction, anti-cancer activity and vaccine development.

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