Two transmembrane dimers of the bovine papillomavirus E5 oncoprotein clamp the PDGF {beta} receptor in an active dimeric conformation [Biochemistry]

The dimeric 44-residue E5 protein of bovine papillomavirus is the smallest known naturally occurring oncoprotein. This transmembrane protein binds to the transmembrane domain (TMD) of the platelet-derived growth factor β receptor (PDGFβR), causing dimerization and activation of the receptor. Here, we use Rosetta membrane modeling and all-atom molecular dynamics simulations...

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