Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on V{gamma}9V{delta}2 T cell activation [Immunology and Inflammation]

Human Vγ9Vδ2 T cells respond to microbial infections as well as certain types of tumors. The key initiators of Vγ9Vδ2 activation are small, pyrophosphate-containing molecules called phosphoantigens (pAgs) that are present in infected cells or accumulate intracellularly in certain tumor cells. Recent studies demonstrate that initiation of the Vγ9Vδ2 T...

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