Interleukin-8 in cancer pathogenesis, treatment and follow-up

Immune responses are characterized by the activation of leukocytes and migration of hematopoietic cells to secondary lymphoid organs or to the site of inflammation [1]. Under inflammatory conditions, the expression of specific chemokines, a class of soluble small proteins with potent chemotactic activity, is markedly up-regulated [2]. Chemokines constitute a large family of structurally related polypeptide signaling molecules characterized by their ability to promote the directed chemotaxis of leukocytes.

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