Extended Interneuronal Network of the Dentate Gyrus

Publication date: 8 August 2017
Source:Cell Reports, Volume 20, Issue 6
Author(s): Gergely G. Szabo, Xi Du, Mikko Oijala, Csaba Varga, Jack M. Parent, Ivan Soltesz
Local interneurons control principal cells within individual brain areas, but anecdotal observations indicate that interneuronal axons sometimes extend beyond strict anatomical boundaries. Here, we use the case of the dentate gyrus (DG) to show that boundary-crossing interneurons with cell bodies in CA3 and CA1 constitute a numerically significant and diverse population that relays patterns of activity generated within the CA regions back to granule cells. These results reveal the existence of a sophisticated retrograde GABAergic circuit that fundamentally extends the canonical interneuronal network.

Graphical abstract

Teaser

Szabo et al. describe an extended interneuronal network in the hippocampal circuitry that supplies the dentate gyrus with GABAergic inhibition and includes external interneurons. Such boundary-crossing cells channel sharp-wave ripple-related activity patterns from the downstream CA regions back to the dentate gyrus.


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