Association of the Salivary Triggering Receptor Expressed on Myeloid Cells/ its Ligand Peptidoglycan Recognition Protein 1 Axis With Oral Inflammation Kidney Disease.

Association of the Salivary Triggering Receptor Expressed on Myeloid Cells/ its Ligand Peptidoglycan Recognition Protein 1 Axis With Oral Inflammation Kidney Disease.

J Periodontol. 2017 Aug 28;:1-17

Authors: Nylund KM, Ruokonen H, Sorsa T, Heikkinen AM, Meurman JH, Ortiz F, Tervahartiala T, Furuholm J, Bostanci N

Abstract
BACKGROUND: Triggering Receptor Expressed on Myeloid Cells (TREM-1) is a cell-surface receptor involved in amplification of inflammatory response to bacterial infections, along with its ligand peptidoglycan recognition protein 1 (PGLYRP1). TREM-1 is shed by matrix metalloproteinases (MMPs) to its soluble (s) form. The aim of the study was to investigate association of sTREM-1 and PGLYRP1 with oral inflammatory burden among chronic kidney disease (CKD) patients at predialysis and post-transplantation stages.
METHODS: 144 CKD patients were examined at predialysis and oral infection foci were treated prior to kidney transplantation. 53 patients of them were available for follow-up after transplantation. Oral inflammatory burden was assessed by Periodontal Inflammatory Burden Index (PIBI) and Total Dental Index (TDI). sTREM-1, PGLYRP1, IL-1β were measured in saliva by ELISA, and MMP-8 by IFMA.
RESULTS: In the predialysis stage, sTREM-1 and PGLYRP1 were positively associated with IL-1β, MMP-8 and PIBI. More specifically, patients with deeper PPD (≥ 2 sites with ≥ 6mm) had higher concentrations of salivary sTREM-1 and PGLYRP1 compared to those with shallower PPD. PGLYRP1 and IL-1β associated with a higher number of teeth (> 25). On the follow-up, higher PGLYRP1 and sTREM-1 were associated with one or more sites with ≥ 4mm PPD.
CONCLUSION: sTREM-1 and PGLYRP1 are elevated in CKD patients with poor oral health and positively correlate with the number of active periodontal pockets, following oral infection therapy. Moreover, they positively correlate with MMP-8 and IL-1β. Hence, salivary TREM-1- PGLYRP1 axis could be useful as diagnostic marker for oral infection within CKD patients.

PMID: 28846062 [PubMed - as supplied by publisher]

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