Antimicrobial susceptibility pattern of extended-spectrum beta-lactamases producing organisms isolated in a Tertiary Care Hospital, Bangladesh

Mohammad Jobayer, Zeenat Afroz, Sultana Shazeda Nahar, Ayesha Begum, Shahin Ara Begum, SM Shamsuzzaman

International Journal of Applied and Basic Medical Research 2017 7(3):189-192

Context: Infection caused by extended-spectrum beta-lactamases (ESBL) producing organism is a major problem regarding antibiotic resistance. Aims: The aim of this study was to find out the antibiogram of ESBL producing organisms isolated from various samples. Settings and Design: This cross-sectional study was carried out in the Department of Microbiology of a Tertiary Care Hospital, Dhaka, Bangladesh from January to June 2014. Subjects and Methods: One Hundred and seventy-nine ESBL producing Gram-negative organisms detected phenotypically by double-disc synergy test were enrolled in this study. Required data were collected from the records of the Microbiology laboratory. Results: ESBL production was detected in 16.07% (179/1114) of isolated organism. Of Escherichia coli, 15.75% were ESBL producers; 14.01% Pseudomonas spp., 36.84% Proteus spp., 18.57% Klebsiella spp., and 21.05% of Acinetobacter spp., were ESBL producers. Maximum (43.58%) ESBL producers were isolated from surgery departments, and wound swabs yielded majority (53%) of them. About 13% ESBL producers were isolated in outdoor patients mostly from community-acquired infections. Most ESBL producers were resistant to commonly used antibiotics. Carbapenems especially imipenem was the most effective drug showing excellent sensitivity; colistin and piperacillin/tazobactam also had better sensitivity result. Most of the ESBL producers showed a good sensitivity to amikacin, but all of them were highly resistant to ciprofloxacin. Conclusions: ESBL production should be detected routinely in all Microbiology laboratories. Infection control, rational use of antibiotics must be done promptly to prevent the development and spread of ESBL producing organisms.

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2vWnxKh
via IFTTT