Volatile Organic Compounds: Upcoming Role in Diagnosis of Invasive Mould Infections

AbstractPurpose of ReviewBreath testing for fungal respiratory infections has great promise as samples can be obtained by non-invasive, repeatable techniques that can be done on a wide range of patients including children, the confused and from those in the intensive care unit (ICU). We have reviewed progress toward development of test applicable to clinical practice.Recent FindingsMany volatile organic compounds (VOCs) have been identified, especially from key pathogens such asAspergillus fumigatus, but very few clinical trials have been performed. The most convincing of these demonstrated thatAspergillus species could be identified by gas chromatography with mass spectrometry in breath samples of at risk patients with high sensitivity (94%) and specificity (93%) compared with the Europea...

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