Publication date: Available online 26 July 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Elisa Carvalho de Siqueira, Silvia Ferreira de Sousa, Josiane Alves França, Marina Gonçalves Diniz, Thaís dos Santos Fontes Pereira, Rennan Garcias Moreira, Pablo Agustin Vargas, Ricardo Santiago Gomez, Carolina Cavalieri Gomes
Background: Glandular odontogenic cyst (GOC) is an uncommon developmental cyst. Its molecular pathogenesis is unclear and deep sequencing technologies may identify causative low-frequency variants in tumors. Objective: We investigated in GOC mutations in 50 genes commonly altered in human cancers Methods: Targeted next-generation sequencing was used to interrogate a panel of approximately 2,800 mutations in GOC. Results: Six missense single nucleotide variations (SNVs) were reported. Three SNVs (TP53 rs1042522, KDR rs1870377 and KIT rs3822214) are listed as "common SNPs" at the UCSC Genome Browser. The other SNVs (PIK3CA p.Glu689Lys, PIK3CA p.Ala708Thr and TP53 p.Leu289Phe) are predicted to have deleterious or damaging effects on the proteins, but they showed very low frequency in our samples and could not be further validated by orthogonal methods. Conclusion: No pathogenic SNV was detected in this cohort of GOC. Further studies with larger gene panels or whole exome sequencing are needed in order to reveal the genetic basis of GOC.
from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2uE5NQI
via IFTTT
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Αρχειοθήκη ιστολογίου
-
►
2023
(272)
- ► Φεβρουαρίου (141)
- ► Ιανουαρίου (131)
-
►
2022
(2066)
- ► Δεκεμβρίου (80)
- ► Σεπτεμβρίου (170)
- ► Φεβρουαρίου (190)
- ► Ιανουαρίου (203)
-
►
2021
(7399)
- ► Δεκεμβρίου (186)
- ► Σεπτεμβρίου (472)
- ► Φεβρουαρίου (851)
-
►
2020
(2517)
- ► Δεκεμβρίου (792)
- ► Σεπτεμβρίου (21)
- ► Φεβρουαρίου (28)
-
►
2019
(12076)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (4765)
- ► Ιανουαρίου (5155)
-
►
2018
(3144)
- ► Δεκεμβρίου (3144)
-
▼
2017
(66935)
- ► Δεκεμβρίου (1995)
- ► Σεπτεμβρίου (12424)
-
▼
Ιουλίου
(12782)
-
▼
Ιουλ 26
(379)
- Solid lipid nanoparticles improve octyl gallate an...
- Communication in pediatric oncology: State of the ...
- VIncristine, irinotecan, and temozolomide in child...
- Outcomes of matched sibling donor bone marrow tran...
- Novel activating BRAF fusion identifies a recurren...
- Management of chemotherapy-induced febrile neutrop...
- Reliable assessment of the incidence of childhood ...
- Rethinking reconsent when minors reach adult age i...
- Transverse myelitis as an unexpected complication ...
- On Heat and Mass Transfer within Thermally Shocked...
- BVH expansion allows for greater head, shoulders, ...
- Give boys vaccine to fight HPV pandemic, says expe...
- BVH expansion allows for greater head, shoulders, ...
- Diving into cancer recovery with hyperbaric | Quee...
- Push to raise head, neck cancer awareness - SBS
- Breast cancer family history leads to early breast...
- Giant oesophageal gastrointestinal stromal tumour ...
- Type I talon cusp on mandibular incisor
- Between fire and ice: refractory hypothermia and w...
- Through the Glass Brightly
- It Takes Two: One Resects, One Reconstructs
- Contributors
- Systemic Treatment for Squamous Cell Carcinoma of ...
- Multidisciplinary Approach to Head and Neck Cancer
- Psychosocial Distress and Distress Screening in Mu...
- Immunotherapy
- Veterans' Preferences for Remote Management of Chr...
- Through the Glass Brightly
- It Takes Two: One Resects, One Reconstructs
- Multidisciplinary Approach to Head and Neck Cancer
- Contributors
- Systemic Treatment for Squamous Cell Carcinoma of ...
- Psychosocial Distress and Distress Screening in Mu...
- Forthcoming Issues
- CME Accreditation Page
- Immunotherapy
- Copyright
- More than Just Mitoses: Complete Care of the Patie...
- Contents
- West Nile virus
- Identification of differentially expressed splice ...
- Toowoomba smoker, drinker warns: 'they took my voi...
- Guideline recommendations and antimicrobial resist...
- Associations of anthropometry since birth with sag...
- Profiles of children's social-emotional health at ...
- Respiratory syncytial virus: a systematic scientom...
- Medication incidents in primary care medicine: a p...
- Ability to join the workforce and work productivit...
- Common attributes in retired professional crickete...
- Recruitment and retention in a 10-month social net...
- “Analysis of the correlation between dental arch a...
- Targeted next-generation sequencing of glandular o...
- In Vitro Maturation of Human iPSC-Derived Neuroepi...
- Effect of superheated-steam roasting on physicoche...
- Simultaneous occurrence of fibroblastic osteosarco...
- Half the atoms inside your body came from across t...
- Galectin-8 regulates targeting of Gp135/podocalyxi...
- Palmitoylation is a prerequisite for dimerization-...
- The Alzheimer's Disease-protective CD33 splice var...
- Crystal structure of the human Polε B-subunit...
- Search for DNA Damage by Human Alkyladenine DNA Gl...
- Thrombospondin-1 (TSP-1), a new bone morphogenetic...
- Efficient Methylation of C2 in L-Tryptophan by the...
- Rise in e-cigarette use linked to increase in smok...
- The antibiotic course has had its day
- E-cigarette use and associated changes in populati...
- Push to raise head, neck cancer awareness - NEWS.c...
- – Androgen deprivation therapy and cardiovascular ...
- Mesenchymal stem/stromal cell extracellular vesicl...
- Facile assembly and loading of theranostic polymer...
- Harmful Contaminants Found In Florida Drinking Wat...
- Clinical Features of Psoriatic Arthritis: a Compre...
- Ahead of print: Comparison of two cold compression...
- BMJ: Euratom withdrawal will put patients at risk
- Impact of the Korean Diagnosis-Related Groups paym...
- Unilateral Headache Status after Intra-Aortic Ball...
- Electrochemical Evaluation of trans-Resveratrol Le...
- Hexavalent Chromium Removal from Model Water and C...
- A Correlation between the Higgs Mass and Dark Matter
- Extraction and Optimization of Natural Dye from Ha...
- Nontrivial Solutions for Time Fractional Nonlinear...
- Numerical and Experimental Investigation on the St...
- Determination of Selected Polycyclic Aromatic Comp...
- Case Report of a Satin Guinea Pig with Fibrous Ost...
- A Study of Time Series Model for Predicting Jute Y...
- Bearing Fault Detection by One-Dimensional Convolu...
- An Interstitial 4q Deletion with a Mosaic Compleme...
- Efficacy of CDK inhibitor dinaciclib in vitro and ...
- World Head and Neck Cancer day - ABC Online
- “Non è abbastanza malata, niente cure per lei”. Ma...
- Biomechanical evaluation of a novel hybrid reconst...
- The feasibility of cold atmospheric plasma in the ...
- World Head and Neck Cancer day - ABC Online
- World Head and Neck Cancer day - ABC Online
- Pathway discovery using transcriptomic profiles in...
- Liver disease predicts mortality in patients with ...
- Rise in e-cigarette use linked to increase in smok...
- The antibiotic course has had its day
- E-cigarette use and associated changes in populati...
- Smallest satellite ever paves way for planned inte...
-
▼
Ιουλ 26
(379)
Ετικέτες
Πληροφορίες
Τετάρτη 26 Ιουλίου 2017
Targeted next-generation sequencing of glandular odontogenic cyst: a preliminary study
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αναζήτηση αυτού του ιστολογίου
! # Ola via Alexandros G.Sfakianakis on Inoreader
-
Publication date: 1 May 2019 Source: Talanta, Volume 196 Author(s): Ruiqing Long, Te Li, Chaoying Tong, Lihui Wu, Shuyun Shi Abstract...
-
Oral Cancer Rapid Test Kit Market Rugged Expansion Foreseen by 2024 MilTech Oral cancer is one of the largest group of cancers ...
-
Related Articles SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,