Regulation of fetal male germ cell development by members of the TGF β superfamily

Publication date: Available online 19 July 2017 Source:Stem Cell Research Author(s): Cassy Spiller, Guillaume Burnet, Josephine Bowles There is now substantial evidence that members of the transforming growth factor-β (TGFβ family) regulate germ cell development in the mouse fetal testis. Correct development of germ cells during fetal life is critical for establishment of effective spermatogenesis and for avoiding the formation of testicular germ cell cancer in later life. Here we consider the evidence for involvement of various TGFβ family members, attempt to reconcile discrepancies and clarify what we believe to be the likely in vivo roles of these factors. (Source: Stem Cell Research)

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