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Δευτέρα 24 Ιουλίου 2017

Low SIRT3 expression contributes to tumor progression, development and poor prognosis in human pancreatic carcinoma

Publication date: Available online 23 July 2017 Source:Pathology - Research and Practice Author(s): Shanshan Huang, Xiong Chen, Jiawei Zheng, Yufang Huang, Li Song, Yin Yin, Jianping Xiong SIRT3, an important mitochondrial protein, may act as either an oncogene or tumor suppressor depending on the tumor-type. The aim of this study was to investigate the expression of SIRT3 in pancreatic carcinoma (PC) and its clinical association in PC patients. Immunohistochemistry was adopted to investigate the expression of SIRT3 in cancer and corrresponding adjacent non-cancer tissues across 79 patients with PC. The log-rank test and Cox hazard model were used to estimate the relationship between SIRT3 expression and prognosis. The staining results revealed that SIRT3 negative expression was more comm...

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

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