Frequent Loss of Inositol Polyphosphate-5-Phosphatase in Oropharyngeal Squamous Cell Carcinoma.

Frequent Loss of Inositol Polyphosphate-5-Phosphatase in Oropharyngeal Squamous Cell Carcinoma.

J Eur Acad Dermatol Venereol. 2017 Jul 11;:

Authors: Patel AB, Mangold AR, Costello CM, Nagel TH, Smith ML, Hayden RE, Sekulic A

Abstract
There is an incomplete understanding in the pathogenesis of oropharyngeal squamous cell carcinoma (OPSCC) and cancer broadly. It is essential to discover new pathways of normal cell-cycle regulation and oncogenesis. We identified that the loss of inositol polyphosphate-5-phosphatase (INPP5A) may play a role in the development and progression of cutaneous squamous cell carcinoma (SCC).(1) Loss of INPP5A has been previously linked to cancer development and progression.(2) This article is protected by copyright. All rights reserved.

PMID: 28696004 [PubMed - as supplied by publisher]

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