Nature Reviews Cancer 17, 453 (2017). doi:10.1038/nrc.2017.64 Author: Anna Dart Westerlund et al. found that combining the DNA demethylating drug 5-aza-deoxycytidine with the differentiation-promoting therapy retinoic acid inhibited tumour growth and prolonged survival in mouse xenograft models of high-risk neuroblastoma. This treatment resulted in high hypoxia-inducible factor 2α (HIF2α) levels but not HIF1α, and (Source: Nature Reviews Cancer)
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Epigenetics: Tumour suppressive HIF2 α
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