Effect of axial vertical vibration on degeneration of lumbar intervertebral discs in modified bipedal rats: An in-vivo study

Publication date: Available online 27 July 2017
Source:Asian Pacific Journal of Tropical Medicine
Author(s): Xiao Liang, Hao Shen, Wei-Dong Shi, Shan Ren, Wei Jiang, Hao Liu, Peng Yang, Zhi-Yong Sun, Jun Lin, Hui-Lin Yang
ObjectiveTo assess the effects of axial vibrations on gene expression and lumbar intervertebral disc degeneration in vivo.MethodsA modified bipedal rat model was established using a brachial plexus rhizotomy approach to imitate human upright posture. The experimental animals were randomly divided into three groups: control, vertical vibration, and whole-body vibration. Gene expression in degeneration of the intervertebral discs was assessed by reverse transcription-quantitative polymerase chain reaction.ResultsThe expression of aggrecan, Col1α1, Col2α1, and decorin were shown to be up-regulated in 14-week-old rats in the vertical vibration and whole-body vibration groups, whereas biglycan and versican expression was down-regulated in 14-week-old rats of the two experimental groups. Furthermore, biglycan and versican expression levels were shown to be lower in the whole-body vibration group than in the vertical vibration group (P < 0.05).ConclusionsThis in-vivo study demonstrated that vibrations can influence the expression of anabolic genes. Furthermore, whole-body vibrations seem to have a greater effect in this regard than vertical vibrations. A new method is expected to relieve the low back pain of the patients through our research.



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