Circulating microRNAs panel as a diagnostic tool for discrimination of HCV-associated hepatocellular carcinoma

Publication date: Available online 24 July 2017 Source:Clinics and Research in Hepatology and Gastroenterology Author(s): Hamdy E. Abouzeid Ali, Rehab Abdel Hameed, Heba Effat, Emad K. Ahmed, Azza A. Atef, Sabry K. Sharawi, Mohamed Ali, Zakaria Y. Abd Elmageed, Abdel Hady Abdel Wahab Early diagnosis of hepatocellular carcinoma (HCC) can significantly improve the overall survival of HCC patients. However, current diagnostic markers are compromised and limited by their low sensitivity and specificity. In this work, circulating microRNAs (miRs) were utilized as a diagnostic tool to test their efficiency to segregate HCC and hepatitis C virus (HCV)-infected patients from healthy subjects. Nine HCC-related miRs (miR-21, miR-30c, miR-93, miR-122, miR-125b, miR-126, miR-130a, miR-193b and miR-22...

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