Temporal lobe epilepsy (TLE) can lead to intense changes in cardiac autonomic functions during both interictal and ictal periods (Lotufo et al., 2012; Eggleston et al., 2014). Tachycardia, defined as a decrease in the ECG R-R intervals (RR) (increase in heart rate), is the most common cardiac change occurring during epileptic seizures (Opherk and Hirsch, 2002; O'Regan and Brown, 2005; Toth et al., 2010) whereas bradycardia occurs in only 2% of them (Moseley et al., 2010). Tachycardia was proposed as a biomarker providing a somatic indicator of temporal lobe (TL) seizure onset (Osorio, 2014; Schiecke et al., 2014; Osorio and Manly, 2014; Jeppesen et al., 2015; Osorio and Manly, 2015; Behbahani et al., 2016; Van de Vel et al., 2016), opening the way to automatized and noninvasive seizure detection and treatment delivery prior to, or at the onset of, a TL seizure.
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,