Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2012: General view of the pathogens' antibacterial susceptibility

Publication date: Available online 29 June 2017
Source:Journal of Infection and Chemotherapy
Author(s): Katsunori Yanagihara, Akira Watanabe, Nobuki Aoki, Tetsuya Matsumoto, Masaki Yoshida, Junko Sato, Tomotaro Wakamura, Keisuke Sunakawa, Junichi Kadota, Hiroshi Kiyota, Satoshi Iwata, Mitsuo Kaku, Hideaki Hanaki, Yoshinobu Ohsaki, Satoru Fujiuchi, Manabu Takahashi, Kenichi Takeuchi, Hiroaki Takeda, Hideki Ikeda, Makoto Miki, Susumu Nakanowatari, Hiroshi Takahashi, Mutsuko Utagawa, Hajime Nishiya, Sayoko Kawakami, Eriko Morino, Jin Takasaki, Kazuhisa Mezaki, Naohiko Chonabayashi, Chie Tanaka, Hideko Sugiura, Hajime Goto, Takeshi Saraya, Daisuke Kurai, Yasuhiro Katono, Rika Inose, Yoshihito Niki, Takahiro Takuma, Makoto Kudo, Shigeru Ehara, Yoshimi Sato, Hiroki Tsukada, Nobuei Watabe, Yasuo Honma, Hiroshige Mikamo, Yuka Yamagishi, Atsushi Nakamura, Minoru Ohashi, Masafumi Seki, Shigeto Hamaguchi, Masahiro Toyokawa, Yasunori Fujikawa, Noriko Mitsuno, Akira Ukimura, Takayuki Miyara, Takahito Nakamura, Keiichi Mikasa, Kei Kasahara, Koji Ui, Saori Fukuda, Akihiro Nakamura, Mika Morimura, Mikio Yamashita, Yoshio Takesue, Yasunao Wada, Keisuke Sugimoto, Nobuchika Kusano, Motoko Nose, Eiichirou Mihara, Masao Kuwabara, Masao Doi, Yaeko Watanabe, Hirokazu Tokuyasu, Satoshi Hino, Kiyoshi Negayama, Hiroshi Mukae, Toshinori Kawanami, Toshiyuki Ota, Masaki Fujita, Junichi Honda, Kazufumi Hiramatsu, Yosuke Aoki, Mami Fukuoka, Hiroki Magarifuchi, Zenzo Nagasawa, Norihito Kaku, Jiro Fujita, Futoshi Higa, Masao Tateyama
The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from the patients in Japan was conducted by Japanese Society of Chemotherapy, Japanese association for infectious diseases and Japanese society for Clinical Microbiology in 2012.The isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period between January and December in 2012 by three societies. Antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by Clinical Laboratory Standard Institutes.Susceptibility testing was evaluated in 1236 strains (232 Staphylococcus aureus, 225 Streptococcus pneumoniae, 16 Streptococcus pyogenes, 231 Haemophilus influenzae, 147 Moraxella catarrhalis, 167 Klebsiella pneumoniae and 218 Pseudomonas aeruginosa). Ratio of methicillin-resistant S. aureus was 51.3%, and those of penicillin-intermediate S. pneumoniae was 0.4%. Among H. influenzae, 5.6% of them were found to be β-lactamase-producing ampicillin-resistant strains, and 37.2% to be β-lactamase-non-producing ampicillin-resistant strains. Extended spectrum β-lactamase-producing K. pneumoniae and multi-drug resistant P. aeruginosa with metallo β-lactamase were 4.2% and 3.2%, respectively.Continuous national surveillance is important to determine the actual situation of the resistance shown by bacterial respiratory pathogens to antimicrobial agents.



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