Indications and outcomes for elective dissection of level V in primary parotid cancer

xlomafota13 shared this article with you from Inoreader Indications and outcomes for elective dissection of level V in primary parotid cancer Via Head & Neck Abstract Background The extent of cervical lymphadenectomy required for primary parotid cancer is not well-established. Methods In this retrospective case–control study, 84 patients who underwent primary parotidectomy and neck dissection for primary parotid cancer between 2010 and 2019 were identified and analyzed. Results Of the 84 patients, 37 underwent elective level V neck dissection. All six (16.0%) who had occult level V nodes had clinically evident, preoperative anterior cervical metastases, a statistically significant finding. No other clinical factors are correlated with posterior neck involvement. There was no significant difference in disease-free or overall survival for patients with occult level V disease relative to positive lymph nodes in other levels. Conclusions Patients with clinically evident anterolateral cervical lymphatic metastases from parotid cancer preoperatively have high rates of occult level V nodes. Level V neck dissection can be avoided in cN0 patients and offered no survival advantage. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Experimental model of unpredictable maternal stress and diabetes risk of offspring: An immunohistochemical study

xlomafota13 shared this article with you from Inoreader Experimental model of unpredictable maternal stress and diabetes risk of offspring: An immunohistochemical study Via histochem Acta Histochem. 2022 Mar 15;124(3):151878. doi: 10.1016/j.acthis.2022.151878. Online ahead of print. ABSTRACT The effect of stress on the occurrence of diabetes mellitus (DM) is commonly reported in recent studies. Maternal stress may have a negative effect on the later life of offspring. However, most studies only investigated long-term intrauterine stress on behavioral, emotional, psychological, and immunological disorders of offspring. The relationship between maternal st ress and DM occurrence in the later life period of offspring is not known. This rat model study aimed to evaluate the susceptibility of offspring to DM after exposure to intrauterine stress. The purpose of this study is to examine serum glucose levels of mothers and offspring exposed to maternal stress and to evaluate pancreatic tissues pathologically and immunohistochemically. Twelve, Wistar Albino female rats were equally divided into two groups: controls and maternal stress groups. Normal routine conditions were applied to the control group without any stress. The pregnant rats in the maternal stress group were exposed to chronic unpredictable stressors throughout the 21-day gestation. One female and one male offspring and mothers from each term delivery were randomly selected and euthanatized at the 35th day. During the necropsy, blood and pancreatic tissue samples were collected from both mothers and pups. High serum glucose levels from mothers and offspring in the maternal str ess group and the control group were compared. Additionally, histopathological examinations assessed the increased cell degeneration in mother rats and offspring. Immunohistochemical examinations revealed decreased insulin, amylin, and insulin receptor expressions and slightly increased glucagon expression in Langerhans islet cells in the maternal stress group. These results indicated that maternal stress may be a predisposing factor for DM in both mothers and offspring in their later life periods. PMID:35303510 | DOI:10.1016/j.acthis.2022.151878 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

'Internal mammary artery perforator flap for anterior thoracic and upper abdominal wall reconstruction: 16 case series'

xlomafota13 shared this article with you from Inoreader "Internal mammary artery perforator flap for anterior thoracic and upper abdominal wall reconstruction: 16 case series" Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2022 Feb 26:S1748-6815(22)00105-X. doi: 10.1016/j.bjps.2022.02.027. Online ahead of print. NO ABSTRACT PMID:35304858 | DOI:10.1016/j.bjps.2022.02.027 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Extensor indicis proprius transfer for the extensor pollicis longus tendon rupture with a two-incision technique

xlomafota13 shared this article with you from Inoreader Extensor indicis proprius transfer for the extensor pollicis longus tendon rupture with a two-incision technique Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2022 Mar 2:S1748-6815(22)00129-2. doi: 10.1016/j.bjps.2022.02.047. Online ahead of print. NO ABSTRACT PMID:35304851 | DOI:10.1016/j.bjps.2022.02.047 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Relationship Between Pitch Discrimination and Acoustic Voice Measures in a Cohort of Female Speakers

xlomafota13 shared this article with you from Inoreader The Relationship Between Pitch Discrimination and Acoustic Voice Measures in a Cohort of Female Speakers Via Journal of Voice Evidence across a range of musically trained, hearing disordered and voice disordered populations present conflicting results regarding the relationship between pitch discrimination (PD) and voice quality. PD characteristics of female speakers with and without a musical training background and no self-reported voice disorder, and the relationship between PD and voice quality in this particular population, have not been investigated. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

BMI as a risk factor for the development of chronic rhinosinusitis: a prospective population-based study

xlomafota13 shared this article with you from Inoreader BMI as a risk factor for the development of chronic rhinosinusitis: a prospective population-based study Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Mar 19. doi: 10.1007/s00405-022-07320-y. Online ahead of print. ABSTRACT PURPOSE: Obesity is a growing, global health problem and previous cross-sectional studies have demonstrated an association between obesity and chronic rhinosinusitis (CRS). There is, however, a lack of prospective studies regarding the impact of obesity on developing (new-onset) CRS. METHODS: Questionnaire-based data (n = 5769) relating to new-onset CRS and Body Mass Index (BMI) were collected in 2013 and 2018 from the Telemark population study in Telemark, Norway. Odds ratios for the risk of new-onset CRS in 2018 in relation to BMI in 2013 were calculated, adjusted for smoking habits, asthma, gender and age. RESULTS: When comparing the group with normal weight (18.5 ≤ BMI < 25) with the obese group (BMI ≥ 30), the odds of new-onset CRS was 53% higher [OR 1.53 (1.11, 2.10)] in the obese group. CONCLUSION: CR S is a multifactorial disease with different phenotypes and it is important to consider obesity when assessing patients with CRS in a clinical setting. PMID:35305138 | DOI:10.1007/s00405-022-07320-y View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Molecular diagnosis and targeted treatment of advanced follicular cell-derived thyroid cancer in the precision medicine era

xlomafota13 shared this article with you from Inoreader Molecular diagnosis and targeted treatment of advanced follicular cell-derived thyroid cancer in the precision medicine era Via radioactive iodine Cancer Treat Rev. 2022 Mar 15;106:102380. doi: 10.1016/j.ctrv.2022.102380. Online ahead of print. ABSTRACT Most malignant thyroid tumours are initially treated with surgery or a combination of surgery and radioactive iodine (RAI) therapy. However, in patients with metastatic disease, many tumours become refractory to RAI, and these patients require alternative treatments, such as locoregional therapies and/or systemic treatment with multikinase inhibitors. Improvements in our under standing of the genetic alterations that occur in thyroid cancer have led to the discovery of several targeted therapies with clinical efficacy. These alterations include NTRK (neurotrophic tyrosine receptor kinase) gene fusions, with the tropomyosin receptor kinase inhibitors larotrectinib and entrectinib both approved by the European Medicines Agency and in other markets worldwide. Inhibitors of aberrant proteins resulting from alterations in RET (rearranged during transfection) and BRAF (B-Raf proto-oncogene) have also shown promising efficacy, and so far have received approval by the US Food and Drug Administration. Selpercatinib, a RET kinase inhibitor, was approved for use in Europe in early 2021. With the discovery of multiple actionable targets, it is imperative that effective testing strategies for these genetic alterations are integrated into the diagnostic armamentarium to ensure that patients who could potentially benefit from targeted treatments are identified. In this review, we offer our recommendations on the optimal testing strategies for detecting genetic alterations in thyroid cancer that have the potential to be targeted by molecular therapy. We also discuss the future of treatments for thyroid cancers, including the use of immune checkpoint inhibitors, and new generations of targeted treatments that are being developed to counter acquired tumour resistance. PMID:35305441 | DOI:10.1016/j.ctrv.2022.102380 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The effects of Cricothyroid Visor Maneuver (CVM) therapy on the voice characteristics of patients with muscular tension dysphonia: A Case Series Study

xlomafota13 shared this article with you from Inoreader The effects of Cricothyroid Visor Maneuver (CVM) therapy on the voice characteristics of patients with muscular tension dysphonia: A Case Series Study Via Journal of Voice The purpose of this study was to assess the effects of a novel manual therapy, the Cricothyroid visor maneuver (CVM) therapy, on acoustic, auditory perceptual and self-assessment ratings in Muscle tension dysphonia (MTD) patients. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Manual Therapy for Patients With Radiation-Associated Trismus After Head and Neck Cancer

xlomafota13 shared this article with you from Inoreader Manual Therapy for Patients With Radiation-Associated Trismus After Head and Neck Cancer Via JAMA Otolaryngology–Head & Neck Surgery Online First This case series study examines the effect size and associations of response to manual therapy to increase oral opening in the setting of radiation-associated trismus. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Clinical Factors Predictive of Lymph Node Metastasis in Thyroid Cancer Patients: A Multivariate Analysis

xlomafota13 shared this article with you from Inoreader Clinical Factors Predictive of Lymph Node Metastasis in Thyroid Cancer Patients: A Multivariate Analysis Via radioactive iodine J Am Coll Surg. 2022 Apr 1;234(4):691-700. doi: 10.1097/XCS.0000000000000107. ABSTRACT BACKGROUND: Early-stage thyroid cancers have excellent survival. However, lymph node metastases (LNM) confer a worse prognosis and are not always known preoperatively. Therefore, investigation on the clinical and histological factors predictive of LNM in thyroid cancers was conducted to tailor the extent of surgery and radioactive iodine therapy. STUDY DESIGN: Multivariate logistic regressi ons were performed based on retrospective data from thyroid cancer patients seen between 2013 and 2020 at a single institution. RESULTS: Among 913 patients, mean age was 49.4 years, 76.5% were female, 58.3% were White, 21.2% were Black, and 27.9% had LNM. In the multivariate analyses in which the outcome was LNM, White (odds ratio [OR] 1.74, 95% CI 0.98 to 3.15, p = 0.064) and Hispanic patients (OR 2.36, 95% CI 0.97 to 5.77, p = 0.059) trended toward higher risk of LNM compared to Black patients, whereas age (OR 0.98, 95% CI 0.97 to 1.00, p = 0.008) showed protective effect. Tumor size (OR 1.04, 95% CI 1.01 to 1.07, p = 0.007), extrathyroidal extension (OR 2.46, 95% CI 1.53 to 3.97, p < 0.001), lymphovascular invasion (OR 6.30, 95% CI 3.68 to 11.14, p < 0.001), and multifocality (OR 1.47, 95% CI 1.01 to 2.12, p = 0.042) were associated with higher risk of LNM. In another model with outcome as >5 LNM, tumor size (OR 1.07, 95% CI 1.03 to 1.11, p = 0.001), age (OR 0.95, 95% CI 0.93 to 0.97, p < 0.001), extrathyroidal extension (OR 3.20, 95% CI 1.83 to 5.61, p < 0.001), and lymphovascular invasion (OR 6.82, 95% CI 3.87 to 12.17, p < 0.001) remained significant predictors. CONCLUSION: Our analyses demonstrated and confirmed that age, tumor size, extrathyroidal extension, and lymphovascular invasion are independent predictors of significant LNM, thereby conferring higher risk of recurrence. Risk of LNM based on these patient characteristics should be considered when planning an operative approach. PMID:35290290 | DOI:10.1097/XCS.0000000000000107 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Pediatric morphometric study to guide the optimized implantation of the Osia® 2 implant system

xlomafota13 shared this article with you from Inoreader Pediatric morphometric study to guide the optimized implantation of the Osia<sup>®</sup> 2 implant system Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Mar 16. doi: 10.1007/s00405-022-07338-2. Online ahead of print. ABSTRACT PURPOSE: Continuous technological advances result in the availability of new bone conduction hearing implants, of which their suitability for pediatric patients is of major concern. The CochlearTMOsia® 2 is a new active osseointegrated steady-state implant system that uses digital piezoelectric stimulation to treat hearing loss. The implant in the United States was approved for patients aged 12 years and above, whereas the CE mark is independent of age, the only requirement is body weight of at least 7 kg. Therefore, further clinical studies are required to assess device characteristics in younger patients. The aim of our study was to perform a morphometric study among 5-12-year-old children, and to develop a surgical protocol for Osia 2 system implantation based on these findings. METHODS: We examined r etrospectively cranial CT scans of 5-12-year-old patients from our clinical database. We measured the bone and soft-tissue thickness in the region of interest, and the position of the sigmoid sinus. 3D printed temporal bones were also used for planning. RESULTS: Soft-tissue thickness varied between 3.2 ± 0.5 mm and 3.6 ± 0.6 mm and bone thickness varied between 3.5 ± 1.1 mm and 4.7 ± 0.3 mm. The sigmoid sinus was located 1.3 ± 0.2 cm posterior to the ear canal, and the anterior distance was 4.8 ± 0.9 to 7.1 ± 1.1 mm. CONCLUSIONS: Our morphometric studies showed that patients aged 5-12 have different anatomical dimensions compared to adults, but that implantation of the Osia 2 system is feasible in these patients using an altered implant positioning recommended by our data. The Cochlear™ Osia® 2 is, therefore, an option for hearing rehabilitation in younger pediatrics. PMID:35292851 | DOI:10.1007/s00405-022-07338-2 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nipple delay prior to nipple-sparing mastectomy: the protective effect on nipple-areola complex ischaemia

xlomafota13 shared this article with you from Inoreader Nipple delay prior to nipple-sparing mastectomy: the protective effect on nipple-areola complex ischaemia Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2022 Feb 19:S1748-6815(22)00074-2. doi: 10.1016/j.bjps.2022.02.005. Online ahead of print. ABSTRACT BACKGROUND: Nipple-sparing mastectomy (NSM) has become increasingly popular over the past decade, offering perceived superior cosmetic outcomes and psychological benefits. The main concern in NSM is that of nipple-areola complex (NAC) ischaemia, occurring in up to 15% of cases. We investigate the utility of nipple delay (ND) in protecting the NAC from ischaemic complications. METHODS: A retrospective study of all NSM for a single surgeon from 2010 to 2020 was performed, with those not receiving a prior ND procedure included as a control arm. Variables were recorded, including time to mastectomy from delay, degree of breast ptosis, cup size, mastectomy weight, previous radiotherapy, and presence of ischaemic risk factors. Outcomes recorded were the development of NAC ischaemia, graded from epidermolysi s to partial or full-thickness necrosis (FTN). RESULTS: A total of 62 women for a total of 84 breasts were part of the delay cohort. Ten (12%) breasts in the delay group developed ischaemic complications, with only five breasts developing FTN requiring debridement. Moreover, 33 women for a total of 43 breasts were part of the non-delay cohort. A total of 14 (33%) breasts in the non-delay cohort developed ischaemic complications, with six breasts developing FTN requiring debridement. Delay was protective against ischaemic complications with an OR 0.28 (p=0.007). Mastectomy weight of >600 g and >400 g predicted the development of ischaemic complications in the delay and non-delay cohorts, respectively. CONCLUSION: ND was shown to protect against the development of ischaemic complications prior to NSM, with the greatest protective effects shown in those with morphologically large breasts. PMID:35296381 | DOI:10.1016/j.bjps.2022.02.005 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.