5 Top CKD Apps for Primary Care Physicians

Chronic renal disease is common in primary care settings and so are its comorbidities. In brief here, 5 apps you might want at hand. (Source: CancerNetwork)

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Disrupted Physiological Reactivity Among Children with a History of Suicidal Ideation: Moderation by Parental Expressed Emotion-Criticism

Publication date: Available online 13 October 2017
Source:Biological Psychology
Author(s): Kiera M. James, Mary L. Woody, Cope Feurer, Anastacia Y. Kudinova, Brandon E. Gibb
ObjectiveThe goal of this study was to examine physiological reactivity during parent-child interactions in children with and without a history of suicidal ideation (SI), a group known to be at increased risk for suicidal thoughts and behaviors in the future. We also examined the potential moderating role of parental expressed emotion-criticism (EE-Crit) to determine whether the presence of parental criticism may help to identify a subgroup of children with a history of SI most at risk for physiological dysregulation.MethodParticipants were 396 children (age 7-11; 54% male, 71.7% Caucasian) and their biological parent. Children's levels of high frequency heart rate variability (HF-HRV) were assessed during a resting baseline period followed by a positive and negative discussion with their parent. Additionally, parents completed the Five-Minute Speech Sample to determine levels of EE-Crit toward their child, and children completed an interview assessing their history of SI.ResultsConsistent with our hypothesis, we found that exposure to parental criticism moderated the relation between a child's history of SI and their HF-HRV reactivity to the discussions. Specifically, while most children exhibited the typical pattern of HF-HRV suppression from baseline to both interactions, the highest risk children (i.e., children with a history of SI who also had highly critical parents) did not display any change in HF-HRV across the tasks, suggesting a failure to engage a typical psychophysiological response during emotional contexts.ConclusionsThese results suggest a specific physiological mechanism that may place these children at risk for suicidal thoughts and behaviors in the future.



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Fluoride in the drinking water top tip

Top teeth tips: Happy Smiles dentist Astrid Hooper has a warning about sugary snacks and drinks for parents, suggesting that cavities are preventable with a few simple changes. Saturday is World Cavity Free Future Day, and dentists are using it to remind parents of the importance of keeping healthy teeth and gums.

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Global networks of small telescopes will chase companion signals of gravitational waves

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Balneotherapeutic effects of high mineral spring water on the atopic dermatitis-like inflammation in hairless mice via immunomodulation and redox balance

Atopic dermatitis (AD) is a chronic relapsing allergic inflammatory skin disease that currently affects millions of children and adults worldwide. Drugs used to treat these inflammatory diseases include anti-h...

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No, we are not—we keep forgetting the right ventricle

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Title page/Section Editors

Publication date: November 2017
Source:Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Volume 1865, Issue 11, Part B





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Biophysics in Canada

Publication date: November 2017
Source:Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Volume 1865, Issue 11, Part B
Author(s): John Baenziger, Lewis Kay, Albert Berghuis, Peter Tieleman




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Fluorescence lifetime of Rhodamine B in aqueous solutions of polysaccharides and proteins as a function of viscosity and temperature

Photochem. Photobiol. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7PP00330G, Paper

Ruben Mercade-Prieto, Luis Rodriguez Rivera, Xiao Dong Chen
Rhodamine B (RhB) is a well known dye extensively used in thermometric studies, either considering the decrease of the fluorescence intensity or the lifetime ([small tau]) with temperature. Lifetime measurements are...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Effects of UV-B radiation on the infectivity of Magnaporthe oryzae and rice disease-resistant physiology in Yuanyang terrace

Photochem. Photobiol. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7PP00139H, Paper

Xiang Li, yongmei he, Chunmei Xie, Yanqun Zu, Fangdong Zhan, Xinyue Mei, Yang Xia, Yuan Li
The traditional rice variety "Baijiaolaojing" was implanted in Yuanyang terrace (1600 m altitude) under field conditions. The effects of the enhanced UV-B radiation (0 kJ[middle dot]m^-2, 2.5 kJ[middle dot]m^-2, 5.0 kJ[middle dot]m^-2 and...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Effect of incubation temperature after devitrification on quality parameters in human sperm cells

Publication date: Available online 13 October 2017
Source:Cryobiology
Author(s): Pamela Uribe, Christian Rojas, Juan Meriño, Fabiola Zambrano, Juana V. Villegas, Favián Treulen, Rodrigo Boguen, Vladimir Isachenko, Evgenia Isachenko, Raúl Sánchez
Sperm cryopreservation is common in assisted reproduction laboratories, providing a therapeutic option for several clinical conditions. This process has been optimized; however, the effect of post-thaw incubation temperature has been poorly studied. This work analyzed the effect of incubation temperature after devitrification on human sperm quality. Spermatozoa from normozoospermic donors were cryopreserved by vitrification. After devitrification, the spermatozoa were separated into two aliquots: (i) incubated at room temperature (RT, 22-25 °C) and (ii) incubated at 37 °C. Reactive oxygen species (ROS), viability, mitochondrial membrane potential (ΔΨM), phosphatidylserine externalization and motility were analyzed immediately after devitrification (control) and after 2, 4 and 6 h. Spermatozoa incubated at RT showed a conserved viability and ΔΨM compared to the control, while the incubation at 37 °C promoted a decrease in these parameters. The ROS levels were increased at both incubation conditions. The progressive motility was decreased in all experimental groups and the decrease was more pronounced under incubation at RT. No increase in phosphatidylserine externalization was observed. In conclusion, prior to use in assisted reproduction procedures, devitrified spermatozoa at RT conserve a better viability and ΔΨM than at 37 °C.



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Improved stability of live attenuated vaccine gdhA derivative Pasteurella multocida B:2 by freeze drying method for use as animal vaccine

Publication date: Available online 13 October 2017
Source:Cryobiology
Author(s): Siti Nur Hazwani Oslan, Murni Halim, Nurfahanah Amirah Ramle, Mohd Zamri Saad, Joo Shun Tan, Mohd Rizal Kapri, Arbakariya B. Ariff
The efficacy of attenuated strain of gdhA derivative Pasteurella multocida B:2 mutant as a live vaccine to control haemorrhagic septicaemia (HS) disease in cattle and buffaloes has been demonstrated. In order to use P. multocida B:2 mutant as a commercial product, it is essential to optimise its formulation for high viability and stability of the live cells. The effectiveness of freeze-drying process using different protective agent formulations for improving cells viability was explored. Sugar and nitrogen compounds were used as protective agents in freeze-drying and the capability of these compounds in maintaining the viability of mutant P. multocida B:2 during subsequent storage was investigated. A complete loss in viability of freeze-dried mutant P. multocida B:2 was monthly observed until 6–12 months of storage at -30 °C, 4 °C and 27 °C when nitrogen compound or no protective agent was added. Trehalose and sucrose showed significantly high survival rate of 93–95% immediately after freeze-drying and the viability was retained during the subsequent storage at -30 °C and 4 °C. A smooth cell surface without any cell-wall damage was observed for the cells formulated with trehalose under scanning electron micrograph. This study presented a freeze-drying process generating a dried live attenuated vaccine formulation with high stability for commercial applications.



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Evidence for a complex formation between CYP2J5 and mEH in living cells by FRET analysis of membrane protein interaction in the endoplasmic reticulum (FAMPIR)

Abstract

The potential complex formation between microsomal epoxide hydrolase (mEH) and cytochrome P450-dependent monooxygenase (CYP) has been a subject of research for many decades. Such an association would enable efficient substrate channeling between CYP and mEH and as such represent an attractive strategy to prevent deleterious accumulation of harmful metabolic by-products such as CYP-generated epoxide intermediates. However, such complex formation is experimentally difficult to prove, because CYP and mEH are membrane-bound proteins that are prone to unspecific aggregation after solubilization. Here, we report the development of a FRET-based procedure to analyze the mEH–CYP interaction in living cells by fluorescence-activated cell sorting. With this non-invasive procedure, we demonstrate that CYP2J5 and mEH associate in the endoplasmic reticulum of recombinant HEK293 cells to the same extent as do CYP2J5 and its indispensible redox partner cytochrome P450 reductase. This presents final proof for a very close proximity of CYP and mEH in the endoplasmic reticulum, compatible with and indicative of their physical interaction. In addition, we provide with FAMPIR a robust and easy-to-implement general method for analyzing the interaction of ER membrane-resident proteins that share a type I topology.

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N - tert -butyloxycarbonyl-Phe-Leu-Phe-Leu-Phe (BOC2) inhibits the angiogenic activity of heparin-binding growth factors

Abstract

The peptides N-tert-butyloxycarbonyl-Phe-Leu-Phe-Leu-Phe (BOC2) and BOC-Met-Leu-Phe (BOC1) are widely used antagonists of formyl peptide receptors (FPRs), BOC2 acting as an FPR1/FPR2 antagonist whereas BOC1 inhibits FPR1 only. Extensive investigations have been performed by using these FPR antagonists as a tool to assess the role of FPRs in physiological and pathological conditions. Based on previous observations from our laboratory, we assessed the possibility that BOC2 may exert also a direct inhibitory effect on the angiogenic activity of vascular endothelial growth factor-A (VEGF-A). Our data demonstrate that BOC2, but not BOC1, inhibits the angiogenic activity of heparin-binding VEGF-A₁₆₅ with no effect on the activity of the non-heparin-binding VEGF-A₁₂₁ isoform. Endothelial cell-based bioassays, surface plasmon resonance analysis, and computer modeling indicate that BOC2 may interact with the heparin-binding domain of VEGF-A₁₆₅, thus competing for heparin interaction and preventing the binding of VEGF-A₁₆₅ to tyrosine kinase receptor VEGFR2, its phosphorylation and downstream signaling. In addition, BOC2 inhibits the interaction of a variety of heparin-binding angiogenic growth factors with heparin, including fibroblast growth factor 2 (FGF2) whose angiogenic activity is blocked by the compound. Accordingly, BOC2 suppresses the angiogenic potential of human tumor cell lines that co-express VEGF-A and FGF2. Thus, BOC2 appears to act as a novel multi-heparin-binding growth factor antagonist. These findings caution about the interpretation of FPR-focusing experimental data obtained with this compound and set the basis for the design of novel BOC2-derived, FPR independent multi-target angiogenesis inhibitors.

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Oral siRNA Delivery to Treat Colorectal Liver Metastases

ACS Nano

DOI: 10.1021/acsnano.7b05547

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Anomalous Polarized Raman Scattering and Large Circular Intensity Differential in Layered Triclinic ReS2

ACS Nano

DOI: 10.1021/acsnano.7b05321

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Pregnant Women Hospitalized with Chikungunya Virus Infection, Colombia, 2015

M. Escobar et al.

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Clinical trial design and recommendations: collectively, we can take them

Abstract

There is dynamic opportunity to advance medical research and clinical trial innovation in the USA and throughout the world. Identified problems and solutions in the clinical research and clinical trial enterprise have emerged over recent years. Strategic plans, public reports, expertise panels and international agreements have been produced, and now is the time to move forward collectively. Recommendations should be reviewed, especially because global healthcare can take them. A robust and future medical research enterprise hinges on maximized clinical trial efficiency, both in the USA and abroad.

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PRIMUM NON NOCERE : now and again an echo of DPD with capecitabine

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Horses bred to look like cartoons are part of a worrying trend

A colt with googly eyes and a very "dished" head is the latest example of a trend for animals with "cute" looks that raise health risks, says Danny Chambers

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