@Prime2 Let us know what you are looking for and we will try to send over. Everything is open on our website.

@Prime2 Let us know what you are looking for and we will try to send over. Everything is open on our website.

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/891053922835628036
via IFTTT

John Kelso, longtime Austin humor columnist, dead at 73 - KFDA

Austin American-Statesman

John Kelso, longtime Austin humor columnist, dead at 73 KFDA AUSTIN, Texas (AP) - John Kelso, longtime humor columnist for the Austin American-Statesman, has died in Austin at the age of 73. Kelso, who since 2015 had been battling a cancer that cost him his larynx, died Friday of complications from a recent fall ... John Kelso, longtime columnist who kept Austin chuckling, has diedMyStatesman.com all 6 news articles »

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2tQNJpf
via IFTTT

Transoral robotic surgery cuts patient recovery time - MultiBriefs Exclusive (blog)

Transoral robotic surgery cuts patient recovery time MultiBriefs Exclusive (blog) "Without the robot, tongue and throat cancers are among the most difficult tumors to surgically remove," said Dr. Chin, an otolaryngology, head and neck surgeon at the hospital. Previous surgical methods required surgeons cut into the neck to access ...

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2vQYh57
via IFTTT

Influence of remaining coronal tooth structure on fracture resistance and failure mode of restored endodontically treated maxillary incisors

Publication date: Available online 27 July 2017
Source:The Journal of Prosthetic Dentistry
Author(s): Domingo Santos Pantaleón, Brian R. Morrow, David R. Cagna, Cornelis H. Pameijer, Franklin Garcia-Godoy
Statement of problemLimited information is available on the effect of an incomplete ferrule because of the varying residual axial wall heights and the volume of residual tooth structure on the fracture resistance of endodontically treated and restored maxillary incisors.PurposeThe purpose of this in vitro investigation was to examine the effect of varying residual axial wall heights, residual coronal tooth structure, and the absence of 1 proximal axial wall on the fracture resistance and failure mode of endodontically treated teeth restored with metal posts.Material and methodsSixty intact human maxillary central incisors were divided into 6 groups (n=10): no ferrule (NF), 2-mm complete ferrule (CF2), 2-mm (IF2), 3-mm (IF3), and 4-mm (IF4) incomplete ferrules missing a single interproximal wall, and a control group that had a 6-mm incomplete ferrule (IF6). Cast metal post-and-cores were placed in all experimental specimens except for controls. Control specimens received 1 interproximal cavity preparation extending to the root canal access and a composite resin restoration. Complete metal crowns were then cemented on all specimens. Completed specimens were subjected to thermocycling (6000 cycles, 5°C/55°C) followed by the immediate testing of fracture resistance. Failed specimens were sectioned buccolingually and evaluated to identify the failure mode. The data were analyzed with an analysis of variance (ANOVA) and the Student-Newman-Keuls multiple comparison test (α=.05).ResultsAn incomplete ferrule (IF2) with 1 interproximal wall missing had significantly reduced fracture resistance (697 N) compared with a complete ferrule (932 N). An increase of 3 to 4 mm of remaining wall height improved fracture resistance, from 844 N (IF3) to 853 N (IF4). Partial decementation was noticed in 8 NF and 5 IF2 specimens. IF3 and IF4 had no decementations. Radicular fractures and cracks (catastrophic failure) were observed in all IF2, IF3, and IF4, 9 CF2, and 6 NF specimens. In 7 specimens without posts (IF6, control), composite resin foundation and/or coronal dentin fracture were observed and the failure was considered repairable.ConclusionsThe results of this in vitro study indicated that specimens with a 2-mm ferrule of uniform height were more resistant to fracture than specimens with a 2-mm ferrule and 1 missing interproximal wall. An increased wall height of 3 or 4 mm was associated with a significant increase in fracture resistance and can compensate for the missing interproximal wall.



from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2tQQarV
via IFTTT

Genetic association of pro-inflammatory cytokine gene polymorphisms with coronary artery disease (CAD) in a North Indian population

Publication date: 10 September 2017
Source:Gene, Volume 628
Author(s): Sarabjit Mastana, Swayam Prakash, Elizabeth C. Akam, Melissa Kirby, Martin R. Lindley, Nakul Sinha, Suraksha Agrawal
BackgroundCytokines regulate the expression of inflammatory molecules which destabilize the atheromatic plaques. This study focuses on studying the association of inflammatory cytokine polymorphisms like TNF-α −308 (G/A), TNF-β +252 (A/G), IL-6 −174 (G/C) and IL-6 −597 (G/A), and IFN-ɣ +874 (T/A) with coronary artery disease (CAD) among north Indian patients.Materials and methods143 CAD and 137 normal healthy controls were recruited in this study. DNA extraction was carried out by high salting out method. TNF-α −308 (G/A) (rs1800797), TNF-β +252 (A/G) (rs909253), IL-6 −174 (G/C) (rs1800795), IL6 −597 (G/A) (rs1800797), and IFN-ɣ +874 (T/A) (rs2430561) SNPs were genotyped by TaqMan®SNP genotyping assays. Different statistical analyses were performed using SPSS v 22.0 and SNPStats. p≤0.05 was considered significant.ResultsSignificant risk association with CAD was found for TNF-α −308 (G/A) "A" allele (OR=5.6, CI 1.8–17.4, p=0.001) and TNF-β +252 (A/G) "G" allele (OR=3.4, CI=1.9–6.0, p<0.001). However, no statistical significance was found for IL-6 −174 (G/C) or IL6 −597 (G/A), with CAD. TNF-α −308 (G/A), and TNF-β +252 (A/G) haplotype "GG" "AG" increased CAD risk significantly (GG haplotype, adjusted OR=2.6, CI 1.4–5.0, p=0.003 and AG haplotype OR=8.5, CI 2.2–33.35, p=0.002) after adjustments for age, sex, TC, TG, HDL, APOB, smoking and diet.DiscussionThe present study found significant risk association for TNF-α −308 (G/A), and TNF-β +252 (A/G) genotypes, alleles and haplotypes, with CAD in a North Indian population.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2v7Vp60
via IFTTT

North Korea launches ICBM with potential to reach New York

An intercontinental ballistic missile launched by North Korea landed in Japanese waters. Experts say the range of such a missile could reach the US east coast

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2tKIiV0
via IFTTT

North Korea launches ICBM with potential to reach New York

An intercontinental ballistic missile launched by North Korea landed in Japanese waters. Experts say the range of such a missile could reach the US east coast

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2tKIiV0
via IFTTT

Comparative analysis of stirred catalytic basket bio-reactor for the production of bio-ethanol using free and immobilized Saccharomyces cerevisiae cells

The successful industrial production of ethanol and fine chemicals requires the development of new biocatalytic reactors and support materials to achieve economically viable processes. In this work, a Stirred-...

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2vf0YR5
via IFTTT

Important new study sheds light on childhood cancer in Africa. https://t.co/JijlFlgabq https://t.co/ajjZGEqbFg

Important new study sheds light on childhood cancer in Africa. https://t.co/JijlFlgabq https://t.co/ajjZGEqbFg

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/891018064074080256
via IFTTT

Impact of adjuvant systemic chemotherapy on wound healing and cosmetic outcome in 224 women treated with accelerated partial breast irradiation using interstitial brachytherapy

Publication date: Available online 27 July 2017
Source:Brachytherapy
Author(s): Ashwini Budrukkar, Prakash Pandit, Tabassum Wadasadawala, Ritu Raj Upreti, Rakesh Jalali, Sudeep Gupta, Tanuja Shet, Vani Parmar, Rajendra Badwe, Rajiv Sarin
PurposeTo evaluate the impact of timing of adjuvant chemotherapy on wound healing and cosmetic outcome in women treated with accelerated partial breast irradiation (APBI).Methods and MaterialsBetween August 2000 to December 2011, 224 women were treated with APBI using multicatheter interstitial high-dose-rate brachytherapy. Patients were treated to a dose of 34 Gy/10#/5–7 days with bid regimen. Systemic chemotherapy was administered as per the standard guidelines.ResultsMulticatheter interstitial brachytherapy technique was open cavity in 136 (60%) and closed cavity in 88 (40%). Adjuvant chemotherapy was given in 117 (52%). Wound complications (WCs) were observed in 24 patients (11%), which included wound infections (WIs) in 20 and wound dehiscence in 14. The median gap between chemotherapy and APBI was 13 days in women who developed WCs, 20 days for prechemo, and 32 days for postchemo APBI in its absence. On multivariate analysis, gap between APBI and chemotherapy of ≤3 weeks was the only significant factor (p = 0.03) affecting WCs. Acute WI (p = 0.01) and two-dimensional planning (p = 0.04) had significant impact on cosmesis resulting in fair to poor cosmetic outcome.ConclusionsGap of ≤3 weeks between APBI and chemotherapy resulted in increased WCs. WI and two-dimensional planning resulted in poorer cosmetic outcome. We recommend gap of at least 3 weeks for optimal outcome.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2haeDm3
via IFTTT

Intermediate dose–volume parameters and the development of late rectal toxicity after MRI-guided brachytherapy for locally advanced cervix cancer

Publication date: Available online 27 July 2017
Source:Brachytherapy
Author(s): Reem Ujaimi, Michael Milosevic, Anthony Fyles, Akbar Beiki-Ardakani, Marco Carlone, Haiyan Jiang, Patricia Lindsay, Jason Xie, Rachel Gerber, Jennifer Croke, Julia Skliarenko, Wilfred Levin, Kathy Han
PurposeThe dose delivered to the most exposed 2 cm³(D2cm3) of the rectum and bladder is predictive of late rectal and bladder toxicity in cervix cancer patients. We investigated the predictive value of intermediate doses to the rectum and bladder for late rectal/bladder toxicity after MRI-guided brachytherapy for patients with locally advanced cervix cancer.Methods and MaterialsToxicity was prospectively graded using Common Toxicity Criteria for Adverse Events v4.0 and retrospectively verified for women with Stage IB–IVA cervix cancer treated consecutively with MRI-guided brachytherapy between 2008 and 2013. The minimum equivalent dose in 2 Gy fractions delivered to 0.1, 1, 2, 5, and 10 cm³ of the rectum and bladder and the absolute volume of the rectum receiving 55, 60, 65, 70, and 75 Gy3 (V55–75) were collected. The association between dose–volume parameters and Grade 2+ rectal/bladder toxicity was examined using logistic regression.ResultsWith a median followup of 44 months, cumulative incidences of Grade 2+ rectal and bladder toxicity among the 106 patients were 29% and 15% at 3 years, respectively. All the dose–volume parameters were significantly associated with late Grade 2+ rectal and bladder toxicity (p < 0.05), except for bladder D0.1cm3. On multivariable logistic regression, both D2cm3 > 70 Gy3 and V55 > 11 cm³ (p < 0.05) were predictive of late Grade 2+ rectal toxicity, with improved model fitting and higher area under the curve compared with the model with D2cm3 > 70 Gy3 alone.ConclusionsIn this study, V55 was predictive of late Grade 2+ rectal toxicity. Adding V55 to D2cm3 improved prediction accuracy.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2eUwTiQ
via IFTTT

Performance of a palladium-103 line source for prostate brachytherapy implants: A Phase I trial

Publication date: Available online 27 July 2017
Source:Brachytherapy
Author(s): Richard Stock, David Beyer, Jed Kaminetsky, William Ge
PurposeTo evaluate the use of a polymer-encapsulated palladium-103 (¹⁰³ Pd) source with a unique linear radioactive distribution in prostate brachytherapy. This feasibility study assessed dosimetry, ease and efficiency of use, and side effects. The number of needles required for adequate coverage was the primary end point.Methods and MaterialsCivaString ¹⁰³ Pd Model CS10 implants were preplanned for 25 patients. CivaStrings were custom manufactured according to plan. CivaStrings were implanted with 18 gauge needles. Post-implant dosimetry was performed at 3-6 weeks.ResultsMonotherapy (125 Gy) was prescribed for 11 implants. External beam radiation with CivaString boost (100 Gy) was prescribed for 14 implants. The mean time to implant the sources was 23.5 min. The number of planned needles and prostate sizes ranged from 14 to 25 and 21-101 cm3, respectively. 70% of implants in prostates less than 50 cm3 required ≤17 needles. Planned source strength ranged from 2.8 U/cm to 3.9 U/cm. Total source strength averaged 216 U (130-323 U) for monotherapy and 154 U (92.4-245 U) for boost. Nomograms were generated at both prescription dose levels.ConclusionsThe linear ¹⁰³Pd source provides good dose coverage to the prostate. Prostate volume changes were minimal suggesting minimal swelling using the CivaString device.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2h9Q357
via IFTTT

John Kelso, Longtime Austin Humor Columnist, Dead at 73 - U.S. News & World Report

Austin American-Statesman

John Kelso, Longtime Austin Humor Columnist, Dead at 73 U.S. News & World Report Kelso, who since 2015 had been battling a cancer that cost him his larynx, died Friday of complications from a recent fall, the American-Statesman reported . Kelso had joined the newspaper in 1976 and began wiring his column several times a week in 1977. John Kelso, longtime columnist who kept Austin chuckling, has diedMyStatesman.com all 5 news articles »

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2tQUF5P
via IFTTT

Predictors of positive esophagogastroduodenoscopy outcomes in children and adolescents: a single center experience

Esophagogastroduodenoscopy (EGD) has become a key element in the diagnosis and therapy of many gastrointestinal diseases affecting children. The aim of this study was to evaluate predictors of positive outcome...

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2uGqbCu
via IFTTT

Bacteriological assessment of stethoscopes used by healthcare workers in a tertiary care centre of Nepal

Stethoscope is a medical device universally used by health care workers. Stethoscope may transmit pathogens among patients and health care workers if it is not disinfected. The objective of this study was to, ...

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2vRwq58
via IFTTT

Prognostic value of total tumor volume in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy

Few studies have evaluated the prognostic value of total tumor volume (TTV), which reflects both the primary tumor volume and nodal tumor volume, in NPC. Furthermore, the relationship between TTV and survival ...

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2vRxJAL
via IFTTT

Successful treatment with anti-programmed-death-1 antibody in a relapsed natural killer/T-cell lymphoma patient with multi-line resistance: a case report

Extranodal natural killer/T-cell lymphoma (NKTCL), nasal type, is an aggressive malignancy with poor prognosis. Currently, there is no recommended standard therapy for relapsed NKTCL.

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2uGyA8X
via IFTTT

Building blocks of alien cells found on Saturn’s largest moon

The discovery of two compounds that could help make cells only adds to Titan's image as the most promising place in our solar system to look for alien life

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2v4SzPG
via IFTTT

Flatworms can still ‘see’ even after they are decapitated

Biologically simple they may be, but planarian flatworms have evolved two completely different ways to detect light – and one doesn't involve their heads

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2uJX4wo
via IFTTT

Smart glasses let you turn off the lights in the blink of an eye

A pair of glasses that can harness the movement around your eye when you blink could be used to manipulate the world around you

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2v57DNn
via IFTTT