A reverse form of Linburg-Comstock variation with comments on its etiology and demonstration of interactive 3D portable document format

xlomafota13 shared this article with you from Inoreader A reverse form of Linburg-Comstock variation with comments on its etiology and demonstration of interactive 3D portable document format Via radiol anat Surg Radiol Anat. 2021 Nov 13. doi: 10.1007/s00276-021-02858-8. Online ahead of print. ABSTRACT PURPOSE: Two most common variations of flexor pollicis longus include its accessory head and its connection with the flexor digitorum profundus of the index (Linburg-Comstock variation). In addition, while three-dimensional (3D) screening has widely been used in anatomical education, its use as reporting tool in anatomical research is still limited. The objective of this study is to report a previously unrecognized form of the accessory head of flexor pollicis longus, discuss the potential etiology of Linburg-Comstock variation, and pilot the 3D scanning of a large-scale anatomical structure. METHODS: An unusual tendon slip was discovered during a routine dissection in the anterior compartment of the right forearm of a 54-year-old male cadaver. A 3D scanner was used to capture the surface topography of the specimen and an interactive portable document format (PDF) was created. RESULTS: An anomalous tendon was found originating from the lateral aspect of the flexor digitorum profundus muscle. This variant tendon then inserted onto the medial surface of the flexor pollicis longus tendon before entering the carpal tunnel. The variation resembles a reverse form of Linburg-Comstock variation, because pulling this variant tendon resulted in simultaneous flexion of the interphalangeal joint of thumb. CONCLUSION: Surgeons should be aware of the rev erse Linburg-Comstock variation, because it may not be detectable by the conventional provocative testing. Linburg-Comstock variation may be classified as an anatomical variant or a secondarily acquired condition depending on its type. Our demonstration of interactive 3D-PDF file highlights its potential use for delivering anatomical information in future cadaveric studies. PMID:34775526 | DOI:10.1007/s00276-021-02858-8 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Localization of the neuropeptide manserin in rat dorsal root ganglia: Involvement in nociceptive function

xlomafota13 shared this article with you from Inoreader Localization of the neuropeptide manserin in rat dorsal root ganglia: Involvement in nociceptive function Via histochem Acta Histochem. 2021 Nov 11;123(8):151812. doi: 10.1016/j.acthis.2021.151812. Online ahead of print. ABSTRACT Manserin, a neuropeptide discovered in the rat brain, is distributed in the spiral ganglion of the inner ear and carotid body, suggesting it is also localized in another neuron cluster. In this study, we examined manserin's localization in the dorsal root ganglion (DRG) and spinal cord of adult Wistar rats using immunohistochemical analyses. The DRG consists of neuro filament (NF) 200-positive large cells and two types of small cells (calcitonin gene-related peptide (CGRP)-positive peptidergic neurons and isolectin B4 (IB4)-positive non-peptidergic neurons). Manserin was localized in some of the small cells. Fluorescence double immunostaining showed that manserin-positive cells corresponded to some of the CGRP-positive cells. The DRG comprises pseudo-unipolar cells that receive sensory information from the skin and viscera and project to each layer of the dorsal horn of the spinal cord. Manserin was localized in the CGRP-positive layer I and II outer, but not in the IB4-positive layer II inner. These results suggest manserin is localized in CGRP-positive cells in the DRG, projects to the dorsal horn of the spinal cord, and is secreted with other neuropeptides, such as CGRP, to participate in nociceptive function. PMID:34775224 | DOI:10.1016/j.acthis.2021.151812 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Ramadan fasting during treatment with external beam radiotherapy

xlomafota13 shared this article with you from Inoreader Ramadan fasting during treatment with external beam radiotherapy Via Association française pour l'étude du cancer Bull Cancer. 2021 Nov 11:S0007-4551(21)00304-0. doi: 10.1016/j.bulcan.2021.05.010. Online ahead of print. ABSTRACT INTRODUCTION: Many Muslim cancer patients insist on fasting during the month of Ramadan, even during treatment. The purpose of this observational study is to study the practice of fasting, in patients receiving external radiation therapy. METHODS: Our study was conducted during the month of Ramadan 1441 (2018) in the radiotherapy department of Ibn Rochd University Hospital of Casablanca. We included all patients who received external radiotherapy during this period. We thus collected the characteristics of patients, disease and treatment modalities. After an interview, with a pre-established questionnaire, we were able to establish the observance of the fast. RESULTS: We collected a total of 209 patients. The most frequently represented locations were breast cancer followed by gynecological cancers in 35.4% and 18.7% respectively. All our patients were fasting Ramadan before the diagnosis of cancer, however, only 39.2% were fasting during the treatment by radiotherapy, and just 40% of patients have discussed the possibility of fasting with their oncologist. In multivariate analysis, the stage of the disease was the only factor related to the fasting status of our patients. DISCUSSION: Even under treatment, many of our patients fast during the month of Ramadan. Further studies are needed to evaluate the tolerance of fasting in order to better answer the question "can I fast?". PMID:34776116 | DOI:10.1016/j.bulcan.20 21.05.010 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Moxetumomab pasudotox-Third line in Hairy cell leukemia

xlomafota13 shared this article with you from Inoreader Moxetumomab pasudotox-Third line in Hairy cell leukemia Via Association française pour l'étude du cancer Bull Cancer. 2021 Nov 11:S0007-4551(21)00378-7. doi: 10.1016/j.bulcan.2021.07.011. Online ahead of print. NO ABSTRACT PMID:34776118 | DOI:10.1016/j.bulcan.2021.07.011 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Medicinal plants used by patients to fight cancer

xlomafota13 shared this article with you from Inoreader Medicinal plants used by patients to fight cancer in northwestern Algeria Via Association française pour l'étude du cancer Bull Cancer. 2021 Nov 11:S0007-4551(21)00441-0. doi: 10.1016/j.bulcan.2021.09.017. Online ahead of print. ABSTRACT Cancer is among the deadliest diseases in the world, especially in developed countries where modern treatments are not available to everyone. In North Africa, and especially in Algeria, few herbal treatments against cancer have been documented despite the richness of flora in these countries. This research aim to documents the medicinal plants used by patient to fight cancer in the northwest of Algeria. Data were collected through ethnobotanical surveys engaging 211 cancer patients in hospitals (departments of medical oncology) in two of the largest provinces in northwest Algeria (Tiaret and Tlemcen). The data were organized into usage reports (UR), while the Informant Consensus Factor (ICF) was calculated to evaluate agreement among informants. The patients investigated were mainly women, of middle age (41-50 years) and i lliterate. In total, 53 medicinal plants used against several types of cancer have been identified. These plants are dominated by Lamiaceae, Apiaceae and Rosaceae. The leaves and powder of plants are most often used in traditional preparations often mixed with honey. The plants most often cited in the survey were Aristolochia longa, Aquilaria malaccensis, Ephedra alata subsp. alenda, while the most often treated cancer were breast, cervical, colorectal and stomach. 23 plants are not known as a treatment against cancers in North Africa, while 25 plants already known as treatment for cancer were cited here to treat specific new types of this disease. PMID:34776117 | DOI:10.1016/j.bulcan.2021.09.017 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Translating Access to Outcomes: The Impact of Socioeconomic Status on Completion of Breast Reconstruction at a National Cancer Institute (NCI)-Designated Cancer Center: Impact of SES on Completion

xlomafota13 shared this article with you from Inoreader Translating Access to Outcomes: The Impact of Socioeconomic Status on Completion of Breast Reconstruction at a National Cancer Institute (NCI)-Designated Cancer Center: Impact of SES on Completion Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Sep 20:S1748-6815(21)00424-1. doi: 10.1016/j.bjps.2021.08.034. Online ahead of print. ABSTRACT The purpose of this study was to determine the impact of socioeconomic status (SES) on the completion of breast reconstruction, as defined by the percent of patients undergoing NAC reconstruction. Patients (n=949) who underwent primary breast reconstruction following a mastectomy recorded from 2007 to 2017 were divided into groups based on the median household income of their residential zip code (>/< $67,640). A three-step protocol was designed to (1) broadly compare between patients of low and high SES who were stratified by race and reconstruction type, (2) compare a smaller subset of low SES and high SES patients via propensity matching for demographic, baseline health, and oncologic factors, and (3) elucidate the strongest predictors of non-completion and delayed completion among low SES patients . Patients of lower SES appear less likely to complete NAC reconstruction, especially following staged reconstruction. That this finding presents in staged, but not immediate reconstruction, and disappears with propensity matching for oncologic factors suggests that reduced completion in patients of low SES may be attributable to advanced cancer staging and aggressive adjuvant therapy. Furthermore, expander conversion to autologous reconstruction significantly increased the likelihood of NAC reconstruction in multivariable analysis, and adjuvant radiation therapy significantly increased the time to NAC reconstruction. Further investigation will solidify the relationship between SES, cancer staging, and completion of reconstruction in a multi-site patient population. Larger multivariable analyses may also uncover other factors that can be modified or addressed to increase completion and optimize reconstruction for patients at risk of discontinuation. PMID:34776390 | DOI:10.1016/j.bjps.2021.08.034 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A supportive donor nerve for long-term facial paralysis: Anatomical analysis of the posterior auricular nerve and micro-anatomical comparison with zygomatic nerve

xlomafota13 shared this article with you from Inoreader A supportive donor nerve for long-term facial paralysis: Anatomical analysis of the posterior auricular nerve and micro-anatomical comparison with zygomatic nerve Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Oct 22:S1748-6815(21)00490-3. doi: 10.1016/j.bjps.2021.09.049. Online ahead of print. ABSTRACT BACKGROUND: The posterior auricular nerve (PAN) is an inspiring candidate for the additional axonal source in long-term facial paralysis to improve the functional results of the cross-facial nerve (FN) graft technique. However, no studies have analyzed the PAN's axonal load and its microscopic anatomy to assess its utilization in facial reanimation. The present study aims to examine the anatomical and microscopic features of the PAN to analyze its feasibility as a donor nerve. METHODS: The bilateral facial side of 14 fresh frozen adult human cadavers was examined for the study. The PAN's anatomical course was recorded, and nerve specimens from the PAN and zygomatic nerve (ZN) were obtained to compare their microscopic anatomy and axon counts using a light microscope and transmission electron microscop e. RESULTS: The PAN's average branching distance and its course length were 5.8 ± 2.69 mm and 59.2 ± 5.85, respectively. The mean number of myelinated axons was 600.28 ± 69.97 in the PAN and 728.85 ± 166.31 in the ZN. This difference between the two nerves was statistically significant (p = 0.002). However, considering the gender variable, the mean axon counts of PAN and ZN were statistically similar for face sides and their average. Furthermore, the ultrastructural anatomy of both nerves was similar in electron microscopic evaluation. CONCLUSIONS: The present study confirms that the PAN is a proper candidate to be a supportive donor nerve due to its isolated site, consistent anatomical course, convenient ultrastructural anatomy as well as axonal load. PMID:34776387 | DOI:10.1016/j.bjps.2021.09.049 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Head and neck research in plastic surgery-Ahead of the rest? An analysis of abstracts presented at British association of plastic reconstructive and aesthetic surgeons meetings

xlomafota13 shared this article with you from Inoreader Head and neck research in plastic surgery-Ahead of the rest? An analysis of abstracts presented at British association of plastic reconstructive and aesthetic surgeons meetings Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Oct 22:S1748-6815(21)00492-7. doi: 10.1016/j.bjps.2021.09.047. Online ahead of print. ABSTRACT INTRODUCTION & AIMS: Historically, the head and neck (H&N) discipline has been integral to the service a plastic surgeon provides. Recently, it has been postulated that its popularity is declining. The output of scientific meetings may indicate the popularity of each sub-speciality interest, also allowing comparison with other H&N conferences. AIM: To analyse the proportion of H&N themed, podium and poster presentations from British Association of Plastic Reconstructive and Aesthetic Surgeons' (BAPRAS) scientific meetings and the resulting contribution to published literature. MATERIAL AND METHODS: H&N-themed abstracts were identified from finalised programmes of the biannual BAPRAS meetings between 2008 and 2015. PubMed and Google Scholar databases were searched using keywor ds and author names from each abstract to identify subsequent publication in a peer-reviewed journal. RESULTS: Overall, 19.3% (350/1815) of BAPRAS abstracts were H&N themed. The publication rate of H&N abstracts was 40.3% (141/350), comprising 43.0% (114/265) of podium and 31.8% (27/85) of poster presentations. H&N reconstruction and cleft and craniofacial were the most frequent topics, with facial palsy having the lowest conversion rate at 15.4%. The mean time to publication was 17.8 months. Research was published in 39 journals, with a mean impact factor of 2.151 (range = 0.772-11.541). The most popular journal was Journal of Plastic, Reconstructive & Aesthetic Surgery (JPRAS; 31.7%; 45/141). Published abstracts originated from 17 different countries. The senior author was a plastic surgeon in 77.3% of abstracts. CONCLUSIONS: From the multiple potential sub-specialties, H&N-themed abstracts consistently contributed 20% of all research presented at B APRAS. The 40.3% publication rate exceeds the international average of scientific meetings. H&N remains a prominent field in the armamentarium of a plastic surgeon. PMID:34776391 | DOI:10.1016/j.bjps.2021.09.047 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Orbito-Cranial Gunshot Injuries with Retained Sinonasal Bullets

xlomafota13 shared this article with you from Inoreader Orbito-Cranial Gunshot Injuries with Retained Sinonasal Bullets Via leak of cerebrospinal fluid J Maxillofac Oral Surg. 2021 Dec;20(4):551-557. doi: 10.1007/s12663-020-01365-4. Epub 2020 Apr 17. ABSTRACT INTRODUCTION: Gunshot injuries to the sino-orbital region are rare. In South Africa, where gunshot injuries are common, sino-orbital gunshot injuries are encountered. Sino-orbital gunshot injuries are associated with trauma to surrounding facial and intracranial structures. Therefore, the management of these injuries may be complex and often requires an interdisciplinary approach. AIMS: To review the management of orbito-cranial gunshot injuries with retained sinonasal bullets. PATIENTS AND METHODS: Three cases of orbito-cranial gunshot injuries with retained sinonasal bullets were reviewed. Two cases were complicated by cerebrospinal fluid leaks with ensuing meningitis. The retained bullets in all three cases were successfully removed via a transnasal endoscopic approach. CONCLUSION: Sino-orbital gunshot injuries are rare, but may be encountered in areas with high frequencies of gun violence. An associated anterior skull base fracture with CSF rhinorrhoea poses a risk for meningitis and a low threshold for diagnosis and treatment of meningitis should be maintained. Retained bullets in the paranasal sinuses do not pose an immediate risk and may be removed on an elective basis. PMID:34776683 | PMC:PMC8555000 | DOI:10.1007/s12663-020-01365-4 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Ewing Sarcoma of the Ethmoid Sinus in an Adult

xlomafota13 shared this article with you from Inoreader Ewing Sarcoma of the Ethmoid Sinus in an Adult Via ear nose throat Ear Nose Throat J. 2021 Nov 14:1455613211053426. doi: 10.1177/01455613211053426. Online ahead of print. ABSTRACT Extraskeletal Ewing sarcoma (EES) is a relatively rare primary tumor of the soft tissues predominantly affecting men in the second and third decades of life. They are a less common form of the cancerous growth known as an Ewing sarcoma, which occurs in bones or soft tissue such as cartilage. Head and neck ESS can require intervention including endoscopic sinus sur gery, septoplasty, inferior turbinectomy, and left internal nasal valve repairs with septal cartilage This is a case report on an unusual presentation of ESS in the sinonasal region. PMID:34779260 | DOI:10.1177/01455613211053426 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Radiation‐Associated Sarcoma of the Head and Neck: Incidence, Latency, and Survival

xlomafota13 shared this article with you from Inoreader Radiation‐Associated Sarcoma of the Head and Neck: Incidence, Latency, and Survival Via The Laryngoscope Objectives/Hypothesis Radiation-associated sarcomas of the head and neck (RASHN) are known but rare sequelae after radiation for squamous cell carcinoma. The purpose of this study was to characterize RASHN, estimate the risk of RASHN in head and neck squamous cell patients after therapeutic radiation, and compare their survival to that of patients with de novo sarcomas of the head and neck (dnSHN). Study Design Retrospective database analysis. Methods RASHN and dnSHN cases were collected from the Surveillance, Epidemiology, and End Results Database to identify risk factors and calculate incidence and latency. Survival was compared between RASHN and dnSHN. Results The risk of RASHN was 20.0 per 100,000 person-years. The average latency period was 124.2 months (range 38–329). The cumulative incidence of RASHN at 20 years was 0.13%. Oral cavity and oropharynx primaries demonstrate increased risk. Five-year overall survival of RASHN was 22.4% compared to 64.5% for dnSHN. Conclusions RASHN are confirmed to be rare. RASHN have poor overall survival and worse survival compared to dnSHN. The impact of intensity-modulated radiation therapy protocols on this risk is unknown. Modifiable risk factors of smoking and alcohol consumption continue to dwarf radiation therapy as risk factors of second primary head and neck cancers. Level of Evidence 3 Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.