Functional Outcomes and Postoperative Cerebral Venous Sinus Thrombosis after Translabyrinthine Approach for Vestibular Schwannoma Resection: A Radiographic Demonstration of Anatomic Predictors

xlomafota13 shared this article with you from Inoreader Functional Outcomes and Postoperative Cerebral Venous Sinus Thrombosis after Translabyrinthine Approach for Vestibular Schwannoma Resection: A Radiographic Demonstration of Anatomic Predictors Via Journal of Neurological Surgery Part B: Skull Base J Neurol Surg B Skull Base DOI: 10.1055/s-0040-1722716 Introduction While regarded as an effective surgical approach to vestibular schwannoma (VS) resection, the translabyrinthine (TL) approach is not without complications. It has been postulated that postoperative cerebral venous sinus thrombosis (pCVST) may occur as a result of injury and manipulation during surgery. Our objective was to identify radiologic, surgical, and patient-specific risk factors that may be associated with pCVST. Methods The Institutional Review Board (IRB) approval was obtained and the medical records of adult patients with VS who underwent TL craniectomy at University Hospitals Cleveland Medical Center between 2009 and 2019 were reviewed. Demographic data, radiographic measurements, and tumor characteristics were collected. Outcomes assessed included pCVST and the modified Rankin score (mRS). Results Sixty-one patients ultimately met inclusion criteria for the study. Ten patients demonstrated radiographic evidence of thrombus. Patients who developed pCVST demonstrated shorter internal auditory canal (IAC) to sinus distance (mean: 22.5 vs. 25.0 mm, p = 0.044) and significantly smaller petrous angles (mean: 26.3 vs. 32.7 degrees, p = 0.0045). Patients with good mRS scores (<3) appeared also to have higher mean petrous angles (32.5 vs. 26.8, p = 0.016). Koos' grading and tumor size, in our study, were not associated with thrombosis. Conclusion More acute petrous angle and shorter IAC to sinus distance are objective anatomic variables associated with pCVST in TL surgical approaches. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Transoral Endoscopic Localization of the Parapharyngeal Internal Carotid Artery

xlomafota13 shared this article with you from Inoreader Transoral Endoscopic Localization of the Parapharyngeal Internal Carotid Artery Via Journal of Neurological Surgery Part B: Skull Base J Neurol Surg B Skull Base DOI: 10.1055/s-0040-1722229 Objectives To define transoral endoscopic surgical landmarks for the parapharyngeal segment of the internal carotid artery (ppICA) using cadaveric dissection. Materials and Methods Ten fresh cadaveric heads were dissected to demonstrate the parapharyngeal space anatomy and course of the ppICA as seen in a transoral approach. Anatomical measurements of the distance between the ppICA and bony landmarks were recorded and analyzed. Results The stylohyoid ligament, styloglossus, and stylopharyngeus could be considered to be the safe anterior boundary of the ppICA in the transoral approach; among them, the styloid ligament was the most rigid tissue. Dissection between the stylopharyngeus muscle and superior pharyngeal constrictor muscle provides direct access to the ppICA. At the level of the skull base, the distance from the root of the styloid process to the lateral margin of the external aperture of the carotid canal on the left side and on the right side was 8.57 ± 1.97 and 8.80 ± 1.21 mm, respectively. At the level of the maxillary tuberosity, the distance from the ppICA to the maxillary tuberosity on the left side and on the right side was 31.48 ± 2.24 and 31.01 ± 2.88 mm, respectively. Conclusion The endoscopic-assisted transoral approach can facilitate exposure of the ppICA. The root of the styloid process, styloid ligament, and maxillary tuberosity are critical landmarks in the identification of the ppICA in the transoral approach. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Long-term management of lenvatinib-treated thyroid cancer patients: a real-life experience at a single institution.

xlomafota13 shared this article with you from Inoreader Long-term management of lenvatinib-treated thyroid cancer patients: a real-life experience at a single institution. Via radioactive iodine Related Articles Long-term management of lenvatinib-treated thyroid cancer patients: a real-life experience at a single institution. Endocrine. 2021 Feb 03;: Authors: Porcelli T, Luongo C, Sessa F, Klain M, Masone S, Troncone G, Bellevicine C, Schlumberger M, Salvatore D Abstract PURPOSE: The efficacy of lenvatinib for advanced and progressive radioactive iodine refractory differentiated thyroid cancer is well established. Herein, we retrospectively evaluated the long-term safety and efficacy of lenvatinib in 23 patients treated at a single Institution. METHODS: Clinical data of all patients treated for a differentiated thyroid cancer with lenvatinib from April 2015 to September 2020 were retrospectively analyzed. RESULTS: A total of 23 patients were included. In all, 21 patients received lenvatinib as first-line systemic therapy. Median age at initiation of lenvatinib treatment was 68 (44-90) years. Median duration of the study from initiation of lenvatinib to study end was 23 (2-65) months. The indication for lenvatinib treatment was documented progression of distant metastases in 20 patients and of locally advanced disease in the other 3 and median duration of lenvatinib therapy was 15 (2-64) months. Best treatment responses were: partial response in 6 patients, stable disease in 14, progressive disease in 1, and not evaluable in 2. Median progression-free survival was 25 months (95% CI: 12-40) and median overall survival was 46 months (95% CI: 28-65). Three patients had to discontinue lenvatinib treatment due to serious adverse events and no drug-related death was observed. Ten patients continued lenvatinib for more than 24 months and the only newly registered adverse event after t his period of time was one case of G2 proteinuria. Six patients continued lenvatinib treatment beyond documented tumor progression due to oligoprogression or slowly progressive disease (median time 18.5 months, 8-42 months). A total of 14 patients were alive at the end of the study: 11 showed partial response/stable disease on lenvatinib, including 3 who had a stable disease after local ablative therapy for oligoprogressive metastases; 3 had to change treatment, including 2 for lenvatinib-related serious adverse events and 1 for progressive disease. CONCLUSIONS: Long-term lenvatinib treatment is safe and some patients may experience persistent long-term control of the disease. Late treatment-related AEs rarely occurred. Oligoprogressive and slowly progressive disease can be managed without treatment withdrawal as long as there are some clinical benefits. PMID: 33537956 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The content management system ILIAS

xlomafota13 shared this article with you from Inoreader Message: ILIAS is an open-source web-based learning management system. It supports learning content management and tools for collaboration, communication, evaluation and assessment. The software is published under the GNU General Public License and can be run on any server that supports PHP and MySQL. Wikipedia [Electronic learning for otorhinolaryngology students using the content management system ILIAS]. Via hno Related Articles [Electronic learning for otorhinolaryngology students using the content management system ILIAS]. HNO. 2021 Feb 03;: Authors: van Bonn SM, Grajek JS, Großmann W, Bernd HE, Rettschlag S, Mlynski R, Weiss NM Abstract BACKGROUND: With increasing access to online teaching materials, traditional teaching methods at universities need to be questioned in the context of digital transformation. The aim of this study was to evaluate whether electronic learning may serve as or replace conventional internship in otorhinolaryngology. MATERIALS AND METHODS: A completely digital electronic learning concept was created and made available at the online learning platform ILIAS. Students were introduced to the program. Four learning units (neck [I], pharynx/larynx [II], nose [III], ear [IV]) were set up, with a topic-related multiple-choice test at the end of each unit. The students took part in the evaluation before and after completion of the course. RESULTS: A total of 105 students participated in the evaluation before and 85 students after the electronic learning program. After completing the courses, the majority of students (52.94%) stated to be more satisfied with the content and the presentation of the learning sequences as well as with their own self-control concerning learning pace and time management compared to the situation before completing the program (34.29%; p < 0.0001). The majority of students (54.12%) stated that they would appreciate the electronic learning program in addition to practical internship. CONCLUSION: The electronic learning program is a promising approach to supplement traditional learning and internships. An expansion of digital teaching proposals should be supported based on this study. PMID: 33537879 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Image‐guided robots for low dose rate (LDR) prostate brachytherapy: perspectives on safety in design and use

xlomafota13 shared this article with you from Inoreader Image‐guided robots for low dose rate (LDR) prostate brachytherapy: perspectives on safety in design and use Via The International Journal of Medical Robotics and Computer Assisted Surgery ABSTRACT Background Image‐guided brachytherapy (BT) robots can be used to assist urologists during seed implantation, thereby improving therapeutic effects. However, safety issues must be considered in the design of such robots, including their structure, mechanical movements, function, materials, and actuators. Previous reviews focused on image‐guided prostate BT robot technology (e.g., imaging and robot navigation technology and robot system introduction); however, this review is the first time that safety issues have been investigated as part of a study on low dose rate (LDR) prostate BT robots. Methods Multiple electronic databases were searched for LDR prostate BT robot articles published during the last 24 years (1996–2020), with a particular focus on two aspects of robots: safety in design and use. Results We retrieved a total of 26 LDR prostate BT robots. BT robots were divided into ultrasound, CT, MRI, and fusion‐guided systems. The conditions associated with each system were then analyzed to develop a set of requirements for the safety of prostate BT robots. Recommendations are also provided for future BT robot development. Conclusions The transrectal approach for prostate seed implantation is safer than the traditional transperineal approach. Research into the control of a steerable needle by the urologists and robot, the needle deflection model, and robotic automated needle changing and seed injection equipment should be pursued in a future study. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

COVID-19 associated anxiety enhances tinnitus

xlomafota13 shared this article with you from Inoreader COVID-19 associated anxiety enhances tinnitus Via Tinnitus by Li Xia, Gang He, Yong Feng, Xiaoxu Yu, Xiaolong Zhao, Shankai Yin, Zhengnong Chen, Jian Wang, Jiangang Fan, Chuan Dong To investigate if the anxiety associated with coronavirus disease 2019 (COVID-19) is a promoting factor to tinnitus. A retrospective research design collected from 188 tinnitus patients, was used to compare the clinical characteristics of tinnitus between the patients in 2020 under pandemic pressure and those from the matching period in 2019. While anxiety was quantified using the Zung's Self-rating Anxiety Scale (SAS), tinnitus severity was evaluated using the Tinnitus Handicap Inventory (THI) questionnaire and the test of tinnitus loudness (TL). The assessments were repeated after the sound therapy plus educational counselling (STEC) for 38 patients in 2020 and 58 patients in 2019 and compared with EC alone therapy for 42 patients in 2020 and 17 patients in 2019. A large increase in anxiety was evident in 2020 in both case rate and SAS. The treatment of both methods was less effective in 2020. SAS, THI and TL were all deteriorated after the EC alone treatment in 2020, while an im provement was seen in 2019. This suggests that EC alone could not counteract the stress by COVID-19 at all, and the stress, if not managed well, can significantly increase the severity of tinnitus and associated anxiety. By using the EC subgroup in virtual control, we conclude that anxiety can serve as a promoting factor to tinnitus. We believe that this is the first study report that confirm the causative/promotive role of anxiety on tinnitus during COVID-19 pandemic. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Validation of the Nasal Obstruction Symptom Evaluation Scale in Pediatric Patients

xlomafota13 shared this article with you from Inoreader Validation of the Nasal Obstruction Symptom Evaluation Scale in Pediatric Patients Via The Laryngoscope Objective/Hypothesis The Nasal Obstruction Symptom Evaluation (NOSE) is a disease specific quality of life instrument developed and validated in adults. The objective of this study is to evaluate the validity of the NOSE scale for pediatric nasal obstruction. We also examined the effect of septoplasty with bilateral inferior turbinate reduction in this population. Study Design A validation study at a tertiary care children's hospital. Methods Thirty‐eight pediatric patients who underwent septoplasty and bilateral inferior turbinate reduction between 2014 and 2018 were included. Patients were administered the NOSE instrument on the day of their clinic evaluation, the day of surgery, and at their 6 to 8‐week post‐operative appointment. A sample of 40 pediatric patients with non‐rhinologic complaints was also included. Confirmatory factor analysis was performed to evaluate the factorial validity of the NOSE instrument. Results Of the 78 patients included, the mean age was 15.4 years (SD 3.4). In the confirmatory factor analysis, factor loadings were all significant and ranged from 0.95 to 0.99. Internal consistency reliability using Omega and maximal reliability H indices were well above recommended standards (Omega = 0.983 and maximal H = 0.988). Test–retest reliability was also adequate. Mean NOSE scores significantly improved following surgery (from 96.7 [SD 6.2] to 8.8 [SD 7.8]; mean difference = −87.9; 95% CI: −84.5, −91.3; P < .001). Similar improvements were observed across age groups. Conclusions The NOSE scale is a valid and reliable quality of life instrument for pediatric patients with nasal obstruction. Nasal septoplasty with bilateral turbinate reduction substantially improved symptoms of nasal obstruction. Level of Evidence 4 Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Relationship between back posture and early orthodontic treatment in children

xlomafota13 shared this article with you from Inoreader Relationship between back posture and early orthodontic treatment in children Via Head & Face Medicine The purpose of this study was to analyze the relationship between body posture and sagittal dental overjet in children before and after early orthodontic treatment with removable functional orthodontic applian... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Diagnostic Value of Butanol Threshold Test in COVID-19 Related Olfactory Dysfunction

xlomafota13 shared this article with you from Inoreader Diagnostic Value of Butanol Threshold Test in COVID-19 Related Olfactory Dysfunction Via Otolaryngology Indian Abstract Olfactory and taste dysfunction has been reported as a specific, preliminary symptom in COVID-19, but a few comparative studies with quantitative tests are reported. In this study, we aimed to compare the butanol olfactory threshold values between COVID-19 patients and healthy volunteers.A cross-sectional study was designed. A total of 53 patients were included in the COVID-19 group and the control group. The definitive diagnosis of COVID-19 was made with reverse-transcription polymerase chain reaction (RT-PCR) test. Frequency of odor and taste dysfunction and other head and neck system-specific and other symptoms were recorded. Afterward, olfactory threshold values determined according to Connecticut Chemosensory Clinical Research Center (CCCRC) test principle for study groups. 21 patients included in the COVID-19 group and 32 patients in the control group. Symptom onset time was 7.1 ± 3.1 (min: 3, max: 14) days for COVID-19 patients. The most common sympto m in the otolaryngology system was olfactory dysfunction (n = 15, 71.4%). The butanol olfactory threshold value was determined as an average of 4.4 ± 1.9 in the COVID-19 group and 6.4 ± 0.8 in the control group (p < 0.001, 95% CI 2.9–1.0). The sensitivity of the butanol threshold test for COVID-19 related olfactory dysfunction was 80.0% and the specificity was 66.6%. For differential, early and initial, diagnosis of COVID-19, complaint of the smell dysfunctions, and impairment butanol threshold may be a distinctive indicator. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Tracheoesophageal puncture closure with annular mucosal flap

xlomafota13 shared this article with you from Inoreader Tracheoesophageal puncture closure with annular mucosal flap Via Head & Neck Abstract Background To present an effective and easily applicable method for tracheoesophageal puncture (TEP) closure by using a localized annular flap instead of bulky and distant flaps. Methods The medical records of patients who underwent TEP closure surgery with the annular mucosal flap technique between July 2012 and August 2018 were retrospectively reviewed. Fistula size, indication for closure, duration of surgery, radiotherapy status, and surgery results were analyzed. Results We have used our technique in nine patients. No postoperative bleeding, wound infection, esophageal stenosis, and tracheostoma stenosis occurred. In all these patients except one, successful closure was achieved. None of the patients had a recurrence of the TEP. Conclusion The annular mucosal flap technique for TEP closure is easy and quick to apply. The patient's oral feeding at the sixth hour after procedure without using a nasogastric tube makes the technique preferable as a priority. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A phase II study of nimotuzumab (TheraCim‐hR3) concurrent with cisplatin/radiotherapy in patients with locally advanced head and neck squamous cell carcinoma

xlomafota13 shared this article with you from Inoreader A phase II study of nimotuzumab (TheraCim‐hR3) concurrent with cisplatin/radiotherapy in patients with locally advanced head and neck squamous cell carcinoma Via Head & Neck Abstract Background The efficacy of a combination of nimotuzumab, a humanized monoclonal antibody to the epidermal growth factor receptor, with chemoradiation in locally advanced head and neck squamous cell carcinoma (HNSCC) was evaluated in a phase II study. Methods Patients with stage III/IV HNSCC received 3‐weekly cisplatin 100 mg/m2 for three cycles and weekly nimotuzumab 200 mg for 8 weeks concurrently with radiotherapy. Primary endpoint was best overall response (BOR) and secondary endpoint was progression‐free survival (PFS). Results Thirty‐seven patients were included; the majority were Chinese (76%), male (89%), and had stage IVA/IVB HNSCC (92%). BOR of complete and partial response was seen in 22/37 (59%) and 10/37 (27%) patients, respectively. Median PFS was 17.5 months (95% CI: 11.1–54.5) and 3‐year PFS was 40.4% (95% CI: 24.3–55.9). The frequency and type of adverse events observed were similar to standard chemoradiation. Conclusion The combination of nimotuzumab with cisplatin and radiotherapy was safe and achieved high response rates in HNSCC. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.