The brain's traffic problems

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New Products

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Understanding preeclampsia

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News at a glance

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Journey to jorumycin

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Shake-up threatens novel U.S. ecology facility

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Observation of magnetically tunable Feshbach resonances in ultracold 23Na40K + 40K collisions

Resonances in ultracold collisions involving heavy molecules are difficult to simulate theoretically and have proven challenging to detect. Here we report the observation of magnetically tunable Feshbach resonances in ultracold collisions between potassium-40 (⁴⁰K) atoms and sodium-23–potassium-40 (²³Na⁴⁰K) molecules in the rovibrational ground state. We prepare the atoms and molecules in various hyperfine levels of their ground states and observe the loss of molecules as a function of the magnetic field. The atom-molecule Feshbach resonances are identified by observing an enhancement of the loss. We have observed 11 resonances in the magnetic field range of 43 to 120 gauss. The observed atom-molecule Feshbach resonances at ultralow temperatures probe the three-body potential energy surface with exceptional resolution and will help to improve understanding of ultracold collisions.

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Did neurons arise from an early secretory cell?

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Why we need fetal tissue research

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In Congo, fighting a virus and a groundswell of fake news

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An anti-ammonia probiotic

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Dueling spacecraft look deep into Saturn and Jupiter

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Addressing a hairy problem

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Pain spreads from shutdown

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Agriculturally dominated landscapes reduce bee phylogenetic diversity and pollination services

Land-use change threatens global biodiversity and may reshape the tree of life by favoring some lineages over others. Whether phylogenetic diversity loss compromises ecosystem service delivery remains unknown. We address this knowledge gap using extensive genomic, community, and crop datasets to examine relationships among land use, pollinator phylogenetic structure, and crop production. Pollinator communities in highly agricultural landscapes contain 230 million fewer years of evolutionary history; this loss was strongly associated with reduced crop yield and quality. Our study links landscape–mediated changes in the phylogenetic structure of natural communities to the disruption of ecosystem services. Measuring conservation success by species counts alone may fail to protect ecosystem functions and the full diversity of life from which they are derived.

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Flotilla launches large survey of Antarctic krill

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CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency

A wide range of human diseases result from haploinsufficiency, where the function of one of the two gene copies is lost. Here, we targeted the remaining functional copy of a haploinsufficient gene using CRISPR-mediated activation (CRISPRa) in Sim1 and Mc4r heterozygous mouse models to rescue their obesity phenotype. Transgenic-based CRISPRa targeting of the Sim1 promoter or its distant hypothalamic enhancer up-regulated its expression from the endogenous functional allele in a tissue-specific manner, rescuing the obesity phenotype in Sim1 heterozygous mice. To evaluate the therapeutic potential of CRISPRa, we injected CRISPRa-recombinant adeno-associated virus into the hypothalamus, which led to reversal of the obesity phenotype in Sim1 and Mc4r haploinsufficient mice. Our results suggest that endogenous gene up-regulation could be a potential strategy to treat altered gene dosage diseases.

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The bones of Bears Ears

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The cerebellum and reward-driven behavior

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Reversing chromatin dynamics for development

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