Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

Παρασκευή 21 Δεκεμβρίου 2018

The changes of cognitive function after brain-blast injury

Changes of inflammatory factors, reactive oxygen species and cognitive function in mice after brain-blast injury p. 258
Ying Liu, Yun-En Liu, Chang-Ci Tong, Hong-Xu Jin
DOI:10.4103/2221-6189.248025
Objective: To study the changes of cognitive function in mouse after brain-blast injury. Methods: Fourty healthy male C57BL/6 mice were randomly divided into model group and control group. After 24 h of injury, histopathological changesc and reactive oxygen species changes were observed under microscope; while changes of inflammatory cytokines content were determined by Western-blot. Four weeks later, Morris water maze method was used to detect the cognition impairment. Results: HE staining showed blast induced brain injury in C57BL/6 mice. Compared with normal control group, the expression of IL-1β,IL-4, IL-6 were significantly increased in brain tissue of model group whereas IL-10 was significantly decreased (P<0.05); ROS expression in the hippocampus of model group mice was significantly increased compared with that in the control group. Morris water maze showed cognition impairment in mice after brain-blast injury. Conclusions: Brain-blast injury causes cognition impairment in mice, which may be related to the occur of inflammatory change and oxidative stress in the early stage.
http://www.jadweb.org/currentissue.asp?sabs=y

The role of regulatory T cells (Tregs) at late stages of stroke

Effect of partial depletion of CD25+ T cells on neurological deficit and tissue damage in acute cerebral ischemia rat models p. 247
Ana L Rodriguez-Perea, Johanna Gutierrez-Vargas, Mauricio Rojas, Gloria P Cardona-Gomez, Paula A Velilla
DOI:10.4103/2221-6189.248029
Objective: To evaluate the role of regulatory T cells (Tregs) at late stages of stroke. Methods: Anti-CD25 antibody (or PBS as a control) was injected to reduce the pool of Tregs in Wistar rats; then, ischemia was induced transiently by middle cerebral artery occlusion during 60 min and reperfusion was allowed for 7 d. Then, Treg frequency was analyzed in peripheral blood, spleen and lymph nodes. Neurological score (0-6) and infarct volume were also determined. Results: Nine days after injection, the CD4+CD25+ T cells were reduced by 70.4%, 44.8% and 57.9% in peripheral blood, spleen and lymph nodes, respectively compared to PBS-treated rats. In contrast, the reduction of CD4+FOXP3+ T cells was lower in the same compartments (38.6%, 12.5%, and 29.5%, respectively). The strongest reduction of CD25+CD4+ T cells was observed in those FOXP3-negative cells in blood, spleen and lymph nodes (77.8%, 52.8%, and 60.7%, respectively), most likely corresponding to activated T cells. Anti-CD25-treated transient middle cerebral artery occlusion rats had a lower neurological deficit and did not develop tissue damage compared with PBS-treated animals. Conclusions: These findings suggest that treatment with anti-CD25 in our model preferentially reduce the T cell population with an activated phenotype, rather than the Treg population, leading to neuroprotection by suppressing the pathogenic response of effector T cells.
http://www.jadweb.org/currentissue.asp?sabs=y

Intranasal ketamine as an analgesic agent for acute pain management in emergency department

: A literature review p. 241
Abdolghader Pakniyat, Morteza Qaribi, Dorin Rahnama Hezaveh, Ali Abdolrazaghnejad
DOI:10.4103/2221-6189.248028
Ketamine is a well-known dissociative anesthetic agent, and has been used over 50 years. Intranasal pathway is a mucosal way for absorbing agents to directly affect in brain via olfactory sheets, bypassing first pass metabolism and the blood brain barrier. The current uses of intranasal ketamine as an analgesic agent for acute pain management in emergency department are discussed in this review article. Using "ketamine", "pain or analgesia", and "intranasal" as keywords, a search of google scholar, Pubmed, web of science, and Medline database from 1970 until 2017 was performed. Finally, from 1 204 papers extracted via primary search, 1 088 papers were omitted and finally 10 studies were considered for further assessment. There were four observational studies, one case series and report and 5 clinical trials. Ketamine was used for acute pain control due to musculoskeletal trauma, burns, and painful procedures. A total of 390 cases were included in these studies. The studies used ketamine with doses ranging 0.45-1.25 mg/kg via intranasal pathway. Intranasal ketamine provides relatively rapid, well tolerated, and clinically significant analgesia for emergency department patients. Considering the lack of adequate studies and undetermined intranasal dose, it is better to conduct further high quality investigation in both adults and pediatrics.
http://www.jadweb.org/currentissue.asp?sabs=y

Endogenous endophthalmitis secondary to melioidosis in paediatric patients

Endogenous endophthalmitis secondary to melioidosis in paediatric patients: Case series and review article p. 234
Wendy Ong Chin Feng, Wee Min Teh, Wan-Hazabbah Wan Hitam, Haslina Mohammad Ali
DOI:10.4103/2221-6189.248027
Endogenous endophthalmitis is a devastating infection of the eye which can lead to permanent blindness. We report two rare cases of paediatric endogenous endophthalmitis secondary to melioidosis with contrasting visual outcomes. Both patients presented with acute painful visual loss with poor vision on presentation after exposure to open water sources (swimming at two separate locations with waterfalls). Both were diagnosed to have melioidosis endogenous endophthalmitis based on the ocular features clinically and via positive melioidosis serology. They otherwise did not exhibit any symptoms and signs suggestive of systemic melioidosis infection. Even though the two children demonstrated severe ocular involvement, ocular culture from vitreous and aqueous sampling taken from one of the patients did not yield any positive results. No ocular sampling was taken from the other patient. After standard antimicrobial treatment, the first patient responded well with good visual recovery without requiring any surgical intervention for the endophthalmitis. In contrast, our second patient ended up with poor visual outcome despite undergoing multiple intravitreal antibiotic injections and early pars plana vitrectomy. This is because he developed extensive retinal detachment due to the aggressive ocular infection. The diagnosis of endogenous endophthalmitis due to ocular melioidosis remains challenging and requires a high index of suspicion in areas endemic for the causative organism. Early empirical antibiotic treatment should be initiated in suspicious cases, even though the treatment outcomes may vary greatly
http://www.jadweb.org/currentissue.asp?sabs=y

A quantitative model of relation between respiratory-related blood pressure fluctuations and the respiratory sinus arrhythmia

Abstract

In order to propose an interpretation of recent experimental findings concerning short-term variability of arterial blood pressure (ABP), heart rate variability (HRV), and their dependence on body posture, we develop a qualitative dynamical model of the short-term cardiovascular variability at respiratory frequency (HF). It shows the respiratory-related blood pressure fluctuations in relation to the respiratory sinus arrhythmia (RSA). Results of the model-based analysis show that the observed phenomena may be interpreted as buffering of the respiratory-related ABP fluctuations by heart rate (HR) fluctuations, i.e., the respiratory sinus arrhythmia. A paradoxical enhancement (PE) of the fluctuations of the ABP in supine position, that was found in experiment, is explained on the ground of the model, as an ineffectiveness of control caused by the prolonged phase shift between the the peak of modulation of the pulmonary flow and the onset of stimulation of the heart. Such phasic changes were indeed observed in some other experimental conditions. Up to now, no other theoretical or physiological explanation of the PE effect exists, whereas further experiments were not performed due to technical problems. Better understanding of the short-term dynamics of blood pressure may improve medical diagnosis in cardiology and diseases which alter the functional state of the autonomous nervous system.

Graphical Abstract

A simple mathematical model of cardiorespiratory dynamics. A novel class of mathematical models of blood pressure dynamics in humans allows to represent respiratory modulation of Arterial Blood Pressure. The model shows how the phase shift in neural control of the heart rate may produce Paradoxic Enhancement of respiratory Blood Pressure fluctuations. Observed in experiment. The model has many options for further development.

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Smile aesthetics as perceived by dental students: a cross-sectional study

Abstract

Background

An aesthetic smile has a number of components, and people generally equate a good dental appearance with success in many areas of life. The features that determine smile aesthetics could provide significant insights into post-treatment satisfaction and may predict a patient's objectives when undergoing treatment. The purpose of this study was to evaluate how smile characteristics are perceived by dental students.

Methods

The study was performed in 431 local and international dental students at the Lithuanian University of Health Sciences. The study data were collected using a three-part questionnaire. The first part of the questionnaire included sociodemographic items, i.e., student gender, age, nationality, and years of study; the second consisted of questions about facial aesthetic features; and the third elicited responses to photographs of 17 different smiles retrieved from the Lithuanian University of Health Sciences Clinic of Orthodontics database. The smile aesthetics were evaluated according to their dentolabial, dentogingival, dental, and dental arch characteristics using a 5-point numeric rating scale (1, best; 5, worst). The data were analysed using the Pearson's chi-square and Mann-Whitney U tests.

Results

The study included 336 local and 95 international dental students (132 men [30.6%], 299 women [69.4%]). Significantly more women than men focused on a person's teeth when communicating (41.5% vs.32.6%, p < 0.005). Women were more critical than men when evaluating gingival smile, the 'golden proportion', occlusal cant, and dental crowding. The most unfavourable smile characteristics were identified in the dental analysis category, with hypodontia ranked as the worst smile feature (mean numeric rating scale score 4.71).

Conclusion

Among dental students, the most distracting characteristics of a smile when determining its attractiveness were hypodontia, gingival smile, a reversed curvature of the occlusal plane, and dental crowding.

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[ASAP] Synthesis of 2-Aryloxy-1,3-dienes from Phenols and Propargyl Carbonates

TOC Graphic

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b11159

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[ASAP] Enhancement of Antiaromatic Character via Additional Benzoannulation into Dibenzo[,]pentalene: Syntheses and Properties of Benzo[]naphtho[2,1-]pentalene and Dinaphtho[2,1-,]pentalene

TOC Graphic

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b11530

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[ASAP] Divalent Ytterbium Complex-Catalyzed Homo- and Cross-Coupling of Primary Arylsilanes

TOC Graphic

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b12138

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Micro-robots powered by chemistry grasp and creep

Micro-robots powered by chemistry grasp and creep

Micro-robots powered by chemistry grasp and creep, Published online: 21 December 2018; doi:10.1038/d41586-018-07870-4

Gel sheets immersed in liquid could crawl forward like inchworms.

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Egypt and Pakistan had highest rise in research output in 2018

Egypt and Pakistan had highest rise in research output in 2018

Egypt and Pakistan had highest rise in research output in 2018 , Published online: 21 December 2018; doi:10.1038/d41586-018-07841-9

Global production of scientific papers hit an all-time high this year, estimates show, with emerging economies rising fastest.

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How a major AI conference is attempting to tackle its culture problem

How a major AI conference is attempting to tackle its culture problem

How a major AI conference is attempting to tackle its culture problem, Published online: 21 December 2018; doi:10.1038/d41586-018-07839-3

Nature talks to Katherine Heller and Hal Daumé, machine-learning researchers who are starting to address the thorny issues related to sexism and diversity surrounding the NeurIPS meeting.

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Daily briefing: Your final Nature Briefing of 2018 — and the science to look out for next year

Daily briefing: Your final Nature Briefing of 2018 — and the science to look out for next year

Daily briefing: Your final <i>Nature Briefing </i>of 2018 — and the science to look out for next year, Published online: 21 December 2018; doi:10.1038/d41586-018-07886-w

Trends for 2019, science lyrics for classic carols and how to embrace academic rejection.

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