Pediatric inflammatory myofibroblastic tumor of the bladder with ALK–FN1 fusion successfully treated by alectinib

alexandrossfakianakis shared this article with you from Inoreader Pediatric inflammatory myofibroblastic tumor of the bladder with ALK–FN1 fusion successfully treated by alectinib via Pediatric Blood & Cancer Abstract An inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm characterized by the proliferation of myofibroblasts and inflammatory cell infiltration. Although radical resection is the only established treatment strategy for IMT, it can cause functional disorders when vital organs are affected. We describe a case of pediatric IMT of the bladder with FN1–ALK (fibronectin 1–anaplastic lymphoma kinase) fusion. Radical resection might lead to urinary disturbance due to the large tumor size at diagnosis. However, the tumor was successfully treated with alectinib, a second-generation ALK inhibitor, followed by transurethral resection of the bladder tumor without any complications. View on Web

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Automatic Dental Biofilm Detection Based on Deep Learning

alexandrossfakianakis shared this article with you from Inoreader Automatic Dental Biofilm Detection Based on Deep Learning via Journal of Clinical Periodontology Abstract Aim To estimate the automated biofilm detection capacity of the U-Net neural network on tooth images. Material and methods Two datasets of intraoral photographs taken in the frontal and lateral views of permanent and deciduous dentitions were employed. The first dataset consisted of 96 photographs taken before and after applying a disclosing agent and was used to validate the domain's expert biofilm annotation (intraclass correlation coefficient = 0.93). The second dataset comprised 480 photos, with or without orthodontic appliances, without disclosing agents, and was used to train the neural network to segment the biofilm. Dental biofilm labeled by the dentist (without disclosing agents) was considered the ground-truth. Segmentation performance was measured using accuracy, F1 score, sensitivity, and specificity. Results The U-Net model achieved an accuracy of 91.8%, F1 score of 60.6%, specificity of 94.4%, and sensitivity of 67.2%. The accuracy was higher in the presence of orthodontic appliances (92.6%). Conclusion Visually segmenting dental biofilm employing a U-Net is feasible and can assist professionals and patients in identifying dental biofilm, thus improving oral hygiene and health. This article is protected by copyright. All rights reserved. View on Web

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Baricitinib or imatinib in hospitalized COVID‐19 patients: results from COVINIB, an exploratory randomized clinical trial.

alexandrossfakianakis shared this article with you from Inoreader Baricitinib or imatinib in hospitalized COVID‐19 patients: results from COVINIB, an exploratory randomized clinical trial. via Journal of Medical Virology ABSTRACT Background Baricitinib and imatinib are considered therapies for COVID-19, but their ultimate clinical impact remains to be elucidated, so our objective is to determine whether these kinase inhibitors provide benefit when added to standard care in hospitalized COVID-19 patients. Methods Phase-2, open-label, randomized trial with a pick-the-winner design conducted from September 2020 to June 2021 in a single Spanish center. Hospitalized adults with COVID-19 pneumonia and a symptom duration ≤ 10 days were assigned to 3 arms: imatinib (400 mg qd, 7 days) plus standard-care, baricitinib (4 mg qd, 7 days) plus standard-care, or standard-care alone. Primary outcome was time to clinical improvement (discharge alive or a reduction of 2 points in an ordinal scale of clinical status) compared on a day-by-day basis in order to identify differences ≥ 15% between the most and least favorable groups. Secondary outcomes included oxygenation and ventilatory support requirements, additional therapies administered all-cause mortality and safety. Results 165 patients analyzed. Predefined criteria for selection of the most advantageous arm were met for baricitinib, but not for imatinib. However, no statistically significant differences were observed in formal analysis, but a trend towards better results in patients receiving baricitinib was found compared to standard care alone (HR for clinical improvement 1.41, 95%CI 0.96-2.06; HR for discontinuing oxygen 1.46, 95%CI 0.94-2.28). No differences were found regarding additional therapies administered or safety. Conclusions Baricitinib plus standard care showed better results for hospitalized COVID-19 patients, being the most advantageous therapeutic strategy among those proposed in this exploratory clinical trial. This article is protected by copyright. All rights reserved. View on Web

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Dentine thickness in maxillary fused molars depends on the fusion type: An ex vivo micro‐CT study

alexandrossfakianakis shared this article with you from Inoreader Dentine thickness in maxillary fused molars depends on the fusion type: An ex vivo micro‐CT study via International Endodontic Journal Abstract Aim The present study aimed to determine and compare the dentine thickness around the root canals of maxillary molars with fusion using micro-computed tomography (micro-CT). Methodology A total of 120 fused maxillary molars having more than a single canal with distinct canal orifices near the cementoenamel junction were selected from a pool of extracted maxillary molars, which were scanned on a micro-CT device (SkyScan 1172, Bruker-microCT, Kontich, Belgium). The minimum dentine thickness around the root canals in furcal direction was measured using CTAn software (v.1.18.8 Bruker-microCT) at each millimetre. The specimens were grouped according to their fusion type, and dentine thickness around the canals was compared. The data were statistically analysed using ANOVA and post hoc Tukey-Kramer tests following an assessment of the normality of their distribution with the Kolmogorov-Smirnov test (p .05). Results Dentine thickness showed a statistically significant decrease at 2 mm below the orifice irrespective of fusion type. The minimum dentine thickness values were detected around the second mesiobuccal canal as 0.30 mm at 6 mm below orifice. Dentine thickness around the mesiobuccal canal significantly greater in fusion type 1 than those of types 2 and 3 (p < .05), while those of distobuccal and palatal canals were significantly thinner in type 3 fusion compared to type 1 or 6 (p < .05). Conclusion Minimum dentine thickness values at the danger zone of distobuccal and palatal canals change according to the fusion type in fused maxillary second molars. View on Web

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Epstein–Barr Virus‐Positive Hemophagocytic Lymphohistiocytosis Following COVID‐19 Vaccination in a Pediatric Patient

alexandrossfakianakis shared this article with you from Inoreader Epstein–Barr Virus‐Positive Hemophagocytic Lymphohistiocytosis Following COVID‐19 Vaccination in a Pediatric Patient via Pediatric Blood & Cancer View on Web

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Oncologic Outcomes After Clinically Node-Negative Salvage Laryngectomy

alexandrossfakianakis shared this article with you from Inoreader Oncologic Outcomes After Clinically Node-Negative Salvage Laryngectomy via JAMA Otolaryngology–Head & Neck Surgery Current Issue This cohort study investigates the association of electiv e neck dissection vs observation with oncologic outcomes among patients who received clinically node-negative salvage total laryngectomy. View on Web

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Brief Tele–Cognitive Behavioral Treatment for Head and Neck Cancer Survivors With Body Image Distress

alexandrossfakianakis shared this article with you from Inoreader Brief Tele–Cognitive Behavioral Treatment for Head and Neck Cancer Survivors With Body Image Distress via JAMA Otolaryngology–Head & Neck Surgery Current Issue This randomized clinical trial evaluates the acceptabilit y and preliminary efficacy of BRIGHT (Building a Renewed ImaGe after Head and neck cancer Treatment), a brief tele–cognitive behavioral therapy, at reducing body image distress among survivors of head and neck cancer. View on Web

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Auricular Reconstruction for Relapsing Polychondritis

alexandrossfakianakis shared this article with you from Inoreader Auricular Reconstruction for Relapsing Polychondritis via JAMA Otolaryngology–Head & Neck Surgery Current Issue This case report describes a woman in her early 20s who p resented to the hospital with an acquired auricular deformity after an ear piercing and was diagnosed with recurrent polychondritis that required total auricular reconstruction. View on Web

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Wide-Field Optical Coherence Tomography to Evaluate Tissue in Oral Cavity and Oropharynx

alexandrossfakianakis shared this article with you from Inoreader Wide-Field Optical Coherence Tomography to Evaluate Tissue in Oral Cavity and Oropharynx via JAMA Otolaryngology–Head & Neck Surgery Current Issue This qualitative study compares wide-field optical cohere nce tomography imaging with standard hematoxylin and eosin slides for margin analysis in squamous cell carcinoma of the oral cavity and oropharynx. View on Web

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Long-term Outcomes of Turbinate Surgery in Patients With Allergic Rhinitis

alexandrossfakianakis shared this article with you from Inoreader Long-term Outcomes of Turbinate Surgery in Patients With Allergic Rhinitis via JAMA Otolaryngology–Head & Neck Surgery Current Issue This systematic review and meta-analysis investigates the long-term outcomes and safety of turbinate surgery in patients with medically refractory allergic rhinitis. View on Web

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Somatic genomic imbalances in ‘tumour-free’ surgical margins of oral cancer

alexandrossfakianakis shared this article with you from Inoreader Somatic genomic imbalances in 'tumour-free' surgical margins of oral cancer via International Journal of Oral and Maxillofacial Surgery via MedWorm.com Up to 30% of oral squamous cell carcinoma (OSCC) patients develop local recurrence and distant metastasis. The molecular status of histologically cancer-free tumour margins could be a critical factor in predicting tumour behaviour. The aim of this study was to detect somatic genomic imbalances in OSCC with emphasis on the surgical margins. DNA was isolated from tumour tissues, margin tissues, and blood samples (used as control) obtained from 11 OSCC patients, and genome-wide array comparative genomic hybridization was performed. (Source: International Journal of Oral and Maxillofacial Surgery) View on Web

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