Baricitinib or imatinib in hospitalized COVID‐19 patients: results from COVINIB, an exploratory randomized clinical trial.

alexandrossfakianakis shared this article with you from Inoreader Baricitinib or imatinib in hospitalized COVID‐19 patients: results from COVINIB, an exploratory randomized clinical trial. via Journal of Medical Virology ABSTRACT Background Baricitinib and imatinib are considered therapies for COVID-19, but their ultimate clinical impact remains to be elucidated, so our objective is to determine whether these kinase inhibitors provide benefit when added to standard care in hospitalized COVID-19 patients. Methods Phase-2, open-label, randomized trial with a pick-the-winner design conducted from September 2020 to June 2021 in a single Spanish center. Hospitalized adults with COVID-19 pneumonia and a symptom duration ≤ 10 days were assigned to 3 arms: imatinib (400 mg qd, 7 days) plus standard-care, baricitinib (4 mg qd, 7 days) plus standard-care, or standard-care alone. Primary outcome was time to clinical improvement (discharge alive or a reduction of 2 points in an ordinal scale of clinical status) compared on a day-by-day basis in order to identify differences ≥ 15% between the most and least favorable groups. Secondary outcomes included oxygenation and ventilatory support requirements, additional therapies administered all-cause mortality and safety. Results 165 patients analyzed. Predefined criteria for selection of the most advantageous arm were met for baricitinib, but not for imatinib. However, no statistically significant differences were observed in formal analysis, but a trend towards better results in patients receiving baricitinib was found compared to standard care alone (HR for clinical improvement 1.41, 95%CI 0.96-2.06; HR for discontinuing oxygen 1.46, 95%CI 0.94-2.28). No differences were found regarding additional therapies administered or safety. Conclusions Baricitinib plus standard care showed better results for hospitalized COVID-19 patients, being the most advantageous therapeutic strategy among those proposed in this exploratory clinical trial. This article is protected by copyright. All rights reserved. View on Web

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Dentine thickness in maxillary fused molars depends on the fusion type: An ex vivo micro‐CT study

alexandrossfakianakis shared this article with you from Inoreader Dentine thickness in maxillary fused molars depends on the fusion type: An ex vivo micro‐CT study via International Endodontic Journal Abstract Aim The present study aimed to determine and compare the dentine thickness around the root canals of maxillary molars with fusion using micro-computed tomography (micro-CT). Methodology A total of 120 fused maxillary molars having more than a single canal with distinct canal orifices near the cementoenamel junction were selected from a pool of extracted maxillary molars, which were scanned on a micro-CT device (SkyScan 1172, Bruker-microCT, Kontich, Belgium). The minimum dentine thickness around the root canals in furcal direction was measured using CTAn software (v.1.18.8 Bruker-microCT) at each millimetre. The specimens were grouped according to their fusion type, and dentine thickness around the canals was compared. The data were statistically analysed using ANOVA and post hoc Tukey-Kramer tests following an assessment of the normality of their distribution with the Kolmogorov-Smirnov test (p .05). Results Dentine thickness showed a statistically significant decrease at 2 mm below the orifice irrespective of fusion type. The minimum dentine thickness values were detected around the second mesiobuccal canal as 0.30 mm at 6 mm below orifice. Dentine thickness around the mesiobuccal canal significantly greater in fusion type 1 than those of types 2 and 3 (p < .05), while those of distobuccal and palatal canals were significantly thinner in type 3 fusion compared to type 1 or 6 (p < .05). Conclusion Minimum dentine thickness values at the danger zone of distobuccal and palatal canals change according to the fusion type in fused maxillary second molars. View on Web

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Epstein–Barr Virus‐Positive Hemophagocytic Lymphohistiocytosis Following COVID‐19 Vaccination in a Pediatric Patient

alexandrossfakianakis shared this article with you from Inoreader Epstein–Barr Virus‐Positive Hemophagocytic Lymphohistiocytosis Following COVID‐19 Vaccination in a Pediatric Patient via Pediatric Blood & Cancer View on Web

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Oncologic Outcomes After Clinically Node-Negative Salvage Laryngectomy

alexandrossfakianakis shared this article with you from Inoreader Oncologic Outcomes After Clinically Node-Negative Salvage Laryngectomy via JAMA Otolaryngology–Head & Neck Surgery Current Issue This cohort study investigates the association of electiv e neck dissection vs observation with oncologic outcomes among patients who received clinically node-negative salvage total laryngectomy. View on Web

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Brief Tele–Cognitive Behavioral Treatment for Head and Neck Cancer Survivors With Body Image Distress

alexandrossfakianakis shared this article with you from Inoreader Brief Tele–Cognitive Behavioral Treatment for Head and Neck Cancer Survivors With Body Image Distress via JAMA Otolaryngology–Head & Neck Surgery Current Issue This randomized clinical trial evaluates the acceptabilit y and preliminary efficacy of BRIGHT (Building a Renewed ImaGe after Head and neck cancer Treatment), a brief tele–cognitive behavioral therapy, at reducing body image distress among survivors of head and neck cancer. View on Web

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Auricular Reconstruction for Relapsing Polychondritis

alexandrossfakianakis shared this article with you from Inoreader Auricular Reconstruction for Relapsing Polychondritis via JAMA Otolaryngology–Head & Neck Surgery Current Issue This case report describes a woman in her early 20s who p resented to the hospital with an acquired auricular deformity after an ear piercing and was diagnosed with recurrent polychondritis that required total auricular reconstruction. View on Web

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Wide-Field Optical Coherence Tomography to Evaluate Tissue in Oral Cavity and Oropharynx

alexandrossfakianakis shared this article with you from Inoreader Wide-Field Optical Coherence Tomography to Evaluate Tissue in Oral Cavity and Oropharynx via JAMA Otolaryngology–Head & Neck Surgery Current Issue This qualitative study compares wide-field optical cohere nce tomography imaging with standard hematoxylin and eosin slides for margin analysis in squamous cell carcinoma of the oral cavity and oropharynx. View on Web

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Long-term Outcomes of Turbinate Surgery in Patients With Allergic Rhinitis

alexandrossfakianakis shared this article with you from Inoreader Long-term Outcomes of Turbinate Surgery in Patients With Allergic Rhinitis via JAMA Otolaryngology–Head & Neck Surgery Current Issue This systematic review and meta-analysis investigates the long-term outcomes and safety of turbinate surgery in patients with medically refractory allergic rhinitis. View on Web

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Somatic genomic imbalances in ‘tumour-free’ surgical margins of oral cancer

alexandrossfakianakis shared this article with you from Inoreader Somatic genomic imbalances in 'tumour-free' surgical margins of oral cancer via International Journal of Oral and Maxillofacial Surgery via MedWorm.com Up to 30% of oral squamous cell carcinoma (OSCC) patients develop local recurrence and distant metastasis. The molecular status of histologically cancer-free tumour margins could be a critical factor in predicting tumour behaviour. The aim of this study was to detect somatic genomic imbalances in OSCC with emphasis on the surgical margins. DNA was isolated from tumour tissues, margin tissues, and blood samples (used as control) obtained from 11 OSCC patients, and genome-wide array comparative genomic hybridization was performed. (Source: International Journal of Oral and Maxillofacial Surgery) View on Web

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Inhibiting Cardiac Autophagy Suppresses Zika Virus Replication

alexandrossfakianakis shared this article with you from Inoreader Inhibiting Cardiac Autophagy Suppresses Zika Virus Replication via Journal of Medical Virology Abstract Zika Virus (ZIKV) infection is a global threat. Other than the congenital neurological disorders it causes, ZIKV infection has been reported to induce cardiac complications. However, the precise treatment plans are unclear. Thus, illustrating the pathogenic mechanism of ZIKV in the heart is critical to providing effective prevention and treatment of ZIKV infection. The mechanism of autophagy has been reported recently in Dengue virus infection. Whether or not autophagy participates in ZIKV infection and its role remains unrevealed. This study successfully established the in vitro cardiomyocytes and in vivo mouse models of ZIKV infection to investigate the involvement of autophagy in ZIKV infection. The results showed that ZIKV infection is both time and gradient-dependent. The key autophagy protein, LC3B, increased remarkably after ZIKV infection. Meanwhile, autophagic flux was detected by immunofluorescence. Applying autophagy inhibitors decreased the LC3B levels. F urthermore, the number of viral copies was quantified to evaluate the influence of autophagy during infection. We found that autophagy was actively involved in the ZIKV infection and the inhibition of autophagy could effectively reduce the viral copies, suggesting a potential intervention strategy for reducing ZIKV infection and the undesired complications caused by ZIKV. This article is protected by copyright. All rights reserved. View on Web

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Needle‐free injection system delivery of ZyCoV‐D DNA vaccine demonstrated improved immunogenicity and protective efficacy in Rhesus macaques against SARS‐CoV‐2

alexandrossfakianakis shared this article with you from Inoreader Needle‐free injection system delivery of ZyCoV‐D DNA vaccine demonstrated improved immunogenicity and protective efficacy in Rhesus macaques against SARS‐CoV‐2 via Journal of Medical Virology Abstract The apprehension of needles related to injection site pain, risk of transmitting the blood borne pathogens and effective mass immunization have led to the development of needle free injection system (NFIS). Here, we evaluated the efficacy of the NFIS and needle injection system (NIS) for the delivery and immunogenicity of DNA vaccine candidate ZyCOV-D in Rhesus macaques against SARS-CoV-2 infection. Briefly, twenty rhesus macaques were divided into five groups (4 animals each) i.e., I (1 mg dose by NIS), II (2mg dose by NIS), III [1mg dose by NFIS], IV (2mg dose by NFIS) and V (phosphate-buffer saline). The macaques were immunized with the vaccine candidates/PBS intradermally on day 0, 28 and 56. Subsequently, the animals were challenged with live SARS-CoV-2 after 15 weeks of the first immunization. Blood, nasal swab, throat swab, and bronchoalveolar lavage fluid specimens were collected on 0, 1, 3, 5 and 7 days post infection from each animal to determine immune response and vira l clearance. Amongst all the five groups, 2mg dose by NFIS elicited significant titers of IgG and neutralizing antibody after immunization with enhancement in their titers post virus challenge. Besides this, it also induced increased lymphocyte proliferation and cytokine response. The minimal viral load post-SARS-CoV-2 challenge and significant immune response in the immunized animals demonstrated efficiency of NFIS in delivering 2mg ZyCOV-D vaccine candidate. This article is protected by copyright. All rights reserved. View on Web

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