Perioperative Antibiotic Use in Endoscopic Endonasal Skull Base Surgery

xlomafota13 shared this article with you from Inoreader Perioperative Antibiotic Use in Endoscopic Endonasal Skull Base Surgery Via Journal of Neurological Surgery Part B: Skull Base J Neurol Surg B Skull Base DOI: 10.1055/s-0041-1736409 Background Improved evidence-based guidelines on the optimal type and duration of antibiotics for patients undergoing endoscopic endonasal transsphenoidal surgery (EETS) are needed. We analyze the infectious complications among a large cohort of EETS patients undergoing a standardized regimen of cefazolin for 24 hours, followed by cephalexin for 7 days after surgery (clindamycin if penicillin/cephalosporin allergic). Methods A retrospective review of 132 EETS patients from 2018 to 2020 was conducted. Patient, tumor, and surgical characteristics were collected, along with infection rates. Multivariate logistic regression determined the variable(s) independently associated with infectious outcomes. Results Nearly all patients (99%) received postoperative antibiotics with 78% receiving cefazolin, 17% receiving cephalexin, 3% receiving clindamycin, and 2% receiving other antibiotics. Fifty-three patients (40%) had an intraoperative cerebrospinal fluid (CSF) leak, and three patients (2%) developed a postoperative CSF leak requiring surgical repair. Within 30 days, no patients developed meningitis. Five patients (4%) developed sinusitis, two patients (3%) developed pneumonia, and one patient (1%) developed cellulitis at a peripheral intravenous line. Two patients (2%) developed an allergy to cephalexin, requiring conservative management. After adjustment for comorbidities and operative factors, presence of postoperative infectious complications was independently associated with increased LOS (β = 3.7 days; p = 0.001). Conclusion Compared with reported findings in the literature, we report low rates of infectious complications and antibiotic intolerance, despite presence of a heavy burden of comorbidities and high intraoperative CSF leak rates among our cohort. These findings support our standardized 7-day perioperative antibiotic regimen. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Endoscopic measurement of nasal septum perforations

xlomafota13 shared this article with you from Inoreader Endoscopic measurement of nasal septum perforations Via hno HNO. 2021 Oct 11. doi: 10.1007/s00106-021-01102-4. Online ahead of print. ABSTRACT BACKGROUND: Nasal septum perforations (NSP) have many uncomfortable symptoms for the patient and a highly negative impact on quality of life. NSPs are closed using patient-specific implants or surgery. Implants are created either under anesthesia using silicone impressions or using 3D models from CT data. Disadvantages for patient safety are the increased risk of morbidity or radiation exposur e. MATERIALS AND METHODS: In the context of otorhinolaryngologic surgery, we present a gentle approach to treating NSP with a new image-based, contactless, and radiation-free measurement method using a 3D endoscope. The method relies on image information only and makes use of real-time capable computer vision algorithms to compute 3D information. This endoscopic method can be repeated as often as desired in the clinical course and has already proven its accuracy and robustness for robotic-assisted surgery (RAS) and surgical microscopy. We expand our method for nasal surgery, as there are additional spatial and stereoperspective challenges. RESULTS: After measuring 3 relevant parameters (NSP extension: axial, coronal, and NSP circumference) of 6 patients and comparing the results of 2 stereoendoscopes with CT data, it was shown that the image-based measurements can achieve comparable accuracies to CT data. One patient could be only partially evaluated because the NSP was larger than the endoscopic field of view. CONCLUSION: Based on the very good measurements, we outline a therapeutic procedure which should enable the production of patient-specific NSP implants based on endoscopic data only. PMID:34633475 | DOI:10.1007/s00106-021-01102-4 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The value of vestibular function tests combined with high stimulus rate auditory brainstem response in Vestibular Migraine

xlomafota13 shared this article with you from Inoreader The value of vestibular function tests combined with high stimulus rate auditory brainstem response in Vestibular Migraine Via Clinical Otolaryngology Abstract We retrospectively analysed the value of vestibular function tests combined with high stimulus rate auditory brainstem response in vestibular migraine. All patients were tested by caloric test, vHIT, and high stimulus rate ABR. The abnormal values of single test including caloric test, vHIT, and high stimulus rate ABR were low. The abnormal values of high stimulus rate ABR combined with vHIT were significantly higher than that of the other two groups. No significant differences among the three combined tests and high stimulus rate ABR combined with vHIT. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Expression of epithelial membrane protein (EMP) 1, EMP 2, and EMP 3 in thyroid cancer

xlomafota13 shared this article with you from Inoreader Expression of epithelial membrane protein (EMP) 1, EMP 2, and EMP 3 in thyroid cancer Via Cellular and Molecular Biology Histol Histopathol. 2021 Oct 7:18378. doi: 10.14670/HH-18-378. Online ahead of print. ABSTRACT Purpose Epithelial membrane protein (EMP) 1, EMP2, and EMP3 are expressed in various types of tumors and have been reported to be involved in carcinogenesis. In this study, we aimed to investigate the expression of these proteins in primary and metastatic thyroid cancer and its clinical implication. Methods EMP1, EMP2, and EMP3 immunohistochemistry was performed using tissue microarrays of 545 primary thyroid carcinomas [338 papillary thyroid carcinoma (PTC), 111 follicular carcinoma (FC), 69 medullary carcinoma (MC), 23 poorly differentiated carcinoma (PDC), and 4 anaplastic carcinoma (AC)] and 59 recurrent or metastatic PTCs. Results EMP1 showed high expression in AC, PTC, FC (P<0.001), and EMP2 was highly expressed in AC (P<0.001). EMP1 and EMP2 were not expressed in stromal cells. Expression of EMP3 in tumor cells [EMP3 (T)] was hig her in PDC, PTC, and AC (P<0.001), and expression in stromal cells [EMP3 (S)] was observed only in AC and PTC (P=0.001). The expression of EMP1 (P=0.002) and EMP3 (T) (P<0.001) was higher in conventional PTC than in follicular variant PTC. PTC with BRAF V600E mutation showed higher expression of EMP1 (P<0.001), EMP3 (T) (P<0.001), and EMP3 (S) (P=0.012) than PTC without BRAF V600E mutation. In the PTC without BRAF V600E mutation group, expression of EMP3 (S) was associated with shorter disease free survival (P=0.004). Metastatic PTC showed higher EMP2 (3.4% vs. 0%, P=0.022) and lower EMP3 (T) (44.1% vs. 66%, P=0.001) than primary PTC. Conclusions Expression of EMP1, EMP2, and EMP3 is different according to the subtypes of thyroid cancer. Further studies are needed to determine their role as prognostic markers and treatment target in thyroid cancer. PMID:34617578 | DOI:10.14670/HH-18-378 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Surgical Preservation of Parathyroid Function During Total Thyroidectomy Can Be Improved by Intraoperative Imaging

xlomafota13 shared this article with you from Inoreader Surgical Preservation of Parathyroid Function During Total Thyroidectomy Can Be Improved by Intraoperative Imaging Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 10, Page 456-458, October 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Ultrasound Appearance Does Not Improve Thyroid Cancer Risk Predicted by Molecular Testing

xlomafota13 shared this article with you from Inoreader Ultrasound Appearance Does Not Improve Thyroid Cancer Risk Predicted by Molecular Testing Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 10, Page 437-440, October 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hybrid [18F]FDG PET/MR Has High Sensitivity and Specificity in the Detection of Recurrent Differentiated Thyroid Cancer

xlomafota13 shared this article with you from Inoreader Hybrid [18F]FDG PET/MR Has High Sensitivity and Specificity in the Detection of Recurrent Differentiated Thyroid Cancer Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 10, Page 447-451, October 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Real-World Thyrotropin Suppression Practices for Low-Risk Papillary Thyroid Cancer Exceed Guideline Recommendations

xlomafota13 shared this article with you from Inoreader Real-World Thyrotropin Suppression Practices for Low-Risk Papillary Thyroid Cancer Exceed Guideline Recommendations Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 10, Page 441-443, October 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Multiparametric Analysis of Speaking Fundamental Frequency in Genetically Related Speakers Using Different Speech Materials: Some Forensic Implications

xlomafota13 shared this article with you from Inoreader Multiparametric Analysis of Speaking Fundamental Frequency in Genetically Related Speakers Using Different Speech Materials: Some Forensic Implications Via Journal of Voice Objective: To assess the speaker-discriminatory potential of a set of fundamental frequency estimates in intraidentical twin pair comparisons and cross-pair comparisons (i.e., among all speakers). Participants: A total of 20 Brazilian Portuguese speakers of the same dialect, namely 10 male identical twin pairs aged between 19 and 35, were recruited. Method: the participants were recorded directly through professional microphones while taking part in a spontaneous dialogue over mobile phones. Acoustic measurements were performed in connected speech samples, and in lengthened vowels, at least 160 ms long produced during spontaneous speech. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Temporal bone computed tomography checklist-TeSLANO: introduction of a standardized preoperative imaging evaluation for middle ear surgery

xlomafota13 shared this article with you from Inoreader Temporal bone computed tomography checklist-TeSLANO: introduction of a standardized preoperative imaging evaluation for middle ear surgery Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Oct 7. doi: 10.1007/s00405-021-07112-w. Online ahead of print. ABSTRACT PURPOSE: Aim of the study was to evaluate if the introduction of the imaging checklist TeSLANO would improve the identification of crucial anatomical findings from temporal bone computed tomography (TBCT) scans among a cohort of Otolaryngology residents. STUDY DESIGN: Single-blinded prospective cohort study. SETTING: Tertiary care university hospital and referral center for otology and skull base surgery. METHODS: The cohort was composed by eight Otorhinolaryngology residents (four junior and four senior) that were individually asked to identify all relevant anatomic findings from preoperative TBCT scans. Supervising surgeon showed to each resident four TBCT scans before and four after the introduction of a systematic checklist evaluation system based on the TeSLANO acronym. Statistical analysis was performed using McNemar's test and results were considered significant with a P value < 0.05. RESULTS: Introduction of the checklist improved global identification of critical anatomical structures from 48.75 to 89.17% (P < 0.05). The postimplementation identification percentage improved for both the senior and junior groups (P < 0.05). CONCLUSIONS: The imaging checklist TeSLANO allows a systematic approach to review TBCT scans and significantly improves identification of critical anatomical structures in Otorhinolaryngology residents. PMID:34618226 | DOI:10.1007/s00405-021-07112-w View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cells

	Albumin Might Attenuate Bacteria-Induced Damage on Kupffer Cells for Patients with Chronic Liver Disease Hao Lin et al.		The TGF-β/NADPH Oxidases Axis in the Regulation of Liver Cell Biology in Health and Disease Macarena Herranz-Itúrbide et al.
	Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders Stefano Sechi et al.		The Critical Role of Growth Factors in Gastric Ulcer Healing: The Cellular and Molecular Mechanisms and Potential Clinical Implications Andrzej S. Tarnawski et al.

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MicroRNA-146b-5p suppresses cholangiocarcinoma cells by targeting TRAF6 and modulating p53 translocation

xlomafota13 shared this article with you from Inoreader MicroRNA-146b-5p suppresses cholangiocarcinoma cells by targeting TRAF6 and modulating p53 translocation Via histochem Acta Histochem. 2021 Oct 1;123(7):151793. doi: 10.1016/j.acthis.2021.151793. Online ahead of print. ABSTRACT BACKGROUND: In view of the poor prognosis and high mortality of cholangiocarcinoma, there is a need for new therapeutic strategies. This study aims to reveal the biological function of miR-146b-5p in cholangiocarcinoma cell and its possible mechanism. METHODS: The expression level and prognostic information on miR-146b-5p in cholangiocarcinoma were obtained in T CGA database. The biological function of miR-146b-5p on proliferation and vitality of cholangiocarcinoma cell HUCCT-1 was examined by EdU and MTT assay, and the apoptosis of HUCCT-1 cells transfected with miR-146b-5p mimic, mimic control, inhibitor, inhibitor control was detected by flow cytometry analysis. The western blot was done to evaluate the effect of miR-146b-5p targeting substrate and the expression of p53 in whole-cell protein and mitochondria fractions. RESULTS: Our finding revealed that miR-146b-5p expression in patients with CHOL was lower than the normal group(p＜0.001). MiR-146b-5p expression was down-regulated in human cholangiocarcinoma HUCCT-1 and RBE cells compared to normal control HIBEC and other cancer cells. The miR-146b-5p mimic could inhibit HUCCT-1 cell proliferation (p＜0.05) and promote HUCCT-1 cell apoptosis significantly (p＜0.05). The results of western blot showed that miR-146b-5p mimic could directly target TRAF6 3'UTR region and up-regulate the expression of p53 in mitochondria and miR-146b-5p inhibitor could down-regulated the level of p53 in mitochondria. CONCLUSION: MiR-146b-5p is a cholangiocarcinoma suppressor by inhibiting cell proliferation and promoting cell apoptosis with targeting TRAF6, possibly via modulating p53 translocation to mitochondria. PMID:34610483 | DOI:10.1016/j.acthis.2021.151793 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.