Lymphography change after liposuction: Possible neo-lymphangiogenesis by surgical trauma

xlomafota13 shared this article with you from Inoreader Lymphography change after liposuction: Possible neo-lymphangiogenesis by surgical trauma Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Jun 3:S1748-6815(21)00258-8. doi: 10.1016/j.bjps.2021.05.006. Online ahead of print. NO ABSTRACT PMID:34172402 | DOI:10.1016/j.bjps.2021.05.006 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

New European Medicines Agency approval: Tucatinib in association with trastuzumab and capecitabine for the treatment of HER2-positive metastatic breast cancer previously treated

xlomafota13 shared this article with you from Inoreader New European Medicines Agency approval: Tucatinib in association with trastuzumab and capecitabine for the treatment of HER2-positive metastatic breast cancer previously treated Via Association française pour l'étude du cancer Bull Cancer. 2021 Jun 22:S0007-4551(21)00175-2. doi: 10.1016/j.bulcan.2021.04.004. Online ahead of print. NO ABSTRACT PMID:34172272 | DOI:10.1016/j.bulcan.2021.04.004 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma

xlomafota13 shared this article with you from Inoreader SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Jun 25. doi: 10.1007/s00405-021-06955-7. Online ahead of print. ABSTRACT PURPOSE: It is of obvious interest to identify clinical prognosis-related oncogenes in HNSCC (head and neck squamous cell carcinoma). METHODS: Based on the available datasets within the TCGA (The Cancer Genome Atlas) and the GEO (Gene Expression Omnibus) databases, the potential mechanism of action of the SEC61G (SEC61 translocon subunit gamma) gene in HNSCC tumorigenesis was explored by several bioinformatics approaches. RESULTS: There was a higher expression level of SEC61G in primary HNSCC tumor tissues than in normal tissues. Moreover, highly expressed SEC61G was statistically associated with the poor survival prognosis of HNSCC patients. When HPV (human papilloma virus) was considered, we also observed a relatively lower proportion of "arm-level gain" and "high amplification" types of CNA (copy-number alteration) in the HNSCC-HPV (+) group than in the HNSCC-HPV (-) group. Additionally, we identified SEC61G CAN-correlated genes, such as CCT6A (chaperonin-containing TCP1 subunit 6A) and HUS1 (HUS1 checkpoint clamp component), and found a correlation between SEC61G copy-number segments and prognosis related to overall and progression-free survival intervals of HNSCC patients. Moreover, the molecular regulation mechanisms of the spliceosome, ribosome, proteasome degradation, cell adhesion, and immune infiltration of B and CD8+ T cells may contribute to the involvement of SEC61G in the pathogenesis of HNSCC. CONCLUSIONS: The SEC61G gene was identified for the first time as a prognostic biomarker of HNSCC. The detailed underlying mechanism merits further research. PMID:34173014 | DOI:10.1007/s00405-021-06955-7 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Audiological results and subjective benefit of an active transcutaneous bone-conduction device in patients with congenital aural atresia

xlomafota13 shared this article with you from Inoreader Audiological results and subjective benefit of an active transcutaneous bone-conduction device in patients with congenital aural atresia Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Jun 26. doi: 10.1007/s00405-021-06938-8. Online ahead of print. ABSTRACT PURPOSE: To review functional and subjective benefit after implantation of an active transcutaneous bone conduction device (BCD) in patients with congenital microtia with atresia or stenosis of the external auditory canal. METHODS: Retrospective chart analysis and questionnaire on the subjective impression of hearing ( Speech, Spatial and Qualities of Hearing Scale (SSQ-B) of patients treated between 2012 and 2015. RESULTSRESULTS: 18 patients (24 ears) with conductive or mixed hearing loss in unilateral (n = 10) or bilateral (n = 8) atresia were implanted with a BCD. No major complications occurred after implantation. Preoperative unaided air conduction pure tone average at 0.5, 1, 2 and 4 kHz (PTA 4 ) was 69.2 ± 11.7 dB, while postoperative aided PTA 4 was 33.4 ± 6.3 dB, resulting in a mean functional hearing gain of 35.9 +/- 15.6 dB. Preoperatively, the mean monosyllabic word recognition score was 22.9 % ± 22.3 %, which increased to 87.1 % +/- 15.1 % in the aided condition. The Oldenburger Sentence Test at S0N0 revealed a decrease in signal-to-noise-ratio from - 0.58 ± 4.40 dB in the unaided to - 5.67 ± 3.21 dB in the postoperative aided condition for all patients investigated. 15 of 18 patients had a subjective benefit showing a positive SSQ-B score (mean 1.7). CONCLUSION: The implantation of an active bone conduction device brings along subjective and functional benefit for patients with conductive or combined hearing loss. PMID:34173875 | DOI:10.1007/s00405-021-06938-8 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Effects of Neurodevelopmental Therapy on Feeding and Swallowing Activities in Children with Cerebral Palsy

xlomafota13 shared this article with you from Inoreader The Effects of Neurodevelopmental Therapy on Feeding and Swallowing Activities in Children with Cerebral Palsy Via swallowing exercises Dysphagia. 2021 Jun 25. doi: 10.1007/s00455-021-10329-w. Online ahead of print. ABSTRACT This study investigated the effect of the structured Neurodevelopmental Therapy Method-Bobath (NDT-B) approach on the feeding and swallowing activity of patients with cerebral palsy (CP) and feeding difficulties. In addition to feeding and oral motor intervention strategies (OMIS), and nutrition-related caregiver training (NRCT), and the NDT-B, which was structured to increase trunk and postura l control, was added to the therapy program. Forty patients with CP, with a mean age of 3.25 ± 0.927 years, were classified using the Gross Motor Function Classification System, Eating and Drinking Ability Classification System, and Mini-Manual Ability Classification System. The patients were randomly assigned into two groups as OMIS + NRCT (n = 20) and OMIS + NRCT + NDT-B (n = 20). The program was applied for 6 weeks, 2 days/week, for 45 min. The patients were evaluated using the Trunk Impairment Scale, Schedule for Oral Motor Assessment, and the Pediatric Quality of Life Inventory before and after 6 weeks. The trunk control of the OMIS + NRCT + NDT-B group was superior to the other group (P = 0.026). Although there was an improvement in the groups according to the subcategories of SOMA, the OMIS + NRCT + NDT-B group was superior in the trainer cup and puree subcategories of SOMA (P = 0.05). A significant correlation was observed between trunk control and oral motor functions in c hildren with CP, and the eating function of children in the OMIS + NRCT + NDT-B group further improved. NDT-B-based neck and trunk stabilization exercises should be added to the treatment programs.Trial Registration NCT04403113. PMID:34173063 | DOI:10.1007/s00455-021-10329-w View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Supracricoid Partial Laryngectomy With and Without Neoadjuvant Chemotherapy in Glottic Cancer

xlomafota13 shared this article with you from Inoreader Supracricoid Partial Laryngectomy With and Without Neoadjuvant Chemotherapy in Glottic Cancer Via The Laryngoscope Objectives/Hypothesis To demonstrate that a group of patients who are not considered candidates for organ preservation can achieve organ preservation through neoadjuvant chemotherapy + surgery and to determine if there are differences regarding organ preservation, disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS) after comparing such group with another one undergoing standard treatment. Methods Patients with laryngeal cancer were retrospectively analyzed and divided into two groups. Group A included patients who were initially treated with supracricoid laryngectomy. Group B included patients with T3N0 glottic squamous cell carcinoma with arytenoid fixation. Patients were offered neoadjuvant chemotherapy. Both groups underwent bilateral selective neck dissection of lymph nodes (II–V) and intentional search of the Delphian lymph nodes. Results Thirty-four patients were assigned to group A of surgery alone, and 16 patients were included in group B of induction chemotherapy. No statistical differences were found regarding sex, tumor localization, histological diagnosis, TNM staging, recurrence, or organ preservation. DFS, OS, and CSS at 60 months were the same in both groups. No statistical differences were found when comparing induction versus noninduction groups according to the T-stage in DFS, OS, and CSS. Conclusions Neoadjuvant chemotherapy allows to perform conservative surgery in patients with poor functional prognosis or who are not good candidates for organ preservation at first. We could perform safe surgery, and there was no more recurrence. Hence DFS is not modified (i.e., there was no more recurrence); consequently, OS and CSS are not affected. Neoadjuvant chemotherapy plus supracricoid partial laryngectomy-cricohyoidoepiglottopexy is an oncologically safe procedure that preserves basic functions such as breathing, phonation, and swallowing. Level of Evidence 3 Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The impact of COVID‐19 on elective otolaryngology surgery in a rural hospital in the United Kingdom

xlomafota13 shared this article with you from Inoreader The impact of COVID‐19 on elective otolaryngology surgery in a rural hospital in the United Kingdom Via Clinical Otolaryngology Abstract A return to normal surgical practice following the first wave of the COVID-19 pandemic was expected to be limited by extra precautions put in place to mitigate the risks posed by the Sars-Cov2 virus to patients and theatre staff. Rates of COVID-19 infection within the local authority area remained well below national levels from August 2020-February 2021 despite a surge in cases during the second wave. Despite low levels of COVID-19 infection there was a 16.2% reduction in the number of operating lists and a 31.2% reduction in the number of surgical procedures performed. There was a significant increase in the number of cancellations (p=0.011) year on year. The results suggest that the ability of Otolaryngological departments to clear the backlog of cases caused by the postponement of non-urgent surgery during 2020 will be limited as long as the extra precautions remain. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The role of sepsis screening, SIRS and qSOFA in Head and Neck Infections: An Audit of 104 Patients

xlomafota13 shared this article with you from Inoreader The role of sepsis screening, SIRS and qSOFA in Head and Neck Infections: An Audit of 104 Patients Via Clinical Otolaryngology Abstract Sepsis is associated with high morbidity and mortality and is a known complication of infections of the head and neck. Screening for sepsis should be conducted on admission in order to identify patients at risk and provide early intervention. Compliance with sepsis screening was poor on an ENT ward in a district general hospital, however this can be improved further by education and visual reminders such as poster or a clerking proforma. The most common head and neck infections admitted to a district general hospital were tonsillitis, peritonsillar cellulitis and peritonsillar abscesses. The incidence of sepsis as a complication of head and neck infections is very rare if using the qSOFA criteria. Using SIRS criteria may result in overidentification of sepsis and may lead to excessive and inappropriate clinical management in patients who could otherwise be managed less aggressively. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Increased incidence of unilateral sudden sensorineural hearing loss in patients with hematological malignancies requiring hematopoietic stem cell transplantation

xlomafota13 shared this article with you from Inoreader Increased incidence of unilateral sudden sensorineural hearing loss in patients with hematological malignancies requiring hematopoietic stem cell transplantation Via Clinical Otolaryngology Abstract Haematopoietic stem cell transplantation (HSCT) may dramatically alter the immunity of a recipient Transient immunodeficiency that occurs before and after HSCT could be associated with the development of sudden sensorineural hearing loss (SSNHL), which is presumed to be often due to viral aetiology We found an incidence of SSNHL of 29.4 per 10,000 person-years in patients receiving HSCT, 12-fold higher than reported for background population incidence Development of SSNHL tended to cluster early after diagnosis of haematological malignancies, rather than around date of treatment with HSCT Increased risk of unilateral SSNHL in patients with haematological malignancy may relate to underlying disease rather than treatment View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Prognosis and Outcomes in Early Stage Glottic Carcinoma Involving the Anterior Commissure Treated with Laser CO2 Surgery: A Retrospective Observational Analysis

xlomafota13 shared this article with you from Inoreader Prognosis and Outcomes in Early Stage Glottic Carcinoma Involving the Anterior Commissure Treated with Laser CO2 Surgery: A Retrospective Observational Analysis Via Otolaryngology Indian Abstract The anterior commissure (AC) is the area where the vocal cords attach to the thyroid cartilage through Broyles' ligament. Many authors argue that involvement of the anterior commissure in early stage glottic carcinoma (I, II) constitutes a risk factor for local recurrence. The objective of this study is to evaluate whether anterior commissure involvement in early stage glottis cancer is an independent risk factor for recurrence and mortality. The study included all those patients diagnosed with glottis carcinoma in stages I and II of the AJCC treated by transoral laser surgery at the Hospital San Pedro (Logroño, Spain) between 2005 and 2015. Patients were divided into two groups according to the presence (AC1) or absence (AC0) of involvement of the commissure. Of 29 patients treated, 44.8% were AC1. Patients with anterior commissure involvement had more local recurrence (p = 0.2701); higher mortality rate (p = 0.2256); lower disease-f ree survival (p = 0.0881) and a lower overall survival (p = 0.0331). The 5-year survival rate was 24.5% lower in patients with invasion of the anterior commissure. The involvement of the anterior commissure is an independent risk factor that should be considered in the prognosis of laryngeal cancer. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Respiratory‐swallow coordination in a rat model of chemoradiation

xlomafota13 shared this article with you from Inoreader Respiratory‐swallow coordination in a rat model of chemoradiation Via Head & Neck Abstract Background Chemoradiation treatment (CRT) for head and neck cancer (HNC) is associated with postswallow inhale events that elevate the risk of penetration/aspiration. The purpose of this study was to assess the validity of a rat model for investigating the effect of CRT on respiratory-swallow coordination. Methods Videofluoroscopic swallow study was performed on 10 Sprague-Dawley rats 3 months post-CRT (3 mg/kg Cisplatin, 10 fractions of 4.5 Gy/day radiotherapy to tongue base), and 10 naïve controls. We examined the effect of CRT on swallow apnea duration, diaphragm movement, and bolus kinematics. Results CRT rats had a significant increase in postswallow inhale (p = 0.008), which was associated with significantly longer swallow apnea durations, lower diaphragm displacement at swallow onset, and faster pharyngoesophageal bolus speed. Conclusion The rat CRT model is valid for the study of respiratory-swallow coordination due to the consistency of findings in this study with those reported in clinical CRT studies in HNC. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Intranasal Steroid Use and Satisfaction in Allergic Rhinitis: A Cross-Sectional Study from an Asian Perspective

xlomafota13 shared this article with you from Inoreader Intranasal Steroid Use and Satisfaction in Allergic Rhinitis: A Cross-Sectional Study from an Asian Perspective Via O.R.L. Journal for oto-rhino-laryngology and its borderlands Background: Intranasal steroid (INS) is the most effective medication class for controlling allergic rhinitis (AR) symptoms; however, its effectiveness is limited by patient compliance. Previous studies have explored INS use, compliance, satisfaction, and experience. There is, however, no Asian study on these factors in entirety. Objective: We aimed to investigate the rate of compliance to usage of INS and explore the reasons for noncompliance in our local populati on. Methods: We conducted a prospective cross-sectional study on 65 AR patients in a tertiary hospital. Recruited patients were administered a questionnaire to collect data about symptoms, INS use, and concerns they may have. Statistical analysis was performed using SPSS. Results: The overall compliance rate to INS was 63.1%. Noncompliance was associated with increased frequency of dosing (p = 0.050), presence of sensory attributes (p = 0.041), and forgetfulness (p = 0.049). The top 3 most frequent sensory attributes experienced by patients include throat rundown (29.2%), aftertaste (21.5%), and immediate taste (20.0%). There was a significant difference between brands of INS with regard to sensory attributes experienced (p = 0.003) but no side effects (p = 0.070). Conclusions: Identifying risk factors for noncompliance to INS can help health-care providers address difficulties faced by patients and hence i ncrease compliance, allowing better control of AR symptoms. ORL View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.