Association between sex and survival in patients with head and neck spindle cell carcinoma

xlomafota13 shared this article with you from Inoreader Association between sex and survival in patients with head and neck spindle cell carcinoma Via Head & Neck Abstract Background Head and neck spindle cell carcinoma (HNSpCC) is a rare histological variant associated with worse outcomes. Our objective was to identify clinicopathological factors associated with survival in patients with HNSpCC compared to patients with conventional head and neck squamous cell carcinoma (HNSCC). Methods Using clinical data from the Surveillance, Epidemiology, and End Results database, we performed a survival analysis in patients with HNSpCC or HNSCC between 2004 and 2016. Results A total of 458 HNSpCC and 77 104 HNSCC were identified, including 17% and 16% female, respectively. Five‐year disease‐specific survival (DSS) was 63.90% and 73.90% in patients with HNSpCC and HNSCC, respectively. Sex (hazard ratio [HR] for females = 2.816; CI: 1.139–6.965; p = 0.025) was significantly associated with DSS in HNSpCC while no association was observed between sex and DSS in HNSCC. Conclusion HNSpCC in women is a specific subgroup of HNSCC, which is associated with a poor prognosis. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Tension pneumocephalus following an implant removal from spine

xlomafota13 shared this article with you from Inoreader Tension pneumocephalus following an implant removal from spine Via leak of cerebrospinal fluid BMJ Case Rep. 2021 Feb 24;14(2):e239694. doi: 10.1136/bcr-2020-239694. ABSTRACT Pneumocephalus is commonly seen after skull and maxillofacial fractures. It can also occur following cerebrospinal fluid leak after skull base surgery and epidural catheter placement. We report a rare case report of a 20-year-old man who developed tension pneumocephalus following implant removal from the spine. He responded well to the conservative treatment without any neurological complications. PMID:33627348 | DOI:10.1136/bcr-2020-239694 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Aggressive Differentiated Thyroid Cancer due to EML4e13-ALKe20 Fusion: A Case Presentation and Review of the Literature

xlomafota13 shared this article with you from Inoreader Aggressive Differentiated Thyroid Cancer due to EML4e13-ALKe20 Fusion: A Case Presentation and Review of the Literature Via radioactive iodine Case Rep Endocrinol. 2021 Feb 15;2021:8837399. doi: 10.1155/2021/8837399. eCollection 2021. ABSTRACT BACKGROUND: Differentiated thyroid cancer (DTC) is an indolent malignancy. It rarely presents with aggressive local invasion and/or distant metastatic disease. Patient findings. We describe a case of a 30-year-old man with a locally aggressive form of papillary thyroid cancer with EML4e13-ALKe20 fusion (EML4: echinoderm microtubule-associated protein-like 4; ALK: anaplastic lymphoma kinase). He presented with right-side cervical lymphadenopathy with a highly suspicious right-side thyroid nodule. Total thyroidectomy and level IV lymph node resection showed extensive bilateral disease, with extrathyroidal and extranodal extension. FDG-PET CT scan following surgery confirmed the presence of significant residual disease in the neck area. He underwent bilateral lateral lymph node dissection followed by radioactive iodine treatment. Somatic mutation testing showed EML4e13-ALKe20 fusion. Summary. This case represents an aggressive form of DTC with EML4e13-ALKe20 fusion. The rapid progression of clinical signs and symptoms and the local extension beyond the thyroid and lymph nodes with the persistence of high-volume local disease after thyroidectomy highlight the aggressive nature of this mutation and the importance of performing genetic analysis to guide future treatments and determine prognosis. CONCLUSION: This case highlights the importance of using molecular diagnostics in patient care, especially if the presentation is unusual for DTC. A thorough evaluation of the tumor pathology and the somatic mutational profile analysis are important for obtaining vital therapeutic and prognostic guidance. PMID:33628533 | PMC:PMC7899757 | DOI:1 0.1155/2021/8837399 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Long-term course after inpatient speech therapy: educational and language development of children with severe specific language impairment (SLI)

xlomafota13 shared this article with you from Inoreader Long-term course after inpatient speech therapy: educational and language development of children with severe specific language impairment (SLI) Via hno HNO. 2021 Feb 24. doi: 10.1007/s00106-021-01005-4. Online ahead of print. ABSTRACT BACKGROUND: Studies from primarily English-speaking countries have shown that specific language impairments can lead to disadvantages in educational and professional development. Corresponding studies for Germany have not been published. This study surveys the educational and language outcomes of adolescents and young adults who were treated in an inpatient setting during childhood. MATE RIALS AND METHODS: A total of 193 young adults who had received inpatient treatment between 1998 and 2005 at the Department of Communication Disorders of the Department of Otorhinolaryngology, Head, and Neck Surgery (ENT) of the Mainz University Medical Center were assessed. The cohort was contacted by telephone and interviewed about aspects of their educational and language development using a specially developed questionnaire. It was possible to include 70 participants in the study. RESULTS: Almost half (48.6%; n = 34) of the participants had attended a regular elementary school and 50% (n = 35) attended a special school with a focus on speech-language development (others: 1.4%, n = 1). Regarding school-leaving qualifications, 31.5% (n = 22) finished school with an Abitur/Fachabitur (high-school-level certificate), 33% (n = 23) with a Realschulabschluss (secondary school certificate), 30% (n = 21) with a Hauptschulabschluss (lower secondary certificate), and 4% (n = 3) with a special school certificate. Only one participant left school without a qualification. Of the interviewed participants, 71% (n = 50) do not feel any speech language limitations anymore. CONCLUSION: The results indicate a positive educational and language development of children with SLI after inpatient treatment in Germany. Over 90% of the participants finished school with a regular certification and most of them do not feel any speech and language limitations anymore. PMID:33629146 | DOI:10.1007/s00106-021-01005-4 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

X-shaped lateral neck lump on swallowing

xlomafota13 shared this article with you from Inoreader A Systematic Review of the Omohyoid Muscle Syndrome (OMS): Clinical Presentation, Diagnosis, and Treatment Options Via otol rhinol Ann Otol Rhinol Laryngol. 2021 Feb 25:3489421995037. doi: 10.1177/0003489421995037. Online ahead of print. ABSTRACT OBJECTIVE: Omohyoid muscle syndrome (OMS) is a condition that causes a X-shaped lateral neck lump on swallowing, caused by the failure of the central tendon of the omohyoid muscle to restrict movement of the muscle during swallowing. We aim to review the etiology, pathophysiology, diagnostic tests, and management options for this condition. DATA SOURCES: Pubmed, MEDLINE, EMBASE, and Cochrane databases were searched for all articles and abstracts related to OMS up to 29th July 2020. REVIEW METHODS: A systematic review was performed, data extracted from relevant full text articles. Both quantitative data and qualitative data were analyzed. RESULTS: Twenty cases of OMS were reported. Patients presented at a mean age of 36.0. All cases were Asian. There is a 7:3 ratio of males to females. The most common symptom was a transient neck mass. Most cases were managed conservatively with good prognosis. Open or endoscopic transection of the muscle and ultrasound-guided botulinum toxin injection were 3 treatment options, with no recurrence at 4 years, 6 months, and 6 months respectively. CONCLUSION: OMS could be genetic as all cases were Asian in ethnicity. The deep cervical fascia which usually envelopes the omohyoid muscle may be weakened by stress as 20% of cases had a preceding traumatic event. Real-time ultrasonography e stablishes the diagnosis, demonstrating the anterolateral displacement of the sternocleidomastoid muscle by a thickened omohyoid muscle during swallowing. Surgical transection can achieve cure, but due to limited studies available, they should be reserved for patients who are extremely bothered. Intramuscular injection of botulinum toxin is an effective alternative, but recurrence is expected. PMID:33626894 | DOI:10.1177/0003489421995037 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A Systematic Review of the Omohyoid Muscle Syndrome (OMS): Clinical Presentation, Diagnosis, and Treatment Options

xlomafota13 shared this article with you from Inoreader A Systematic Review of the Omohyoid Muscle Syndrome (OMS): Clinical Presentation, Diagnosis, and Treatment Options Via otol rhinol Ann Otol Rhinol Laryngol. 2021 Feb 25:3489421995037. doi: 10.1177/0003489421995037. Online ahead of print. ABSTRACT OBJECTIVE: Omohyoid muscle syndrome (OMS) is a condition that causes a X-shaped lateral neck lump on swallowing, caused by the failure of the central tendon of the omohyoid muscle to restrict movement of the muscle during swallowing. We aim to review the etiology, pathophysiology, diagnostic tests, and management options for this condition. DATA SOURCES: Pubmed, MEDLINE, EMBASE, and Cochrane databases were searched for all articles and abstracts related to OMS up to 29th July 2020. REVIEW METHODS: A systematic review was performed, data extracted from relevant full text articles. Both quantitative data and qualitative data were analyzed. RESULTS: Twenty cases of OMS were reported. Patients presented at a mean age of 36.0. All cases were Asian. There is a 7:3 ratio of males to females. The most common symptom was a transient neck mass. Most cases were managed conservatively with good prognosis. Open or endoscopic transection of the muscle and ultrasound-guided botulinum toxin injection were 3 treatment options, with no recurrence at 4 years, 6 months, and 6 months respectively. CONCLUSION: OMS could be genetic as all cases were Asian in ethnicity. The deep cervical fascia which usually envelopes the omohyoid muscle may be weakened by stress as 20% of cases had a preceding traumatic event. Real-time ultrasonography e stablishes the diagnosis, demonstrating the anterolateral displacement of the sternocleidomastoid muscle by a thickened omohyoid muscle during swallowing. Surgical transection can achieve cure, but due to limited studies available, they should be reserved for patients who are extremely bothered. Intramuscular injection of botulinum toxin is an effective alternative, but recurrence is expected. PMID:33626894 | DOI:10.1177/0003489421995037 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Tympanostomy Tubes-Where We Were, Where We Are, and Where We Will Be: A State-of-The-Art Review

xlomafota13 shared this article with you from Inoreader Tympanostomy Tubes-Where We Were, Where We Are, and Where We Will Be: A State-of-The-Art Review Via ear nose throat Ear Nose Throat J. 2021 Feb 24:145561321997612. doi: 10.1177/0145561321997612. Online ahead of print. NO ABSTRACT PMID:33626919 | DOI:10.1177/0145561321997612 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Combined treatment of ureteropelvic junction obstruction and renal calculi with Robot Assisted Laparoscopic Pyeloplasty and Laser Lithotripsy in children: case report and non systematic review of the literature

xlomafota13 shared this article with you from Inoreader Combined treatment of ureteropelvic junction obstruction and renal calculi with Robot Assisted Laparoscopic Pyeloplasty and Laser Lithotripsy in children: case report and non systematic review of the literature Via The International Journal of Medical Robotics and Computer Assisted Surgery Summary: Objective(s) The incidence of urinary tract stone disease is steadily increasing in both adult and paediatric populations. This condition develops due to different factors: dietary or metabolic alterations, infection and congenital anatomic malformations. Standard indications and treatments for children are analogous to the ones indicated for adults. Extracorporeal shock wave lithotripsy (SWL), ureterorenoscopy (URS), percutaneous nephrolithotomy (PCNL) should be preferred to more invasive techniques. Moreover, the introduction of laparoscopic and robot assisted laparoscopic approaches have improved surgical outcomes, lowering the bleeding risk with higher stone‐free rates, even in complicated cases. Despite these well‐known improvements, there are few reports regarding laparoscopic robot assisted management for urinary tract stone disease in paediatric patients under the age of ten, especially with concomitant treatment of ureteropelvic junction obstruction and multiple calyceal stones. Patient and Method(s) A four years old child was referred for recurrent right abdominal flank pain, macroscopic haematuria and a previous history of urinary tract infections. A computed tomography of the abdomen showed right ureteropelvic junction obstruction associated with multiple unilateral stones located in the renal pelvis and in the interpolar renal calyces. Due to its complexity, we held a multidisciplinary meeting with paediatric surgeons and nephrologists to determine optimal treatment. As a result, a combined robot assisted laparoscopic pyeloplasty and renal calculi holmium laser lithotripsy using a digital flexible ureteroscope through an abdominal robotic trocar was performed. No post‐surgical complications were recorded and the patient was discharged within 48 hours following surgery. At subsequent regular follow‐up examinations over a period of 24 months, no signs of recurrence were detected for both ureteropelvic junction obstruction and stone disease. Result(s) Robot Assisted Laparoscopic Pyeloplasty with concomitant laser lithotripsy is a reasonable treatment option for designated young paediatric patients with challenging ureteropelvic junction obstruction complicated by urolithiasis, especially in cases where stones are not amenable with standard procedures. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Association Between Habitual Snoring and Cognitive Performance in Preadolescent Children

xlomafota13 shared this article with you from Inoreader Association Between Habitual Snoring and Cognitive Performance in Preadolescent Children Via JAMA Otolaryngology–Head & Neck Surgery Online First This cross-sectional study uses a baseline data set from the on going Adolescent Brain and Cognitive Development study to examine the extent to which potential confounding factors modify the association between parent-reported habitual snoring and cognitive outcomes among preadolescent children. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Otolaryngologic Manifestations in Pediatric Inflammatory Multisystem Syndrome Temporally Associated With COVID-19

xlomafota13 shared this article with you from Inoreader Otolaryngologic Manifestations in Pediatric Inflammatory Multisystem Syndrome Temporally Associated With COVID-19 Via JAMA Otolaryngology–Head & Neck Surgery Online First This cohort study describes the various otolaryngologic manifes tations in and rates among patients 18 years or younger with pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Laryngeal and Tracheal Pressure Injuries in Patients With COVID-19

xlomafota13 shared this article with you from Inoreader Laryngeal and Tracheal Pressure Injuries in Patients With COVID-19 Via JAMA Otolaryngology–Head & Neck Surgery Online First To the Editor The important study by Fiacchini and colleagues of laryngotracheal complications in ventilated patients with coronavirus disease 2019 (COVID-19) reported a staggering 47% incidence of full-thickness tracheal erosion (FTTE) and tracheoesophageal fistulae (TEF). These findings raise critical questions about ensuring safe, high-quality care for intubated patients. Although intense research has focused on the molecular basis of COVID-19, pathogenesis of pneumonitis, and novel therapeutics; far less work has addressed the prevalence and pathogenesis of iatrogenic injury—particularly with respect to airway device-related pressure injuries. Injury at the level of the tracheal cuff likely accounts for the preponderance of FTTE and TEF reported, and tissue injury may occur at any site where there is contact between a device and the aerodigestive tract. Risk is highest in patients with overzealous cuff inflation, high-dose steroids, prone ventilation, prolonged intubation, feeding tubes, or impaired wound healing from diabetes or radiation—a perfect storm for patients with COVID-19. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.