Robot-assisted Cochlear Implant Electrode Array Insertion in Adults: A Comparative Study With Manual Insertion

alexandrossfakianakis shared this article with you from Inoreader Robot-assisted Cochlear Implant Electrode Array Insertion in Adults: A Comparative Study With Manual Insertion Via Otology & Neurotology - Published Ahead-of-Print Objective: To describe the first cochlear array insertions using a robot-assisted technique, with different types of straight or precurved electrode arrays, compared with arrays manually inserted into the cochlea. Study Design: Retrospective review. Setting: Tertiary otologic center. Patients: Twenty cochlear implantations in the robot-assisted group and 40 in the manually inserted group. Interventions: Cochlear implantations using a robot-assisted technique (RobOtol) with straight (eight Cochlear CI522/622, and eight Advanced Bionics Hifocus Slim J) or precurved (four Advanced Bionics Hifocus Mid-Scala) matched to manual cochlear implantations. Three-dimensional reconstruction images of the basilar membrane and the electrode array were obtained from pre- and postimplantation computed tomography. Main Outcome Measures: Rate and localization of scalar translocations. Results: For straight electrode arrays, scalar translocations occurred in 19% (3/16) of the robot-assisted group and 31% (10/32) of the manually inserted group. Considering the number of translocated electrodes, this was lower in the robot-assisted group (7%) than in the manually inserted group (16%) (p  View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

ΦΕΚ 5486/12-12-2020 τΒ΄ Έκτακτα μέτρα προστασίας της δημόσιας υγείας από τον κίνδυνο περαιτέρω διασποράς του κορωνοϊού COVID-19 από 13/12/2020 έως 7/1/2021

alexandrossfakianakis shared this article with you from Inoreader ΦΕΚ 5486/12-12-2020 τΒ΄ Έκτακτα μέτρα προστασίας της δημόσιας υγείας από τον κίνδυνο περαιτέρω διασποράς του κορωνοϊού COVID-19 από 13/12/2020 έως 7/1/2021 Via Ιατρικός Σύλλογος Πάτρας ΦΕΚ 5486/2020 τΒ΄ Αριθμ. Δ1α/ΓΠ.οικ. 80189 Έκτακτα μέτρα προστασίας της δημόσιας υγείας από τον κίνδυνο περαιτέρω διασποράς του κορωνοϊού COVID-19 στο σύνολο της Επικράτειας για το διάστημα από την Κυριακή 13 Δεκεμβρίου 2020 και ώρα 6:00 έως και την Πέμπτη 7 Ιανουαρίου 2021 και ώρα 6:00. Δείτε το ΦΕΚ: View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Ν.4761/ΦΕΚ 248 A’/13.12.2020 Εθνική Εκστρατεία Εμβολιασμού κατά του κορωνοϊού COVID-19 κλπ

alexandrossfakianakis shared this article with you from Inoreader Ν.4761/ΦΕΚ 248 A'/13.12.2020 Εθνική Εκστρατεία Εμβολιασμού κατά του κορωνοϊού COVID-19 κλπ Via Ιατρικός Σύλλογος Πάτρας N 4761 ΦΕΚ 248/13-12-2020 τΑ΄ Αναδιοργάνωση του Ταμείου Αρχαιολογικών Πόρων και Απαλλοτριώσεων και μετονομασία του σε Οργανισμό Διαχείρισης και Ανάπτυξης Πολιτιστικών Πόρων, προβολή της πολιτιστικής κληρονομιάς στο εξωτερικό, ρυθμίσεις για το Ιστορικό Μουσείο Κρήτης και το μουσείο «Φοίβος Ανωγειανάκης» και άλλες διατάξεις. ΜΕΡΟΣ Ζ' ΡΥΘΜΙΣΕΙΣ ΣΤΟ ΠΛΑΙΣΙΟ ΤΩΝ ΕΚΤΑΚΤΩΝ ΜΕΤΡΩΝ ΚΑΤΑ ΤΟΥ ΤΟΥ ΚΟΡΩΝΟΪΟΥ COVID-19 Άρθρο 70 Παράταση της ισχύος των πιστωτικών σημειωμάτων λόγω ακύρωσης ή αναβολής πολιτιστικών εκδηλώσεων – Τροποποίηση του άρθρου 16 του ν. 4708/2020 Άρθρο 71 Ενταλματοποίηση και καταβολή δεδουλευμένων εφημεριών και αποζημίωση δαπανών από εξετάσεις βιολογικού υλικού Άρθρο 72 Επιτροπή διαπραγμάτευσης τιμής φαρμάκων – Συμπλήρωση εξουσιοδοτικής διάταξης – Τροποποίηση του άρθρου 254 του ν. 4512/2018 Άρθρο 73 Διενέργεια ελέγχων φορείας του κορωνοϊού COVID -19 για επιδημιολογικούς λόγους Άρθρο 74 Εθνική Εκστρατεία Εμβολιασμού κατά του κορωνοϊού COVID-19 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Loss of exosomal miR-146a-5p from cancer-associated fibroblasts after androgen deprivation therapy contributes to prostate cancer metastasis

alexandrossfakianakis shared this article with you from Inoreader Loss of exosomal miR-146a-5p from cancer-associated fibroblasts after androgen deprivation therapy contributes to prostate cancer metastasis Via Journal of Experimental & Clinical Cancer Research - Latest Articles Androgen deprivation therapy (ADT) is the backbone of therapy for advanced prostate cancer (PCa). Despite the good initial response, castration resistance and metastatic progression will inevitably occur. Canc... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The biomarkers related to immune related adverse events caused by immune checkpoint inhibitors

alexandrossfakianakis shared this article with you from Inoreader The biomarkers related to immune related adverse events caused by immune checkpoint inhibitors Via Journal of Experimental & Clinical Cancer Research - Latest Articles The enthusiasm for immune checkpoint inhibitors (ICIs), an efficient tumor treatment model different from traditional treatment, is based on their unprecedented antitumor effect, but the occurrence of immune-r... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

MIEF2 over-expression promotes tumor growth and metastasis through reprogramming of glucose metabolism in ovarian cancer

alexandrossfakianakis shared this article with you from Inoreader MIEF2 over-expression promotes tumor growth and metastasis through reprogramming of glucose metabolism in ovarian cancer Via Journal of Experimental & Clinical Cancer Research - Latest Articles Increasing evidence has revealed the close link between mitochondrial dynamic dysfunction and cancer. MIEF2 (mitochondrial elongation factor 2) is mitochondrial outer membrane protein that functions in the reg... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

BRAFV600E mutation impinges on gut microbial markers defining novel biomarkers for serrated colorectal cancer effective therapies

alexandrossfakianakis shared this article with you from Inoreader BRAFV600E mutation impinges on gut microbial markers defining novel biomarkers for serrated colorectal cancer effective therapies Via Journal of Experimental & Clinical Cancer Research - Latest Articles Colorectal cancer (CRC) harboring BRAFV600E mutation exhibits low response to conventional therapy and poorest prognosis. Due to the emerging correlation between gut microbiota and CRC carcinogenesis, we investig... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

CircRNA_0000392 promotes colorectal cancer progression through the miR-193a-5p/PIK3R3/AKT axis

alexandrossfakianakis shared this article with you from Inoreader CircRNA_0000392 promotes colorectal cancer progression through the miR-193a-5p/PIK3R3/AKT axis Via Journal of Experimental & Clinical Cancer Research - Latest Articles Circular RNAs (circRNAs), important members of the noncoding RNA family, have been recently revealed to play a role in the pathogenic progression of diseases, particularly in the malignant progression of cance... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Activity of Ligustrum robustum (Roxb.) Blume extract against the biofilm formation and exopolysaccharide synthesis of Streptococcus mutans

alexandrossfakianakis shared this article with you from Inoreader Activity of Ligustrum robustum (Roxb.) Blume extract against the biofilm formation and exopolysaccharide synthesis of Streptococcus mutans Via Molecular Oral Microbiology Abstract Ligustrum robustum (Roxb.) Blume is utilized as a traditional Chinese herbal tea with various health benefits and protective effects. Streptococcus mutans is an important cariogenic oral bacteria species. The present study aimed to assess the influence of Ligustrum. robustum extract (LRE) on the biofilm formation of S. mutans and the mechanism of its action, as well as to identify its chemical components. For chemical identification, HPLC‐MS and NMR were applied and four identified phytochemicals were reported (Ligurobustoside B, Ligurobustoside N, Ligurobustoside J and Ligurobustoside C). The dose‐dependent (0.5 to 2.0 μg/μL) antimicrobial toxicity of LRE against S. mutans biofilm formation and exopolysaccharide (EPS) synthesis were evaluated by Confocal laser scanning microscopy (CLSM), Crystal violet stain and CFU counting. The microstructure of S. mutans biofilm treated with LRE was investigated both on glass coverslips an d ex vivo bovine dental enamel by Scanning electron microscopy (SEM). Moreover, LRE downregulated the expression of S. mutans glucosyltransferase‐encoding genes gtfB, gtfC and gtfD, and the quorum sensing (QS) factors comD and comE, suggesting its toxic mechanism. In addition, the result of CCK‐8 test on human oral cells revealed an acceptable biocompatibility of LRE. These findings indicated the possible application of this daily consumed herbal tea for caries prevention. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

[ASAP] Synthesis and Screening of α-Xylosides in Human Glioblastoma Cells

alexandrossfakianakis shared this article with you from Inoreader [ASAP] Synthesis and Screening of α-Xylosides in Human Glioblastoma Cells Via Molecular Pharmaceutics: Latest Articles (ACS Publications) Molecular Pharmaceutics DOI: 10.1021/acs.molpharmaceut.0c00839 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Die Stimulation des Nervus hypoglossus in der Behandlung der obstruktiven Schlafapnoe – Aktualisiertes Positionspapier der Arbeitsgemeinschaft Schlafmedizin der DGHNO-KHC

alexandrossfakianakis shared this article with you from Inoreader Die Stimulation des Nervus hypoglossus in der Behandlung der obstruktiven Schlafapnoe – Aktualisiertes Positionspapier der Arbeitsgemeinschaft Schlafmedizin der DGHNO-KHC Via Laryngo-Rhino-Otologie Laryngorhinootologie DOI: 10.1055/a-1327-1343 Die Stimulation des Nervus hypoglossus (HNS) zur Behandlung der obstruktiven Schlafapnoe (OSA) hat seit der ersten Stellungnahme der Arbeitsgemeinschaft Schlafmedizin der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie (DGHNO) einen festen Stellenwert erhalten. Die vorhandenen 3 Systeme unterscheiden sich in der technischen Ausgestaltung des ähnlichen Grundprinzips. Für die unilaterale atmungsgesteuerte HNS existieren hier mehrere Vergleichsstudien, Registeranalysen mit 4-stelligen Patientenzahlen und mehrjährigen Nachsorgeergebnissen. Die kontinuierliche HNS verzichtet auf die Atmungserkennung, und im Gegensatz zum atmungsgesteuerten HNS is t eine Schlafendoskopie zur Indikationsstellung nicht notwendig. Die bilaterale kontinuierliche HNS ist als einziges Verfahren teilimplantierbar; hierzu liegen erste Machbarkeitsstudien vor. Wesentlich für die Indikation ist die mit schlafmedizinischer Expertise beurteilte Non-Adhärenz der Überdrucktherapie bei einer mindestens mittelgradigen OSA in individueller Abwägung von weiteren Therapieoptionen. Die implantierende Klinik steht im Mittelpunkt der interdisziplinären Therapieverantwortung und ist bei Therapieproblemen Hauptansprechpartner. Dies erklärt die strukturellen Anforderungen zur Sicherung der Ergebnisqualität und Minimierung von Komplikationen. Die Nachsorge der HNS-versorgten Patienten kann sehr gut sektoren- und fachdisziplinübergreifend erfolgen, wobei Mindestangaben zur Behandlungswirkung und Nutzung dokumentiert werden sollten. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Characterization of Sensorineural Hearing Loss in Adult Patients With Sickle Cell Disease: A Systematic Review and Meta-analysis

a.sfakia shared this article with you from Inoreader Characterization of Sensorineural Hearing Loss in Adult Patients With Sickle Cell Disease: A Systematic Review and Meta-analysis Via Otology & Neurotology Current Issue Objectives and Main Outcome Measures: To determine the prevalence of sensorineural hearing loss (SNHL) attributable to sickle cell disease (SCD) in the global adult population and to identify factors contributing to its severity. Study Design: Systematic Review and Meta-analysis. Methods: We performed a comprehensive literature search for scientific articles in PubMed, Scopus, CINAHL, Web of Science, and the Cochrane Library that reported the incidence of hearing loss in populations over 18 years of age with SCD. Results: We identified 138 studies from the initial search, 12 of which met inclusion criteria and were utilized for data analysis. A total of 636 SCD patients and 360 controls were included in the Cochrane Review Manager 5.3 meta-analysis. There was a statistically significant increase in the prevalence of SNHL in adults with SCD compared with the general population with a cumulative risk ratio (RR) of 6.03. Conclusions: This is the first systematic investigation of the relationship between SCD and SNHL in adult patients across the globe. SNHL is more prevalent in patients with SCD, specifically those of the HbSS genotype, than the general population likely due to the pathophysiology of the disease and its effects on labyrinthine microvasculature. The increased prevalence of SNHL in the adult SCD population warrants future research into the predictors of SNHL severity and merits routine audiometric monitoring of adult SCD patients. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.