Αρχειοθήκη ιστολογίου

Πέμπτη 13 Δεκεμβρίου 2018

International Forum of Allergy & Rhinology

Computational fluid dynamics after endoscopic endonasal skull base surgery—possible empty nose syndrome in the context of middle turbinate resection
Guillermo Maza MD, Chengyu Li PhD, Jillian P. Krebs High school Diploma, Bradley A. Otto MD, Alexander A. Farag MD, Ricardo L. Carrau MD, FACS, Kai Zhao PhD

Version of Record online: 29 November 2018

Changes in the clinical and histological characteristics of Chinese chronic rhinosinusitis with nasal polyps over 11 years
Weiqing Wang MD, Yali Gao MBBS, Zhenzhen Zhu MBBS, Yang Zha MD, Xiaowei Wang MD, Fang Qi MD, Liangrui Zhou MBBS, Junyi Pang MBBS, Zhiqiang Gao MS, Wei Lv MD

Version of Record online: 29 November 2018

Impaired eating‐related quality of life in chronic rhinosinusitis
Nicholas R. Rowan MD, Zachary M. Soler MD, MSc, Kristina A. Storck MSPH, Florence Othieno MD, Kimia G. Ganjaei BA, Timothy L. Smith MD, MPH, Rodney J. Schlosser MD

Version of Record online: 28 November 2018

Patterns of olfactory dysfunction in chronic rhinosinusitis identified by hierarchical cluster analysis and machine learning algorithms
Justin C. Morse MD, Meghan H. Shilts MS, Kim A. Ely MD, Ping Li MD, Quanhu Sheng PhD, Li‐Ching Huang PhD, Todd J. Wannemuehler MD, Naweed I. Chowdhury MD, Rakesh K. Chandra MD, Suman R. Das PhD, Justin H. Turner MD, PhD

Version of Record online: 28 November 2018

Endoscopic Evaluation of the Eustachian Tube: assessment of a novel tool for grading Eustachian tube inflammation
Edward D. McCoul MD, MPH, Scott I. Mayer BS, Abtin Tabaee MD, Jeffrey C. Bedrosian MD, Michael J. Marino MD

Version of Record online: 28 November 2018

Noninvasive exosomal proteomic biosignatures, including cystatin SN, peroxiredoxin‐5, and glycoprotein VI, accurately predict chronic rhinosinusitis with nasal polyps
Sarina K. Mueller MD, Angela L. Nocera MS, Simon T. Dillon PhD, Xuesong Gu PhD, Olaf Wendler PhD, Hasan H. Otu PhD, Towia A. Libermann PhD, Benjamin S. Bleier MD, FACS

Version of Record online: 28 November 2018

Induction of smell through transethmoid electrical stimulation of the olfactory bulb
Eric H. Holbrook MD, Sidharth V. Puram MD, PhD, Reiner B. See MD, Aaron G. Tripp BS, CNIM, Dinesh G. Nair M.D, M. Tech, Ph.D

Version of Record online: 27 November 2018

Effect of rock fragment content on erosion processes of disturbed soil accumulation under field scouring conditions

Abstract

Purpose

Soil and water erosion from high rock fragment content disturbed soil accumulation severely threatens ecological security. Evaluation of the quantitative influence of rock fragment content on soil erosion processes was the basic research for soil and water conservation.

Materials and methods

Field simulation scouring experiments were conducted on the disturbed soil accumulation experimental plot. A 10 × 1-m2 plot with 28 gradients was established on Changwu Experimental Station in the Loess Plateau, China. Tap water was applied at the top of the plot with the four different flow discharge rates of 1.3 × 10−4, 1.7 × 10−4, 2.1 × 10−4 and 2.5 × 10−4 m3 s−1 to simulate surface runoff processes. The experimental plots underlying surfaces were filled with different rock fragment content of 20%, 40% and 0%. The soil used in these experimental plots was a silty loam from the disturbed soil accumulation formed by expressway construction in the loess plateau areas. The disturbed soil accumulation site was located near the G70 Fujian–Yinchuan expressway and the vegetation cover was very low. The mean diameter of rock fragments was 22 mm in these experiments, and the rock fragments were unsmooth, angular crushed stone taken from the quarry in the Changwu County.

Results and discussion

The results showed that rock fragment content of 20% and 40% could significantly decreased runoff and sediment (P < 0.05), although there was no significantly different between 20 and 40%. The rock fragments decreased mean flow velocity by 43 to 55% in mean flow velocity compared to the pure soil. Furthermore, the flow was laminar flow in the rock fragments slope. The rock fragments significantly decreased flow shear stress (52–89%), stream power (63–89%), unit stream power (41–59%), runoff kinetic energy (67–88%) and unit energy of the water-carrying section (81–89%) compared with the pure soil. With increased rock fragment content, the rill erodibility decreased. The rill erodibility was estimated to be 1.4 × 10−3 s m−1, 0.7 × 10−3 s m−1 and 0.5 × 10−3 s m−1, under the condition of pure soil, rock fragment content of 20% and 40%, respectively.

Conclusions

Low rock fragment content (< 40%) in disturbed soil accumulation significantly decreased runoff and sediment. With the rock fragment content increased, the rill erodibility was decreased. Appropriate rock fragment content could be used to control soil erosion on disturbed soil accumulation in practice. The important parameters from this study will be helpful for disturbed soil accumulation erosion prediction model establishment.



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Taiwan Journal of Ophthalmology (Taiwan J Ophthalmol)

EDITORIAL 

Pediatric retina: A challenging yet fascinating fieldp. 179
Wei-Chi Wu
DOI:10.4103/tjo.tjo_123_18  
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REVIEW ARTICLESTop

Foveal hypoplasia and optical coherence tomographic imagingp. 181
Hiroyuki Kondo
DOI:10.4103/tjo.tjo_101_18  
Foveal hypoplasia is a retinal disorder in which there is a lack of full development of the morphology of the fovea. The optical coherence tomography (OCT) and functional findings are presented in relation to the underlying genetic and developmental conditions. Recent advancements of high-resolution OCT imaging have unveiled characteristics of foveal hypoplasia that were not detected by conventional imaging methods. An absence of a foveal pit does not necessarily imply poor visual acuity, and the maturation of the cone photoreceptors is important for the visual acuity. Regardless of the degree of the development of the inner retinal layers, the visual acuity can be preserved as in diseases such as Stickler syndrome that is a newly identified retinal disorder associated with foveal hypoplasia.
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The importance of early diagnosis of Stickler syndrome: Finding opportunities for preventing blindnessp. 189
Michael J Shapiro, Michael P Blair, Mark A Solinski, David L Zhang, Sayena Jabbehdari
DOI:10.4103/tjo.tjo_97_18  
Stickler Syndrome (SS) is a significant cause of retinal blindness in children. The immediate cause of blindness is retina detachment from giant retinal tear (GRT). It is frequently diagnosed late and the giant retinal tear (GRT) may be complicated by high-grade proliferative vitreoretinopathy (PVR). The surgery for the combined GRT with PVR has limited structural results and the vision mainly remains impaired. In order to improve the visual outcomes, we propose an organized program oriented toward early diagnosis and surveillance. Adding an effective prophylaxis may maintain normal vision in a high percent of patients. The critical diagnostic moments for this program are prenatal and at birth. The tools include a directed history, general physical exam and advanced ophthalmologic exam looking for the particular features of SS. Some features may need advanced skills transfer, because they are not reliably taught in retina fellowships. Much of this program requires a partnership with obstetricians, pediatricians, neonatologists and geneticists. Finally, we review the evidence regarding prophylaxis and discuss our approach in the absence of guidance from a randomized clinical trial.
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Knudson to embryo selection: A story of the genetics of retinoblastomap. 196
Vrushali Athavale, Vikas Khetan
DOI:10.4103/tjo.tjo_37_18  
Retinoblastoma, the most common primary intraocular malignancy of the young, is a prototype hereditary cancer. Due to its fairly predictable Mendelian inheritance, easily examinable tumors, and early age of presentation, RB has served as the most extensively studied model for genetics in cancer. The genetic strides in RB have progressed at an exponential rate since the 1970s. The highly morbid, reasonably curable and distinctly predictable inheritance pattern of RB; not to mention its propensity to affect our young, forms the basis of aggressively encouraging genetic diagnosis in all patients of RB. In this article, we present the basic and clinically relevant concepts of the genetics retinoblastoma.
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Stage 5 retinopathy of prematurity: An updatep. 205
Parveen Sen, Smriti Jain, Pramod Bhende
DOI:10.4103/tjo.tjo_61_18  
Retinopathy of prematurity (ROP) is one of the most common causes of preventable blindness in children. In spite of the availability of various treatment options, and favorable results with timely intervention, many infants present to the ophthalmologists in the advanced end stage of the disease due to lack of awareness especially in the developing nations. This blinding or Stage 5 of ROP presents with total retinal detachment and has to be managed surgically. The surgical techniques for Stage 5 ROP are unique and demanding. The successful anatomical results after surgery are only seen in 20%–50% of cases. In spite of a successful anatomical result, the visual outcome may be slow and limited. The use of newer pharmacological adjuncts has shown promising results. Because of heterogeneity of presentation of the disease severity, a genetic predisposition has also been proposed. A concerted effort from the pediatricians, ophthalmologists, and healthcare workers is required to establish effective screening and treatment guidelines to prevent blindness due to ROP. Till then surgical management has to be done. Parents must be educated regarding the limited visual benefits of surgery and the need for prolonged follow-up. This review gives a comprehensive overview of the pathogenesis, clinical aspects, surgical interventions, and their outcomes and future prospects of Stage 5 ROP.
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Current concepts and techniques of vitrectomy for retinopathy of prematurityp. 216
Shunji Kusaka
DOI:10.4103/tjo.tjo_102_18  
Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide. ROP screening and interventions (e.g., laser ablation and anti-vascular endothelial growth factor [VEGF] therapy) at the right time can reduce disease activity and prevent retinal detachment. However, sometimes, ROP is refractory to treatment, leading to tractional retinal detachment (TRD), requiring surgical intervention, such as vitrectomy. Vitrectomy for Stage 5 ROP (total retinal detachment) is beneficial in preventing total blindness in some patients. However, it has poor anatomical and functional results. Vitrectomy (lens-sparing vitrectomy, if possible) should be performed at Stage 4A ROP (partial TRD not involving the macula) because the anatomical and functional results are much better.
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Retinal detachments in the pediatric populationp. 222
Nicola Yi'an Gan, Wai-Ching Lam
DOI:10.4103/tjo.tjo_104_18  
In this review, we present a concise summary of the more commonly seen types of retinal detachments (RDs) that one can encounter in pediatric patients. A spectrum of diseases from rhegmatogenous RD in Stickler syndrome, Marfan syndrome, and choroidal coloboma to exudative RD in Coats disease, to tractional RD in persistent fetal vasculature, and combined RDs in familial exudative vitreoretinopathy are described with the management pearls for each.
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Special considerations for pediatric vitreoretinal surgeryp. 237
Nicola Y Gan, Wai-Ching Lam
DOI:10.4103/tjo.tjo_83_18  
In this review, the authors present special considerations a vitreoretinal surgeon should take into account before embarking on surgery in a pediatric eye. First, the anatomy of a pediatric eye is different from an adult and changes as the child grows. This is important especially in relation to the placement of transconjunctival ports. The structural characteristics of the sclera are also different, with lower scleral rigidity found in pediatric eyes. When considering vitrectomy, a posterior pars plicata lens-sparing technique should be considered. However, this may not be possible in complicated total detachments where anterior translimbal vitrectomy may be the method of choice. Scleral buckles are preferred for certain cases, and division of the encirclage is advocated in children below the age of 2 years, once the retina has stabilized. Enzymatic vitreolysis has been described as a preoperative adjunct to enhance complete detachment of the posterior hyaloid and reduce iatrogenic retinal breaks. However, its use in pediatric eyes has been limited, and larger studies are warranted. Finally, postoperative visual rehabilitation and treatment of amblyopia are key to maximizing functional outcomes in the pediatric patient. Co-management with a pediatric ophthalmologist and enlisting the co-operation of the parents are essential.
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ORIGINAL ARTICLETop

Bevacizumab or laser for aggressive posterior retinopathy of prematurityp. 243
Michael Blair, Jose Maria Garcia Gonzalez, Laura Snyder, Sidney Schechet, Mark Greenwald, Michael Shapiro, Sarah Hilkert Rodriguez
DOI:10.4103/tjo.tjo_69_18  
PURPOSE: The purpose of this study was to report the rate of reactivation and structural outcome, after the laser or bevacizumab treatment for aggressive posterior retinopathy of prematurity (APROP). METHODS:Retrospective chart review was conducted on consecutive infants with APROP treated with (1) laser or (2) bevacizumab, followed by fluorescein angiography and prophylactic laser to the persistent avascular retina.RESULTS: Thirty-six eyes of 19 patients were included in this study. The mean gestational age was 24.5 weeks with a mean birth weight of 632 g in the bevacizumab group and 24.7 weeks and 777 g in the laser group. Unfavorable outcome occurred in 1 of 22 eyes treated with bevacizumab and in 5 of 14 eyes in the laser group (P = 0.002). Reactivation requiring treatment was common in both groups, 9/22 after bevacizumab and 6/14 after laser (ns). CONCLUSION: Regardless of the initial treatment reactivation requiring retreatment is common in eyes with APROP. The unfavorable structural outcome was significantly more common after initial laser treatment than after initial bevacizumab treatment.
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CASE REPORTTop

Short-term postoperative perfluoro-n-octane tamponade for pediatric recurrent retinal detachmentp. 249
Kiet-Phang Ling, An-Lun Wu, Chi-Chun Lai, Wei-Chi Wu
DOI:10.4103/tjo.tjo_100_18  
We report a case with multiple recurrences of retinal detachment (RD) with severe proliferative vitreoretinopathy in a 12-year-old child who underwent vitrectomy using a heavy liquid perfluoro-n-octane (PFO) as a short-term postoperative tamponade. He had an encircling band and three vitrectomies with gas, followed by silicone oil tamponade for retinal redetachment prior to the use of PFO as a short-term tamponade. Short-term PFO tamponade was used in which inferior retinal reattachment was considered to be difficult with conventional gas or silicone oil tamponade, especially in regard to proper postoperative posturing. The PFO was left in the eye for 1 week, and the retina remained reattached after removal of the PFO which was replaced with silicone oil tamponade in this case. PFO appears feasible and tolerable as a short-term postoperative tamponade in the management of complex pediatric RD.
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Autoimmune Neutropenia of Infancy,Prevalence of Pseudomonas Skin Infections

Autoimmune Neutropenia of Infancy- Unexpected Prevalence of Pseudomonas Skin Infections
http://www.bloodjournal.org/content/132/Suppl_1/4940

Nov 21st, 2018 - Background: Autoimmune neutropenia of infancy (AIN), the most frequent type of severe neutropenia in young children, occurs due to recognition of membrane antigens by anti-neutrophil antibodies, resulting in peripheral neutrophil destruction. Despite the often severe and prolonged neutropenia, serious infectious complications are less frequent in AIN compared with other etiologies of severe neu...

Allergic Rhinitis Center


Putative Microbial Population Shifts Attributable to Nasal Administration of Streptococ... 
Preview
https://www.ncbi.nlm.nih.gov/pubmed/30535674
Probiotics and Antimicrobial Proteins; De Grandi R, Drago L et. al.

Dec 12th, 2018 - Changes in bacterial composition of nasal microbiota may alter the host's susceptibility to several infectious and allergic diseases such as chronic rhinosinusitis and allergic rhinitis. The aim of this study was to evaluate the effects of 1-week ...

Nasal nitric oxide in the inferior turbinate surface decreases with intranasal steroids... Preview
https://www.ncbi.nlm.nih.gov/pubmed/30527902
Auris, Nasus, Larynx; Takahara D, Kono T et. al.

Dec 12th, 2018 - It remains controversial whether nasal nitric oxide (NO) serves as a reliable parameter to evaluate treatment efficacy in patients with allergic rhinitis (AR). The measurement of local nasal NO levels has been shown to be a sensitive marker for th...

Prospective observational study validating the German version of the Control of Allergi... Preview
https://www.ncbi.nlm.nih.gov/pubmed/30514843
NPJ Primary Care Respiratory Medicine; Werner CU, Koch L et. al.

Dec 6th, 2018 - The Control of Allergic Rhinitis and Asthma Test (CARAT10), developed by Portuguese experts, is the only questionnaire assessing asthma control under additional consideration of a frequently concurrent allergic rhinitis (AR), providing sub-scores ...

Discriminating severe seasonal allergic rhinitis. Results from a large nation-wide data... Preview
https://www.ncbi.nlm.nih.gov/pubmed/30485327
PloS One; Caimmi D, Baiz N et. al.

Nov 28th, 2018 - Allergic rhinitis (AR) is a chronic disease affecting a large amount of the population. To optimize treatment and disease management, it is crucial to detect patients suffering from severe forms. Several tools have been used to classify patients a...

Der p 1-specific regulatory T cell response during house dust mite allergen immunotherapy. Preview
https://www.ncbi.nlm.nih.gov/pubmed/30485456
Allergy Boonpiyathad T, Sokolowska M et. al.

Nov 28th, 2018 - Allergen-specific immunotherapy (AIT) is the only available treatment for allergic diseases that can induce specific immune tolerance to allergens. The key mechanisms involved in this process include changes in allergen-specific regulatory T (Treg...

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Guidelines  9 results

Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision. Preview
https://www.ncbi.nlm.nih.gov/pubmed/28602936
The Journal of Allergy and Clinical Immunology; Brożek JL, Bousquet J et. al.

Jun 13th, 2017 - Allergic rhinitis (AR) affects 10% to 40% of the population. It reduces quality of life and school and work performance and is a frequent reason for office visits in general practice. Medical costs are large, but avoidable costs associated with lo...

Clinical practice guideline: Allergic rhinitis. Preview
https://www.ncbi.nlm.nih.gov/pubmed/25644617
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery; Seidman MD, Gurgel RK et. al.

Feb 4th, 2015 - Allergic rhinitis (AR) is one of the most common diseases affecting adults. It is the most common chronic disease in children in the United States today and the fifth most common chronic disease in the United States overall. AR is estimated to aff...

Clinical practice guideline: allergic rhinitis executive summary.Preview
https://www.ncbi.nlm.nih.gov/pubmed/25645524
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery; Seidman MD, Gurgel RK et. al.

Feb 4th, 2015 - The American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) has published a supplement to this issue featuring the new Clinical Practice Guideline: Allergic Rhinitis. To assist in implementing the guideline recommendations, ...

Practical guide to skin prick tests in allergy to aeroallergens.Preview
https://www.ncbi.nlm.nih.gov/pubmed/22050279
Allergy Bousquet J, Heinzerling L et. al.

Nov 5th, 2011 - This pocket guide is the result of a consensus reached between members of the Global Allergy and Asthma European Network (GA(2) LEN) and Allergic Rhinitis and its Impact on Asthma (ARIA). The aim of the current pocket guide is to offer a comprehen...

Immunotherapy for allergic rhinitis. Preview
https://www.ncbi.nlm.nih.gov/pubmed/21848757
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology; Walker SM, Durham SR et. al.

Aug 19th, 2011 - Allergic rhinitis (AR) affects more than 20% of the population in the United Kingdom and western Europe and represents a major cause of morbidity that includes interference with usual daily activities and impairment of sleep quality. This guidance...

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Drugs  1,283 results see all →

Clinicaltrials.gov  1,227 results

Effects of Intranasal Fluticasone Plus Azelastine on Airway Inflammation in Patients With Asthma & Allergic Rhinitis 
https://clinicaltrials.gov/ct2/show/NCT02953106

Oct 31st, 2018 - The unified allergic airway describes patients who have both asthma and allergic rhinitis. Both conditions have similar underlying pathophysiology in terms of T-helper 2 (Th2) cell activation. Patients with unified allergic airway disease have a g...

Seinäjoki Adult Asthma Study 
https://clinicaltrials.gov/ct2/show/NCT02733016

Oct 26th, 2018 - At baseline visit the diagnostic studies performed were: spirometry, PEF (peak expiratory flow) follow-up, other respiratory physiology measurements, laboratory, skin-prick, AQ20 (Airways questionnaire 20), 15D, background data. At follow-up visit...

Study to Investigate Effects of CAL-101 in Subjects With Allergic Rhinitis Exposed to Allergen in an Environmental Chamber 
https://clinicaltrials.gov/ct2/show/NCT00836914

Oct 23rd, 2018 - A Phase I, randomized, double-blind crossover study of CAL-101, an oral inhibitor of phosphatidylinositol 3-kinase (PI3K) delta, in patients with allergic rhinitis.

Study on Association Between Treatment of Allergic Rhinitis and Cognitive Ability in Children 
https://clinicaltrials.gov/ct2/show/NCT03714945

Oct 22nd, 2018 - INTRODUCTION Allergic rhinitis is the reportedly second most common reported chronic health condition in Hong Kong children under the age of 14, with the Child Health Survey 2005-2006 indicating a prevalence of 24.5%. Allergic rhinitis is a type I...

Effects of Broccoli Sprout Extract on Allergy Rhinitis 
https://clinicaltrials.gov/ct2/show/NCT02885025

Oct 18th, 2018 - Allergic rhinitis is a common illness suffered among US Veterans. Despite the availability of medications, many patients fail to get adequate control of symptoms especially in high pollutant areas. Southern California air pollutants, like diesel e...

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News  567 results

Gestational, umbilical cord vitamin D levels don't predict atopic disease in offspring
https://www.mdedge.com/obgyn/article/190119/obstetrics/gestational-umbilical-cord-vitamin-d-levels-dont-predict-atopic
Jeff Craven

Dec 3rd, 2018 - Vitamin D levels measured in maternal sera during gestation and in umbilical cord blood were not predictive of the prevalence of eczema, food allergy, asthma and allergic rhinitis in children at ages 2 years and 5 years, according to study results.

Allergy Testing in Dermatology and Beyond
https://www.mdedge.com/cutis/article/189678/practice-management/allergy-testing-dermatology-and-beyond
MDedge Dermatology; Ashley D. Lundgren, MD

Nov 28th, 2018 - Allergy testing typically refers to evaluation of a patient for suspected type I or type IV hypersensitivity. 1,2 The possibility of type I hypersensitivity is raised in patients presenting with food allergies, allergic rhinitis, asthma, and immedi.

New Drug Combinations for Asthma, COPD at CHEST 2018
https://www.medscape.com/viewarticle/902774

Oct 1st, 2018 - SAN ANTONIO — New combinations of known and experimental drugs will be explored at the American College of Chest Physicians Annual Meeting as the pharmaceutical search for better control of asthma and chronic obstructive pulmonary disease (COPD) c...

Fast Five Quiz: Test Your Knowledge About Fall Allergies
https://www.medscape.com/viewarticle/884925

Sep 21st, 2018 - Although many people associate allergies with the growth and development of plants in spring and summer, allergic symptoms are very common in the fall as well. Ragweed is the biggest allergy trigger during the fall season, but mold, dust mites, an...

Advise parents on validity of AD-associated conditions
https://www.mdedge.com/familypracticenews/article/172058/atopic-dermatitis/advise-parents-validity-ad-associated-conditions
Heidi Splete, Family Practice News

Aug 7th, 2018 - Atopic dermatitis is becoming more prevalent in the industrialized world, along with other atopic disorders, including allergic rhinitis and asthma, according to Douglas W. Kress, MD, of the department of dermatology at the University of Pittsburg.

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Hydration differences between the major and minor grooves of DNA revealed from heat capacity measurements

Abstract

The nature of water on the surface of a macromolecule is reflected in the temperature dependence of the heat effect, i.e., the heat capacity change, ΔCp, that accompanies its removal on forming a complex. The relationship between ΔCp and the nature of the surface dehydrated cannot be modeled for DNA by the use of small molecules, as previously done for proteins, since the contiguous surfaces of the grooves cannot be treated as the sum of small component molecules such as nucleotides. An alternative approach is used here in which ΔCp is measured for the formation of several protein/DNA complexes and the calculated contribution from protein dehydration subtracted to yield the heat capacity change attributable to dehydration of the DNA. The polar and apolar surface areas of the DNA dehydrated on complex formation were calculated from the known structures of the complexes, allowing heat capacity coefficients to be derived representing dehydration of unit surface area of polar and apolar surface in both grooves. Dehydration of apolar surfaces in both grooves is essentially identical and accompanied by a reduction in ΔCp by about 3 J K−1 mol−12)−1, a value of somewhat greater magnitude than observed for proteins {ΔCp = − 1.79 J K−1 mol−12)−1}. In contrast, dehydration of polar surfaces is very different in the two grooves: in the minor groove ΔCp increases by 2.7 J K−1 mol−12)−1, but in the major groove, although ΔCp is also positive, it is low in value: + 0.4 J K−1 mol−12)−1. Physical explanations for the magnitudes of ΔCp are discussed.



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