This article provides reviewers with guidance on methods for identifying and processing evidence to understand intervention implementation.
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Τετάρτη 6 Δεκεμβρίου 2017
Cochrane Qualitative and Implementation Methods Group Guidance Paper 3: Methods for Assessing Evidence on Intervention Implementation
UConn Professor Honored for Prosthodontic Humanitarian Efforts
John R. Agar, DDS, MA, FACP , was honored with the Distinguished Service Award by the American College of Prosthodontists at the Annual Awards & President's Dinner during the 47th Annual Session of the ACP held in San Francisco from Nov. 1-4, 2017. The Distinguished Service Award recognizes an individual with the characteristics of a true humanitarian and outstanding service to the ACP.
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Parents of teen who died after getting wisdom teeth pulled accept $2M settlement
A Minnesota family whose vibrant and active daughter died after going into cardiac arrest while getting her wisdom teeth pulled agreed to a more than $2 million settlement against the dentist in November, according to court papers. On June, 9, 2015, Sydney Galleger, 17, was treated by Paul C. Tompach at Edina Oral and Maxillofacial Surgery for the routine procedure, court documents said.
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Geographic access to mammography facilities and frequency of mammography screening
Assess the association between geographic access to mammography facilities and women's mammography utilization frequency.
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Fever in pregnancy and offspring head circumference
To examine whether maternal fever during pregnancy is associated with reduced head circumference and risk of microcephaly at birth.
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Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey (Chlorocebus aethiops sabaeus)
Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey (Chlorocebus aethiops sabaeus)
Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey (<i>Chlorocebus aethiops sabaeus</i>), Published online: 06 December 2017; doi:10.1038/ijo.2017.301
Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey (Chlorocebus aethiops sabaeus)
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A workshop on ‘Dietary sweetness—Is it an issue?’
A workshop on 'Dietary sweetness—Is it an issue?'
A workshop on 'Dietary sweetness—Is it an issue?', Published online: 06 December 2017; doi:10.1038/ijo.2017.296
A workshop on 'Dietary sweetness—Is it an issue?'
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Response to: ‘Jangle fallacy epidemic in obesity research: A comment on Ruddock et al. (2017)’
Response to: 'Jangle fallacy epidemic in obesity research: A comment on Ruddock et al. (2017)'
Response to: 'Jangle fallacy epidemic in obesity research: A comment on Ruddock <i>et al.</i> (2017)', Published online: 06 December 2017; doi:10.1038/ijo.2017.290
Response to: 'Jangle fallacy epidemic in obesity research: A comment on Ruddock et al. (2017)'
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With Innovation Booming, Dental Stocks Will Make You Smile
As you look for ways to diversify your portfolio within health care, be sure to give the dental industry some attention While any savvy investor has a portion of their portfolio diversified into the health care sector, very few make it a point to focus on specific health care niches. However, if you actually take the time to do some due diligence in this area, you will find the dental industry is booming .
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An abrupt bleeding of the anteriorly- displaced sigmoid sinus: a rare complication of myringoplasty
The location of the sigmoid sinus within the mastoid cavity is quite variable. An anteriorly- displaced vertical segment of the sigmoid sinus constitutes an uncommon but dangerous anatomical variation that sur...
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Table of Contents
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 125, Issue 1
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Society Page
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 125, Issue 1
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Information for Readers
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 125, Issue 1
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Editorial Board
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 125, Issue 1
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Comparison of contact radiographed and stained histological sections for osseointegration analysis of dental implants: an in vivo study
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 125, Issue 1
Author(s): Oliver Bissinger, Carolin Götz, Anke Jeschke, Bernhard Haller, Klaus-Dietrich Wolff, Pascal Kaiser, Andreas Kolk
ObjectivesHistology is still regarded as the gold-standard to determine bone implant contact (BIC) as a parameter representing implant stability. As the further processing of cut slices for contact radiography (CR) to stained and polished histological sections is time consuming and error prone, our aim was to assess agreement between CR and Giemsa-eosin (GE) stained sections with regard to dental implants.Study DesignThreaded dental titanium implants (n = 54) from the maxillae of Goettingen minipigs were evaluated. After 28 and 56 days, BIC and the ratio of bone volume to total volume (BV/TV; 1000 μm) were determined on the same sections by using CR and GE staining, and the results were compared.ResultsModerate differences for BIC (0.6%; P = .53) and BV/TV (1.3%; P = .01) between the methods were determined, in which CR overestimated BIC and BV/TV. A strong correlation was seen between the modalities concerning BIC (28 days: r = 0.84; 56 days: r = 0.85; total: r = 0.85) and BV/TV (r = 0.96; r = 0.94; r = 0.96; all: P < .0001).ConclusionsCR enabled determination of the bone-to-implant interface in comparison with GE-stained sections. BIC and BV/TV were slightly overestimated but correlated strongly between the methods. Therefore, if BIC and BV/TV are sufficient endpoints, CR is adequate and no further preparation and staining are necessary.
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Biological significance of 5-hydroxymethylcytosine in oral epithelial dysplasia and oral squamous cell carcinoma
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 125, Issue 1
Author(s): Maria Carolina Cuevas-Nunez, Camilla Borges F. Gomes, Sook-Bin Woo, Matthew R. Ramsey, Xiaoxin L. Chen, Shuyun Xu, Ting Xu, Qian Zhan, George F. Murphy, Christine G. Lian
ObjectivesThe aim of this study was to determine the levels of 5-hydroxylmethylcytosine (5-hmC) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) compared with those in benign, reactive inflammatory lesions and to explore whether DNA hydroxymethylation may serve as a novel biomarker for early diagnosis and prognosis of OSCC.Study DesignThe study included normal mucosa from uninvolved margins of 9 fibromas, 10 oral lichen planus, 15 OED, and 23 OSCC. Cultured human keratinocyte lines from benign oral mucosa, OED, and OSCC, as well as a murine model in which OSCC was induced with 4-nitroquinoline-1-oxide, were also evaluated.ResultsProgressive loss of 5-hmC from benign oral mucosal lesions to OED and OSCC was documented in patient samples. Decreased levels in 5-hmC that typify OED and OSCC were also detectable in human cell lines. Moreover, we characterized similar alterations in 5-hmC in an animal model of OED/OSCC.ConclusionsThis study demonstrated that 5-hmC distinguishes OED and OSCC from benign lesions with high sensitivity and specificity. Consequently, loss of 5-hmC may be useful for the diagnosis of OED with potential implications for therapy of OSCC.
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Creative Contract Packaging LLC Issues An Allergen Alert Regarding 4 Ounce Jars Of Herb-Ox® Beef Flavor Granulated Bouillon Due To Potential Presence Of Undeclared Milk
Creative Contract Packaging LLC is voluntarily recalling 4,412 cases, or 13,236 total pounds, of two code dates of HERB-OX® Beef Flavor Granulated Bouillon, due to the potential presence of an undeclared milk allergen.
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Validation of a new experimental model of extrusive luxation on maxillary molars of rats: a histological study
Abstract
Background/aim
The aim of this study was to test and validate a new model of extrusive luxation trauma on maxillary first molars of rats.
Material and methods
Forty adult male rats (Rattus norvegicus albinus, Wistar; weight = 230–250 g), 45 days old, were divided into eight groups (n = 5): control groups, in which animals were not subjected to any procedure and waited 1 day (GC1D) or 3 days (GC3D) for euthanasia, and experimental groups, in which animals were subjected to forces of 1100cN, 1300cN, or 1500cN and waited 1 or 3 days for euthanasia (GT1100/1D, GT1100/3D, GT1300/1D, GT1300/3D, GT1500/1D, GT1500/3D). In animals of the experimental groups, trauma was produced by an extrusive force in maxillary first right molars. Four-micrometer serial cuts stained with hematoxylin and eosin (HE) were made. Descriptive microscopic analysis of first upper right molar and semi-quantitative analysis (scores 1 to 4) of intensity of acute and chronic inflammation and vascular changes in the periodontal ligament and active and inactive external root resorption were conducted. The distribution of scores in the groups was compared using the Freeman-Halton extension of Fisher's exact test. The significance level was 5%.
Results
It was observed that vascular disorders (bleeding) on the periodontal ligament became more evident with increasing extrusive force.
Conclusions
This new method was capable of generating histological changes, proving its secure application in this research area. The 1500cN force produced more damage on the periodontal ligament.
Clinical relevance
The validation of a new experimental method can produce more reliable evidence in further research.
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The state of basic services in small towns
Successive governments have poured billions of dollars into efforts to improve access to basic services for regional Australians but a new report questions whether that money has reached the towns that need it most. The Pillars of Communities report compiles 30 years of data to reveal the level of access to professionals working in 10 basic services, such as health and education, in towns with populations between 200 and 5000.
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Shakespeare’s fathers and daughters
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Three-Dimensional Static Articulation Accuracy of Virtual Models—Part II: Effect of Model Scanner-CAD Systems and Articulation Method
Abstract
Purpose
Accurate maxillomandibular relationship transfer is important for CAD/CAM prostheses. This study compared the 3D-accuracy of virtual model static articulation in three laboratory scanner-CAD systems (Ceramill Map400 [AG], inEos X5 [SIR], Scanner S600 Arti [ZKN]) using two virtual articulation methods: mounted models (MO), interocclusal record (IR).
Materials and Methods
The master model simulated a single crown opposing a 3-unit fixed partial denture. Reference values were obtained by measuring interarch and interocclusal reference features with a coordinate measuring machine (CMM). MO group stone casts were articulator-mounted with acrylic resin bite registrations while IR group casts were hand-articulated with poly(vinyl siloxane) bite registrations. Five test model sets were scanned and articulated virtually with each system (6 test groups, 15 data sets). STL files of the virtual models were measured with CMM software. dRR, dRC, and dRL, represented interarch global distortions at right, central, and left sides, respectively, while dRM, dXM, dYM, and dZM represented interocclusal global and linear distortions between preparations.
Results
Mean interarch 3D distortion ranged from –348.7 to 192.2 μm for dRR, –86.3 to 44.1 μm for dRC, and –168.1 to 4.4 μm for dRL. Mean interocclusal distortion ranged from –257.2 to –85.2 μm for dRM, –285.7 to 183.9 μm for dXM, –100.5 to 114.8 μm for dYM, and –269.1 to –50.6 μm for dZM. ANOVA showed that articulation method had significant effect on dRR and dXM, while system had a significant effect on dRR, dRC, dRL, dRM, and dZM. There were significant differences between 6 test groups for dRR, dRL dXM, and dZM. dRR and dXM were significantly greater in AG-IR, and this was significantly different from SIR-IR, ZKN-IR, and all MO groups.
Conclusions
Interarch and interocclusal distances increased in MO groups, while they decreased in IR groups. AG-IR had the greatest interarch distortion as well as interocclusal superior-inferior distortion. The other groups performed similarly to each other, and the overall interarch distortion did not exceed 0.7%. In these systems and articulation methods, interocclusal distortions may result in hyper- or infra-occluded prostheses.
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Digitized Speech Characteristics in Patients with Maxillectomy Defects
Abstract
Purpose
Accurate evaluation of speech characteristics through formant frequency measurement is important for proper speech rehabilitation in patients after maxillectomy. This study aimed to evaluate the utility of digital acoustic analysis and vowel pentagon space for the prediction of speech ability after maxillectomy, by comparing the acoustic characteristics of vowel articulation in three classes of maxillectomy defects.
Materials and Methods
Aramany's classifications I, II, and IV were used to group 27 male patients after maxillectomy. Digital acoustic analysis of five Japanese vowels—/a/, /e/, /i/, /o/, and /u/—was performed using a speech analysis system. First formant (F1) and second formant (F2) frequencies were calculated using an autocorrelation method. Data were plotted on an F1-F2 plane for each patient, and the F1 and F2 ranges were calculated. The vowel pentagon spaces were also determined. One-way ANOVA was applied to compare all results between the three groups.
Results
Class II maxillectomy patients had a significantly higher F2 range than did Class I and Class IV patients (p = 0.002). In contrast, there was no significant difference in the F1 range between the three classes. The vowel pentagon spaces were significantly larger in class II maxillectomy patients than in Class I and Class IV patients (p = 0.014).
Conclusion
The results of this study indicate that the acoustic characteristics of maxillectomy patients are affected by the defect area. This finding may provide information for obturator design based on vowel articulation and defect class.
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Patterson rings Opening Bell at Nasdaq
New Patterson Cos. CEO Mark Walchirk got a chance this week to meet and recognize the work of some valuable Patterson employees at the Nasdaq Opening Bell ceremony on Tuesday.
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Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies
Abstract
Background
Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC) to examine racial/ethnic differences in epidemiological characteristics with suspected involvement in epithelial ovarian cancer (EOC) aetiology. Methods
We used multivariable logistic regression to estimate associations for 17 reproductive, hormonal and lifestyle characteristics and EOC risk by race/ethnicity among 10 924 women with invasive EOC (8918 Non-Hispanic Whites, 433 Hispanics, 911 Blacks, 662 Asian/Pacific Islanders) and 16 150 controls (13 619 Non-Hispanic Whites, 533 Hispanics, 1233 Blacks, 765 Asian/Pacific Islanders). Likelihood ratio tests were used to evaluate heterogeneity in the risk factor associations by race/ethnicity. Results
We observed statistically significant racial/ethnic heterogeneity for hysterectomy and EOC risk (P = 0.008), where the largest odds ratio (OR) was observed in Black women [OR = 1.64, 95% confidence interval (CI) = 1.34–2.02] compared with other racial/ethnic groups. Although not statistically significant, the associations for parity, first-degree family history of ovarian or breast cancer, and endometriosis varied by race/ethnicity. Asian/Pacific Islanders had the greatest magnitude of association for parity (≥3 births: OR = 0.38, 95% CI = 0.28–0.54), and Black women had the largest ORs for family history (OR = 1.77, 95% CI = 1.42–2.21) and endometriosis (OR = 2.42, 95% CI = 1.65–3.55). Conclusions
Although racial/ethnic heterogeneity was observed for hysterectomy, our findings support the validity of EOC risk factors across all racial/ethnic groups, and further suggest that any racial/ethnic population with a higher prevalence of a modifiable risk factor should be targeted to disseminate information about prevention.from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2isIKDd
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Associations between genetic variants associated with body mass index and trajectories of body fatness across the life course: a longitudinal analysis
Abstract
Background
The genetic associations with trajectories of body fatness over the life course remain unknown. Methods
We used a group-based modelling approach to identify trajectories of body fatness from age 5 years up to 65 for 7277 women from the Nurses' Health Study and 4645 men from the Health Professionals Follow-up Study. We created a genetic risk score (GRS) based on 97 variants associated with adulthood body mass index (BMI) and estimated its association with trajectories using logistic regression. Results
We identified four distinct trajectories: lean-medium, medium-medium, lean-heavy and medium-heavy. The GRS increased across the four groups in that order (P < 0.001); 47% of women and 45% of men in the first decile of the GRS were in the lean-medium group, and these proportions reduced to 26% and 28%, respectively, for the highest decile. The corresponding proportions in the medium-heavy group were 8% and 5%, increasing to 21% and 14%, respectively. For women, compared with the odds of being in the lean-medium group, a 10-allele increment in the GRS was associated with a 40% [95% confidence interval (CI), 27–54%], 43% (30–58%), and 115% (91–143%) increase in the odds of being in the medium-medium, lean-heavy and medium-heavy groups, respectively. For men, the corresponding increases in the odds were 26% (12–42%), 27% (13–43%), and 81% (53–115%), respectively. Conclusions
Individuals with genetic variants for adulthood BMI were more likely to maintain a heavy body shape and gain weight throughout life. These findings support a persistent effect of genetic variants on body fatness across the lifespan.from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2irSsWy
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The Midwife's Labour and Birth Handbook, 4th Edition
 |  | Praise for the previous edition: "…An outstanding handbook. It will be a familiar volume on most midwifery bookshelves, providing an excellent guide to midwifery focused care of both woman and child in the birthing setting." Providing a practical and comprehensive guide to midwifery care, The Midwife's Labour and Birth Handbook continues to promote best practice and a safe, satisfying birthing experience with a focus on women-centred Read More... |
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Advanced Nutrition and Dietetics in Obesity
 | | This addition to the British Dietetic AssociationAdvanced Nutrition and Dietetics book series is written for clinicians and researchers who work with any aspect of obesity and its comorbid conditions. Featuring contributions from leading researchers and practitioners from around the globe Advanced Nutrition and Dietetics in Obesity offers a uniquely international perspective on what has become a worldwide public health crisis. Read More... |
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Risk factors for intraoperative bradycardia during ear, nose, throat and maxillofacial surgery
Abstract
Intraoperative bradycardia (IOB) is one of the most common cardiac arrhythmias observed in clinical anaesthetic practice. Controlled hypotension, as a strategy of lowering patient's blood pressure during anesthesia has been practiced for decades in head and neck surgery. The aim of our study was to determine the incidence and the risk factors for intraoperative bradycardia in maxillofacial, ear, nose and throat surgery, as well as to determine whether controlled hypotension affects the occurrence of IOB. The retrospective study included 2304 patients who underwent maxillofacial, ear, nose or throat surgery. We studied the influence of: sex, age, comorbidity, type of surgery, duration of anesthesia and controlled hypotension on the occurrence of IOB. IOB was registered in 473 patients (20.5%). Patients with controlled hypotension had IOB significantly more often than patients without controlled hypotension (33.9 vs 15.1%) (p = 0.000). The significant predictors of IOB were: age (OR = 1.158; 95% CI = 1.068–1.256; p = 0.000), sex (OR = 0.786; 95% CI = 0.623–0.993; p = 0.043), ischemic heart disease (OR = 2.016; 95% CI = 1.182–3.441; p = 0.010); ear surgery (OR = 1.593; 95% CI = 1.232–2.060; p = 0.000), anesthesia duration, (OR = 1.006; 95% CI = 1.004–1.007; p = 0.000) and controlled hypotension (OR = 2.204; 95% CI = 1.761–2.758; p = 0.000). IOB is common in maxillofacial, ear, nose and throat surgery, particularly in male, older age and patients with ishemic heart disease. The ear surgery, longer anesthesia duration and controlled hypotension raise the risk for occurrence of IOB.
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Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population-based study
Abstract
Background
Helicobacter pylori is an important etiologic factor for peptic ulcers and gastric cancer, one of the top ten leading causes of cancer death in Puerto Rico. However, the prevalence of H. pylori infections in this population was previously unknown. The aim of this study was to examine the seroprevalence of H. pylori and its associated risk factors in Puerto Rico.
Materials and Methods
A cross-sectional study was designed using an existing population-based biorepository. Seropositivity was determined using the Premier™H. pylori immunoassay. Helicobacter pylori seroprevalence was estimated with 95% confidence using marginal standardization following logistic regression. To assess the risk factors associated with H. pylori seropositivity, a multivariable log-binomial model was fitted to estimate the prevalence ratio (PR) and its 95% confidence interval (95% CI).
Results
A total of 528 population-based serum samples were analyzed. The mean age of the study population was 41 ± 12 years, of whom 55.3% were females. The overall seroprevalence of H. pylori was 33.0% (95% CI = 28.3%-38.1%). Increasing age and having <12 years of education were significantly (P < .05) associated with H. pylori seropositivity in the multivariable model; however, residing in counties with low population density reached marginal significance (P = .085).
Conclusions
We report that H. pylori infection is common among Hispanics living in Puerto Rico. The H. pylori seroprevalence observed in Puerto Rico is similar to the seroprevalence reported in the overall population of the United States. The association between H. pylori seroprevalence and the risk factors analyzed offers insight into the epidemiology of gastric cancer in Puerto Rico and warrants further investigation.
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Head and neck Merkel cell carcinoma: a retrospective case series and critical literature review with emphasis on treatment and prognosis.
| Related Articles |
Head and neck Merkel cell carcinoma: a retrospective case series and critical literature review with emphasis on treatment and prognosis.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Dec 01;:
Authors: Papadiochos I, Patrikidou A, Patsatsi A, Mangoudi D, Thuau H, Vahtsevanos K
Abstract
OBJECTIVE: Merkel cell carcinoma (MCC) is a rare cutaneous malignancy with a high recurrence and mortality rates. More than half of MCCs occur in the head and neck region. This paper aims to present a retrospective case series study of primary MCCs of the head and neck treated in our department over 12 years.
STUDY DESIGN: Six patients were identified, and their characteristics, treatment modalities, and outcomes are reported. A critical review of the current literature is also included to provide up-to-date information on MCCs with special emphasis on treatment modalities and disease prognosis.
RESULTS: Management of head and neck MCCs requires early and accurate diagnosis and includes surgery, radiotherapy, and/or combination chemotherapy. Accurate cervical nodal staging is of paramount importance before establishing the definite treatment plan.
CONCLUSIONS: The results of both our case series and literature data review indicate that elective management of regional lymph nodes is recommended instead of an observation approach for patients with no identifiable disease in the lymph nodes (cN0). Because the majority of MCCs arise in the head and neck region, oral and maxillofacial surgeons are likely be the first professionals who will encounter this disease and should therefore be aware of the current diagnostic and treatment modalities.
PMID: 29203339 [PubMed - as supplied by publisher]
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Connecting science and practice: Focus and directions for the next 10 years
Volume 19, Issue 6, December 2017, Page 539-540
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Recovery of language function and brain metabolism in a patient with crossed aphasia: 2-year follow-up of brain FDG PET images
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IRNAS Vitaprint opens doors to 3D bioprinted tissue research
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Conspecific negative density dependence in a long-lived conifer, yew Taxus baccata L.
Abstract
Conspecific negative density dependence in tree species can have major consequences for structuring of communities, yet in temperate forests this phenomenon remains largely unexplored. We investigated density-dependent recruitment in the long-lived conifer yew (Taxus baccata L.), for which low levels of regeneration have been linked with reduced light availability beneath conspecific canopies and speculative autotoxic effects. We combined in situ assessment of yew regeneration in a temperate forest in southwest Ireland with ex situ pot experiments to assess whether light and/or beneath conspecific canopy conditions inhibit the germination and early growth of yew. In field experiments, recruitment was related to distance from adult conspecifics, with higher levels of regeneration found in areas not beneath yew canopies. However, reduced light availability beneath the dense yew canopy was not responsible for this pattern, with abundant seedlings found in areas of equivalent or even lower light availability. Pot experiments showed that seedling survival was highest in deep shade treatments. Experiments also demonstrated that the addition of yew needles negatively affected seedling growth, but not seed germination. Together, our results suggest that under natural forest conditions, the absence of regeneration beneath mature yew canopies, often attributed to low light availability, may at least be partly related to substances in yew canopy or leaf leachates.
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An oral pharyngeal scope for objective oropharyngeal examination: a new device for oropharyngeal study
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Relationship between cognitive function and balance in a community-dwelling population in Japan
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Incidence and survival of sinonasal adenocarcinoma by site and histologic subtype
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Age, memory loss and perceptions of dementia in South Asian ethnic minorities
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TIO Networks Announces Data Breach Exposing Records of 1.6 Million Customers
PayPal recently acquired the company TIO Networks to use as their payment processor. The purchase price was $238 million and now it looks like that purchase may have come with an expected surprise… a data breach.
The good news is that PayPal has not done any type of integration between their data and that of TIO which means that if you have a PayPal account, that info was not involved.
As I continue to stress, if this can happen to companies that are working constantly to prevent these types of breaches, everyone needs to be as vigilant as possible to keep their data and the data of their business secure.
Here is what the company has to say:
TIO Networks Provides Update on Suspension of Operations
SAN JOSE, Calif. – December 1, 2017 – PayPal Holdings, Inc. (Nasdaq: PYPL) today announced an update on the suspension of operations of TIO Networks (TIO), a publicly traded payment processor PayPal acquired in July 2017. A review of TIO's network has identified a potential compromise of personally identifiable information for approximately 1.6 million customers. The PayPal platform is not impacted in any way, as the TIO systems are completely separate from the PayPal network, and PayPal's customers' data remains secure.
As announced on November 10, PayPal suspended the operations of TIO to protect customer data as part of an ongoing investigation of security vulnerabilities of the TIO platform. This ongoing investigation has identified evidence of unauthorized access to TIO's network, including locations that stored personal information of some of TIO's customers and customers of TIO billers. As a result, PayPal is taking steps to protect affected customers.
TIO has also begun working with the companies it services to notify potentially affected individuals, and PayPal is working with a consumer credit reporting agency to provide free credit monitoring memberships. Individuals who are affected will be contacted directly and receive instructions to sign up for monitoring.
More information has been posted at www.tio.com.
About PayPal
Fueled by a fundamental belief that having access to financial services creates opportunity, PayPal (Nasdaq: PYPL) is committed to democratizing financial services and empowering people and businesses to join and thrive in the global economy. Our open digital payments platform gives PayPal's 218 million active account holders the confidence to connect and transact in new and powerful ways, whether they are online, on a mobile device, in an app, or in person. Through a combination of technological innovation and strategic partnerships, PayPal creates better ways to manage and move money, and offers choice and flexibility when sending payments, paying or getting paid. Available in more than 200 markets around the world, the PayPal platform, including Braintree, Venmo and Xoom, enables consumers and merchants to receive money in more than 100 currencies, withdraw funds in 56 currencies and hold balances in their PayPal accounts in 25 currencies. For more information on PayPal, visit http://ift.tt/29ctqcr. For PayPal financial information, visit http://ift.tt/2krcnch.
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Global Health Journal Club: Is Honey Effective as a Treatment for Chemotherapy-induced Mucositis in Paediatric Oncology Patients?
Global Health Journal Club: Is Honey Effective as a Treatment for Chemotherapy-induced Mucositis in Paediatric Oncology Patients?
J Trop Pediatr. 2017 Nov 30;:
Authors: Friend A, Rubagumya F, Cartledge P
Abstract
Oral mucositis (OM) is an inflammatory response of mucosal epithelium to the cytotoxic effects of chemotherapy and radiotherapy causing severe oral pain and ulceration, which may complicate the management of cancer. The Mucositis Prevention Guideline Development Group has developed an international guideline for the prevention of mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation. Evidence-based preventative strategies include cryotherapy, low-level light therapy and keratinocyte growth factor. However, these strategies are often not available in resource-poor settings. There is some evidence that honey may be a suitable treatment for OM in adult patients. We performed a literature search of 11 databases to find papers exploring the use of honey to treat chemotherapy-associated mucositis in paediatric oncology patients. We found four papers, which provide Grade C evidence that honey is effective as a preventative and therapeutic measure for OM in paediatric oncology patients.
PMID: 29207005 [PubMed - as supplied by publisher]
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Assessment of the ability of V920 recombinant vesicular stomatitis-Zaire ebolavirus vaccine to replicate in relevant arthropod cell cultures and vector species.
Assessment of the ability of V920 recombinant vesicular stomatitis-Zaire ebolavirus vaccine to replicate in relevant arthropod cell cultures and vector species.
Hum Vaccin Immunother. 2017 Dec 05;:0
Authors: Bergren NA, Miller MR, Monath TP, Kading RC
Abstract
V920, rVSVΔG-ZEBOV-GP, is a recombinant vesicular stomatitis-Zaire ebolavirus vaccine which has shown an acceptable safety profile and provides a protective immune response against Ebola virus disease (EVD) induced by Zaire ebolavirus in humans. The purpose of this study was to determine whether the V920 vaccine is capable of replicating in arthropod cell cultures of relevant vector species and of replicating in live mosquitoes. While the V920 vaccine replicated well in Vero cells, no replication was observed in Anopheles or Aedes mosquito, Culicoides biting midge, or Lutzomyia sand fly cells, nor in live Culex or Aedes mosquitoes following exposure through intrathoracic inoculation or feeding on a high-titer infectious blood meal. The insect taxa selected for use in this study represent actual and potential epidemic vectors of VSV. V920 vaccine inoculated into Cx. quinquefasciatus and Ae. aegypti mosquitoes demonstrated persistence of replication-competent virus following inoculation, consistent with the recognized biological stability of the vaccine, but no evidence for active virus replication in live mosquitoes was observed. Following administration of an infectious blood meal to Ae. aegypti and Cx. quinquefasciatus mosquitoes at a titer several log10 PFU more concentrated than would be observed in vaccinated individuals, no infection or dissemination of V920 was observed in either mosquito species. In vitro and in vivo data gathered during this study support minimal risk of the vector-borne potential of the V920 vaccine.
PMID: 29206076 [PubMed - as supplied by publisher]
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Toxicity of docetaxel, carboplatin, and trastuzumab combination as adjuvant or neo-adjuvant treatment for Her2 positive breast cancer patients and impact of colony-stimulating factor prophylaxis.
Toxicity of docetaxel, carboplatin, and trastuzumab combination as adjuvant or neo-adjuvant treatment for Her2 positive breast cancer patients and impact of colony-stimulating factor prophylaxis.
Breast J. 2017 Dec 05;:
Authors: Bayo J, Aviñó V, Toscano F, Jiménez F
Abstract
While the docetaxel, carboplatin, and trastuzumab (TCH) regimen is one of the standard treatments in Her2-positive breast cancer, however, acute toxicities, especially those related to the high rate of neutropenia are consistently reported. Primary: To compare the toxicity of TCH in current clinical practice vs the toxicity observed in the pivotal study, comparing the toxicity in patients that received primary prophylaxis (PP) with colony-stimulating factors vs those that did not receive PP. Secondary: To describe the demographic and clinical characteristics of the study sample, as well as the adverse effects and survival. The data regarding 95 patients were analyzed. Observed toxicity (hematological and extra-hematological) was greater compared to the pivotal study, with the exception of neuropathy and neutropenia. Toxicities "PP" vs "no PP": Extra-hematological grade 3-4 toxicities: Significant reduction was observed in the "PP" group vs the "no PP" group referred to fatigue, stomatitis, nausea, and vomiting. Hematological grade 3-4 toxicities: Lesser neutropenia, leukopenia, and febrile neutropenia were observed in the "PP" group. Complications associated to treatment: No grade 3-4 cardiac toxicity, leukemia or deaths were recorded. DFS and OS: After a mean follow-up of 22.9 months, only one bone metastatic relapse was detected (DFS: 98.9%; OS: 100%). The combination TCH is very active and effective as adjuvant and neo-adjuvant therapy in Her2-positive breast cancer, and is currently regarded as standard treatment. However, global toxicity as well as hematological toxicity is elevated. The incorporation of PP to TCH significantly reduces hematological toxicity and some of the global toxicity, thus favoring treatment implementation and lessening the clinical complications. We therefore recommend generalization of PP with colony-stimulating factors in patients receiving TCH.
PMID: 29205665 [PubMed - as supplied by publisher]
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Mean Platelet Volume: A Reliable Marker of Inflammation in Recurrent Apthous Stomatitis and Behçet Disease?
| Related Articles |
Mean Platelet Volume: A Reliable Marker of Inflammation in Recurrent Apthous Stomatitis and Behçet Disease?
Indian Dermatol Online J. 2017 Nov-Dec;8(6):468-470
Authors: Şenel E, Acar B, Demir E
Abstract
Background: Mean platelet volume (MPV) is an indicator of platelet activation and aggregation. MPV has been found to be related with the inflammation of certain disorders in recent studies.
Aims: We sought to investigate whether MPV could be an indicator of inflammation in patients with Behçet disease (BD) and recurrent apthous stomatitis (RAS).
Materials and Methods: Our study was designed as a retrospective case-control study and data was retrieved from our institutional database. We randomly generated a total of three study groups from our clinical archive. All controls were sex and age-matched and randomly selected by computer. Eighty-five patients with BD, 82 patients with RAS, and 721 healthy controls were included for the study design. We compared mean MPV values in the patient groups and controls.
Results: We found no difference in the mean MPV value between BD group and BD-control group. The mean MPV value was significantly higher in patients with RAS than that in the RAS-control group (9.11 ± 1.01 fL vs. 8.76 ± 1.15 fL, P = 0.045). There was no difference in mean MPV level between BD and RAS group.
Conclusion: The association between MPV and inflammatory skin diseases such as BD and RAS should be investigated prospectively in case-control studies.
Limitations: Retrospective study design.
PMID: 29204391 [PubMed]
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Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance.
| Related Articles |
Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance.
J Biol Chem. 2017 Dec 04;:
Authors: Zhang WC, Du LJ, Zheng XJ, Chen XQ, Shi C, Chen BY, Sun XN, Li C, Zhang YY, Liu Y, Xiao H, Leng Q, Jiang X, Zhang Z, Sun S, Duan SZ
Abstract
Type I IFN production and signaling in macrophages play critical roles in innate immune responses. High salt (i.e. high concentrations of NaCl) has been proposed to be an important environmental factor that influences immune responses in multiple ways. However, it remains unknown whether high salt regulates type I IFN production and signaling in macrophages. Here, we demonstrated that high salt promoted IFNβ production and its signaling in both human and mouse macrophages, and consequentially primed macrophages for strengthened immune sensing and signaling when challenged with viruses or viral nucleic acid analogues. Using both pharmacological inhibitors and RNA interference we showed that these effects of high salt on IFNβ signaling were mediated by the p38 MAPK/ATF2/AP1 signaling pathway. Consistently, high salt increased resistance to vesicle stomatitis virus (VSV) infection in vitro. In vivo data indicated that a high-salt diet protected mice from lethal VSV infection. Taken together, these results identify high salt as a crucial regulator of type I IFN production and signaling, shedding important new light on the regulation of innate immune responses.
PMID: 29203528 [PubMed - as supplied by publisher]
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Long-term follow-up of tonsillectomy efficacy in children with PFAPA syndrome.
| Related Articles |
Long-term follow-up of tonsillectomy efficacy in children with PFAPA syndrome.
Braz J Otorhinolaryngol. 2017 Nov 21;:
Authors: Aktas O, Aytuluk HG, Caliskan SK, Erdur O, Cirik AA
Abstract
INTRODUCTION: The role of tonsillectomy in the periodic fever, aphthous stomatitis, pharyngitis, and adenitis, PFAPA syndrome, is controversial. Although some studies reported high success rates with tonsillectomy, further investigations are needed with larger numbers of patients.
OBJECTIVE: To seek the long-term outcomes of tonsillectomy in PFAPA syndrome.
METHODS: Case series; multi-center study. The study comprised 23 patients with PFAPA syndrome who underwent surgery (tonsillectomy with or without adenoidectomy) between January 2009 and November 2014.
RESULTS: 21 (91%) of 23 patients had complete resolution immediately after surgery. One patient had an attack 24h after surgery, but has had no further attacks. One patient had three attacks with various intervals, and complete remission was observed after 3 months.
CONCLUSIONS: Tonsillectomy is a good option for the treatment of PFAPA syndrome.
PMID: 29203159 [PubMed - as supplied by publisher]
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Bibliometric analysis of literature on toxic epidermal necrolysis and Stevens-Johnson syndrome: 1940 - 2015.
  | Related Articles |
Bibliometric analysis of literature on toxic epidermal necrolysis and Stevens-Johnson syndrome: 1940 - 2015.
Orphanet J Rare Dis. 2017 Jan 18;12(1):14
Authors: Sweileh WM
Abstract
BACKGROUND: Stevens Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but fatal adverse skin reactions that affect all age groups. In order to better understand literature on this topic, we conducted a bibliometric study using Scopus database to shed light on number and growth of publications, most active countries, institutions, journals and authors involved in publishing articles in this field, citation analysis, top cited articles, international collaboration, role of medications and genetic association. Bibliometric analysis will enrich the literature on these rare conditions and will provide baseline data for future comparison.
RESULTS: Three thousand eight hundred fifty-six journal articles were retrieved. The h-index of retrieved documents was 95. Growth rates of publications were highest from 1966 to 1975 and from 2006 to 2015. The United States of America (n = 640; 16.57%) was the leading country in number of publications. However, French and Japanese researchers and institutions were most active in publishing articles on SJS and TEN. International collaboration among active countries was relatively low and ranges from 32.5% for Swiss researchers and 1.47% for Spanish researchers. The most frequently mentioned medication in retrieved articles was carbamazepine (n = 146) followed by phenytoin (n = 114) and allopurinol (n = 112). Mycoplasma infection was mentioned in 111 articles. Most documents on SJS and TEN were published in dermatology journals, specifically Archives of Dermatology. However, in the last decade, top cited articles appeared in dermatology and pharmacogenetic journals. Carbamazepine was frequently encountered with Han Chinese and HLA-B 1502 terms while allopurinol was frequently encountered with HLA-B 5801 and Japanese terms.
CONCLUSION: Bibliometric analysis reveals that research publications on SJS and TEN have been increasing since the l940s, with relatively low international collaboration. Documents are being published, not only in dermatology journals, but also in genetic, public health and general medicine journals. Research on SJS and TEN can be helpful to clinicians and researchers not only to document complications and fatal outcomes, but also to identify potential causative agents and potential ethnic variations to note gaps in research.
PMID: 28100272 [PubMed - indexed for MEDLINE]
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Local failure after radical radiotherapy of non-small cell lung cancer in relation to the planning FDG-PET/CT
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Forty years of landmark trials undertaken by the Danish Breast Cancer Cooperative Group (DBCG) nationwide or in international collaboration
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Age, memory loss and perceptions of dementia in South Asian ethnic minorities
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Polymer-infiltrated ceramic CAD/CAM inlays and partial coverage restorations: 3-year results of a prospective clinical study over 5 years
Abstract
Objective
The aim of this prospective clinical 5-year study was to evaluate the long-term behavior of monolithic computer-aided design and computer-aided manufacturing (CAD/CAM)-fabricated minimally invasive polymer-infiltrated ceramic network (PICN) inlays and partial coverage restorations (PCR).
Material and methods
Posterior teeth of 47 patients were restored with 103 restorations (45 inlays, 58 PCRs). After defect-oriented preparations, monolithic PICN restorations of VITA Enamic were fabricated with a CAD/CAM system (inEoS blue/CEREC inLab MCXL) and adhesively bonded (Variolink II). Clinical reevaluations were so far performed at baseline and 6, 12, 24, and 36 months after insertion according to modified United States Public Health Service (USPHS) criteria. Absolute failures were demonstrated by Kaplan-Meier survival rate and relative failures by Kaplan-Meier success rate. A logistic regression model was adjusted for modified USPHS criteria to investigate time and restoration effects (p < 0.05).
Results
After an observation time of 3 years, survival rates were 97.4% for inlays and 95.6% for PCRs. Three restorations had to be replaced due to clinically unacceptable fractures. Secondary caries and debonding were not observed. The 3-year Kaplan-Meier success rate was 84.8% for inlays and 82.4% for PCRs. The decrease in marginal adaption (p = 0.0005), increase in marginal discoloration (p < 0.0001), and surface roughness (p = 0.0005) over time were significant. Color match and anatomic form were excellent. No significant differences were found between both types of restorations for survival (p = 0.716) and success rate (p = 0.431).
Conclusions
Minimally invasive PICN restorations showed a favorable clinical performance over an observation period of 36 months. However, clinical long-term data have to be awaited.
Clinical relevance
PICN restorations are a suitable treatment option for posterior inlays and PCRs.
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Squamous cell carcinoma of unknown primary of the head and neck: Favorable prognostic factors comparable to those in oropharyngeal cancer
Abstract
Background
Treatment for squamous cell carcinoma (SCC) of unknown primary consists of radiotherapy (RT) +/- chemotherapy or neck dissection +/- adjuvant RT/chemoradiotherapy (CRT). We compared these strategies and identified prognostic factors.
Methods
From 1993 to 2015, 75 patients with SCC of unknown primary had RT-based or surgery-based treatment. Primary endpoints were overall survival (OS) and disease-free survival (DFS). Event-time distributions were estimated using the Kaplan-Meier method.
Results
Five-year OS and DFS for RT-based and surgery-based treatments were similar (OS 73% vs 68%, respectively; DFS 65% vs 64%, respectively). Among 38 patients with p16 data, 76% were p16 positive and showed improved 5-year DFS (90% vs 33%; P = .001) and OS (96% vs 33%; P < .001). Smoking history ≤10 pack-years conferred better 5-year DFS (88% vs 49%; P < .001) and OS (91% vs 59%; P < .001).
Conclusion
RT-based and surgery-based treatments produced similar outcomes. Patients with p16-positive disease with ≤10 pack-years of smoking history and limited nodal stage constitute a "low-risk" group in SCC of unknown primary similar to that in oropharyngeal cancer.
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Value of double mucoperiosteal flaps to prevent restenosis in Draf IIb/III: first clinical report
Abstract
Exposed drilled bone in Draf IIb and III procedures promotes restenosis by inducing osteitis and neo-osteogenesis.
This reaction can be avoided by covering bone with local mucoperiosteal flap that optimize the healing process
In a series of 16 patients, a septoturbinal flap (STF) and lateral based nasoseptal flap (LNSF) are harvested to cover the posterior and anterior edge of the frontal cavity, respectively.
These flaps do not overlap and can be harvested from the same side.
Clinical feasibility of double mucoperiosteal flaps in Draf IIb and III was demonstrated with promising results in terms of frontal cavity restenosis prevention (93.75% success rate). A favorable healing process was noted with minimal crusting during the postoperative period.
This article is protected by copyright. All rights reserved.
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Cross-sectional follow up of voice outcomes in children who have a history of airway reconstruction surgery
Abstract
Objectives
This study reports vocal function in a cross-section of children with subglottic stenosis. Each child had a history of laryngotracheal reconstruction and/or cricotracheal resection surgery. Vocal function was measured using laryngoscopy, acoustic analysis, perceptual evaluation and impact of voice on quality of life.
Design
All patients aged >5 years with history of laryngotracheal reconstruction and/or cricotracheal resection surgery at the Scottish National Complex Airways service were invited to participate.
Setting
Data was gathered in the Royal Hospital for Children in Glasgow in a single out-patient appointment.
Participants
Twelve out of fifty-six former patients (aged 5 – 27) provided a voice sample and eleven consented to awake laryngoscopy. All consented for detailed evaluation of their medical records.
Main outcome measures
Acoustic analysis of fundamental frequency and pitch perturbation was conducted on sustained vowel [a]. Perceptual evaluation was conducted by four trained listeners on a series of spoken sentences. Impact on quality of life was measured using the Paediatric Voice Related Quality of Life questionnaire. Laryngeal function was descriptively evaluated.
Results
Four children had normal voice acoustically, perceptually and in relation to voice related quality of life. One of these had vocal fold nodules unrelated to surgical history. Two other children had 'near normal' vocal function, defined where most voice measurements fell within the normal range.
Conclusions
Normal or 'near normal' voice is a possible outcome for children who have had this surgery. Where there is an ongoing complex medical condition, voice outcome may be poorer.
This article is protected by copyright. All rights reserved.
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The organ transplanted patient in the dental clinic
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The organ transplanted patient in the dental clinic
Swiss Dent J. 2017;127(11):984-986
Authors: Schenkel JS, Müller N, Rostetter C, Gander T, Lübbers HT
PMID: 29199776 [PubMed]
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Nouvelle procédure pour la réalisation de prothèses totales intégrée au flux de travail numérique
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Nouvelle procédure pour la réalisation de prothèses totales intégrée au flux de travail numérique
Swiss Dent J. 2017;127(11):976-983
Authors: Reichelt J, Bär G, Poerschke F, Stark H, Enkling N, Kraus D
PMID: 29199775 [PubMed]
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Neuartige Herstellung von Totalprothesen im digitalen Workflow
| Related Articles |
Neuartige Herstellung von Totalprothesen im digitalen Workflow
Swiss Dent J. 2017;127(11):967-975
Authors: Reichelt J, Bär G, Poerschke F, Stark H, Enkling N, Kraus D
PMID: 29199774 [PubMed]
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Injizierte dermale Füllermaterialien – ein spezieller Befund der Mundhöhlenschleimhaut
| Related Articles |
Injizierte dermale Füllermaterialien – ein spezieller Befund der Mundhöhlenschleimhaut
Swiss Dent J. 2017;127(11):964-965
Authors: Meier T, Kirchhoff J, Andreoni C, Pfaltz M, Bornstein MM
PMID: 29199773 [PubMed]
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Frischhaltefolie als Lagerungsmedium für avulsierte Zähne. Eine In-vitro-Pilotstudie
| Related Articles |
Frischhaltefolie als Lagerungsmedium für avulsierte Zähne. Eine In-vitro-Pilotstudie
Swiss Dent J. 2017;127(11):960-963
Authors: Zeissler-Lajtman A, Connert T, Kühl S, Filippi A
PMID: 29199772 [PubMed]
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Cling film as storage medium for avulsed teeth. An in vitro pilot study
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Cling film as storage medium for avulsed teeth. An in vitro pilot study
Swiss Dent J. 2017;127(11):954-959
Authors: Zeissler-Lajtman A, Connert T, Kühl S, Filippi A
Abstract
The long-term prognosis of avulsed teeth primarily depends on the behavior at the scene of the accident. Lay people are not able to perform an immediate replantation. Therefore, particular significance belongs to the cellphysiologic storage of avulsed teeth. The aim of this pilot study was to evaluate whether cling film facilitates the survival of periodontal ligament cells in vitro. For this purpose, healthy human third molars were used. They were cut into root slices, which were stored in one of five test media: SOS Zahnbox ® , UHT milk (4 °C), sterile isotonic saline solution, tap water, and cling film. Following storage periods of 2 hours, 6 hours, and 24 hours in the respective medium, slices were cultivated at 37 °C and 5% CO 2 . After 2 days, 7 days, and 14 days in culture, surviving periodontal ligament cells of each slice were assessed quantitatively. Apart from tap water, all investigated media promoted cell survival. At the time of 2 hours, storage in cling film facilitated the highest cell growth compared to all other media. At the time of 6 hours, teeth stored in cling film sho wed cell growth comparable to that observed in the SOS Zahnbox ®. The results of this pilot study indicate that cling film possibly could be used as an alternative transport medium for a storage period of up to 6 hours.
PMID: 29199771 [PubMed]
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The organ transplanted patient in the dental clinic
| Related Articles |
The organ transplanted patient in the dental clinic
Swiss Dent J. 2017;127(10):884-886
Authors: Schenkel JS, Müller N, Rostetter C, Gander T, Lübbers HT
PMID: 29199770 [PubMed]
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La technique zurichoise de tunnélisation. Utilisation adjuvante de ligatures en caoutchouc pour le traitement des atteintes de furcation
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La technique zurichoise de tunnélisation. Utilisation adjuvante de ligatures en caoutchouc pour le traitement des atteintes de furcation
Swiss Dent J. 2017;127(10):876-883
Authors: Müller C, Zaruba M, Gartenmann S, Lampe-Bless K, Schmidlin PR
PMID: 29199420 [PubMed]
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Die Zürcher Tunnel-Technik. Furkationsmanagement adjuvant mit Gummiligaturen
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Die Zürcher Tunnel-Technik. Furkationsmanagement adjuvant mit Gummiligaturen
Swiss Dent J. 2017;127(10):867-875
Authors: Müller C, Zaruba M, Gartenmann S, Lampe-Bless K, Schmidlin PR
PMID: 29199419 [PubMed]
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Anti-erosive effect of a self-assembling peptide gel
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Anti-erosive effect of a self-assembling peptide gel
Swiss Dent J. 2017;127(10):857-864
Authors: Attin T, Becker K, Wiedemeier DB, Schmidlin PR, Wegehaupt FJ
Abstract
This study analyzed the anti-erosive effect of a self-assembling peptide fibre gel. One hundred and twelve bovine enamel samples were ground flat and subjected to a three times de- and re-mineralization cycle: erosion (5min, HCl, pH2.6) alternated with storage in artificial saliva under agitation. Then, samples were covered with dif-ferent anti-erosive compounds (2min): Duraphat toothpaste (DT), Elmex Erosion Protection Tooth-paste (EET) or Elmex Gelée (EG)– all mixed with saliva (1:3)–, Elmex Erosion Protection Mouth-wash (EEM), Curodont Protect (CP; self-assem-bling peptide gel) or MI Paste Plus (MIP). Untreat-ed, water stored samples served as control. In experiment1, half of the samples of each group were continuously superfused with HCl (pH2.6, 60μl/min, 8min). In experiment2, the second half of samples were subjected to eight cycles, each consisting of application of the respective anti-erosive compound followed by an erosion (60s, HCl, pH2.6), followed by remineralization in artificial saliva (45min). Enamel loss was profi-lometrically determined.In experiment1, EEM and EET performed signifi-cantly better compared to all other compounds. Substance loss of all other compounds did not differ significantly from control. In experiment2, significantly better performance was achieved by EEM and EET. EG showed significantly lower pro-tection than the control. All other applied com-pounds yielded no significant difference com-pared to control.Under the chosen conditions, the self-assembling peptide-containing compound showed no anti-erosive effect.
PMID: 29199414 [PubMed]
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Evaluation of a halitosis clinic over a period of eleven years
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Evaluation of a halitosis clinic over a period of eleven years
Swiss Dent J. 2017;127(10):852-856
Authors: Schumacher MG, Zürcher A, Filippi A
PMID: 29199413 [PubMed]
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Evaluation of a halitosis clinic over a period of eleven years
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Evaluation of a halitosis clinic over a period of eleven years
Swiss Dent J. 2017;127(10):846-851
Authors: Schumacher MG, Zürcher A, Filippi A
Abstract
About every fourth individual suffers at leasttemporarily from oral malodor. The most frequentcause of it is the oral cavity, in particular thetongue coating. In professional halitosis clinics,findings and diagnoses are discussed with thepatients, and individual therapy concepts are designed. Currently, there are only few ev alua- tions of such clinics, which moreover are con- fined to a period of a few weeks or months. The aim of the present work was to evaluate the halitosis clinic of the University Center of Dental Medicine Basel o ver a period of eleven years. For the purpose of a recall, 638 patients w ere con- tacted, who had visited the halitosis clinic be- tween February 2003 and February 2014. Of these, 280 patients answ ered a special question- naire. The halitosis clinic was rated as helpf ul by 81.9% of the respondents. The majority (61.8%) only rarely or never suffered from bad breath anymore and still carried out the recommended tongue cleaning. Ninety-one patients who re- ported to suffer again from oral malodor, could be re-evaluated also clinically. The strictly cause- oriented therapy concept of the halitosis clinic of the Univ ersity Center of Dental Medicine Basel has proved successful over eleven years.
PMID: 29199412 [PubMed]
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Intonation patterns of questions in Malaysian English
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Why you should build your brand around your ideal client
Specialize and focus on defining your ideal client. Once you have every detail about your avatar, consider his or her wants, needs, pain points, challenges, etc., in everything you do, and include that in your business planning.
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Overexpression of osteopontin promotes cell proliferation and migration in human nasopharyngeal carcinoma and is associated with poor prognosis
Abstract
Nasopharyngeal carcinoma (NPC), a malignant tumor at the top and side of the nasopharyngeal cavity, highly occurs in the southern region of China. Cancer cell metastasis is one of the leading causes of death in NPC patients. Osteopontin (OPN), is a phosphorylated extracellular matrix protein with a variety of functions, was found to be overexpressed in many cancers. However, the expression and role of OPN in patients with NPC in Guangxi, China are unclear. Here, we observed that NPC patients had upregulated OPN at mRNA protein and levels. Immunochemistry (IHC) analysis of OPN expression in 68 NPC clinical specimens indicated that high expression of OPN had positive correlation with NPC lymph node metastasis (P = 0.012), distant metastasis (P = 0.001) and TNM staging (P = 0.018). Moreover, compared with relatively low OPN, NPC patients with higher expression of OPN showed a poorer overall survival rate (P = 0.001, log rank test). Multivariate analysis showed that OPN expression in NPC was an independent prognostic marker. The proliferation, apoptosis and migration ability of CEN-2Z cancer cells in NPC were determined by MTT, flow cytometry and wound-healing assays, respectively. Upregulation of OPN in CEN-2Z cancer cells promoted cancer cell proliferation and migration, and suppressed apoptosis. In sum, our result suggests OPN could be used as a valuable oncoprotein and show that overexpression of OPN in NPC may serve as a potential prognostic marker.
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Topical ofloxacin use in G6PD deficiency - safe or unsafe?
Abstract
we have recently treated a paediatric patient with known glucose-6-phosphate dehydrogenase (G6PD) deficiency and wished to communicate to the clinical ENT community the controversies around the use of fluoroquinolone (FQ) antibiotic drops in this patient cohort.
This article is protected by copyright. All rights reserved.
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Polysomnographic Oxygen Saturation Findings for Preteen Children versus Adolescents
Otolaryngology-Head and Neck Surgery, Ahead of Print.
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Incidence of Lingual Tonsil Hypertrophy in Adults with and without Obstructive Sleep Apnea
Otolaryngology-Head and Neck Surgery, Ahead of Print.
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Why Actionable Statements Are Needed for Measurement Development
Otolaryngology-Head and Neck Surgery, Ahead of Print.
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Migraine-Related Aural Fullness: A Potential Clinical Entity
Otolaryngology-Head and Neck Surgery, Ahead of Print.
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Τρίτη 5 Δεκεμβρίου 2017
Can pulpal floor debonding be detected from occlusal surface displacement in composite restorations?
Source:Dental Materials
Author(s): João Batista Novaes, Elissa Talma, Estevam Barbosa Las Casas, Wondwosen Aregawi, Lauren Wickham Kolstad, Sue Mantell, Yan Wang, Alex Fok
ObjectivesPolymerization shrinkage of resin composite restorations can cause debonding at the tooth–restoration interface. Theory based on the mechanics of materials predicts that debonding at the pulpal floor would half the shrinkage displacement at the occlusal surface. The aim of this study is to test this theory and to examine the possibility of detecting subsurface resin composite restoration debonding by measuring the superficial shrinkage displacements.MethodsA commercial dental resin composite with linear shrinkage strain of 0.8% was used to restore 2 groups of 5 model Class-II cavities (8-mm long, 4-mm wide and 4-mm deep) in aluminum blocks (8-mm thick, 10-mm wide and 14-mm tall). Group I had the restorations bonded to all cavity surfaces, while Group II had the restorations not bonded to the cavity floor to simulate debonding. One of the proximal surfaces of each specimen was sprayed with fine carbon powder to allow surface displacement measurement by Digital Image Correlation. Images of the speckled surface were taken before and after cure for displacement calculation. The experiment was simulated using finite element analysis (FEA) for comparison.ResultsGroup I showed a maximum occlusal displacement of 34.7±6.7μm and a center of contraction (COC) near the pulpal floor. Group II had a COC coinciding with the geometric center and showed a maximum occlusal displacement of 17.4±3.8μm. The difference between the two groups was statistically significant (p-value=0.0007). Similar results were obtained by FEA. The theoretical shrinkage displacement was 44.6 and 22.3μm for Group I and II, respectively. The lower experimental displacements were probably caused by slumping of the resin composite before cure and deformation of the adhesive layer.SignificanceThe results confirmed that the occlusal shrinkage displacement of a resin composite restoration was reduced significantly by pulpal floor debonding. Recent in vitro studies seem to indicate that this reduction in shrinkage displacement could be detected by using the most accurate intraoral scanners currently available. Thus, subject to clinical validation, the occlusal displacement of a resin composite restoration may be used to assess its interfacial integrity.
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Characterization, mechanistic analysis and improving the properties of denture adhesives
Source:Dental Materials
Author(s): Afsoon Fallahi, Nona Khadivi, Nima Roohpour, Andrew M. Middleton, Mehdi Kazemzadeh-Narbat, Nasim Annabi, Ali Khademhosseini, Ali Tamayol
ObjectiveDenture adhesives are widely used to avoid the detachment and sliding of dentures. However, the adhesion properties can be affected by variation in mouth conditions such as the level of salivation. The objective of this study was to understand the effect of environmental conditions on the adhesion properties of a commercially available denture adhesive named as Poligrip® Free manufactured by GlaxoSmithKline Ltd., UK and to identify the reasons for the observed variation in its adhesion strength.MethodsThe failure mechanisms of denture adhesive have been assessed through using different physical, mechanical and thermal characterization experiments. All methods were used in different pH, temperatures, and salivation conditions and at the end, a strategy was proposed to overcome the failure of the paste in hyposalivation as well.ResultsIn vitro models mimicking the denture gingival interface were designed to evaluate the adhesion properties of the investigated adhesive. Changes in the adhesion strength in response to three major factors related to the oral conditions including level of salivation, pH, and temperature were measured. The results of lap shear, tensile test, and internal interactions suggested a cohesion failure, where the lowest adhesion strength was due to hyposalivation. Fourier transform infrared spectroscopy (FTIR) and rheological analysis confirmed the importance of hydrogen bonds and hydration in the adhesion strength of the paste.SignificanceThe investigated scenarios are widely observed in patient using denture adhesives and the clinical reports have indicated the inconsistency in adhesion strength of the commercial products. After identifying the potential reasons for such behavior, methods such as the addition of tripropylene glycol methyl ether (TPME) to enhance internal hydrogen bonds between the polymers are proposed to improve adhesion in the hyposalivation scenario.
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Practical and theoretical considerations on the fracture toughness testing of dental restorative materials
Source:Dental Materials
Author(s): Renan Belli, Michael Wendler, José I. Zorzin, Ulrich Lohbauer
BackgroundAn important tool in materials research, development and characterization regarding mechanical performance is the testing of fracture toughness. A high level of accuracy in executing this sort of test is necessary, with strict requirements given in extensive testing standard documents. Proficiency in quality specimen fabrication and test requires practice and a solid theoretical background, oftentimes overlooked in the dental community. Aims: In this review we go through some fundamentals of the fracture mechanics concepts that are relevant to the understanding of fracture toughness testing, and draw attention to critical aspects of practical nature that must be fulfilled for validity and accuracy in results. We describe our experience with some testing methodologies for CAD/CAM materials and discuss advantages and shortcomings of different tests in terms of errors in testing the applicability of the concept of fracture toughness as a single-value material-specific property.
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Bonding strategies for MIH-affected enamel and dentin
Source:Dental Materials
Author(s): Norbert Krämer, Ngoc-Han Nana Bui Khac, Susanne Lücker, Vitus Stachniss, Roland Frankenberger
ObjectivesAim of the present study was to evaluate resin composite adhesion to dental hard tissues affected by molar incisor hypomineralisation (MIH).Methods94 freshly extracted human molars and incisors (53 suffering MIH) were used. 68 teeth (35 with MIH) were used for μ-TBS tests in enamel and dentin, 26 (18 with MIH) for qualitative evaluation. Specimens were bonded with Clearfil SE Bond, Scotchbond Universal, and OptiBond FL. For MIH affected enamel, additional OptiBond FL groups with NaOCl and NaOCl+Icon were investigated. Beside fractographic analysis, also qualitative evaluations were performed using SEM at different magnifications as well as histological sectioning.ResultsHighest μ-TBS values were recorded with dentin specimens (ANOVA, mod. LSD, p<0.05). Results were independent of adhesive and dentin substrate (p>0.05). Pre-test failures did not occur in dentin specimens. Sound enamel specimens exhibited significantly higher μ-TBS values than MIH enamel (p<0.05). The two-step self-etch adhesive (Clearfil SE Bond) and the two-step etch-and-rinse adhesive (Scotchbond Universal) showed the lowest values in affected enamel specimens (p<0.05) with most pre-test failures (p<0.05). OptiBond FL on affected enamel showed better results than Clearfil SE Bond (p<0.05). An additional pre-treatment of affected enamel with NaOCl or NaOCl and Icon did not enhance enamel bonding (p>0.05), however, it caused less pre-test failures (p<0.05). Micromorphological analyses revealed that conventional phosphoric acid etching produces a much less pronounced etching pattern in affected enamel and a porous structure as weak link for the resin-enamel bond was identified.SignificanceBonding to porous hypomineralized MIH enamel is the limiting factor in adhesion to MIH teeth. MIH-affected dentin may be bonded conventionally.
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Summary Low-fidelity, simulation-based psychomotor skills training is a valuable first step in the educational approach to mastering com...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182, Treatment of basilar artery stenosis w...
