The relation of CUN-BAE index and BMI with body fat, cardiovascular events and diabetes during a 6-year follow-up: the Hordaland Health Study

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zB6oY4
via IFTTT

Big Horn Dental collects candy for troops

A dentist's office might be the last place you'd expect to find candy, but Big Horn Dental has quite the collection after its ninth annual Cash for Candy event. Starting the day after Halloween, kids came in with candy and received $1 for every pound they brought in, up to five pounds.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zSxkUe
via IFTTT

Citation analysis may well have a role to play in study identification, but more evaluation and systems development is required

Publication date: Available online 11 November 2017
Source:Journal of Clinical Epidemiology
Author(s): James Thomas




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2yVBFpk
via IFTTT

Perspective. Reoperative Bentall: choice of conduits

Abstract

The Bentall procedure represents the gold standard in the treatment of patients requiring aortic root replacement. The most common indications for redo Bentall are structural degeneration or graft infection. Redo aortic root replacement can be performed with low perioperative morbidity and death. The choice of the best conduit is still up for debate but is mandatory to guarantee the best and most durable option for the patient. New options are available to reduce mortality in older or fragile patients and can modify the conduit choice.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zyh5uW
via IFTTT

Robot-assisted totally endoscopic coronary bypass surgery

Abstract

Totally endoscopic coronary artery bypass (TECAB) surgery can exclusively be undertaken with the aid of operative robots. In the past two decades, surgical remote manipulator systems—predominantly the daVinci® devices—have brought us the reality of endoscopic internal mammary artery harvesting and coronary bypass anastomoses via minimally invasive thoracic port access. Single up to quadruple TECAB interventions are recently feasible; the procedure can be delivered either as beating heart applying endoscopic vacuum stabilizer or under cardioplegic arrest on heart-lung machine. Significant surgical team learning curves are involved in a stepwise development of these complex procedures, including intense dry- and wet-lab trainings, endoscopic internal mammary artery harvesting and manual coronary anastomosis building through a thoracotomy. Increasing number of papers have been published regarding clinical TECAB series in the past decade. In arrested heart TECAB procedures on cardiopulmonary bypass, the conversion rate from port access to larger thoracic incision measures 15.1% and no perioperative mortality is observed in published records. Stroke, kidney failure and atrial fibrillation rates stay at 0.6, 0.4 and 12.9%, respectively. Analysis of beating heart TECAB procedures revealed a conversion rate of 15.3%, perioperative mortality 0.4%, stroke 0.3%, kidney failure 0.6% and atrial fibrillation 9.2%. Additionally, due to the obviously smaller surgical trauma, a remarkable fast return to normal daily activities can be demonstrated in clinical series of robotic assisted coronary bypass surgery. Short-term freedom of major adverse cardiac and cerebral events (MACCE) stays over 90%. Long-term studies reveal 5-year freedom of MACCE in the 75.2 to 83.1% range. Nowadays, total endoscopic coronary artery bypass grafting is a feasible and reproducible surgical method. Advanced hybrid coronary interventions offer complex multivessel TECAB with support of percutaneous coronary interventions (PCI). Combination of the above techniques widens the spectrum of minimally invasive therapeutic solutions concerning multivessel procedure including bilateral internal mammary grafts and drug-eluting stents.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zRLO6v
via IFTTT

Tracheobronchial tear in chest trauma—a diagnostic perplexity

Abstract

Tracheobronchial injuries following blunt chest trauma are uncommon and diagnosed late. Tracheal rupture due to a fall from a height is rare. Early diagnosis and prompt treatment give gratifying results. We present a case of a 42-year-old man who was referred at our hospital with alleged history of fall from a height of about 12 ft from a tree. On presentation, the patient was haemodynamically stable and right-sided ICT was already inserted. There was a minimal surgical emphysema in the neck, a continuous air leak from the chest tube and a partially collapsed right lung on chest X-ray. After a few hours, he desaturated and was intubated. The right lung did not expand in spite of the second apical chest tube, and on ventilation, air leak increased. Tracheabronchial tear was suspected and computerised tomography scan revealed the site of damage and fibreoptic bronchoscopy confirmed the diagnosis. Emergency thoracotomy with primary repair of the right tracheabronchial tear was done. The patient recovered and post-operative course was uneventful.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zxTAlu
via IFTTT

Wide awake

In less time than it takes to blink, I went from sound asleep to wide awake. The only perk? I wouldn't be tempted to have a lazy morning.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2yvZy2A
via IFTTT

Volcanism in slab tear faults is larger than in island-arcs and back-arcs

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2AD7qkt
via IFTTT

Mapping functional diversity from remotely sensed morphological and physiological forest traits

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2yyrByf
via IFTTT

How to Create Your Own Compelling Dental Website Content

Over the years, as I've written and lectured to dentists about website marketing, the concept I have the most difficulty conveying to them is about the value of self-written, unique content.  Dentists resist the idea of writing their own content … Continue reading →

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2iPSU0s
via IFTTT

Beverly Hills Dentist Rodney Raanan Receives Numerous Reviews From Yelp and Google

Renowned Beverly Hills Cosmetic Dentist, Dr Rodney Raanan attained his Bachelor of Science degree in Anthropology at the University of California-Los Angeles . He went on to pursue a career in dentistry and obtained his Doctor of Dental Surgery degree from University of Southern California School of Dentistry .

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2AA0RxZ
via IFTTT

New Bern's big heart shines bright Updated at

Craven County has a long tradition of fundraising events, four of which last weekend raised more than $200,000, helping thousands of people. A number of charitable events spanning three days provided funding and services totaling more than $200,000, with an outreach to thousands of people.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2i7ciqg
via IFTTT

The utility of oral brush cytology in the early detection of oral cancer and oral potentially malignant disorders: A systematic review

Abstract

Objectives

This systematic review aimed to analyze the published evidence for the use of oral brush cytology for the early detection of oral cancer and oral potentially malignant disorders (OPMDs).

Methods

Literature was systematically searched through several databases: MEDLINE, EMBASE, PubMed, SCOPUS, Cochrane Library and Web of Science. Additional review was performed through cross checks on the bibliographies of selected articles. The inclusion criteria involved studies assessing the utility of oral brush cytology on human tissues and its applications in the diagnosis, screening or surveillance of oral cancer or OPMDs.

Results

The search strategy resulted in 343 abstracts or full-text articles, of which 36 met the inclusion criteria. The year of publication ranged from 1994 to 2017, and a total of 4302 samples from OPMDs, oral squamous cell carcinoma, and healthy controls have been investigated. Baby toothbrush, Cytobrush, OralCDx^®, and Orcellex^® are the brushes that were used to obtain transepithelial mucosal samples for conventional and liquid-based cytology evaluation.

Conclusions

Findings from this paper indicate that meaningful evidence-based recommendations for the implementation of a minimally-invasive technique to be utilized as an adjunctive tool for screening and early detection of oral cancer and OPMDs are complicated from the reported studies in the literature. There is need for well-designed clinical studies to assess the accuracy of oral brush cytology utilizing validated cytological assessment criteria for the diagnosis and prediction of OPMDs.

This article is protected by copyright. All rights reserved.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2ACR2Ah
via IFTTT

Hundreds line up for free medical and dental care Read Story Shannon Valladolid

Hundreds of people in the Bay area received free dental, vision and medical service thanks to RAM, Remote Area Medical. RAM is the largest provider of free mobile medical clinics delivering high-quality dental, vision and medical care to underserved and uninsured individuals, children and families.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2iQNeDv
via IFTTT

Dental Management of Patients Who Have Undergone Oral Cancer Therapy.

Dental Management of Patients Who Have Undergone Oral Cancer Therapy.

Dent Clin North Am. 2018 Jan;62(1):131-142

Authors: Villa A, Akintoye SO

Abstract
Oral cancer therapies are associated with orofacial complications that could result in dose-limiting cancer treatment and consequent suboptimal tumor control. Oral cancer treatment complications include oral mucositis, salivary gland hypofunction, odontogenic infections, pain, dermatitis, neurotoxicity, soft tissue fibrosis, trismus, osteoradionecrosis, and potential cancer recurrence. These complications significantly affect cancer survivorship, quality of life, and psychosocial status. Effective dental management of patients with oral cancer involves the coordination of care among several health care professionals before, during, and after cancer therapy. The goal is to minimize complications, and establish optimal quality of life for survivors.

PMID: 29126490 [PubMed - in process]

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zRyvDm
via IFTTT

Dental Treatment Planning for the Patient with Oral Cancer.

Dental Treatment Planning for the Patient with Oral Cancer.

Dent Clin North Am. 2018 Jan;62(1):121-130

Authors: Levi LE, Lalla RV

Abstract
Oral cancer therapy is associated with a multitude of head and neck sequelae that includes, but is not limited to, hyposalivation, increased risk for dental caries, osteoradionecrosis of the jaw, radiation fibrosis syndrome, mucositis, chemotherapy-induced neuropathy, dysgeusia, dysphagia, mucosal lesions, trismus, and infections. Preparing a comprehensive treatment plan for patients undergoing cancer therapy is essential to help minimize their risks for developing these oral and dental complications. In addition, dentists must take into account a patient's ongoing oncologic therapy for those patients who present to the dentist while concurrently receiving cancer treatment.

PMID: 29126489 [PubMed - in process]

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hmrG13
via IFTTT

Even if your child is a little bit older, it's never too late to arrange their first dental visit.

Even if your child is a little bit older, it's never too late to arrange their first dental visit. Most parents do not realise the importance of beginning early dental care.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zCsQxO
via IFTTT

Ethical and legal aspects in the care of singers and actors

Gustavo Polacow Korn, Carlos Michaelis Jr., Vania Rosa Moraes
Braz J Otorhinolaryngol.2017;83:609-10

Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hm0iAf
via IFTTT

Health‐related quality of life and disability in patients with acute unilateral peripheral vestibular disorders

Maria Petri, Magdalena Chirilă, Sorana D. Bolboacă, Marcel Cosgarea
Braz J Otorhinolaryngol.2017;83:611-8

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hmLDFi
via IFTTT

The potential role of amlodipine on experimentally induced bacterial rhinosinusitis

Arzu Tatar, Mukadder Korkmaz, Muhammed Yayla, Elif Polat, Hakan Uslu, Zekai Halici, Secil N. Parlak
Braz J Otorhinolaryngol.2017;83:619-26

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zzYIFl
via IFTTT

Tracheostomy in children: a ten‐year experience from a tertiary center in southern Brazil

Cláudia Schweiger, Denise Manica, Carolina Fischer Becker, Larissa Santos Perez Abreu, Michelle Manzini, Leo Sekine, Gabriel Kuhl
Braz J Otorhinolaryngol.2017;83:627-32

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hm0jnN
via IFTTT

Association between desloratadine and prednisolone in the treatment of children with acute symptoms of allergic rhinitis: a double‐blind, randomized and controlled clinical trial

Gustavo F. Wandalsen, Carolina Miranda, Luis Felipe Ensina, Flavio Sano, Roberto Bleul Amazonas, Joyce Macedo da Silva, Dirceu Solé
Braz J Otorhinolaryngol.2017;83:633-9

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zzts9A
via IFTTT

Are people who have a better smell sense, more affected from satiation?

Seckin Ulusoy, Mehmet Emre Dinc, Abdullah Dalgic, Murat Topak, Denizhan Dizdar, Abdulhalim İs
Braz J Otorhinolaryngol.2017;83:640-5

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hn7jRD
via IFTTT

Significant association between osteoporosis and hearing loss: a systematic review and meta‐analysis

Sikarin Upala, Pattara Rattanawong, Wasawat Vutthikraivit, Anawin Sanguankeo
Braz J Otorhinolaryngol.2017;83:646-52

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zAf14U
via IFTTT

Carotid blowout syndrome in patients treated by larynx cancer

Carlos Miguel Chiesa Estomba, Frank Alberto Betances Reinoso, Alejandra Osorio Velasquez, Olalla Castro Macia, Maria Jesus Gonzalez Cortés, Jesus Araujo Nores
Braz J Otorhinolaryngol.2017;83:653-8

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hkOjDb
via IFTTT

Subjective visual vertical after treatment of benign paroxysmal positional vertigo

Maristela Mian Ferreira, Maurício Malavasi Ganança, Heloisa Helena Caovilla
Braz J Otorhinolaryngol.2017;83:659-64

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zAY62j
via IFTTT

Free Field Word recognition test in the presence of noise in normal hearing adults

Gleide Viviani Maciel Almeida, Angela Ribas, Jorge Calleros
Braz J Otorhinolaryngol.2017;83:665-9

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hlBc4C
via IFTTT

Identification of key genes involved in nasopharyngeal carcinoma

Xue Jiang, Lichun Feng, Baoqiang Dai, Liping Li, Weiwei Lu
Braz J Otorhinolaryngol.2017;83:670-6

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zAeVKA
via IFTTT

Nasal polyposis in cystic fibrosis: follow‐up of children and adolescents for a 3‐year period

Silke Anna Theresa Weber, Renata Mizusaki Iyomasa, Camila de Castro Corrêa, Wellington Novais Mafra Florentino, Giesela Fleischer Ferrari
Braz J Otorhinolaryngol.2017;83:677-82

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hlB5WK
via IFTTT

Arteriovenous malformation of the external ear: a clinical assessment with a scoping review of the literature

Shin Hye Kim, Seung Hoon Han, Yoonjae Song, Chang Sik Park, Jae‐Jin Song
Braz J Otorhinolaryngol.2017;83:683-90

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zBji8k
via IFTTT

Effects of exposure to 2100MHz GSM‐like radiofrequency electromagnetic field on auditory system of rats

Metin Çeliker, Abdulkadir Özgür, Levent Tümkaya, Suat Terzi, Mustafa Yılmaz, Yıldıray Kalkan, Ender Erdoğan
Braz J Otorhinolaryngol.2017;83:691-6

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hkObDH
via IFTTT

Translation and cultural adaptation of the Shame and Stigma Scale (SSS) into Portuguese (Brazil) to evaluate patients with head and neck cancer

William Eduardo Pirola, Bianca Sakamoto Ribeiro Paiva, Eliane Marçon Barroso, David W. Kissane, Claudia Valéria Maseti Pimenta Serrano, Carlos Eduardo Paiva
Braz J Otorhinolaryngol.2017;83:697-704

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zyBhwd
via IFTTT

Polymorphisms in chronic rhinosinusitis with nasal polyps – a systematic review

Vanessa Ramos Pires Dinarte, Anemari Ramos Dinarte dos Santos, Luiza Ferreira de Araújo, Mariah Guieiro Alves dos Reis, Edwin Tamashiro, Fabiana Cardoso Pereira Valera, Wilson Araújo da Silva Júnior, Wilma Terezinha Anselmo‐Lima
Braz J Otorhinolaryngol.2017;83:705-11

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hlAYui
via IFTTT

Facial thread lifting with suture suspension

Joana de Pinho Tavares, Carlos Augusto Costa Pires Oliveira, Rodolfo Prado Torres, Fayez Bahmad Jr.
Braz J Otorhinolaryngol.2017;83:712-9

Resumo - Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zAeNe4
via IFTTT

The facial palsy as first symptom of the temporal bone lung cancer metastasis

Dragoslava Djeric, Ivan Boricic, Nada Tomanovic, Ljiljana Cvorovic, Srbislav Blazic, Miljan Folic, Igor Djoric
Braz J Otorhinolaryngol.2017;83:720-2

Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hlAUL4
via IFTTT

A case of bilateral congenital middle ear cholesteatoma

Mihael Ries, Mirjana Kostić, Jakov Ajduk, Robert Trotić, Vladimir Bedeković
Braz J Otorhinolaryngol.2017;83:723-5

Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hlASCW
via IFTTT

Bilateral parotid glands infection caused by Calmette‐Guerin Bacillus after intravesical therapy for recurrent bladder cancer: a case report

Eviatar Friedlander, Paula Martínez Pascual, Pedro Montilla de Mora, Bartolomé Scola Yurrita
Braz J Otorhinolaryngol.2017;83:726-9

Texto Completo - PDF

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hlAOTI
via IFTTT

Citation analysis is also useful to assess the eligibility of biomedical research works for inclusion in Living systematic reviews

Publication date: Available online 11 November 2017
Source:Journal of Clinical Epidemiology
Author(s): Houcemeddine Turki
In this research letter, I explain how the analysis of the citation network and of the co-citation network of a given topic and the use of the snowballing techniques can be useful to verify the eligibility of a paper for inclusion in the Living Systematic Review (LSR) of that topic.



from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zyMkFM
via IFTTT

52 Savage Shows Off His New Smile

Dallas rapper 52 Savage is flaunting a new pair of pearly whites after receiving a new smile at Bensonhurst Dental in Brooklyn, New York. 52 uploaded several photos to Instagram with staff at the dental office before posting images of his dramatic dental makeover.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2jlxix3
via IFTTT

Re: Bilginaylar K: The Use of Platelet Rich Fibrin for Immediate Closure of Acute Oroantral Communications: An Alternative Approach

We read with interest the study by Bilginaylar1 who used a platelet-rich fibrin (PRF) clot for acute oroantral communication (OC). We agree with Dr Bilginaylar that flapless surgery provides much comfort in acute OC. However, we wish to make a few observations.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2mfBIq9
via IFTTT

Evaluating the association between household air pollution and oral cancer

A World Health Organisation report in 2004 [1] assessed the disease burden from indoor smoke generated from combustion of household solid fuels. The report estimated that globally about 50% of all households especially rural household (90%) utilize solid fuels for domestic use. The solid fuels commonly used were coal in China and biomass (crop residues, animal dung, and wood) in India and Africa. Most of this household have relatively poor ventilation thus increasing the exposure to the smoke. The report revealed that women and young children due to their household roles were the most exposed, resulting in chronic pulmonary disease in women and the children suffered from acute infections of the lower respiratory tract [1].

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2mh3q5O
via IFTTT

Bone autografts & allografts placed simultaneously with dental implants in rabbits

This study compared stability, removal torque, bone implant contact (BIC) and area (BA) of implants installed simultaneously with onlay autografts or allografts in rabbits' tibias.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hlxcBa
via IFTTT

Iatrogenic Cushing's syndrome and adrenal insufficiency in infants on intranasal dexamethasone drops for nasal obstruction – Case series and literature review

The use of intranasal steroid drops for nasal obstruction in infants is common practice and can prevent more invasive surgical procedures; however, it is not without complication. We describe 2 cases of iatrogenic Cushing's secondary to nasal steroids in infants with nasal obstruction, discuss the etiology of this unusual complication, and review previous literature reports. While reporting in the literature is sparse, these cases highlight the risk of development of adrenal insufficiency with usage of nasal steroid drops in infants as well as the need for close monitoring of administration and tapering of the drops.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2mhVqSc
via IFTTT

Citation analysis is also useful to assess the eligibility of biomedical research works for inclusion in Living systematic reviews

In this research letter, I explain how the analysis of the citation network and of the co-citation network of a given topic and the use of the snowballing techniques can be useful to verify the eligibility of a paper for inclusion in the Living Systematic Review (LSR) of that topic.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2AxwIQ7
via IFTTT

Citation analysis may well have a role to play in study identification, but more evaluation and systems development is required

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2i6egae
via IFTTT

Macon County Health Department and Other Organizations Receive Delta Dental Grant

Nov 10 - Through its Community Grants Program, Delta Dental of Illinois Foundation awarded more than $175,000 to 19 nonprofit and community organizations with programs and services that will improve children's dental health in Illinois. Lora Vitek, Director of philanthropy and community relations for Delta, said, "Too many children in Illinois don't receive the dental education and care they need, and therefore, do not routinely practice preventative oral health behaviors and suffer from untreated cavities and more serious oral health problems."

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zC8ZPe
via IFTTT

Volunteers help thousands at four-day free clinic

Sen. Hasegawa and Farhiya Mohamed, executive director of Somali Family Safety Task Force on Oct. 27. On the mainstage at KeyArena were over 750 dentists providing free dental work to more than a thousand patients each day, as the arena transformed from a concert venue and sports arena to a free pop-up clinic. From Oct. 26-29, the Seattle/King County Clinic was held in the KeyArena at the Seattle Center for its fourth year.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2ADDXqn
via IFTTT

Dilemma between health and environmental motives when purchasing animal food products: sociodemographic and nutritional characteristics of consumers

Dietary guidelines in France give quantitative recommendations for intake of meat, fish and dairy products whereas consumers are increasingly concerned by the environmental impacts associated with the producti...

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2mfoiKG
via IFTTT

Clinicopathological Profile of Cervical Tubercular Lymphadenitis with Special Reference to Fine Needle Aspiration Cytology

Abstract

Tuberculosis (TB) is a major killer with a majority of 80–100 per lakh and 2–3% of patients attending our hospital are suffering from tuberculosis. Glandular TB appears to be high in our society. Fifty cases of cervical lymph nodes were collected in ENT department and studied. The diagnosis of TB cervical lymph nodes by disease process is only on 'Histopathological ground'.The aim of the present study is to establish the claim of TB cervical lymph node as a disease process.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2mjnO6C
via IFTTT

Persistence with dimethyl fumarate in relapsing-remitting multiple sclerosis: a population-based cohort study

Abstract

Purpose

To describe patients initiating dimethyl fumarate (DMF) and measure persistence with DMF, discontinuation, and switching in treatment-naïve DMF patients and patients switching to DMF from other multiple sclerosis disease-modifying treatments (DMTs).

Methods

A population-based cohort study of all Stockholm County residents initiating DMF from 9 May 2014 until 31 May 2017. All data were derived from a regional database that collects individual-level data on healthcare and drug utilization of all residents. The study outcomes were persistence with DMF and DMF discontinuation and switching to other DMTs. Persistence was measured as the number of days until either DMF discontinuation (treatment gap ≥ 60 days) or switching to another DMT.

Results

The study included 400 patients (median follow-up = 2.5 years). The majority had previously been treated with other DMTs (61%). Throughout the follow-up period, 124 patients (31%) discontinued DMF and 114 patients (29%) switched treatment. Overall, 34% of patients initiating DMF stopped treatment within 1 year and only 43% of patients remained on DMF at 2 years from treatment initiation.

Conclusions

DMF had a rapid market uptake likely due to high expectations held by both patients and clinicians. However, persistence with DMF in routine clinical practice was found to be low.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2jj5Pf6
via IFTTT

Sino-Nasal Outcome Test-22 quality of life patterns in patients presenting with nasal septal perforation

Abstract

Objectives

To assess the impact of nasal septal perforation on quality of life.

Design

Retrospective cohort study.

Setting

Rhinology clinics from two hospitals in Liverpool, United Kingdom.

Participants

Patients diagnosed with nasal septal perforation (NSP).

Main outcome measures

Patients (n=26) diagnosed with NSP completed the Sino-Nasal Outcome Test-22 (SNOT-22). The collated data was compared with SNOT-22 scores from a cohort of healthy volunteers (n=34) and a cohort of patients (n=30) diagnosed with chronic rhinosinusitis (CRS).

Results

The mean total SNOT-22 score of NSP and CRS cohorts were higher than that observed in healthy volunteers. The mean total SNOT-22 score in the CRS cohort (57.2, standard deviation SD 10.3) was the higher than NSP (50.2, SD 23.5), although this difference did not achieve statistical significance. The mean score for the rhinologic-specific domains (rhinologic symptoms, extra-nasal rhinologic symptoms), ear/facial symptoms and psychological dysfunction domain were higher in the CRS cohort compared to NSP, although statistical significance was only observed in the extranasal rhinologic symptoms domain (11.2, SD 2.4 vs. 6.4, SD 4.1). Conversely, the mean sleep dysfunction domain score for NSP (12.7, SD 7.5) was higher than CRS (10.0, SD 4.9 respectively) although this was not statistically significant.

Conclusions

The present study has assessed the clinimetric and psychometric properties of patients suffering with symptomatic NSP. Future reports should consider inclusion of SNOT-22 data but with the addition of perforation-specific symptoms (nasal crusting, epistaxis, whistling noise).

This article is protected by copyright. All rights reserved.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2iMN93u
via IFTTT

You'll be flossing all your teeth at once with Blizzident's customized 3D-Flosser

Although we've covered some pretty nifty tooth-cleaning gadgets before at Digital Trends, dental floss seems like one of those things you can't really rethink in a big way. It's been commercially available for well over 100 years and, in that time, hasn't changed significantly in appearance.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zyqKRA
via IFTTT

In Reply

Publication date: Available online 11 November 2017
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Kani Bilginaylar




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2mgauQl
via IFTTT

Re: Bilginaylar K: The Use of Platelet Rich Fibrin for Immediate Closure of Acute Oroantral Communications: An Alternative Approach

Publication date: Available online 11 November 2017
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Uğur Gülşen, Mehmet Fatih Şentürk, İlham Mehdiyev




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2yT6cnE
via IFTTT

In-continuity neck dissection: long-term oncological outcomes in squamous cell carcinoma of the buccal mucosa

Publication date: Available online 11 November 2017
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Li Xie, Yuanyuan Zhang, Wenxiao Huang, Jie Chen, Jianjun Yu, Xiao Zhou
PurposeTo introduce in-continuity neck dissection (ND) in squamous cell carcinoma of the buccal mucosa (BMSCC) and to determine its impact on the oncologic outcomes of these patients.MethodsA retrospective review of patients treated for BMSCC between 2006 and 2016 was performed. We adopted Kaplan-Meier analysis and log-rank test of local control (LC), regional control (RC), distant metastasis (DM) and disease specific survival (DSS) of in-continuity ND versus discontinuous ND in 220 previously untreated patients with BMSCC, followed by a multivariate Cox regression that included all significant variables.Results53 patients received discontinuous ND and 167 patients received in-continuity ND. Two groups were comparable. Univariate Kaplan-Meier analysis revealed that the 5-year DSS rates for discontinuous ND group and in-continuity ND group were 38 and 62% (P=0.023), respectively. The 5-year RC rate for in-continuity ND group (81%) was significantly better (P=0.004) than discontinuous ND group (54%). On Cox regression analysis, in-continuity ND significantly contributed to both higher RC rate and subsequently better DSS.ConclusionCompared with discontinuous ND, in-continuity ND predicted favorable oncological outcomes in BMSCC patients. We suggest in-continuity ND as a practical approach in the surgical management of BMSCC.



from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2mgahwx
via IFTTT

Point of Care Tuberculosis Sero-Diagnosis Kit for Wild Animals: Combination of Proteins for Improving the Diagnostic Sensitivity and Specificity

Abstract

Tuberculosis is a significant problem globally for domestic animals as well as captive and free ranging wild life. Rapid point of care (POC) serology kits are well suited for the diagnosis of TB in wild animals. However, wild animals are invariably exposed to environmental non-pathogenic mycobacterium species with the development of cross reacting antibodies. In the present study, POC TB diagnosis kit was developed using a combination of pathogenic Mycobacteria specific recombinant antigens and purified protein derivatives of pathogenic and non-pathogenic Mycobacteria. To benchmark the TB antibody detection kit, particularly in respect to specificity which could not be determined in wildlife due to the lack of samples from confirmed uninfected animals, we first tested well-characterized sera from 100 M. bovis infected and 100 uninfected cattle. Then we investigated the kit's performance using sera samples from wildlife, namely Sloth Bears (n = 74), Elephants (n = 9), Cervidae (n = 14), Felidae (n = 21), Cape buffalo (n = 2), Wild bear (n = 1) and Wild dog (n = 1).In cattle, a sensitivity of 81% and a specificity of 90% were obtained. The diagnostic sensitivity of the kit was 94% when the kit was tested using known TB positive sloth bear sera samples. 47.4% of the in-contact sloth bears turned seropositive using the rapid POC TB diagnostic kit. Seropositivity in other wild animals was 25% when the sera samples were tested using the kit. A point of care TB sero-diagnostic kit with the combination of proteins was developed and the kit was validated using the sera samples of wild animals.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hsVaxX
via IFTTT

Secretoneurin and PE-11 immunoreactivity in the human dental pulp

Publication date: February 2018
Source:Archives of Oral Biology, Volume 86
Author(s): René Steiner, Reiner Fischer-Colbrie, Athanasia Bletsa, Johannes Laimer, Josef Troger
ObjectiveTo explore whether there are differences in the concentration of the secretogranin II-derived peptide secretoneurin and the chromogranin B-derived peptide PE-11 between the healthy and inflamed human dental pulps. Furthermore, colocalization studies with calcitonin gene-related peptide were performed to confirm the sensory origin of the peptidergic nerves in the dental pulp.DesignThe concentrations of secretoneurin and PE-11 were determined by highly sensitive radioimmunoassays in extracts of dental pulps, the molecular form of secretoneurin immunoreactivities by RP-HPLC with subsequent radioimmunoassay and colocalization studies with calcitonin gene-related peptide were performed by double immunofluorescence.ResultsOnly secretoneurin but not PE-11 was detectable by radioimmunoassays whereas nerve fibers could be made visible for both secretoneurin and PE-11. Furthermore, there was a full colocalization of secretoneurin and PE-11 with calcitonin gene-related peptide in immunohistochemical experiments. There were no differences in the concentration of secretoneurin between the healthy and inflamed human dental pulp and moreover, the characterization of the secretoneurin immunoreactivities revealed that only authentic secretoneurin was detected with the secretoneurin antibody.ConclusionsThere is unequivocal evidence that secretoneurin and PE-11 are constituents of the sensory innervation of the human dental pulp and although not exclusively but are yet present in unmyelinated C-fibers which transmit predominantly nociceptive impulses. Secretoneurin might be involved in local effector functions as well, particularly in neurogenic inflammation, given that this is the case despite of unaltered levels in inflamed tissue.



from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2i5J4YJ
via IFTTT

The effects of Icariin on wound healing of extraction sites with administration of Zoledronic and Dexamethasone: A rat model study

Abstract

Objective

This study was intended to investigate the effects of Icariin on the healing of tooth extraction sites under systemic administration of Zoledronic and Dexamethasone.

Method

Thirty female rats underwent bilateral ovariectomy and were randomly assigned to 5 groups: SS group received weekly injection of saline while ZD, ZD+LICA, ZD+MICA and ZD+HICA groups received Zoledronic with Dexamethasone for 8 weeks. One week later, mandibular first molars were extracted in all groups. Then 30, 60, 120mg/kg Icariin were intragastricly given to ZD+LICA, ZD+MICA and ZD+HICA groups daily for 10 weeks while saline was given to SS group and ZD group. Blood samples and mandibles were harvested for examinations after 10 weeks.

Results

Significantly smaller wound area was noted in SS and ZD+HICA groups but the incidence of bisphosphonates-related osteonecrosis of the jaws (BRONJ) was not significantly different. Groups injected with Zoledronic and Dexamethasone had higher C-terminal crosslinked telopeptide of type 1 collagen (CTX-1), tartrate-resistant acid phosphatase 5b (TRACP 5b) and the number of osteoclast cells, with less vascular endothelial growth factor (VEGF) and osteocalcin (OCN). In contrast, CTX-1, TRACP 5b and the number of osteoclast cells declined after using Icariin and promoted VEGF and OCN were noted; and the effects were in a dosage-dependent manner.

Conclusion

Concurrent use of Zoledronic and Dexamethasone inhibits expression of VEGF, OCN and wound healing; and increases the number of osteoclast cells, serum CTX-1 and TRACP-5b after discontinuation for ten weeks. Icariin weakens those effects at a dose-dependent manner but does not influence onset of BRONJ.

This article is protected by copyright. All rights reserved.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zxvKqa
via IFTTT

Effect of non-thermal atmospheric plasma on the dentin-surface topography and composition and on the bond strength of a universal adhesive

This study investigated the effect of application of non-thermal atmospheric plasma (NTAP) on the topography and composition of the dentin surface, as well as the microtensile bond strength (μTBS) of a universal adhesive to NTAP-treated dentin. Exposed flat dentin surfaces from human third molars were either treated with NTAP for 10 and 30 s or untreated (control). The dentin-surface topography and chemical composition were characterized by atomic force microscopy (n = 3) and Raman confocal spectroscopy (n = 5), respectively. The μTBS (n = 8) of Scotchbond Universal to dentin was determined after storage for 24 h and 1 yr, either by direct water exposure or under simulated pulpal pressure. In-situ zymography was used to evaluate the influence of NTAP on the dentin-enzymatic activity. Non-thermal atmospheric plasma produced no remarkable topographical or chemical alterations at the dentin surface; only the amount of phosphate decreased following 10 s of treatment with NTAP. After 1 yr of direct water exposure, the μTBS of NTAP-treated specimens did not differ statistically significantly from that of untreated controls, whereas simulated pulpal pressure-aging resulted in a significantly higher μTBS for NTAP-treated dentin. The dentin-enzymatic activity appeared to be treatment-dependent, but the untreated controls showed more intense fluorescence within the hybrid layer. Scotchbond Universal maintained its μTBS strength after 1 yr of direct water exposure and simulated pulpal pressure, although remarkable statistical differences between treatments were observed depending on the aging condition.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2yuiezX
via IFTTT

Sensory recovery of myomucosal flap oral cavity reconstructions

Abstract

Background

Sensory restoration of the oral cavity is a primary aim of reconstructive surgery in posttraumatic or postablative defects. Sensitivity plays a key role in oral function, whose impairment strongly affects the patient's quality of life. Cheek myomucosal flaps provide a reliable and tissue-like reconstruction of these regions but their sensitive recovery, which we still know little about, deserves thorough assessment.

Methods

In this retrospective study, the myomucosal cheek flaps were tested for different aspects of sensory recovery: touch; 2-point discrimination; pain; sharp/smooth discrimination; ability to feel hot/cold stimulus; stereognosis; and taste.

Results

Fifty-two myomucosal flap reconstructions were investigated. All sensitivity tests showed positive results. When comparison was possible, sensitivity seemed significantly close to the contralateral healthy side. Sensory recovery proved to be even better than that reported on reinnervated microvascular free flap reconstructions of the oral cavity.

Conclusion

Myomucosal flap reconstruction demonstrated a high degree of sensory recovery.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hs0XE7
via IFTTT

Patterns of vascularization and surgical morbidity in juvenile nasopharyngeal angiofibroma: A case series, systematic review, and meta-analysis

Abstract

Background

Vascular patterns of juvenile nasopharyngeal angiofibroma (JNA) are poorly defined. We performed both institutional and systematic literature reviews to characterize the relationship between arterial supply patterns of JNA with intraoperative blood loss and tumor recurrence.

Methods

A retrospective review of 26 patients with JNA treated at our institution from 1995 to 2015 with available angiograms, and systematic reviews and meta-analyses of 828 JNA cases undergoing angiographic embolization published between 1995 and 2015 were completed per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Results

The systematic review (828 cases) found internal carotid artery (ICA) supply in 35.6% of tumors, and 30.8% of tumors received bilateral vascular supply. Our institutional data (n = 26) indicated 69% had bilateral supply. Meta-analysis of data from 5 studies demonstrated ICA/bilateral arterial supply is predictive of increased operative blood loss (P < .01).

Conclusion

Complex vascular contributions to JNA are frequent, underreported, and portends increased blood loss. This information can justifiably be included in staging systems to enhance prognostic counseling of patients.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2jhYLzG
via IFTTT

Dose-finding and efficacy confirmation trial of the superselective intra-arterial infusion of cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (Japan Clinical Oncology Group 1212): Dose-finding phase

Abstract

Background

We are currently undertaking a multi-institutional prospective trial of the superselective intra-arterial infusion of high-dose cisplatin with concomitant radiotherapy for patients with T4aN0M0 or T4bN0M0 locally advanced maxillary sinus squamous cell carcinomas (SCC). We herein report the results of the dose-finding phase.

Methods

The dose-finding phase sought to evaluate the incidence of dose-limiting toxicities and determine the recommended number of cycles of the intra-arterial infusion of cisplatin. In this phase, 100 mg/m² of cisplatin was administered intra-arterially weekly for 7 weeks with concomitant radiotherapy (70 Gy).

Results

All 18 patients received a full dose of radiotherapy. The number of cycles of cisplatin was 7 in 13 patients and 6 in 5 patients. The dose-limiting toxicities were observed in 5 patients.

Conclusion

These results indicated that this therapy is safe and well-tolerated at 7 cycles of cisplatin, which was determined to be the recommended number of cycles for locally advanced maxillary sinus SCC.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hs0XnB
via IFTTT

Flexible next-generation robotic surgical system for transoral endoscopic hypopharyngectomy: A comparative preclinical study

Abstract

Background

The purpose of this cadaveric study was to determine the efficacy of a flexible, next-generation robotic surgical system for transoral robotic hypopharyngectomy.

Methods

A comparative evaluation study of the flexible versus rigid robotic surgical systems for the hypopharynx was conducted using 3 cadavers. Endpoints for assessment were visualization of the hypopharynx, access to the hypopharynx, and difficulty of dissection. Hypopharyngectomy was performed on 3 other cadavers using the da Vinci Sp surgical system.

Results

Access to the apex of the pyriform sinus and the esophageal inlet was easier with the da Vinci Sp than with the da Vinci Si. Dissection with the da Vinci Sp was easier in all areas of the hypopharynx than with the da Vinci Si. Robotic hypopharyngectomy was successfully completed on all cadavers using the da Vinci Sp surgical system.

Conclusion

Preclinical testing in human cadavers suggests that flexible robotic surgery may facilitate successful transoral hypopharyngectomy.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2jj0K6H
via IFTTT

Effect of general anesthesia and intubation on parathyroid levels in normal patients and those with hyperparathyroidism

Abstract

Background

Induction of general anesthesia and endotracheal intubation may precipitate parathyroid hormone (PTH) elevation in patients with primary hyperparathyroidism (HPT). The purposes of this study were to revisit this observation and to study its impact in healthy patients.

Methods

Patients with primary HPT who underwent parathyroidectomy were retrospectively studied. The PTH was sampled and compared: before, immediately after general anesthesia and endotracheal intubation, and 15 minutes after parathyroidectomy. Healthy adults who underwent elective operations were prospectively studied. The PTH was sampled before general anesthesia and endotracheal intubation, immediately after, and 15 minutes later.

Results

Thirty-one patients, aged 28-89 years (mean 60.1 ± 13 years), were retrospectively studied. The PTH was significantly elevated after general anesthesia and endotracheal intubation (P = .014). Fifty patients, aged 21-86 years (mean 54 ± 15 years), were prospectively studied. The PTH elevation after general anesthesia and endotracheal intubation was not significant.

Conclusion

General anesthesia and endotracheal intubation causes an immediate, steep, and significant PTH elevation in patients with primary HPT but only a minor change in healthy adults. The difference may be attributed to an impaired adrenergic response in patients with primary HPT.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2yRecWi
via IFTTT

Efficiency of electrochemotherapy with reduced bleomycin dose in the treatment of nonmelanoma head and neck skin cancer: Preliminary results

Abstract

Background

In the present study, effectiveness of electrochemotherapy was compared in patients with nonmelanoma skin cancer (NMSC) of the head and neck using standard and reduced doses of bleomycin.

Methods

Twenty-eight patients older than 65 years were prospectively treated with electrochemotherapy for nonmelanoma head and neck skin cancer. In the experimental group (n = 12 patients; 24 lesions), reduced bleomycin doses (10 000 IU/m²) were used. In the control group (n = 16 patients; 28 lesions), the standard bleomycin doses (15 000 IU/m²) were used. Tumor responses and side effects were monitored. These two groups were pair matched for the characteristics of patients (age, gender) and their tumors (diameter, histology type, recurrent lesions).

Results

Complete tumor response at 2 months post-electrochemotherapy with the reduced bleomycin dose was 100% and with the standard bleomycin dose it was 96%. No statistically significant difference regarding skin toxicity was observed between the 2 groups (P = .20). Skin toxicity of grade 3 or less was recorded only in the control group (7% of treated lesions).

Conclusion

Presented results show the comparable antitumor effectiveness of electrochemotherapy when using standard or reduced bleomycin dose in elderly patients with nonmelanoma head and neck skin cancer.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2mcP5Y6
via IFTTT

Long-term outcomes after reirradiation in nasopharyngeal carcinoma with intensity-modulated radiotherapy: A meta-analysis

Abstract

Background

The purpose of this clinical review was to summate the published data for the long-term outcomes of reirradiation with intensity-modulated radiotherapy (IMRT) for locally recurrent nasopharyngeal carcinoma (NPC).

Methods

We searched biomedical literature databases for eligible studies published from January 2005 to September 2016. Outcomes of interests were 5-year local failure-free survival, distant failure-free survival, overall survival (OS), and toxicities. Meta-analysis was performed using a random effects model.

Results

We found 4 comparative and 8 noncomparative studies (n = 1768). Reirradiation was associated with pooled event rates of 72% (95% confidence interval [CI] 66%-78%; I² = 84%), 85% (95% CI 82%-88%; I² = 69%), and 41% (95% CI 36%-47%; I² = 80%) for 5-year local failure-free survival, distant failure-free survival, and OS, respectively, with significant heterogeneity among the study results. The pooled event rate for grade 5 toxicities was 33% (95% CI 30%-35%; I² = 0%) with minimal heterogeneity.

Conclusion

Reirradiation with IMRT for locally recurrent NPC could confer long-term disease control and survival but is associated with significant mortality.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2yReb4G
via IFTTT

Ethmoidal adenocarcinoma treated by exclusive endoscopic approach: Focus on learning curve and modification of management

Abstract

Background

The purpose of this study was to investigate the outcome and recurrences for ethmoidal adenocarcinomas treated by exclusive endoscopic surgery in curative intent and investigate the role of the learning curve.

Methods

We conducted a single-center retrospective study, including 60 patients separated in 2 groups (2002-2011 n = 28 and 2012-2015 n = 32).

Results

The global survival rate at 5 years was 72.6%, and the global and local recurrence rates were 21.6% and 13.3%, respectively. The learning curve had significant impact on global survival at 2 years (93.8% vs 77.8%) and on overall and local recurrences, despite the higher rate of T4 classifications in the latter group. This learning curve could be explained by the evolution toward large endoscopic resection, bilateral, with resection of the cribriform plate, and eventually medial maxillectomy, and started on the healthy side.

Conclusion

For selected cases, exclusive endoscopic resection of ethmoid adenocarcinoma achieves results at least as good as craniofacial resection when performed by an experienced cranial base team and including a large endoscopic resection.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2mf8BDl
via IFTTT

Cisplatin-conjugated gold nanoparticles as a theranostic agent for head and neck cancer

Abstract

Background

The purpose of this study was to develop a nanoplatform, which simultaneously acts as radiosensitizer, drug carrier, and tumor imaging agent for head and neck cancer.

Methods

We synthesized 20 nm gold nanoparticles, coated with glucose and cisplatin (CG-GNPs). Their penetration into tumor cells and their cellular toxicity were evaluated in vitro. In vivo experiments were conducted to evaluate their impact on tumor growth and their imaging capabilities.

Results

The CG-GNPs showed efficient penetration into tumor cells and similar cellular toxicity as cisplatin alone. Combined with radiation, CG-GNPs led to greater tumor reduction than that of radiation alone and radiation with free cisplatin. The CG-GNPs also demonstrated efficient tumor imaging capabilities.

Conclusion

Our CG-GNPs have a great potential to increase antitumor effect, overcome resistance to chemotherapeutics and radiation, and allow imaging-guided therapy.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2ySocys
via IFTTT

Prognostic implication of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in patients with recurrent papillary thyroid cancer

Abstract

Background

Fluorine-18 fluorodeoxyglucose positron emission tomography/CT (¹⁸F-FDG PET/CT) has been widely accepted as an effective method for detecting recurrent papillary thyroid cancer (PTC) in patients with increased serum thyroglobulin (Tg) or Tg antibody (TgAb) levels and negative whole-body scintigraphy (WBS) results. The role of WBS as a diagnostic tool in detecting recurrence has relatively decreased recently. However, only a few studies have examined the usefulness of ¹⁸F-FDG PET/CT for evaluating patients with recurrent PTC, regardless of the WBS results. The purpose of this analysis was to evaluate the diagnostic value and prognostic role of ¹⁸F-FDG PET/CT for patients with recurrent PTC, irrespective of their WBS results.

Methods

Sixty-six patients with locoregional recurrent PTC who underwent ¹⁸F-FDG PET/CT and neck CT within 6 months before surgical treatment were included in this retrospective analysis. Imaging findings were compared with postoperative histopathologic results. The diagnostic values of ¹⁸F-FDG PET/CT and neck CT were compared according to the serum Tg and TgAb levels and cervical levels. Each patient's status at the last follow-up was also reviewed, and survival probabilities were estimated using the Kaplan-Meier plot.

Results

The sensitivity, specificity, and diagnostic accuracy of ¹⁸F-FDG PET/CT for the entire patient group were 38.5%, 90.2%, and 58.3%, respectively. The corresponding neck CT values were 55.0%, 85.7%, and 66.7%, respectively. According to the serum Tg and TgAb levels, except for the specificity, most diagnostic values of ¹⁸F-FDG PET/CT were worse than those of the neck CTs, with or without statistical significance. For the high maximum standardized uptake value (SUVmax) group (SUVmax >10) and the low SUVmax group, the median locoregional disease-free survival times were 33.3 months and 81.8 months, respectively (P < .001).

Conclusion

The diagnostic value of ¹⁸F-FDG PET/CT for localizing recurrent lesions was worse than that of the neck CT, irrespective of the WBS results. However, patients with a higher SUVmax showed a significantly worse prognosis than did those with a lower SUVmax. Therefore, we suggest that, in patients with recurrent PTC, ¹⁸F-FDG PET/CT should be considered for prognostication rather than diagnosis.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2mf8yaD
via IFTTT

David Alan Stern: my journey to now

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2mh2heA
via IFTTT

Successful treatment of high-grade pancreatic neuroendocrine neoplasms with everolimus

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2yRcS5M
via IFTTT

Unilateral hippocampal wasting after combined-modality therapy for glioblastoma

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2mh25Mo
via IFTTT

Cone-beam computed tomography (CBCT) for adaptive image guided head and neck radiation therapy

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2yRICYC
via IFTTT

In-office bleaching efficacy on stain removal from CAD/CAM and direct resin composite materials

Abstract

Objective

To evaluate the efficacy of in-office bleaching on stain removal from stained resin composite and ceramic computer-assisted design/computer-assisted manufacturing (CAD/CAM) blocks and direct resin composites.

Methods

Forty disk-shaped samples were fabricated from each of nine materials: six CAD/CAM (VITABLOCS Mark II, Paradigm MZ100, Exp Vita Hybrid Ceramic, VITA ENAMIC, Exp Kerr, and LAVA Ultimate) and three direct resin composites (Filtek Supreme, Venus Diamond, and Filtek Silorane). Samples were randomly divided into five groups (n = 8), each stained with a particular staining solution. Using a calibrated spectrophotometer and a black background, L*a*b* values were assessed before and after 120 days of staining. Samples were subjected to in-office bleaching using 40% hydrogen peroxide gel for one hour. At subsequent assessment, color change (ΔE) was calculated as the difference between L*a*b* values. Both ANOVA and the Duncan test were used to identify differences between groups (α = 0.05).

Results

Bleaching resulted in significant differences in ΔE values for all materials (P < .001). Bleaching efficacy was highly influenced by material composition and staining solution. Residual color values after bleaching for ceramic and hybrid ceramics ranged from −0.49 to 2.35, within the clinically acceptable maximum of 3.3. Values after bleaching for resin-based CAD/CAM ranged from −0.7 to 7.08 while direct resin composites values ranged from −1.47 to 25.13. Coffee left the greatest residual color on all materials.

Conclusions

Based on material nature, 40% hydrogen peroxide bleaching can remove staining. The new resin-based CAD/CAM blocks showed promising results in terms of color stability.

Clinical Significance

Bleaching using 40% hydrogen peroxide can be an effective method to remove stains from dental restorations. In this way, restoration replacement as a result of discoloration may no longer be necessary.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2ACPK8n
via IFTTT

Oral manifestations of systemic disease.

Oral manifestations of systemic disease.

Br Dent J. 2017 Nov 10;223(9):683-691

Authors: Porter SR, Mercadante V, Fedele S

Abstract
While the majority of disorders of the mouth are centred upon the direct action of plaque, the oral tissues can be subject to change or damage as a consequence of disease that predominantly affects other body systems. Such oral manifestations of systemic disease can be highly variable in both frequency and presentation. As lifespan increases and medical care becomes ever more complex and effective it is likely that the numbers of individuals with oral manifestations of systemic disease will continue to rise. The present article provides a succinct review of oral manifestations of systemic disease. In view of this article being part of a wider BDJ themed issue on the subject of oral medicine, this review focuses upon oral mucosal and salivary gland disorders that may arise as a consequence of systemic disease.

PMID: 29123296 [PubMed - in process]

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2mh8ozo
via IFTTT

End of Volume Editorial Board

Volume 10, Issue 3-4, July-December 2017, Page ebi-ebi
.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2jik4Rw
via IFTTT

Social support and one-year outcomes for women participating in prison-based substance abuse treatment programming

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2hrMl7Q
via IFTTT

Local Dentist Office Offers Free Dental Care For Veterans Ahead Of Holiday

Van Buren Family Dentistry located on Fayetteville Road is offering veterans free dental work from 8 a.m. to 3 p.m. in honor of Veterans Day. This opportunity for veterans has been a tradition for a few years at the office.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2Atpqgb
via IFTTT

Preventive effect of kampo medicine (hangeshashin-to, TJ-14) plus minocycline against afatinib-induced diarrhea and skin rash in patients with non-small cell lung cancer.

Preventive effect of kampo medicine (hangeshashin-to, TJ-14) plus minocycline against afatinib-induced diarrhea and skin rash in patients with non-small cell lung cancer.

Onco Targets Ther. 2017;10:5107-5113

Authors: Ichiki M, Wataya H, Yamada K, Tsuruta N, Takeoka H, Okayama Y, Sasaki J, Hoshino T

Abstract
Purpose: Diarrhea and oral mucositis induced by afatinib can cause devastating quality of life issues for patients undergoing afatinib treatment. Several studies have shown that hangeshashin-to (TJ-14) might be useful for chemotherapy-induced diarrhea and oral mucositis. In this study, we investigated the prophylactic effects of TJ-14 for afatinib-induced diarrhea and oral mucositis and minocycline for afatinib-induced skin rash.
Patients and methods: First- and second-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors have become the standard first-line treatment in patients with EGFR-mutated non-small cell lung cancer. The incidence of diarrhea was higher with afatinib than with gefitinib, and we conducted a single-arm Phase II study with afatinib. Patients who had previously undergone treatment with afatinib were ineligible. Both TJ-14 (7.5 g/day) and minocycline (100 mg/day) were administered simultaneously from the start of afatinib administration. The primary end point was the incidence of ≥ grade 3 (G3) diarrhea (increase of ≥7 stools/day over baseline) during the first 4 weeks of treatment. The secondary end points were the incidence of ≥ G3 oral mucositis (severe pain interfering with oral intake) and $ G3 skin toxicity (severe or medically significant but not immediately life-threatening).
Results: A total of 29 patients (nine men and 20 women; median age, 66 years; performance status, 0/1/2: 18/10/1) were enrolled from four centers. Four patients had undergone prior treatment with chemotherapy, including gefitinib or erlotinib. In all, 20 (68.9%) patients and one (3.4%) patient had diarrhea of any grade and ≥ G3, respectively. One (3.4%) patient had ≥ G3 oral mucositis; no patients had ≥ G3 skin rash. A total of 18 (62%) of the 29 patients achieved a partial response.
Conclusion: The present study indicated a trend in which TJ-14 reduced the risk of afatinib-induced diarrhea and minocycline reduced the risk of afatinib-induced skin rash.

PMID: 29123409 [PubMed]

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hnVxGl
via IFTTT

Pathomechanisms of Contact Sensitization

Abstract

Contact sensitization is the initial process involved in the development of an allergic reaction to xenobiotic environmental substances. Here, we briefly describe the differences between irritant and allergic contact dermatitis. Then, we highlight the essential steps involved in the development of an ACD reaction, i.e., the protein binding of haptens, genetic factors influencing the penetration of sensitizers into the skin, the different mechanisms driving the initial development of an inflammatory cytokine micromilieu enabling the full maturation of dendritic cells, the role of pre- and pro-haptens, antigen presentation and T cell activation via MHC and CD1 molecules, dendritic cell (DC) migration, and potential LC contribution as well as the different T cell subsets involved in ACD. In addition, we discuss the latest publications regarding factors that might influence the sensitizing potential such as repeated sensitizer application, penetration enhancers, humidity of the skin, microbiota, Tregs, and phthalates. Last but not least, we briefly touch upon novel targets for drug development that might serve as treatment options for ACD.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2Az506a
via IFTTT

Human rights of refugee-survivors of sexual and gender-based violence with communication disability

.


from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2jhLAPe
via IFTTT

Speech therapy in adolescents with Down syndrome: In pursuit of communication as a fundamental human right

.


from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hsQGaT
via IFTTT

Bilingualism, a human right in times of anxiety: Lessons from California

.


from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2jiY35a
via IFTTT

Protecting the human right to freedom of expression in international law

.


from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hsQyrV
via IFTTT

Fostering human rights through TalkBank

.


from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2jiXYhS
via IFTTT

Clinical and pathologic analyses of tuberculosis in the oral cavity: report of 11 cases.

Clinical and pathologic analyses of tuberculosis in the oral cavity: report of 11 cases.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Sep 28;:

Authors: Ju WT, Fu Y, Liu Y, Tan YR, Dong MJ, Wang LZ, Li J, Zhong LP

Abstract
OBJECTIVE: The aim of this study was to analyze tuberculosis (TB) in the oral cavity according to clinical appearance, clinical differential diagnosis, treatment, and outcome.
STUDY DESIGN: We enrolled 11 patients with TB in the oral cavity between November 2012 and November 2016. Glossal lymphoid TB was excluded. Clinical symptoms, auxiliary examinations, treatments, and outcomes were recorded and analyzed.
RESULTS: The study population comprised 6 men and 5 women, with a mean age of 59 years. Five patients presented with ulcer, 5 with a mass, and 1 with osteomyelitis. Excisional biopsy was performed in 3 patients, mass resection in 7, and curettage of mandibular lesion in 1. After pathologic diagnosis of TB in the oral cavity in 8 patients; 6 of them underwent purified protein derivative examination, and 4 of them had positive results and received drug therapy. The mean follow-up period was 24.9 months, and there was no recurrence.
CONCLUSIONS: TB in the oral cavity is rare and has no specific clinical features. Pathology, acid-fast staining, polymerase chain reaction, and DNA testing for Mycobacterium tuberculosis are useful for final diagnosis. Surgery is recommended as the treatment of choice to achieve good clinical outcomes.

PMID: 29122502 [PubMed - as supplied by publisher]

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2ysanTi
via IFTTT

Prenatal famine exposure and mental health in later midlife

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2AwRi2O
via IFTTT

Young Schema Questionnaire – Short Form Version 3 (YSQ-S3): Preliminary validation in older adults

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2i3CWQU
via IFTTT

‘It is nothing more than a senior moment’: the moderating role of subjective age in the effect of change in memory on self-rated memory

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2AwR4bY
via IFTTT

Communication training interventions for family and professional carers of people living with dementia: a systematic review of effectiveness, acceptability and conceptual basis

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2i42ygj
via IFTTT

Perceptions of neighborhood safety and depressive symptoms among older minority urban subsidized housing residents: the mediating effect of sense of community belonging

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2AwrG67
via IFTTT

Early recurrence in patients undergoing curative resection of colorectal liver oligometastases: identification of its clinical characteristics, risk factors, and prognosis

Abstract

Purpose

Oligometastatic disease can potentially be cured when an optimal approach is performed. Early recurrence after liver resection is an intractable problem, and the clinical implications remain unknown in colorectal liver oligometastases (CLOM) patients. This study aimed to investigate the clinical characteristics, risk factors, and prognosis related to early recurrence in these patients.

Methods

A total of 307 consecutive patients with CLOM undergoing curative liver resection were retrospectively reviewed between September 1999 and June 2016. Early recurrence was defined as any recurrence or death from CLOM that occurred within 6 months of liver resection.

Results

With a median follow-up time of 31.7 months, the 3-year overall survival (OS) and recurrence-free survival rates were 68.7 and 42.5%, respectively. Forty-nine (16.0%) patients developed early recurrence and showed a poorer 3-year OS than those with non-early recurrence (22.3 vs. 75.8%, P < 0.001) or later recurrence (22.3 vs. 52.8 vs. 63.2%, P < 0.001). Moreover, early recurrence was identified as an independent predictor of 3-year OS [hazard ratio (HR) 6.282; 95% confidence interval (CI) 3.980–9.915, P < 0.001]. In multivariate analysis, a node-positive primary tumor [odds ratio (OR) 2.316; 95% CI 1.097–4.892, P = 0.028) and metastatic diameter > 3 cm (OR 2.560; 95% CI 1.290–5.078; P = 0.007) were shown to be risk factors for early recurrence. The salvage liver resection rate for patients with early recurrence was significantly lower than that for patients with later recurrence (4.1 vs. 19.7%, P = 0.010).

Conclusions

Early recurrence should be investigated in routine clinical practice, even in patients with CLOM after curative liver resection. Detailed preoperative comprehensive measurements might help stratify high-risk patients, and a non-surgical treatment for early recurrence might represent an effective alternative.

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2i5HtCc
via IFTTT

Optical assessment of the in vivo tympanic membrane status using a handheld optical coherence tomography-based otoscope

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2iPxTTs
via IFTTT

Physical and chemical properties of model composites containing quaternary ammonium methacrylates

Publication date: Available online 10 November 2017
Source:Dental Materials
Author(s): Marina Lermenn Vidal, Guilherme Ferreira Rego, Gil Mendes Viana, Lucio Mendes Cabral, Juliana Primo Basílio Souza, Nick Silikas, Luis Felipe Schneider, Larissa Maria Cavalcante
ObjectiveInvestigate physical and chemical properties of model composites formulated with quaternary ammonium salt monomers (QAS) at different concentrations and alkyl chains lengthsMethodsQAS with 12 dimethylaminododecyl methacrylate (DMADDM) and 16 dimethylaminohexadecyl methacrylate (DMAHDM) chains lengths were synthesized and incorporated at 5 and 10% in model composites, resulting in four groups: G12.5 (DMADDM 5%), G12.10 (DMADDM 10%), G16.5 (DMAHDM 5%), G16.10 (DMAHDM 10%). One group was used as control group (CG 0%). Degree of conversion (DC); water sorption (WS) and solubility (SL); hygroscopic expansion (HE); degradation temperature (DT); glass transition temperature (Tg) and polymerization shrinkage (PS) were determined. Knoop hardness (KNH), flexural strength (FS) and elastic modulus (EM) were measured before and after storage Data were submitted to ANOVA and Tukey's test (p≤0.05).ResultsDC ranged between 76.1 (G12.10) and 70.7 (G16.5) %; CG had the lowest WS, SL and HE. There was no statistical difference for PS and FS. KHN values ranged between 30.2 (GC) and 25 (G16.10) and after storage the performance was depended on QAS concentration and chain length. For EM, CG had the highest values before and after storage and no difference was observed in the QAS groups before storage. After storage, the results were dependent on QAS concentration (3.5-4.3GPa).SignificanceIn general, the addition of QAS increased composite's degradation compared with the CG. In the tested QAS, the addition of DMADDM at 5% concentration resulted in a less degradable material.



from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2zuoOtV
via IFTTT

Perampanel-associated self-harm ideation after dosage increase

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2iNJ8fr
via IFTTT

Prenatal famine exposure and mental health in later midlife

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2jgD8j1
via IFTTT

Young Schema Questionnaire – Short Form Version 3 (YSQ-S3): Preliminary validation in older adults

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2ht6Gtg
via IFTTT

‘It is nothing more than a senior moment’: the moderating role of subjective age in the effect of change in memory on self-rated memory

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2jhkcRn
via IFTTT

Communication training interventions for family and professional carers of people living with dementia: a systematic review of effectiveness, acceptability and conceptual basis

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2hrqtJO
via IFTTT

Perceptions of neighborhood safety and depressive symptoms among older minority urban subsidized housing residents: the mediating effect of sense of community belonging

.


from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2jlboKp
via IFTTT