Otology & Neurotology - July 2017 - Volume 38 - Issue 6

Dear Otology & Neurotology reader, For more than 35 years, Otology & Neurotology has been publishing original articles relating to both clinical and basic science aspects of otology, neurotology, and cranial base surgery. We are reaching out to you to gain a better understanding of how you read the journal. This is your opportunity to tell us what you like and how we can keep the journal evolving. You can access the survey via the following link: http://ift.tt/2rUpa6Z Please remember to include your name and e-mail address at the end of the survey to be entered into a raffle to win one of ten $100 American Express gift cards. Your contact information will only be used to inform you if you are a winner.   Thank you for your time and insight! Dr. Lawrence Lustig, Editor-in-Chief American Otological Society American Neurotology Society Wolters Kluwer/Lippincott Williams & Wilkins   Otology & Neurotology July 2017 - Volume 38 - Issue 6 pp: 785-922,e68-e189 View Contributor Index Obituary Fred D. Owens, M.D.: Obituary Brackmann, Derald E. Editorial Cochlear Implantation: Vast Unmet Need to Address Deafness Globally Sahin, Mehmet Ilhan; Sagers, Jessica E.; Stankovic, Konstantina M. Review Articles Surgical Management of a Persistent Stapedial Artery: A Review Goderie, Thadé Pieter Marie; Alkhateeb, Waiel Hussain Fadhlallah; Smit, Conrad Frits; Hensen, Erik Frans Emerging Therapies for Sensorineural Hearing Loss Crowson, Matthew Gordon; Hertzano, Ronna; Tucci, Debara L. Audiology Pilot Electroacoustic Analyses of a Sample of Direct-to-Consumer Amplification Products Reed, Nicholas S.; Betz, Joshua; Lin, Frank R.; Mamo, Sara K. Influence of Floating-Mass Transducer Coupling Efficiency for Active Middle-Ear Implants on Speech Recognition Müller, Alexander; Mir-Salim, Parwis; Zellhuber, Nina; Helbig, Ralf; Bloching, Marc; Schmidt, Tobias; Koscielny, Sven; Dziemba, Oliver C.; Plontke, Stefan K.; Rahne, Torsten Dichotic Listening Deficit Associated With Solvent Exposure Landry, Simon P.; Fuente, Adrian Otosclerosis Imaging Criteria to Predict Surgical Difficulties During Stapes Surgery Parra, Claire; Trunet, Stéphanie; Granger, Benjamin; Nguyen, Yann; Lamas, Georges; Bernardeschi, Daniele; Hervochon, Rémi; Tankere, Frédéric Cochlear Implants Cochlear Implant in Severe Impaired Psychiatric Patients: A Case Series Herisanu, Ioana T.; Praetorius, Mark; Mattern, Margarete Intra- and Interobserver Variability of Cochlear Length Measurements in Clinical CT Iyaniwura, John E.; Elfarnawany, Mai; Riyahi-Alam, Sadegh; Sharma, Manas; Kassam, Zahra; Bureau, Yves; Parnes, Lorne S.; Ladak, Hanif M.; Agrawal, Sumit K. Single-Center Study Investigating Foreign Language Acquisition at School in Children, Adolescents, and Young Adults With Uni- or Bilateral Cochlear Implants in the Swiss German Population Beeres-Scheenstra, Renske; Ohnsorg, Claudia; Candreia, Claudia; Heinzmann, Sybille; Castellanos, Susana; De Min, Nicola; Linder, Thomas E. Cost-Effectiveness of Pediatric Cochlear Implantation in Rural China Qiu, Jianxin; Yu, Chongxian; Ariyaratne, Thathya V.; Foteff, Chris; Ke, Zhangmin; Sun, Yi; Zhang, Li; Qin, Feifei; Sanderson, Georgina Comparison of Experts and Residents Performing a Complex Procedure in a Temporal Bone Surgery Simulator Ioannou, Ioanna; Zhou, Yun; Wijewickrema, Sudanthi; Piromchai, Patorn; Copson, Bridget; Kennedy, Gregor; O'Leary, Stephen Evaluation of Cochlear Duct Length Computations Using Synchrotron Radiation Phase-Contrast Imaging Koch, Robert W.; Elfarnawany, Mai; Zhu, Ning; Ladak, Hanif M.; Agrawal, Sumit K. Real-Time Intracochlear Electrocochleography Obtained Directly Through a Cochlear Implant Harris, Michael S.; Riggs, William Jason; Koka, Kanthaiah; Litvak, Leonid M.; Malhotra, Prashant; Moberly, Aaron C.; O'Connell, Brendan P.; Holder, Jourdan; Di Lella, Federico Alberto; Boccio, Carlos Mario; Wanna, George B.; Labadie, Robert F.; Adunka, Oliver F. Prediction of Intraoperative CSF Gusher and Postoperative Facial Nerve Stimulation in Patients With Cochleovestibular Malformations Undergoing Cochlear Implantation Surgery Kamogashira, Teru; Iwasaki, Shinichi; Kashio, Akinori; Kakigi, Akinobu; Karino, Shotaro; Matsumoto, Yu; Yamasoba, Tatsuya Cochlear Implantation in Patients With Usher Syndrome Type IIa Increases Performance and Quality of Life Hartel, Bas P.; van Nierop, Josephine W. I.; Huinck, Wendy J.; Rotteveel, Liselotte J. C.; Mylanus, Emmanuel A. M.; Snik, Ad F.; Kunst, Henricus P. M.; Pennings, Ronald J. E. Hearing Preservation in Pediatric Cochlear Implantation Carlson, Matthew L.; Patel, Neil S.; Tombers, Nicole M.; DeJong, Melissa D.; Breneman, Alyce I.; Neff, Brian A.; Driscoll, Colin L. W. Prosthetic Devices Cochlear Implantation in Adults With Asymmetric Hearing Loss: Benefits of Bimodal Stimulation van Loon, Maarten Caspar; Smits, Cas; Smit, Conrad F.; Hensen, Erik F.; Merkus, Paul Round Window Application of an Active Middle Ear Implant: A Comparison With Hearing Aid Usage in Japan Iwasaki, Satoshi; Usami, Shin-ichi; Takahashi, Haruo; Kanda, Yukihiko; Tono, Tetsuya; Doi, Katsumi; Kumakawa, Kozo; Gyo, Kiyofumi; Naito, Yasushi; Kanzaki, Sho; Yamanaka, Noboru; Kaga, Kimitaka Bone Anchored Hearing Implant Surgery: 1 Year Follow-Up Data Shows No Effect of Hydroxyapatite Coating on Soft Tissue Reaction After Loading at 1 Week Høgsbro, Morten; Agger, Andreas; Johansen, Lars Vendelbo Middle Ear and Mastoid Disease Preliminary Model for the Design of a Custom Middle Ear Prosthesis Kamrava, Brandon; Gerstenhaber, Jonathan A.; Amin, Mamta; Har-el, Yah-el; Roehm, Pamela C. Sonotubometric Assessment for Severity of Patulous Eustachian Tube Takata, Iori; Ikeda, Ryoukichi; Kawase, Tetsuaki; Suzuki, Yoko; Sato, Takeshi; Katori, Yukio; Kobayashi, Toshimitsu Decrease in Pneumococcal Otitis Media Cultures With Concomitant Increased Antibiotic Susceptibility in the Pneumococcal Conjugate Vaccines Era Jabarin, Basel; Pitaro, Jacob; Lazarovitch, Tzilia; Gavriel, Haim; Muallem-Kalmovich, Limor; Eviatar, Ephraim; Marom, Tal Use of Positive Airway Pressure Following Middle Ear Surgery: A Practice Survey of Otologists Ruhl, Douglas S.; Tolisano, Anthony M.; Kesser, Bradley W.; Hashisaki, George T.; Camacho, Macario Pediatric Otology Progression of Unilateral Hearing Loss in Children With and Without Ipsilateral Cochlear Nerve Canal Stenosis: A Hazard Analysis Purcell, Patricia L.; Shinn, Justin R.; Coggeshall, Scott S.; Phillips, Grace; Paladin, Angelisa; Sie, Kathleen C. Y.; Horn, David L. Vestibular Disorders Are Cervical Collars a Necessary Postprocedure Restriction in Patients With Benign Paroxysmal Positional Vertigo Treated With Particle Repositioning Maneuvers? Stewart, Kirsten E.; Whelan, Darren M.; Banerjee, Anirvan Age-Related Increase in Blood Levels of Otolin-1 in Humans Tabtabai, Ryan; Haynes, Laura; Kuchel, George A.; Parham, Kourosh Epidemiology of Dizzy Patient Population in a Neurotology Clinic and Predictors of Peripheral Etiology Muelleman, Thomas; Shew, Matthew; Subbarayan, Rahul; Shum, Axel; Sykes, Kevin; Staecker, Hinrich; Lin, James Current Management Practices in Ménière's Disease Clyde, Joseph W.; Oberman, Benjamin S.; Isildak, Huseyin Ipsilesional Nystagmus Induced by Vibration in Subjects With Ménière's Disease or Vestibular Schwannoma Vargas Gamarra, María Fernanda; Krstulovic, Claudio; Pérez Guillén, Vanesa; Pérez-Garrigues, Herminio Intratympanic Dexamethasone in the Treatment of Ménière's Disease: A Comparison of Two Techniques Beyea, Jason A.; Instrum, Ryan S.; Agrawal, Sumit K.; Parnes, Lorne S. Tumors of the Ear and Cranial Base Endoscopic Infracochlear Approach for Drainage of Petrous Apex Cholesterol Granulomas: A Case Series Wick, Cameron C.; Hansen, Alexander R.; Kutz, Joe Walter Jr.; Isaacson, Brandon Microsurgery for Recurrent Vestibular Schwannoma After Previous Gross Total Resection Perry, Avital; Graffeo, Christopher S.; Copeland, William R. III; Carlson, Matthew L.; Neff, Brian A.; Driscoll, Colin L.; Link, Michael J. Calculating the Tumor Volumes in Vestibular Schwannomas: Are the ABC/2 and Volumetric Methods Comparable? Bathla, Girish; Policeni, Bruno; Hansen, Marlan R.; Berbaum, Kevin Facial Nerve Transcanal Endoscopic Ear Surgery for Excision of a Facial Nerve Venous Malformation With Interposition Nerve Grafting: A Case Report Wick, Cameron C.; Sakai, Mark; Richardson, Timothy E.; Isaacson, Brandon Basic Science The Application of Next-Generation Sequencing for Mutation Detection in Autosomal-Dominant Hereditary Hearing Impairment Gürtler, Nicolas; Röthlisberger, Benno; Ludin, Katja; Schlegel, Christoph; Lalwani, Anil K. The Normal Adult Human Internal Auditory Canal: A Volumetric Multidetector Computed Tomography Study Essbaiheen, Fahad; Hegazi, Tarek; Rosenbloom, Lorne Defining the Hook Region Anatomy of the Guinea Pig Cochlea for Modeling of Inner Ear Surgery Lo, Jonathon; Sale, Phillip; Wijewickrema, Sudanthi; Campbell, Luke; Eastwood, Hayden; O'leary, Stephen John Medical Neurotology Paget's Disease of the Temporal Bone: A Single-Institution Contemporary Review of 27 Patients Deep, Nicholas L.; Besch-Stokes, Jake G.; Lane, John I.; Driscoll, Colin L. W.; Carlson, Matthew L. The Effect of Elevated Intracranial Pressure on Frequency Tuning of Air-Conducted Ocular Vestibular Myogenic Potentials in Ménière's Disease Patients Maxwell, Rebecca; Jerin, Claudia; Gürkov, Robert Letters to the Editor In Response to: Secondary Causes of Dizziness in Patients With MÉniÈre's Disease Mahboubi, Hossein; Moshtaghi, Omid; Ziai, Kasra; Djalilian, Hamid R. In Reply to the Letter to the Editor: "Two Common Second Causes of Dizziness in Patients With MÉniÈre's Disease van Esch, Babette F.; van der Zaag-Loonen, Hester J.; Bruintjes, Tjasse D.; van Benthem, Peter Paul G. Imaging Case of the Month Large Intracavernous Carotid Artery Aneurysm Suzuki, Manabu; Haginomori, Shin-Ichi; Terada, Tetsuya; Inui, Takaki; Ayani, Yusuke; Ozaki, Akiko; Kawata, Ryo; Yamamoto, Kazuhiro Disclaimer: This version of the table of contents may be incomplete. To view the official complete table of contents, please navigate your web browser to the journal's website at Otology & Neurotology. Unsubscribe | Copyright © 2017 | Lippincott Williams & Wilkins | All rights reserved Privacy Policy | Terms of Use | NIH Public Access Policy

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Digital innovations and emerging technologies for enhanced recovery programmes

Abstract

Enhanced recovery programmes (ERPs) are increasingly used to improve post-surgical recovery. However, compliance to various components of ERPs—a key determinant of success—remains sub-optimal. Emerging technologies have the potential to help patients and caregivers to improve compliance with ERPs.Preoperative physical condition, a major determinant of postoperative outcome, could be optimized with the use of text messages (SMS) or digital applications (Apps) designed to facilitate smoking cessation, modify physical activity, and better manage hypertension and diabetes. Several non-invasive haemodynamic monitoring techniques and decision support tools are now available to individualize perioperative fluid management, a key component of ERPs. Objective nociceptive assessment may help to rationalize the use of pain medications, including opioids. Wearable sensors designed to monitor cardio-respiratory function may help in the early detection of clinical deterioration during the postoperative recovery and to address 'failure to rescue'. Activity trackers may be useful to monitor early mobilization, another major element of ERPs. Finally, electronic checklists have been developed to ensure that none of the above-mentioned ERP elements is omitted during the surgical journey.By optimizing compliance to the multiple components of ERPs, digital innovations, non-invasive techniques and wearable sensors have the potential to magnify the clinical and economic benefits of ERPs. Among the growing number of technical innovations, studies are needed to clarify which tools and solutions have real clinical value and are cost-effective.

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Head and Neck Cancer Pain

Pain is a significant morbidity resulting from head and neck cancer. Pain may also be the result of the treatments directed against head and neck cancer. An experienced practitioner may manage this pain by understanding the multifactorial mechanisms of pain and the various pharmacotherapies available. Pain should be managed with multiple medications in a multimodal approach, and nonpharmacologic therapies should be considered as well. (Source: Otolaryngologic clinics of North America)

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Bio-electric field enhancement: the influence on hyaluronan mediated motility receptors in human breast carcinoma.

Authors: Purnell MC Abstract Mechanisms that regulate cancer cell metastasis are often intricately linked to mechanisms that control cell migration in wound repair. Hyaluronan Mediated Motility Receptor (HMMR) encodes a receptor for hyaluronan-mediated motility (RHAMM), a non-integral cell surface hyaluronan receptor and intracellular protein that promotes mitotic spindle formation and cell motility. RHAMM has been found to have increased expression in both cancers and wounds, and when cancers show increased RHAMM expression poor outcomes have occurred. Therefore, RHAMM has been shown to contribute to both natural healing mechanisms and cancer cell pathology. RHAMM is expressed in breast tissue and forms a polarity normalizing complex with BRCA1. Mutations of BRCA1 have been associ...

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S100A1 promotes cell proliferation and migration and is associated with lymph node metastasis in ovarian cancer.

In this study, we examined S100A1 expression in ovarian cancer tissues and normal tissue controls and analyzed the correlation between S100A1 expression and clinicopathological parameters. We found that S100A1 expression was significantly upregulated in ovarian cancer tissues compared with fallopian and normal ovarian epithelium tissues and was significantly associated with lymph node metastasis and International Federation of Gynecology and Obstetrics (FIGO) stages and tumor grades. We then investigated the biological functions of S100A1 in ovarian cancer by cell proliferation, fluorescence-activated cell sorting (FACS), and migration and invasion assays. The results indicated that S100A1 enhanced the ovarian cancer cell proliferation and migration. Together, our findings demonstrated tha...

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Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China.

Authors: Chang Y, Zhang M, Jiang Y, Liu Y, Luo H, Hao C, Zeng P, Zhang L Abstract Conventional cancer treatments include surgery, chemotherapy, and radiation therapy. In recent years, immunotherapy in cancer care has been gaining momentum. Interestingly, an immunotherapeutic regime that employs polysaccharopeptide (PSP), a unique peptide-containing polysaccharide isolated from Coriolus versicolor, has already become a routine clinical practice in Japan since 1977 and in China since 1987. Coriolus versicolor is one of the most well-known traditional food and medicinal mushrooms in China for thousands of years. Medically used PSP is mostly obtained from the extraction of cultured Coriolus versicolor mycelia where β-glucan is the major component. PSP has proven beneficial to survival...

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Plasma apolipoprotein A1 levels at diagnosis are independent prognostic factors in invasive ductal breast cancer.

In conclusion, our data indicate that low apoA1 levels are an independent predictor of the poor clinical outcomes in IDC patients. PMID: 28595037 [PubMed - in process] (Source: Discovery Medicine)

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Evaluation of a physiatrist-directed prehabilitation intervention in frail patients with colorectal cancer: a randomised pilot study protocol

This study has been approved by the Hamilton Integrated Research Ethics Board (HIREB reference number 2015–0090-GRA). The results of this pilot study will be used to design a full-scale study and published in peer-reviewed journals. Trial registration number NCT02531620; Pre-results. (Source: BMJ Open)

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Coding of Barretts oesophagus with high-grade dysplasia in national administrative databases: a population-based cohort study

Conclusions HES is not suitable to support national studies looking at the management of HGD. This is one reason for the UK to adopt an extended ICD system (akin to ICD-10-CM). (Source: BMJ Open)

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Transposition of Subclavian Artery - Is It the Appropriate Choice?

Related Articles

Transposition of Subclavian Artery - Is It the Appropriate Choice?

Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2017 Mar 01;38(1):47-51

Authors: Lazovski N, Jovev S, Babic D, Babic S, Dzemali O

Abstract
INTRODUCTION: To present patients with symptomatic subclavian artery disease and treatment possibility.
CASE REPORT: A 53-year-old female was admitted with vertigo and left arm claudication. Duplex-scan and MSCT arteriography verified subclavian artery occlusion. After the endovascular treatment failure, the patient was switched to surgical treatment - subclavian artery transposition. After the successful surgical treatment, the patient was discharged on the second postoperative day. If the patient is a candidate for surgery, the literature review shows good initial and long-term results after the subclavian artery transposition, and emphasizes this technique as superior.
CONCLUSION: Subclavian carotid transposition is a safe and effective method of treatment in patients after endovascular treatment failure or other indication. Also, the surgical treatment is technically demanding because of the difficult access to the vessel origin, and it requires experienced surgeons.

PMID: 28593884 [PubMed - in process]

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L-Glutamine in vitro Modulates some Immunomodulatory Properties of Bone Marrow Mesenchymal Stem Cells.

Related Articles

L-Glutamine in vitro Modulates some Immunomodulatory Properties of Bone Marrow Mesenchymal Stem Cells.

Stem Cell Rev. 2017 Jun 07;:

Authors: Dos Santos GG, Hastreiter AA, Sartori T, Borelli P, Fock RA

Abstract
Glutamine (GLUT) is a nonessential amino acid that can become conditionally essential under stress conditions, being able to act in the modulation of the immune responses. Mesenchymal stem cells (MSCs) are known to their capability in the modulation of immune responses through cell-cell contact and by the secretion of soluble factors. Considering that GLUT is an immunonutrient and little is known about the influence of GLUT on the capability of MSCs to modulate immune cells, this work aims to investigate how variations in GLUT concentrations in vitro could affect some immunomodulatory properties of MSCs. In order to evaluate the effects of GLUT on MSCs immunomodulatory properties, cell proliferation rates, the expression of NFκB and STAT-3, and the production of IL-1β, IL-6, IL-10, TGF-β and TNF-α by MSCs were assessed. Based on our findings, GLUT at high doses (10 mM) augmented the proliferation of MSCs and modulated immune responses by decreasing levels of pro-inflammatory cytokines, such as IL-1β and IL-6, and by increasing levels of anti-inflammatory cytokines IL-10 and TGF-β. In addition, MSCs cultured in higher GLUT concentrations (10 mM) expressed lower levels of NF-κB and higher levels of STAT-3. Furthermore, conditioned media from MSCs cultured at higher GLUT concentrations (10 mM) reduced lymphocyte and macrophage proliferation, increased IL-10 production by both cells types, and decreased IFN-γ production by lymphocytes. Overall, this study showed that 10 mM of GLUT is able to modify immunomodulatory properties of MSCs.

PMID: 28593472 [PubMed - as supplied by publisher]

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Homocysteine as a Diagnostic and Etiopathogenic Factor in Children with Autism Spectrum Disorder

Journal of Medicinal Food , Vol. 0, No. 0.


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L-Glutamine in vitro Modulates some Immunomodulatory Properties of Bone Marrow Mesenchymal Stem Cells.

Related Articles

L-Glutamine in vitro Modulates some Immunomodulatory Properties of Bone Marrow Mesenchymal Stem Cells.

Stem Cell Rev. 2017 Jun 07;:

Authors: Dos Santos GG, Hastreiter AA, Sartori T, Borelli P, Fock RA

Abstract
Glutamine (GLUT) is a nonessential amino acid that can become conditionally essential under stress conditions, being able to act in the modulation of the immune responses. Mesenchymal stem cells (MSCs) are known to their capability in the modulation of immune responses through cell-cell contact and by the secretion of soluble factors. Considering that GLUT is an immunonutrient and little is known about the influence of GLUT on the capability of MSCs to modulate immune cells, this work aims to investigate how variations in GLUT concentrations in vitro could affect some immunomodulatory properties of MSCs. In order to evaluate the effects of GLUT on MSCs immunomodulatory properties, cell proliferation rates, the expression of NFκB and STAT-3, and the production of IL-1β, IL-6, IL-10, TGF-β and TNF-α by MSCs were assessed. Based on our findings, GLUT at high doses (10 mM) augmented the proliferation of MSCs and modulated immune responses by decreasing levels of pro-inflammatory cytokines, such as IL-1β and IL-6, and by increasing levels of anti-inflammatory cytokines IL-10 and TGF-β. In addition, MSCs cultured in higher GLUT concentrations (10 mM) expressed lower levels of NF-κB and higher levels of STAT-3. Furthermore, conditioned media from MSCs cultured at higher GLUT concentrations (10 mM) reduced lymphocyte and macrophage proliferation, increased IL-10 production by both cells types, and decreased IFN-γ production by lymphocytes. Overall, this study showed that 10 mM of GLUT is able to modify immunomodulatory properties of MSCs.

PMID: 28593472 [PubMed - as supplied by publisher]

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Effect of Ursolic Acid on Metabolic Syndrome, Insulin Sensitivity, and Inflammation

Journal of Medicinal Food , Vol. 0, No. 0.


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Distress from changes in physical appearance and support through information provision in male cancer patients.

Distress from changes in physical appearance and support through information provision in male cancer patients.

Jpn J Clin Oncol. 2017 Jun 08;:1-8

Authors: Nozawa K, Tomita M, Takahashi E, Toma S, Arai Y, Takahashi M

Abstract
Objective: This study aims to reveal the present situation of changes in physical appearance induced by treatment, the effects of these changes on social activities, and support from medical staff in male cancer patients.
Methods: A questionnaire survey was administered to 949 male patients (response rate: 90.1%) visiting the National Cancer Center Hospital in Tokyo over 3 days in January 2015.
Results: The final respondents were 823 patients (mean age: 65.3, standard deviation (SD) = 12.32). Fifty-two percent of the sample, and 79.4% of patients aged under 65 were employed. A total of 84.9% experienced changes in physical appearance, and the highest mean scores of psychological were observed for stoma (3.1) and skin eczema (2.9). A total of 66.4% reported no difference in daily life even after their physical appearance changed. However, patients younger than 65 years old who were employed experienced high social difficulties (12.5%). Many wanted to stop going to work and experienced severe distress in their social lives; 74.1% reported it is important to have the same physical appearance at work as before treatment. The majority of patients obtained information from doctors (35.2%) and consulted with their wife or partner (66.2%) regarding their appearance changes, and 5.7% did not have anyone to consult with.
Conclusion: This study clarified important aspects for supporting male cancer patients: timing, content, target audience and steps of information provision. Appropriate information provision from medical staff prior to treatment can be useful in preparing patients for physical appearance changes and decreasing the severity of symptoms.

PMID: 28595360 [PubMed - as supplied by publisher]

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Antithrombotic Effect of Fermented Ophiopogon japonicus in Thrombosis-Induced Rat Models

Journal of Medicinal Food , Vol. 0, No. 0.


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L-Glutamine in vitro Modulates some Immunomodulatory Properties of Bone Marrow Mesenchymal Stem Cells.

Related Articles

L-Glutamine in vitro Modulates some Immunomodulatory Properties of Bone Marrow Mesenchymal Stem Cells.

Stem Cell Rev. 2017 Jun 07;:

Authors: Dos Santos GG, Hastreiter AA, Sartori T, Borelli P, Fock RA

Abstract
Glutamine (GLUT) is a nonessential amino acid that can become conditionally essential under stress conditions, being able to act in the modulation of the immune responses. Mesenchymal stem cells (MSCs) are known to their capability in the modulation of immune responses through cell-cell contact and by the secretion of soluble factors. Considering that GLUT is an immunonutrient and little is known about the influence of GLUT on the capability of MSCs to modulate immune cells, this work aims to investigate how variations in GLUT concentrations in vitro could affect some immunomodulatory properties of MSCs. In order to evaluate the effects of GLUT on MSCs immunomodulatory properties, cell proliferation rates, the expression of NFκB and STAT-3, and the production of IL-1β, IL-6, IL-10, TGF-β and TNF-α by MSCs were assessed. Based on our findings, GLUT at high doses (10 mM) augmented the proliferation of MSCs and modulated immune responses by decreasing levels of pro-inflammatory cytokines, such as IL-1β and IL-6, and by increasing levels of anti-inflammatory cytokines IL-10 and TGF-β. In addition, MSCs cultured in higher GLUT concentrations (10 mM) expressed lower levels of NF-κB and higher levels of STAT-3. Furthermore, conditioned media from MSCs cultured at higher GLUT concentrations (10 mM) reduced lymphocyte and macrophage proliferation, increased IL-10 production by both cells types, and decreased IFN-γ production by lymphocytes. Overall, this study showed that 10 mM of GLUT is able to modify immunomodulatory properties of MSCs.

PMID: 28593472 [PubMed - as supplied by publisher]

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An in vitro study of the long non-coding RNA TUG1 in tongue squamous cell carcinoma

Abstract

Background

This study sought to study the expression of the long non-coding RNA (lncRNA)taurine-upregulated gene 1 (TUG1) in tongue squamous cell carcinoma (TSCC) and reveal its possible function.

Methods

qRT-PCR was used to evaluate 27 samples of fresh TSCC tissues and adjacent normal tongue tissues. siRNA technology was employed to down-regulate TUG1 expression in CAL-27 and SCC-9 cell lines.The3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay was utilized to assess cell proliferation ability; apoptosis and cell cycle phases were analysed via flow cytometry.

Results

qRT-PCR findings indicated that the lncRNA TUG1 was up-regulated in TSCC tissues compared with adjacent normal tongue tissues(P<0.05). After TUG1 expression was down-regulated using siRNA technology, cell proliferation was significantly inhibited (P<0.05), and the number of cells in S phase was reduced(P<0.05).

Conclusion

The lncRNA TUG1 may represent a potential oncogene in TSCC.

This article is protected by copyright. All rights reserved.

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The experience of physicians in pharmacogenomic clinical decision support within eight German university hospitals.

Related Articles

The experience of physicians in pharmacogenomic clinical decision support within eight German university hospitals.

Pharmacogenomics. 2017 Jun 08;:

Authors: Hinderer M, Boeker M, Wagner SA, Binder H, Ückert F, Newe S, Hülsemann JL, Neumaier M, Schade-Brittinger C, Acker T, Prokosch HU, Sedlmayr B

Abstract
AIM: The aim of this study was to assess the physicians' attitude, their knowledge and their experience in pharmacogenomic clinical decision support in German hospitals.
MATERIALS & METHODS: We conducted an online survey to address physicians of 13 different medical specialties across eight German university hospitals. In total, 564 returned questionnaires were analyzed.
RESULTS: The remaining knowledge gap, the uncertainty of test reimbursement and the physicians' lack of awareness of existing pharmacogenomic clinical decision support systems (CDSS) are the major barriers for implementing pharmacogenomic CDSS into German hospitals. Furthermore, pharmacogenomic CDSS are most effective in the form of real-time decision support for internists.
CONCLUSION: Physicians in German hospitals require additional education of both genetics and pharmacogenomics. They need to be provided with access to relevant pharmacogenomic CDSS.

PMID: 28593816 [PubMed - as supplied by publisher]

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Homocysteine as a Diagnostic and Etiopathogenic Factor in Children with Autism Spectrum Disorder

Journal of Medicinal Food , Vol. 0, No. 0.


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Effect of Ursolic Acid on Metabolic Syndrome, Insulin Sensitivity, and Inflammation

Journal of Medicinal Food , Vol. 0, No. 0.


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Antithrombotic Effect of Fermented Ophiopogon japonicus in Thrombosis-Induced Rat Models

Journal of Medicinal Food , Vol. 0, No. 0.


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IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway

Abstract

Immunoglubulin (Ig)M responses directed to oxidative specific epitopes (OSEs) and nitric oxide (NO)-adducts are significantly associated with major depression and physio-somatic symptoms. End of term serum IgM responses to OSEs and NO-adducts were assayed in pregnant women with (n = 24) and without prenatal depression (n = 25) as well as in 24 non-pregnant women. Associations of IgM/IgA responses to Gram-negative gut commensal bacteria (leaky gut index) and IgA/IgM responses to tryptophan catabolites (TRYCATs) were analyzed. IgM responses to OSEs, but not NO-adducts, were significantly reduced at the end of term. There were no significant associations between IgM responses to OSEs and perinatal depression, whilst IgM responses to NO-adducts, especially NO-cysteinyl, were significantly associated with a lifetime major depression. IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and Citrobacter koseri. IgM responses to NO-adducts and OSEs, especially malondialdehyde and myristic acid, and C-reactive protein (CRP) were inversely associated with TRYCAT pathway activity, whilst a lifetime depression and Pseudomonas putida were positively associated. The attenuation of natural IgM-mediated responses to OSEs at the end of term may indicate lowered activity of this part of the compensatory (anti-)inflammatory reflex system and may be partly explained by lowered bacterial translocation. Increased IgM responses to NO-cysteinyl is a biomarker of lifetime depression and may be induced by bacterial translocation. Natural IgM-mediated autoimmune responses, increased nitrosylation and higher CRP levels may have negative regulatory effects on the TRYCAT pathway.

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Association of Helicobacter pylori infection with Parkinson's diseases: A meta-analysis

Abstract

Background

The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease.

Methods

A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot.

Results

Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively.

Conclusions

This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.

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Association of Helicobacter pylori infection with Parkinson's diseases: A meta-analysis

Abstract

Background

The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease.

Methods

A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot.

Results

Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively.

Conclusions

This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.

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New Cellular Imaging Paves Way for Cancer Treatment

Researchers at the Universities of York and Leiden have pioneered a technique which uses florescent imaging to track the actions of key enzymes in cancer, genetic disorders and kidney disease. Scientists hope this new development will aid drug design for new anti-cancer, inflammation and kidney disease treatments. (Source: eHealth News EU)

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Association of Helicobacter pylori infection with Parkinson's diseases: A meta-analysis

Abstract

Background

The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease.

Methods

A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot.

Results

Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively.

Conclusions

This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.

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Association of Helicobacter pylori infection with Parkinson's diseases: A meta-analysis

Abstract

Background

The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease.

Methods

A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot.

Results

Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively.

Conclusions

This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.

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Circonscript Subcutaneous Arteriovenous Malformation of the Head.

Related Articles

Circonscript Subcutaneous Arteriovenous Malformation of the Head.

Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2017 Mar 01;38(1):41-45

Authors: Mirchevski V, Zogovska E, Chaparoski A, Filipce V, Kostov M, Mirchevski MM

Abstract
The aim of this study is to show the various possibilities to treat this rare malformation, accentuating the results of the early surgical treatment before complications.
MATERIAL: The authors present 8 cases of patients with subcutaneous arteriovenous malformations, 5 females and 3 males (age of 7, 13, 19, 23, 27, 52 and 58 years) treated in the period of 1999 until 2015 at the Clinic for Neurosurgery and the Clinic for Plastic, Aesthetic and Reconstructive Surgery in Skopje, Republic of Macedonia. This malformation has been observed by the parents in the childhood, around the age of 3 years in all cases. Local red circonscripted nodule, soft, with manually discharging tendency and varicose dilated veins have been observed in all cases, deaf on both sides in one case, while in the older case, a cavernous sinus thrombosis caused unilateral exophthalmia, hyaline indurated ophthalmic vein, vertigo, arrhythmia, heart failure and bradypsychia have been observed. The size of the malformation has been from 2.5 to 7 cm. The diagnostics was done using CT, CT-angiography and digital angiography including external carotid angiography. Endocranial arterials peduncle was present in all cases.
RESULTS: Six cases underwent surgery, while two cases were treated with several treatments of endovascular embolization. The follow up has been ranged from 2 to 15 years. All surgically treated patients improved without recurrence, the exophthalmia, bradypsychia and the heart problems regressed, while in patients treated with endovascular non-complete occlusion the AVM decreased, but still remained.
IN CONCLUSION: The Surgical treatment remains a first option if it is possible, and as earlier as possible, while embolization is a useful tool in cases where a complete excision is not possible.

PMID: 28593889 [PubMed - in process]

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Clinical study of blood purification therapy in critical care in Japan: results from the survey research of the Japan Society for Blood Purification in Critical Care in 2013

Abstract

To clarify the clinical status of blood purification therapy (BPT) in critical care in Japan, we conducted a cohort study using data from a nationwide registry of the Japan Society for Blood Purification in Critical Care in 2013. We enrolled 2227 patients treated with BPT (female, 39.1%; mean age, 65.5 ± 12.1 years) in the intensive care units of 43 facilities. Patient characteristics, modes of BPT, and survival rate for each disease were investigated. In total, BPT was performed 3053 times. Continuous renal replacement therapy (CRRT) (57.9%) was the most common mode of BPT, followed by intermittent renal replacement therapy (20.2%) and direct hemoperfusion with the polymyxin B-immobilized fiber column (PMX-DHP) (11.5%). Nafamostat mesilate (84.9%) was most frequently used as the anticoagulant. The 28-day survival rate was 56.8% in all patients. The most common mode for acute kidney injury (AKI) and multiple organ failure was CRRT, while PMX-DHP and CRRT were most common for sepsis. There was no significant difference in survival rates among AKI stages 1–3. Survival rate (38.3%) was significantly lower in patients with acute lung injury (ALI) than in those with multiple organ failure (41.8%) and those with sepsis (46.6%). Multivariate regression analysis revealed that the APACHE II score and the presence of acute ALI and acute hepatic failure were significantly associated with death. This large-scale cohort study showed the clinical status of BPT in Japan. Further investigations are required to clarify the efficacy of BPT for critically ill patients.

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IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway

Abstract

Immunoglubulin (Ig)M responses directed to oxidative specific epitopes (OSEs) and nitric oxide (NO)-adducts are significantly associated with major depression and physio-somatic symptoms. End of term serum IgM responses to OSEs and NO-adducts were assayed in pregnant women with (n = 24) and without prenatal depression (n = 25) as well as in 24 non-pregnant women. Associations of IgM/IgA responses to Gram-negative gut commensal bacteria (leaky gut index) and IgA/IgM responses to tryptophan catabolites (TRYCATs) were analyzed. IgM responses to OSEs, but not NO-adducts, were significantly reduced at the end of term. There were no significant associations between IgM responses to OSEs and perinatal depression, whilst IgM responses to NO-adducts, especially NO-cysteinyl, were significantly associated with a lifetime major depression. IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and Citrobacter koseri. IgM responses to NO-adducts and OSEs, especially malondialdehyde and myristic acid, and C-reactive protein (CRP) were inversely associated with TRYCAT pathway activity, whilst a lifetime depression and Pseudomonas putida were positively associated. The attenuation of natural IgM-mediated responses to OSEs at the end of term may indicate lowered activity of this part of the compensatory (anti-)inflammatory reflex system and may be partly explained by lowered bacterial translocation. Increased IgM responses to NO-cysteinyl is a biomarker of lifetime depression and may be induced by bacterial translocation. Natural IgM-mediated autoimmune responses, increased nitrosylation and higher CRP levels may have negative regulatory effects on the TRYCAT pathway.

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Neuropsychological Profiles Differentiate Alzheimer Disease from Subcortical Ischemic Vascular Dementia in an Autopsy-Defined Cohort.

Related Articles

Neuropsychological Profiles Differentiate Alzheimer Disease from Subcortical Ischemic Vascular Dementia in an Autopsy-Defined Cohort.

Dement Geriatr Cogn Disord. 2017 Jun 09;44(1-2):1-11

Authors: Ramirez-Gomez L, Zheng L, Reed B, Kramer J, Mungas D, Zarow C, Vinters H, Ringman JM, Chui H

Abstract
BACKGROUND/AIMS: The aim of this study was to assess the ability of neuropsychological tests to differentiate autopsy-defined Alzheimer disease (AD) from subcortical ischemic vascular dementia (SIVD).
METHODS: From a sample of 175 cases followed longitudinally that underwent autopsy, we selected 23 normal controls (NC), 20 SIVD, 69 AD, and 10 mixed cases of dementia. Baseline neuropsychological tests, including Memory Assessment Scale word list learning test, control oral word association test, and animal fluency, were compared between the three autopsy-defined groups.
RESULTS: The NC, SIVD, and AD groups did not differ by age or education. The SIVD and AD groups did not differ by the Global Clinical Dementia Rating Scale. Subjects with AD performed worse on delayed recall (p < 0.01). A receiver operating characteristics analysis comparing the SIVD and AD groups including age, education, difference between categorical (animals) versus phonemic fluency (letter F), and the first recall from the word learning test distinguished the two groups with a sensitivity of 85%, specificity of 67%, and positive likelihood ratio of 2.57 (AUC = 0.789, 95% CI 0.69-0.88, p < 0.0001).
CONCLUSION: In neuropathologically defined subgroups, neuropsychological profiles have modest ability to distinguish patients with AD from those with SIVD.

PMID: 28595184 [PubMed - as supplied by publisher]

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Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration

Badran et al. demonstrate an essential contribution of biallelic RELA expression in protecting stromal and epithelial cells from TNF-mediated cell death in patients with chronic mucocutaneous ulceration.

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Association of Helicobacter pylori infection with Parkinson's diseases: A meta-analysis

Abstract

Background

The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease.

Methods

A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot.

Results

Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively.

Conclusions

This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.

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Association of Helicobacter pylori infection with Parkinson's diseases: A meta-analysis

Abstract

Background

The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease.

Methods

A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot.

Results

Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively.

Conclusions

This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.

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Distress from changes in physical appearance and support through information provision in male cancer patients.

Distress from changes in physical appearance and support through information provision in male cancer patients.

Jpn J Clin Oncol. 2017 Jun 08;:1-8

Authors: Nozawa K, Tomita M, Takahashi E, Toma S, Arai Y, Takahashi M

Abstract
Objective: This study aims to reveal the present situation of changes in physical appearance induced by treatment, the effects of these changes on social activities, and support from medical staff in male cancer patients.
Methods: A questionnaire survey was administered to 949 male patients (response rate: 90.1%) visiting the National Cancer Center Hospital in Tokyo over 3 days in January 2015.
Results: The final respondents were 823 patients (mean age: 65.3, standard deviation (SD) = 12.32). Fifty-two percent of the sample, and 79.4% of patients aged under 65 were employed. A total of 84.9% experienced changes in physical appearance, and the highest mean scores of psychological were observed for stoma (3.1) and skin eczema (2.9). A total of 66.4% reported no difference in daily life even after their physical appearance changed. However, patients younger than 65 years old who were employed experienced high social difficulties (12.5%). Many wanted to stop going to work and experienced severe distress in their social lives; 74.1% reported it is important to have the same physical appearance at work as before treatment. The majority of patients obtained information from doctors (35.2%) and consulted with their wife or partner (66.2%) regarding their appearance changes, and 5.7% did not have anyone to consult with.
Conclusion: This study clarified important aspects for supporting male cancer patients: timing, content, target audience and steps of information provision. Appropriate information provision from medical staff prior to treatment can be useful in preparing patients for physical appearance changes and decreasing the severity of symptoms.

PMID: 28595360 [PubMed - as supplied by publisher]

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Association of Helicobacter pylori infection with Parkinson's diseases: A meta-analysis

Abstract

Background

The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease.

Methods

A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot.

Results

Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively.

Conclusions

This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.

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Association of Helicobacter pylori infection with Parkinson's diseases: A meta-analysis

Abstract

Background

The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease.

Methods

A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot.

Results

Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively.

Conclusions

This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.

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Association of Helicobacter pylori infection with Parkinson's diseases: A meta-analysis

Abstract

Background

The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease.

Methods

A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot.

Results

Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively.

Conclusions

This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.

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The impact of exposure to antidepressant medications during pregnancy on neonatal outcomes: a review of retrospective database cohort studies

Abstract

Introduction

Concerns with prescription antidepressant use in pregnant women have instigated the examination of potential associations between fetal exposure to antidepressant medication and outcomes including preterm delivery, congenital malformations, perinatal and post-natal adverse events, persistent pulmonary hypertension, and mortality. The retrospective cohort model is an often utilized study design. The objective of this review is to evaluate the literature on antidepressant use in pregnancy conducted as retrospective cohorts in national/regional medical, or claims databases that assess neonatal and infant outcomes for agreement between studies, ultimately providing a methodological and outcomes summary for future scientific endeavors.

Methods

PubMed was searched for literature relating to antidepressant use and infant outcomes from the earliest available date through July 15, 2016. Studies with a retrospective cohort design and conducted in national/regional medical or claims databases were included. Searched outcomes included preterm delivery, congenital malformations, low birth weight, small for gestational age, persistent pulmonary hypertension of the newborn, and other select adverse events comprising low Apgar score (5 min), convulsions/seizures, respiratory distress/problems, fetal mortality, and infant mortality.

Results

Of the 784 studies identified, 36 retrospective cohort studies met eligibility criteria. An increase in preterm delivery and respiratory distress/problems and no increase in congenital malformation or fetal and infant death were associated with prenatal use of prescription antidepressants by majority consensus (at least 2/3 [67%] of studies).

Conclusions

While consensus indicates that perinatal prescription antidepressant use has consequences for the fetus and infant, there are notable inconsistencies in the literature. More investigations that address prenatal exposure to depression and other important covariates are needed.

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Clinical study of blood purification therapy in critical care in Japan: results from the survey research of the Japan Society for Blood Purification in Critical Care in 2013

Abstract

To clarify the clinical status of blood purification therapy (BPT) in critical care in Japan, we conducted a cohort study using data from a nationwide registry of the Japan Society for Blood Purification in Critical Care in 2013. We enrolled 2227 patients treated with BPT (female, 39.1%; mean age, 65.5 ± 12.1 years) in the intensive care units of 43 facilities. Patient characteristics, modes of BPT, and survival rate for each disease were investigated. In total, BPT was performed 3053 times. Continuous renal replacement therapy (CRRT) (57.9%) was the most common mode of BPT, followed by intermittent renal replacement therapy (20.2%) and direct hemoperfusion with the polymyxin B-immobilized fiber column (PMX-DHP) (11.5%). Nafamostat mesilate (84.9%) was most frequently used as the anticoagulant. The 28-day survival rate was 56.8% in all patients. The most common mode for acute kidney injury (AKI) and multiple organ failure was CRRT, while PMX-DHP and CRRT were most common for sepsis. There was no significant difference in survival rates among AKI stages 1–3. Survival rate (38.3%) was significantly lower in patients with acute lung injury (ALI) than in those with multiple organ failure (41.8%) and those with sepsis (46.6%). Multivariate regression analysis revealed that the APACHE II score and the presence of acute ALI and acute hepatic failure were significantly associated with death. This large-scale cohort study showed the clinical status of BPT in Japan. Further investigations are required to clarify the efficacy of BPT for critically ill patients.

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Association of Helicobacter pylori infection with Parkinson's diseases: A meta-analysis

Abstract

Background

The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease.

Methods

A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot.

Results

Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively.

Conclusions

This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.

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The impact of exposure to antidepressant medications during pregnancy on neonatal outcomes: a review of retrospective database cohort studies

Abstract

Introduction

Concerns with prescription antidepressant use in pregnant women have instigated the examination of potential associations between fetal exposure to antidepressant medication and outcomes including preterm delivery, congenital malformations, perinatal and post-natal adverse events, persistent pulmonary hypertension, and mortality. The retrospective cohort model is an often utilized study design. The objective of this review is to evaluate the literature on antidepressant use in pregnancy conducted as retrospective cohorts in national/regional medical, or claims databases that assess neonatal and infant outcomes for agreement between studies, ultimately providing a methodological and outcomes summary for future scientific endeavors.

Methods

PubMed was searched for literature relating to antidepressant use and infant outcomes from the earliest available date through July 15, 2016. Studies with a retrospective cohort design and conducted in national/regional medical or claims databases were included. Searched outcomes included preterm delivery, congenital malformations, low birth weight, small for gestational age, persistent pulmonary hypertension of the newborn, and other select adverse events comprising low Apgar score (5 min), convulsions/seizures, respiratory distress/problems, fetal mortality, and infant mortality.

Results

Of the 784 studies identified, 36 retrospective cohort studies met eligibility criteria. An increase in preterm delivery and respiratory distress/problems and no increase in congenital malformation or fetal and infant death were associated with prenatal use of prescription antidepressants by majority consensus (at least 2/3 [67%] of studies).

Conclusions

While consensus indicates that perinatal prescription antidepressant use has consequences for the fetus and infant, there are notable inconsistencies in the literature. More investigations that address prenatal exposure to depression and other important covariates are needed.

from ! Medicine by Alexandros G. Sfakianakis via als.fakia on Inoreader http://ift.tt/2t2pqjj
via IFTTT

Clinical study of blood purification therapy in critical care in Japan: results from the survey research of the Japan Society for Blood Purification in Critical Care in 2013

Abstract

To clarify the clinical status of blood purification therapy (BPT) in critical care in Japan, we conducted a cohort study using data from a nationwide registry of the Japan Society for Blood Purification in Critical Care in 2013. We enrolled 2227 patients treated with BPT (female, 39.1%; mean age, 65.5 ± 12.1 years) in the intensive care units of 43 facilities. Patient characteristics, modes of BPT, and survival rate for each disease were investigated. In total, BPT was performed 3053 times. Continuous renal replacement therapy (CRRT) (57.9%) was the most common mode of BPT, followed by intermittent renal replacement therapy (20.2%) and direct hemoperfusion with the polymyxin B-immobilized fiber column (PMX-DHP) (11.5%). Nafamostat mesilate (84.9%) was most frequently used as the anticoagulant. The 28-day survival rate was 56.8% in all patients. The most common mode for acute kidney injury (AKI) and multiple organ failure was CRRT, while PMX-DHP and CRRT were most common for sepsis. There was no significant difference in survival rates among AKI stages 1–3. Survival rate (38.3%) was significantly lower in patients with acute lung injury (ALI) than in those with multiple organ failure (41.8%) and those with sepsis (46.6%). Multivariate regression analysis revealed that the APACHE II score and the presence of acute ALI and acute hepatic failure were significantly associated with death. This large-scale cohort study showed the clinical status of BPT in Japan. Further investigations are required to clarify the efficacy of BPT for critically ill patients.

from ! Medicine by Alexandros G. Sfakianakis via als.fakia on Inoreader http://ift.tt/2s4Dpbt
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Association of Helicobacter pylori infection with Parkinson's diseases: A meta-analysis

Abstract

Background

The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease.

Methods

A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot.

Results

Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively.

Conclusions

This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.

from ! Medicine by Alexandros G. Sfakianakis via als.fakia on Inoreader http://ift.tt/2rdH8PJ
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Association of Helicobacter pylori infection with Parkinson's diseases: A meta-analysis

Abstract

Background

The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease.

Methods

A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot.

Results

Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively.

Conclusions

This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.

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Neuropsychological Profiles Differentiate Alzheimer Disease from Subcortical Ischemic Vascular Dementia in an Autopsy-Defined Cohort.

Related Articles

Neuropsychological Profiles Differentiate Alzheimer Disease from Subcortical Ischemic Vascular Dementia in an Autopsy-Defined Cohort.

Dement Geriatr Cogn Disord. 2017 Jun 09;44(1-2):1-11

Authors: Ramirez-Gomez L, Zheng L, Reed B, Kramer J, Mungas D, Zarow C, Vinters H, Ringman JM, Chui H

Abstract
BACKGROUND/AIMS: The aim of this study was to assess the ability of neuropsychological tests to differentiate autopsy-defined Alzheimer disease (AD) from subcortical ischemic vascular dementia (SIVD).
METHODS: From a sample of 175 cases followed longitudinally that underwent autopsy, we selected 23 normal controls (NC), 20 SIVD, 69 AD, and 10 mixed cases of dementia. Baseline neuropsychological tests, including Memory Assessment Scale word list learning test, control oral word association test, and animal fluency, were compared between the three autopsy-defined groups.
RESULTS: The NC, SIVD, and AD groups did not differ by age or education. The SIVD and AD groups did not differ by the Global Clinical Dementia Rating Scale. Subjects with AD performed worse on delayed recall (p < 0.01). A receiver operating characteristics analysis comparing the SIVD and AD groups including age, education, difference between categorical (animals) versus phonemic fluency (letter F), and the first recall from the word learning test distinguished the two groups with a sensitivity of 85%, specificity of 67%, and positive likelihood ratio of 2.57 (AUC = 0.789, 95% CI 0.69-0.88, p < 0.0001).
CONCLUSION: In neuropathologically defined subgroups, neuropsychological profiles have modest ability to distinguish patients with AD from those with SIVD.

PMID: 28595184 [PubMed - as supplied by publisher]

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L-Glutamine in vitro Modulates some Immunomodulatory Properties of Bone Marrow Mesenchymal Stem Cells.

Related Articles

L-Glutamine in vitro Modulates some Immunomodulatory Properties of Bone Marrow Mesenchymal Stem Cells.

Stem Cell Rev. 2017 Jun 07;:

Authors: Dos Santos GG, Hastreiter AA, Sartori T, Borelli P, Fock RA

Abstract
Glutamine (GLUT) is a nonessential amino acid that can become conditionally essential under stress conditions, being able to act in the modulation of the immune responses. Mesenchymal stem cells (MSCs) are known to their capability in the modulation of immune responses through cell-cell contact and by the secretion of soluble factors. Considering that GLUT is an immunonutrient and little is known about the influence of GLUT on the capability of MSCs to modulate immune cells, this work aims to investigate how variations in GLUT concentrations in vitro could affect some immunomodulatory properties of MSCs. In order to evaluate the effects of GLUT on MSCs immunomodulatory properties, cell proliferation rates, the expression of NFκB and STAT-3, and the production of IL-1β, IL-6, IL-10, TGF-β and TNF-α by MSCs were assessed. Based on our findings, GLUT at high doses (10 mM) augmented the proliferation of MSCs and modulated immune responses by decreasing levels of pro-inflammatory cytokines, such as IL-1β and IL-6, and by increasing levels of anti-inflammatory cytokines IL-10 and TGF-β. In addition, MSCs cultured in higher GLUT concentrations (10 mM) expressed lower levels of NF-κB and higher levels of STAT-3. Furthermore, conditioned media from MSCs cultured at higher GLUT concentrations (10 mM) reduced lymphocyte and macrophage proliferation, increased IL-10 production by both cells types, and decreased IFN-γ production by lymphocytes. Overall, this study showed that 10 mM of GLUT is able to modify immunomodulatory properties of MSCs.

PMID: 28593472 [PubMed - as supplied by publisher]

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An enhancement of antimicrobial efficacy of biogenic and ceftriaxone-conjugated silver nanoparticles: green approach

Abstract

Of the various methods explored for the synthesis of nanoparticles, biogenesis of silver nanoparticles (AgNPs) received great attention due to their versatile properties. In this report, Daucus carota extract was used for the synthesis of AgNPs and ceftriaxone was conjugated with AgNPs to enhance their antimicrobial efficacy. The conjugated and unconjugated AgNPs were characterized by adopting UV-Vis spectroscopy, FTIR, AFM, DLS, and TEM, which revealed the SPR peak at 420 nm and spherical shaped nanoparticles of 20 nm size, respectively. The antimicrobial efficacies of the unconjugated AgNPs and ceftriaxone-conjugated AgNPs were tested against ceftriaxone-resistant human pathogens, Bacillus cereus, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The ceftriaxone-conjugated AgNPs showed high inhibitory action (23 mm) than the unconjugated AgNPs (18 mm) at the concentration of 50 μg/mL. Both the unconjugated and ceftriaxone-conjugated AgNPs were found to be non-toxic on EAC cells at 50 μg/mL. The dose-dependent cytotoxic activities were observed on increasing the concentration of the AgNPs. The ceftriaxone-conjugated AgNPs showed high activity than the unconjugated AgNPs. The enhanced activity could be useful to treat ceftriaxone-resistant human pathogens.

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Citric acid enhanced the antioxidant defense system and chromium uptake by Lemna minor L. grown in hydroponics under Cr stress

Abstract

Phytoextraction is a cost-effective and eco-friendly technique for the removal of pollutants, mainly heavy metal(loids) especially from polluted water and metal-contaminated soils. The phytoextraction of heavy metals is, in general, limited due to the low availability of heavy metals in the growth medium. Organic chelators can help to improve the phytoextraction by increasing metal mobility and solubility in the growth medium. The present research was carried out to examine the possibility of citric acid (CA) in improving chromium (Cr) phytoextraction by Lemna minor (duckweed). For this purpose, healthy plants were collected from nearby marsh and grown in hydroponics under controlled conditions. Initial metal contents of both marsh water and plant were measured along with physico-chemical properties of the marsh water. Different concentrations of Cr and CA were applied in the hydroponics in different combinations after defined intervals. Continuous aeration was supplied and pH maintained at 6.5 ± 0.1. Results showed that increasing concentration of Cr significantly decreased the plant biomass, photosynthetic pigments, leaf area, and antioxidant enzyme activities (like catalase, ascorbate peroxidase, superoxide dismutase, peroxidase). Furthermore, Cr stress increased the Cr concentrations, electrolyte leakage, hydrogen peroxide, and malondialdehyde contents in plants. The addition of CA alleviated the Cr-induced toxicity in plants and further enhanced the Cr uptake and its accumulation in L. minor. The addition of CA enhanced the Cr concentration in L. minor by 6.10, 26.5, 20.5, and 20.2% at 0, 10, 100, and 200 μM Cr treatments, respectively, compared to the respective Cr treatments without CA. Overall, the results of the present study showed that CA addition may enhance the Cr accumulation and tolerance in L. minor by enhancing the plant growth and activities of antioxidant enzymes.

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Intelligent and integrated techniques for coalbed methane (CBM) recovery and reduction of greenhouse gas emission

Abstract

Coalbed methane (CBM) recovery is a crucial approach to realize the exploitation of a clean energy and the reduction of the greenhouse gas emission. In the past 10 years, remarkable achievements on CBM recovery have been obtained in China. However, some key difficulties still exist such as long borehole drilling in complicated geological condition, and poor gas drainage effect due to low permeability. In this study, intelligent and integrated techniques for CBM recovery are introduced. These integrated techniques mainly include underground CBM recovery techniques and ground well CBM recovery techniques. The underground CBM recovery techniques consist of the borehole formation technique, gas concentration improvement technique, and permeability enhancement technique. According to the division of mining-induced disturbance area, the ground well arrangement area and well structure type in mining-induced disturbance developing area and mining-induced disturbance stable area are optimized to significantly improve the ground well CBM recovery. Besides, automatic devices such as drilling pipe installation device are also developed to achieve remote control of data recording, which makes the integrated techniques intelligent. These techniques can provide key solutions to some long-term difficulties in CBM recovery.

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Distribution of phosphorus-solubilizing bacteria in relation to fractionation and sorption behaviors of phosphorus in sediment of the Three Gorges Reservoir

Abstract

Phosphorus (P) fractionation and sorption behavior as well as the abundance and community composition of phosphorus-solubilizing bacteria (PSB) in sediments, including inorganic phosphate-solubilizing bacteria (IPB) and organic phosphate-mineralizing bacteria (OPB), were investigated in 27 sampling sites of five sections in the Three Gorges Reservoir (TGR) in December 2012. The calcium-bound phosphorus (CaCO₃∼P) accounted for the largest part for P fractions in the sediment of TGR, which was paralleled with IPB outnumbering OPB. Furthermore, some PSB isolates, such as Micromonospora sp., Aminobacter sp., and Arthrobacter sp., were shared by the IPB and OPB. Thus, some IPB species functioned as OPB and vise versa, which could be further reflected by a negative and significant relationship between PSB (IPB + OPB) number and content of CaCO₃∼P together with acid-soluble organic phosphorus (ASOP). Spatially, the highest ASOP content in the section Mudong and the highest CaCO₃∼P plus iron-bound phosphorus (Fe(OOH)∼P) as well as equilibrium phosphorus concentration (EPC₀) in the sections of Yunyang and Zigui due to sediment sequestration by the dam, as well as the positive relationship between EPC₀ and the ratios of different phosphorus species and phosphorus sorption maximum (Q _max), jointly indicated pathway diversification and potential risk of phosphorus release mediated by PSB in TGR.

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Microbial community redundancy in anaerobic digestion drives process recovery after salinity exposure

Anaerobic digestion of high-salinity wastewaters often results in process inhibition due to the susceptibility of the methanogenic archaea. The ability of the microbial community to deal with increased salinity levels is of high importance to ensure process perseverance or recovery after failure. The exact strategy of the microbial community to ensure process endurance is, however, often unknown. In this study, we investigated how the microbial community is able to recover process performance following a disturbance through the application of high-salinity molasses wastewater. After a stable start-up, methane production quickly decreased from 625 +/- 17 to 232 35 mL CH4 L-1 d(-1) with a simultaneous accumulation in volatile fatty acids up to 20.5 +/- 1.4 g COD L-1, indicating severe process disturbance. A shift in feedstock from molasses wastewater to waste activated sludge resulted in complete process recovery. However, the bacterial and archaeal communities did not return to their original composition as before the disturbance, despite similar process conditions. Microbial community diversity was recovered to similar levels as before disturbance, which indicates that the metabolic potential of the community was maintained. A mild increase in ammonia concentration after process recovery did not influence methane production, indicating a well-balanced microbial community. Hence, given the change in community composition following recovery after salinity disturbance, it can be assumed that microbial community redundancy was the major strategy to ensure the continuation of methane production, without loss of functionality or metabolic flexibility.

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Detection of acidification limit in anaerobic membrane bioreactors at ambient temperature

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Alectinib Touted as New Standard of Care for ALK-Positive Lung Cancer

The second-generation ALK-inhibitor alectinib should be the new standard of care for first-line treatment of ALK-positive non –small-cell lung cancer, according to a new study. (Source: CancerNetwork)

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